• Title/Summary/Keyword: foot-andmouth disease virus

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Selection of model viruses for foot-and-mouth disease virus-related-experiments (구제역 바이러스를 대체할 모델 바이러스 선별)

  • Kim, Tae-Hwan;Herath, Thilina U. B.;Kim, Jae-Hoon;Lee, Kwang-Nyeong;Park, Jong-Hyeon;Kim, Chul-Joong;Lee, Jong-Soo
    • Korean Journal of Microbiology
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    • v.53 no.4
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    • pp.304-308
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    • 2017
  • Researchers have comparatively fewer opportunities to conduct experiments on foot-and-mouth disease virus (FMDV), owing to the limited availability of biosafety level 3 facilities. Bovine rhinovirus (BRV) and human rhinovirus (HRV), which are genetically closely related to FMDV, have been evaluated in this study as model viruses for FMDV. To discover whether BRV and HRV have similar physicochemical properties as FMDV, virus susceptibility tests have been performed in different physical (pH and heat) and chemical (acidic/alkaline solutions and commercial disinfectants) conditions in vitro. Our data revealed that the physicochemical characteristics of BRV and HRV were nearly similar to those of FMDV.