• Title/Summary/Keyword: focused

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Characteristics of Focused Ultrasound Mediated Blood-Brain Barrier Opening in Magnetic Resonance Images

  • Kyung Won Chang;Seung Woo Hong;Won Seok Chang;Hyun Ho Jung;Jin Woo Chang
    • Journal of Korean Neurosurgical Society
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    • v.66 no.2
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    • pp.172-182
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    • 2023
  • Objective : The blood-brain barrier (BBB) is an obstacle for molecules to pass through from blood to the brain. Focused ultrasound is a new method which temporarily opens the BBB, which makes pharmaceutical delivery or removal of neurodegenerative proteins possible. This study was demonstrated to review our BBB opening procedure with magnetic resonance guided images and find specific patterns in the BBB opening. Methods : In this study, we reviewed the procedures and results of two clinical studies on BBB opening using focused ultrasound regarding its safety and clinical efficacy. Magnetic resonance images were also reviewed to discover any specific findings. Results : Two clinical trials showed clinical benefits. All clinical trials demonstrated safe BBB opening, with no specific side effects. Magnetic resonance imaging showed temporary T1 contrast enhancement in the sonication area, verifying the BBB opening. Several low-signal intensity spots were observed in the T2 susceptibility-weighted angiography images, which were also reversible and temporary. Although these spots can be considered as microbleeding, evidence suggests these are not ordinary microbleeding but an indicator for adequate BBB opening. Conclusion : Magnetic resonance images proved safe and efficient BBB opening in humans, using focused ultrasound.

Decision Analysis with Value Focused Thinking as a Methodology to Access Air Force Officer Retention Alternatives

  • Moon Sang-ho
    • Proceedings of the Korean Statistical Society Conference
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    • 2004.11a
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    • pp.105-110
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    • 2004
  • Decision Analysis(DA) using Value Focused Thinking(VFT) can be an excellent process to deal with hard decisions. The intent of this research is to provide better understanding of the United States Air Force(USAF) officer retention problem. This thesis effort involves building a VFT model to find out more effective alternatives in retaining pilots and non pilots. This model, in conjunction with the results of the post analysis, shows an example of the application of a VFT approach to the USAF officer retention problem.

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Ego-Resilience and Stress Coping Styles of Adolescents (청소년의 자아탄력성과 스트레스 대처방식)

  • Park, Yeon-Seong;Hyun, Eun-Min
    • Journal of Families and Better Life
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    • v.25 no.6
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    • pp.83-94
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    • 2007
  • The purpose of this study was to examine the relationships between ego- resilience and stress coping styles of adolescents. The study also tried to identify differences on stress coping styles based on the level of ego- resilience of adolescents. Ego-resilience showed positive correlations with problem-focused and social support seeking coping styles and a negative correlation with an emotion-focused coping style. Canonical Correlation analysis revealed that self-confidence among four sub-domains of ego-resilience made the most outstanding contributions in predicting stress coping styles of adolescents. The problem-focused coping style had the highest correlation with ego-resilience among the four coping styles. The group of adolescents who had a higher level of ego-resilience reported more problem-focused and social support-seeking coping styles in stressful situations. The results of this study suggested that development of ego-resilience of adolescents who were in the midst of transitions and adjustment problems was important for effective coping strategies.

Family Stress and Psychological Well-being of Single Mothers and Their Children (편모자녀의 가족스트레스와 심리적 복지)

  • Kim, Oh Nam
    • Korean Journal of Child Studies
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    • v.20 no.1
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    • pp.99-114
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    • 1999
  • The purpose of this study was to analyze general trends in family resources, stressors, stress perception, coping styles, and psychological well-being and to investigate the effects of socio-demographic variables and family stress influencing psychological well-being in single mother families. The subjects were the 284 children and their mothers living in Kwangju. The major findings were that: (1) Family resources and stress perceptions were lower than the median. Single mother children's stressors, problem-solving focused coping, life satisfaction, and depression were higher than the median. (2) Children's life satisfaction was influenced by stress perceptions, problem-solving focused coping, and family strength. Children's depression was influenced by stress perceptions, emotion-focused coping, family strength, and problem-solving focused coping.

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The Relation of Parents' Emotion Socialization to the Development of Emotion in Their Young Children (부모의 정서사회화와 유아의 정서성 발달의 관계)

  • Lee, Kang Yi;Choi, In Suk;Sung, Miyoung
    • Korean Journal of Child Studies
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    • v.28 no.3
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    • pp.187-199
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    • 2007
  • The relation of parents' emotion socialization to emotionality in their 5-year-old children was studied in 106 mothers and 105 fathers. They reported on their own family-related emotional expressiveness and on their children's negative emotions by questionnaires; mothers rated children on both positive and negative emotionality. Results showed that mothers expressed positive and negative emotions more frequently, and mothers showed more distress, expressive encouragement, and problem-focused reactions to children's negative emotions than fathers. Mothers' emotional expressiveness was related to children's emotionality, whereas only fathers' negative emotional expressiveness was related to children's negative emotionality. Mothers' distress and punitive reactions were associated with children's positive and negative emotionality. Mothers' problem-focused and emotion-focused and fathers' problem-focused reactions were associated with children's positive emotionality.

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Manufacturing Mechanism of FIB-CVD using Focused Ion Beam (집속이온빔의 가공 공정 메카니즘 연구)

  • 강은구;최병열;이석우;홍원표;최헌종
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2004.10a
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    • pp.925-928
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    • 2004
  • The application of focused ion beam (FIB) technology in micro/nano machining has become increasingly popular. Its use in micro/nano machining has advantages over contemporary photolithography or other micro/nano machining technologies such as small feature resolution, the ability to process without masks and being accommodating for a variety of materials and geometries. This paper was carried out some experiments and verifications of mechanism on FIB-CVD using SMI8800 made by Seiko. FIB-CVD has in fact proved to be commercially useful for repair processes because the beam can be focused down to 0.05$\mu\textrm{m}$ dimensions and below and because the same tool can be used to sputter off material with sub-micrometer precision simply by turning off the gas ambient. Recently the chemical vapour deposition induced ion beam has been required more deposition rate and accurate pattern because of trying to manufacture many micro and nano parts. Therefore this paper suggested the optimization parameters and discussed some mechanism of chemical vapour deposition induced ion beam on FIB-CVD for simple pattern.

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The Effects of Social Support and Coping Styles on Quality of Life in Abused Wives (사회적 지지 및 대처방식이 아내학대 피해여성의 삶의 질에 미치는 영향)

  • Kim, Jeong-Ran;Kim, Kyeong-Shin
    • Korean Journal of Human Ecology
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    • v.16 no.1
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    • pp.27-37
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    • 2007
  • The purposes of present study were to investigate relationships among wife abuse, social support, coping styles, and quality of life, and to examine how abused wives' social support influences coping and quality of life. The subjects were consisted of 144 abused wives in Gwangju, Korea. The major findings are as follows; 1. Problem-focused coping and seeking of social support were different by the wife abuse. 2. Abused wives' quality of life was positively related monthly income, social support, problem-focused coping, and wishful thinking coping. 3. The results of the hierarchical regression analysis indicated that the social support had the strongest impact on abused wives' quality of life. And the problem-focused coping, monthly income, and emotion-focused coping. These variables accounted for 32% of variance of abused wives' quality of life.

A study on the Real time Observation of Microscopic Change with Focused Laser Beam (집속된 레이저빔을 이용한 미소변화의 실시간 관찰에 관한 연구)

  • Jang, Heui-Sung;Lee, Hyuk
    • Proceedings of the KIEE Conference
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    • 1993.11a
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    • pp.356-358
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    • 1993
  • With a focused laser beam, we make a microscopic change on a thin film, and organize the overall system that can observe the change with a microscope. This system utilizes the energy of a laser beam which is focused by a simple lense system. That is a laser beam which has its waist at working distance of a lense. The microscopic change induced by the energy of laser beam focused through a lense can be observed in real time. The experiment with this system shows that the 10mW He-Ne 632.8nm laser can change the black vinyl instantaneously.

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Ion Beam Induced Micro/Nano Fabrication: Shape Fabrication (이온빔을 이용한 마이크로/나노 가공: 형상가공)

  • Kim, Heung-Bae;Hobler, Gerhard
    • Journal of the Korean Society for Precision Engineering
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    • v.24 no.10
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    • pp.109-116
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    • 2007
  • Focused ion beams are a potential tool for micro/nano structure fabrication while several problems still have to be overcome. Redeposition of sputtered atoms limits the accurate fabrication of micro/nano structures. The challenge lies in accurately controlling the focused ion beam to fabricate various arbitrary curved shapes. In this paper a basic approach for the focused ion beam induced direct fabricate of fundamental features is presented. This approach is based on the topography simulation which naturally considers the redeposition of sputtered atoms and sputtered yield changes. Fundamental features such as trapezoidal, circular and triangular were fabricated with this approach using single or multiple pass box milling. The beam diameter(FWHM) and maximum current density are 68 nm and $0.8 A/cm^2$, respectively. The experimental investigations show that the fabricated shape is well suited for the pre-designed fundamental features. The characteristics of ion beam induced direct fabrication and shape formation will be discussed.

Improvement of the Carbon Nanotube Tip by Focused Ion Beam and it Performance Evaluation (탄소나노튜브 팁의 집속이온빔에 의한 개선 및 성능 평가)

  • Han, Chang-Soo;Shin, Young-Hyun;Yoon, Yu-Hwan;Lee, Eung-Sug
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.31 no.1 s.256
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    • pp.139-144
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    • 2007
  • This paper presents development of carbon nanotube (CNT) tip modified by focused ion beam (FIB) and experimental results in non-contact mode of atomic force microscopy (AFM) using fabricated tip. We used an electric field which causes dielectrophoresis, to align and deposit CNTs on a conventional silicon tip. The morphology of the fabricated CNT tip was then modified into a desired shape using focused ion beam. We measured anodic aluminum oxide sample and trench structure to estimate the performance of FIB-modified tip and compared with those of conventional Si tip. We demonstrate that FIB modified tip in non contact mode had superior characteristics than conventional tip in the respects of wear, image resolution and sidewall measurement.