• Journal of Korean Neurosurgical Society
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• 제54권1호
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• pp.1-7
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• 2013

Objective : This study was undertaken in the belief that the atypical antipsychotic drug quetiapine could prevent apoptosis in the penumbra region following ischemia, taking into account findings that show 5-hydroxytryptamine-2 receptor blockers can prevent apoptosis. Methods : We created 5 groups, each containing 6 animals. Nothing was done on the K-I group used for comparisons with the other groups to make sure adequate ischemia had been achieved. The K-II group was sacrificed on the 1st day after transient focal cerebral ischemia and the K-III group on the 3rd day. The D-I group was administered quetiapine following ischemia and sacrificed on the 1st day while the D-II group was administered quetiapine every day following the ischemia and sacrificed on the 3rd day. The samples were stained with the immunochemical TUNEL method and the number of apoptotic cells were counted. Results : There was a significant difference between the first and third day control groups (K-II/K-III : p=0.004) and this indicates that apoptotic cell death increases with time. This increase was not encountered in the drug groups (D-I/D-II : p=1.00). Statistical analysis of immunohistochemical data revealed that quetiapine decreased the apoptotic cell death that normally increased with time. Conclusion : Quetiapine is already in clinical use and is a safe drug, in contrast to many substances that are used to prevent ischemia and are not normally used clinically. Our results and the literature data indicate that quetiapine could help both as a neuronal protector and to resolve neuropsychiatric problems caused by the ischemia in cerebral ischemia cases.

• 한국임상수의학회지
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• 제26권3호
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• pp.259-262
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• 2009

Focal adnexal dysplasia(FAD) is a rare non-neoplastic lesion of adnexal appendages that occurs in dogs and has good prognosis. We report a case in which FAD diagnosis was favored by its histopathological features. A 8-year-old, castrated male American cocker spaniel dog presented with papillomatous masses on the distal phalanx of left forelimb. Histopathologically, the stroma was sharply demarcated from the adjacent dermis and subcutis. The adnexa was surrounded and interspersed with abundant, hyalinized collagen and the numerous sebaceous lobules distributed haphazardly around hair follicles, which is thickened, dilated and tortuous with abundant keratin. Epidermis was acanthotic. Proliferative lesions of the skin region are very common with similar gross features, thus the basic histopathological examination supported by additional diagnostic methods allow to establish the definitive diagnosis in most cases of cutaneous tumor or tumor-like lesions. And it is important that physicians and pathologists are aware of this unusual tumour-like nonneoplastic lesion.

• 한국컴퓨터그래픽스학회논문지
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• 제30권1호
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• pp.11-17
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• 2024

폐암은 크기가 다양하고 유사한 밝기값을 갖는 주변 구조물이 존재하기 때문에 흉부 CT 영상에서 폐암을 정확하게 분할하는 것이 어렵다. 이러한 문제를 해결하기 위해 본 논문에서는 심층 감독을 포함하고 UNet3+를 백본으로 사용하는 폐암 분할 네트워크를 제안한다. 또한, 픽셀 기반, 영역 기반 및 형태 기반의 3가지 구성 요소로 이루어진 하이브리드 병변 초점 손실함수를 제안한다. 이를 통해 배경에 비해 작은 영역을 차지하는 폐암 부분에 집중하고, 불명확한 경계를 처리하는데 도움이 되는 형태 정보를 고려할 수 있다. 제안 방법을 UNet 및 UNet3+와 비교 실험을 통해 검증하였고, 제안 방법은 모든 폐암 크기에서 DSC 측면에서 가장 우수한 성능을 보였다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2000년도 제1회 학술대회 논문집
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• pp.161-162
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• 2000

We propose multi-layer aspheric lenticular lens for rear projection screen to provide wide viewing angle. Each pitch of lenticular lens sheet is divided by three region and image light from projection optical system is propagated widely on each region due to different focal point. Besides, to improve vertical viewing angle of screen, we propose glass bead embedded screen on observer side of lenticular lens.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.305.1-305.1
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• 2002

The temporal profiles of the changes of dopaminergic cell and microglial activation induced by transient cerebral ischemia was investigated in the substantia nigral region which lay outside ischemic areas of rat brain after middle cerebral artery occlusion (MCAO). Transient cerebral ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 2 hand reperfusion was continued for 1, 2. 3. 7. 10. 14. 30, 60. and 120 days. Activated microglial cells were visualized with immunohistochmistry using OX-43 antibody. (omitted)

• 방송공학회논문지
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• 제17권5호
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• pp.789-807
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• 2012

본 논문은 시청안전성을 위한 콘텐츠 제작 가이드라인을 최종 목표로 하여, 콘텐츠의 내용이나 정황과 함께 시청자의 불편감을 유발하는 변위(disparity)의 다양한 요인들을 찾아내는 것을 목적으로 한다. 그 방법으로 네 가지의 스테레오스코픽 콘텐츠를 피험자들이 시청하게 하고 시청자로 하여금 불편감을 느끼는 기간 동안 키를 누르게 하여 실험적인 데이터를 획득한다. 콘텐츠에 대해서는 초점과 그 주위(관심영역, region of interest), 그리고 화면전체에 대하여 변위의 크기와 변화 정도에 대한 데이터를 도출한다. 각 콘텐츠에 대하여 준비한 두 종류의 데이터를 갖고 실제로 콘텐츠를 시청하면서 피험자들이 불편감을 느낀 부분을 분석하여 그 요인들을 찾는다. 모든 콘텐츠에 대한 요인들을 종합적으로 분석하여 요인별 강도를 도출한다. 분석결과는 강도가 큰 요인별부터 실제 콘텐츠의 내용과 더불어 설명한다. 그 결과는 이미 짐작할 수 있는 요인들뿐만 아니라 알려져 있지 않은 요인들까지 실증적으로 보인다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권6호
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• pp.481-485
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• 2009

Cemento-osseous dysplasias are a group of disorders known to originate from periodontal ligament tissues and involve, essentially, the same pathological process. They are usually classified, depending on their extent and radiographic appearances, into three main groups. Periapical cemental dysplasia predominantly involves the periapical region of the anterior mandible. Florid cemento-osseous dysplasia presents with multifocal lesions in the tooth bearing or edentulous areas of the maxilla and mandible, often occurring bilaterally with symmetric involvement. Focal cemento-osseous dysplasia exhibits a single site of involvement in any tooth bearing or edentulous area of the mandible or maxilla, with the posterior mandible representing the most common site. We report the clinical, radiographic and histological findings of 3 types of cemento-osseous dysplasia with a review of literatures.

• 한국어병학회지
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• 제28권3호
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• pp.145-155
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• 2015

The pathogenecity of atypical Aeromonas salmonicida was studied in healthy Oreochromis niloticus. Inoculum at concentration of $1.5{\times}10^8CFU/ml$ and $3{\times}10^8CFU/ml$ was injected into healthy fish through intramuscular and intraperitoneal injections. Experimentally infected Oreochromis niloticus showed ulceration at the dorsal musculature and trunk region in addition to black coloration, congested gills, exophthalmia, and ocular hemorrhage. Congested liver and kidney were recorded in post-mortem examination. Mortality of the experimentally infected Oreochromis niloticus reached 100% after intramuscular injection at concentration of $3{\times}10^8CFU/ml$. Histopathological investigation of infected organs was also performed. There was a focal area of bundles of skeletal musculature showing hyalinization. In addition, hyperplasia, congestion, and fusion were noticed in the gill lamellae. There was also congestion in the blood vessels in the ocular chamber. Severe congestion was also noticed in the central vein of liver associated with focal aggregation of the melanin pigmented cells in the parenchyma. Degenerative changes were noticed in the epithelial cells lining of kidney tubules. Plant extracts carvacrol and its biological precursor cymene were found to be effective in treating experimentally infected Oreochromis niloticus at concentration of 100 or 200 ppm.

• Journal of Korean Neurosurgical Society
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• 제45권3호
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• pp.176-178
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• 2009

Traumatic brainstem hemorrhage after blunt head injury is an uncommon event. The most frequent site of hemorrhage is the midline rostral brainstem. The prognosis of these patients is poor because of its critical location. We experienced a case of traumatic brainstem hemorrhage. A 41-year-old male was presented with drowsy mentality and right hemiparesis after blunt head injury. Plain skull radiographs and brain computerized tomography scans revealed a depressed skull fracture, epidural hematoma, and hemorrhagic contusion in the right parieto-occipital region. But, these findings did not explain the right hemiparesis. T2-weighted magnetic resonance (MR) image of the cervical spine demonstrated a focal hyperintense lesion in the left pontomedullary junction. Brain diffusion-weighted and FLAIR MR images showed a focal hyperintensity in the ventral pontomedullary lesion and it was more prominent in the left side. His mentality and weakness were progressively improved with conservative treatment. We should keep in mind the possibility of brainstem hemorrhage if supratentorial lesions or spinal cord lesions that caused neurological deficits in the head injured patients are unexplainable.

• 한국광학회지
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• 제5권1호
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• pp.37-44
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• 1994

유도 브릴루앙 반사광을 고출력 레이저에 응용할 때 요구되는 반사광 특성이 실험적으로 조사되었다. 집속 렌즈의 초점거리에 따른 유도 브릴루앙 반사광의 peak power 반사율과 위상공액도가 측정되었다. 또한 반사광 가운데 펄스압축된 부분만의 위상공액도가 측정되었다. 초점거리가 긴 경우(f=100cm) 반사광의 peak power가 입사광의 약 2배에 이르렀다. 이때 반사광 중에서 압축된 선두펄스만의 위상공액도는 약 90%로 다른 시간의 펄스보다 위상공액도가 우수했다. 공간적으로는 유도 브릴루앙 이득이 가장 큰 광축부분의 바사관이 최대의 펄스압축, peak power 반사율, 위상공액도를 보여서 유도 브릴루앙 산란을 응용할 때 가장 유용한 부분으로 확인되었다.