• Journal of Korean Neurosurgical Society
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• v.54 no.1
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• pp.1-7
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• 2013

Objective : This study was undertaken in the belief that the atypical antipsychotic drug quetiapine could prevent apoptosis in the penumbra region following ischemia, taking into account findings that show 5-hydroxytryptamine-2 receptor blockers can prevent apoptosis. Methods : We created 5 groups, each containing 6 animals. Nothing was done on the K-I group used for comparisons with the other groups to make sure adequate ischemia had been achieved. The K-II group was sacrificed on the 1st day after transient focal cerebral ischemia and the K-III group on the 3rd day. The D-I group was administered quetiapine following ischemia and sacrificed on the 1st day while the D-II group was administered quetiapine every day following the ischemia and sacrificed on the 3rd day. The samples were stained with the immunochemical TUNEL method and the number of apoptotic cells were counted. Results : There was a significant difference between the first and third day control groups (K-II/K-III : p=0.004) and this indicates that apoptotic cell death increases with time. This increase was not encountered in the drug groups (D-I/D-II : p=1.00). Statistical analysis of immunohistochemical data revealed that quetiapine decreased the apoptotic cell death that normally increased with time. Conclusion : Quetiapine is already in clinical use and is a safe drug, in contrast to many substances that are used to prevent ischemia and are not normally used clinically. Our results and the literature data indicate that quetiapine could help both as a neuronal protector and to resolve neuropsychiatric problems caused by the ischemia in cerebral ischemia cases.

• Journal of Veterinary Clinics
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• v.26 no.3
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• pp.259-262
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• 2009

Focal adnexal dysplasia(FAD) is a rare non-neoplastic lesion of adnexal appendages that occurs in dogs and has good prognosis. We report a case in which FAD diagnosis was favored by its histopathological features. A 8-year-old, castrated male American cocker spaniel dog presented with papillomatous masses on the distal phalanx of left forelimb. Histopathologically, the stroma was sharply demarcated from the adjacent dermis and subcutis. The adnexa was surrounded and interspersed with abundant, hyalinized collagen and the numerous sebaceous lobules distributed haphazardly around hair follicles, which is thickened, dilated and tortuous with abundant keratin. Epidermis was acanthotic. Proliferative lesions of the skin region are very common with similar gross features, thus the basic histopathological examination supported by additional diagnostic methods allow to establish the definitive diagnosis in most cases of cutaneous tumor or tumor-like lesions. And it is important that physicians and pathologists are aware of this unusual tumour-like nonneoplastic lesion.

• Journal of the Korea Computer Graphics Society
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• v.30 no.1
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• pp.11-17
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• 2024

Lung cancer segmentation in chest CT images is challenging due to the varying sizes of tumors and the presence of surrounding structures with similar intensity values. To address these issues, we propose a lung cancer segmentation network that incorporates deep supervision and utilizes UNet3+ as the backbone. Additionally, we propose a hybrid lesion focal loss function comprising three components: pixel-based, region-based, and shape-based, which allows us to focus on the smaller tumor regions relative to the background and consider shape information for handling ambiguous boundaries. We validate our proposed method through comparative experiments with UNet and UNet3+ and demonstrate that our proposed method achieves superior performance in terms of Dice Similarity Coefficient (DSC) for tumors of all sizes.

• 한국정보디스플레이학회:학술대회논문집
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• 2000.01a
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• pp.161-162
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• 2000

We propose multi-layer aspheric lenticular lens for rear projection screen to provide wide viewing angle. Each pitch of lenticular lens sheet is divided by three region and image light from projection optical system is propagated widely on each region due to different focal point. Besides, to improve vertical viewing angle of screen, we propose glass bead embedded screen on observer side of lenticular lens.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.305.1-305.1
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• 2002

The temporal profiles of the changes of dopaminergic cell and microglial activation induced by transient cerebral ischemia was investigated in the substantia nigral region which lay outside ischemic areas of rat brain after middle cerebral artery occlusion (MCAO). Transient cerebral ischemia was induced by intraluminal occlusion of the right middle cerebral artery for 2 hand reperfusion was continued for 1, 2. 3. 7. 10. 14. 30, 60. and 120 days. Activated microglial cells were visualized with immunohistochmistry using OX-43 antibody. (omitted)

• Journal of Broadcast Engineering
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• v.17 no.5
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• pp.789-807
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• 2012

The purpose of this paper is to find various disparity factors in conjunction with situations and contexts of the contents that cause viewer's discomfort, which is to make a content production guideline for viewer's safety, eventually. As a methodology, we extract the experimental data by letting various viewers push a pre-defined key as long as they feel discomfort during watching stereo 3D contents. For each contents, we extract the disparities and disparity changes for the focal point, vicinity of the focal point (ROI, region of interest), and the whole image. For each contents, each point or part of contents is analyzed to find the factors causing discomfort with the two prepared data with watching the contents in 3D. Then, all the analyzed data are re-analyzed to find the strength of each factor. The results from the analyses are explained from the factors having relatively high strength first. It includes the factors that are not known as well as the ones that we can already guess.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.35 no.6
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• pp.481-485
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• 2009

Cemento-osseous dysplasias are a group of disorders known to originate from periodontal ligament tissues and involve, essentially, the same pathological process. They are usually classified, depending on their extent and radiographic appearances, into three main groups. Periapical cemental dysplasia predominantly involves the periapical region of the anterior mandible. Florid cemento-osseous dysplasia presents with multifocal lesions in the tooth bearing or edentulous areas of the maxilla and mandible, often occurring bilaterally with symmetric involvement. Focal cemento-osseous dysplasia exhibits a single site of involvement in any tooth bearing or edentulous area of the mandible or maxilla, with the posterior mandible representing the most common site. We report the clinical, radiographic and histological findings of 3 types of cemento-osseous dysplasia with a review of literatures.

• Journal of fish pathology
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• v.28 no.3
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• pp.145-155
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• 2015

The pathogenecity of atypical Aeromonas salmonicida was studied in healthy Oreochromis niloticus. Inoculum at concentration of $1.5{\times}10^8CFU/ml$ and $3{\times}10^8CFU/ml$ was injected into healthy fish through intramuscular and intraperitoneal injections. Experimentally infected Oreochromis niloticus showed ulceration at the dorsal musculature and trunk region in addition to black coloration, congested gills, exophthalmia, and ocular hemorrhage. Congested liver and kidney were recorded in post-mortem examination. Mortality of the experimentally infected Oreochromis niloticus reached 100% after intramuscular injection at concentration of $3{\times}10^8CFU/ml$. Histopathological investigation of infected organs was also performed. There was a focal area of bundles of skeletal musculature showing hyalinization. In addition, hyperplasia, congestion, and fusion were noticed in the gill lamellae. There was also congestion in the blood vessels in the ocular chamber. Severe congestion was also noticed in the central vein of liver associated with focal aggregation of the melanin pigmented cells in the parenchyma. Degenerative changes were noticed in the epithelial cells lining of kidney tubules. Plant extracts carvacrol and its biological precursor cymene were found to be effective in treating experimentally infected Oreochromis niloticus at concentration of 100 or 200 ppm.

• Journal of Korean Neurosurgical Society
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• v.45 no.3
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• pp.176-178
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• 2009

Traumatic brainstem hemorrhage after blunt head injury is an uncommon event. The most frequent site of hemorrhage is the midline rostral brainstem. The prognosis of these patients is poor because of its critical location. We experienced a case of traumatic brainstem hemorrhage. A 41-year-old male was presented with drowsy mentality and right hemiparesis after blunt head injury. Plain skull radiographs and brain computerized tomography scans revealed a depressed skull fracture, epidural hematoma, and hemorrhagic contusion in the right parieto-occipital region. But, these findings did not explain the right hemiparesis. T2-weighted magnetic resonance (MR) image of the cervical spine demonstrated a focal hyperintense lesion in the left pontomedullary junction. Brain diffusion-weighted and FLAIR MR images showed a focal hyperintensity in the ventral pontomedullary lesion and it was more prominent in the left side. His mentality and weakness were progressively improved with conservative treatment. We should keep in mind the possibility of brainstem hemorrhage if supratentorial lesions or spinal cord lesions that caused neurological deficits in the head injured patients are unexplainable.

• Korean Journal of Optics and Photonics
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• v.5 no.1
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• pp.37-44
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• 1994

The characteristics of stimulated Brillouin scattering wave for applications to high power laser was experimentally investigated. The peak power reflectivity and the phase conjugation fidelity of Stokes wave with respect to the focal length of lens were measured, and the phase conjugation fidelity for a compressed part of the Stokes wave was also investigated. For the long focal length of lens.(f=100 cm), the peak power of the Stokes wave amounts to about twice as high as that of incident wave. The phase conjugation fidelity for the compressed leading pulse is up to 90%, better than that for other temporal parts of the Stokes pulse. In spatial distribution, the Stokes pulse from the axial region has the largest SBS gain, and it has been ascertained as a best candidate to the application due to excellent pulse compression, peak power reflectivity, and good phase conjugation fidelity.