• Biomolecules & Therapeutics
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• 제21권2호
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• pp.89-96
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• 2013

Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerotic vascular disease. Intracellular redox status is tightly regulated by oxidant and antioxidant systems. Imbalance in these systems causes oxidative or reductive stress which triggers cellular damage or aberrant signaling, and leads to dysregulation. Paradoxically, large clinical trials have shown that non-specific ROS scavenging by antioxidant vitamins is ineffective or sometimes harmful. ROS production can be locally regulated by cellular antioxidant enzymes, such as superoxide dismutases, catalase, glutathione peroxidases and peroxiredoxins. Therapeutic approach targeting these antioxidant enzymes might prove beneficial for prevention of ROS-related atherosclerotic vascular disease. Conversely, the development of specific antioxidant enzyme-mimetics could contribute to the clinical effectiveness.

• BMB Reports
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• 제48권1호
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• pp.48-53
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• 2015

Oxidized LDL (oxLDL) performs critical roles in atherosclerosis by inducing macrophage foam cell formation and promoting inflammation. There have been reports showing that oxLDL modulates macrophage cytoskeletal functions for oxLDL uptake and trapping, however, the precise mechanism has not been clearly elucidated. Our study examined the effect of oxLDL on non-muscle myosin heavy chain IIA (MHC-IIA) in macrophages. We demonstrated that oxLDL induces phosphorylation of MHC-IIA (Ser1917) in peritoneal macrophages from wild-type mice and THP-1, a human monocytic cell line, but not in macrophages deficient for CD36, a scavenger receptor for oxLDL. Protein kinase C (PKC) inhibitor-treated macrophages did not undergo the oxLDL-induced MHC-IIA phosphorylation. Our immunoprecipitation revealed that oxLDL increased physical association between PKC and MHC-IIA, supporting the role of PKC in this process. We conclude that oxLDL via CD36 induces PKC-mediated MHC-IIA (Ser1917) phosphorylation and this may affect oxLDL-induced functions of macrophages involved in atherosclerosis.

• 대한기계학회논문집B
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• 제28권6호
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• pp.726-733
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• 2004

The growth of the critical size bubble by diffusion process in viscoelastic medium was treated by an integral method for the concentration boundary layer adjacent to the bubble wall. In this study, we obtained a set of the first order time dependent equations to obtain bubble radius and gas pressure inside the bubble simultaneously. The calculated final cell sizes depending on the initial saturation pressure are in close agreement with the observed ones. The governing equations developed in this study may be used in polymer processing of microcellular foams.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.11-14
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• 2001

In all Rapid Prototyping(RP) processes, computer-aided design(CAD) solid model is sliced into thin layers of uniform, but not necessarily constant, thickness in the building direction. Each cross-sectional layer is successively deposited and, at the same time, bonded onto the previous layer, the stacked layers form a physical part of the model. The objective of this study is to develop a method for obtaining necessary coordinates$(x,\;y,\;\theta_x,\;\theta_y)$ to position linear hotwire of the cutting system in three-dimensional space for the Variable Lamination Manufacturing process (VLM-S), which utilizes expandable polystyrene foam sheet as part material. In order to examine the applicability of the developed method to VLM-S, various three-dimensional shapes, such as a spanner, a patterned columm, and a pyramid were made using data obtained from the method.

• Journal of Advanced Marine Engineering and Technology
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• 제34권7호
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• pp.971-980
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• 2010

In this paper, an artificial neural network (ANN) was employed to build a predicting model for refrigerator structure. The predicting model includes three input variables of the plaque depth (D), width (W) and interval distance(S) on the inner wall. Finite element method was utilized to obtain the data, which would be necessary for the ANN training process. Finally, a genetic algorithm (GA) was applied to find the optimal parameters that leaded to the minimum inner case deformation under operating condition. The optimal combination found is the depth(D) of 2.63mm, the width(W) of 19.24mm and the interval distance(S) of 49.38mm which leaded to the smallest deformation of 1.88mm for the given refrigerator model.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1997년도 추계학술대회 논문집
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• pp.883-886
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• 1997

In all Rapid Prototyping (RP) processes, a CAD solid model is sliced ito thin layers of uniform, but not necessarily constant, thickness in the building direction. Each cross-sectional layer is successively deposited and, at the same tim, bonded onto the previous layer; the stacked layers form a physical part of the model. The objective of this study is to develop a methode for calculating the rotational angle(θ/sub x/, θ/sub y/) of the linear hotwire cutting system in the three-dimensional space for the Variable Lamination Manufacturing process using expandable polystyrene foam sheet (VLM-S). In order to examine the applicability of the developed method to VLM-S, various three-dimensional shapes, such s a screw, an extruded cross, and a figure of Sonokong, were made using the data obtaiend from the method.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2003년도 춘계학술대회 논문집
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• pp.1406-1409
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• 2003

There is a great demand for reducing the amount of material used in mass-produced plastics parts, for material cost constitutes a large percentage of the total cost of 60%. It may be noted that the price of plastics is directly rotated to the price of petroleum. Material reduction therefore decreases the amount of oil needed for the manufacture of plastics and thus help conserve this natural resource. Therefore microcellular foaming process(MCPs) was studied for solving this problems alternatively in 1980's at M.I.T Until now in MCPs carbon dioxide gas was mainly used for microcellular foaming. Besides, Talc was used for reducing the price of plastics. Consequently, we must certificate using the Talc in MCPs according to contents of the Talc.

• Ocean Systems Engineering
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• 제8권2호
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• pp.183-199
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• 2018

The open source software OpenFOAM is utilised to simulate the water entry and hydrodynamic impact process of 2D wedges and ship hull sections. Incompressible multiphase flow solver interDyMFoam is employed to calculate the free fall of structure from air into water using dynamically deforming mesh technique. Both vertical and oblique entry of wedges of various dead-rise angles have been examined. A convergence study of dynamics as well as kinematics of the flow problem is carried out on successively refined meshes. Obtained results are presented and compared to the experimental measurements showing good agreement and reasonable mesh convergence of the solution.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2000년도 춘계학술대회논문집
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• pp.658-663
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• 2000

Slopping phenomena deteriorate the productivity and the stability of operation in oxygen converter process. To predict and prevent that, it needs reliable perception of the internal state of the oxygen converter chamber. Equipment was developed to measure the dynamic and static behavior of the oxygen-blowing lance 3-dimensionally and the measured signal is analyzed in relation to slopping phenomena. It was found that the behavior of the lance is strongly correlated to the change of slag foam height and the instability of molten steel behavior. So slopping phenomena can be predicted by simultaneously analyzing the measured behavior of the lance and the control factors such as the flow rate of oxygen and the height of lance.

• 한국산학기술학회논문지
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• 제6권1호
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• pp.94-103
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• 2005

고강도 저발포 스티로폼을 고온고압 수증기를 사용하지 않고 초고주파를 사용하여 제조하는 공법을 개발하였다. 주파수 13.6 MHz이고 출력 7kW의 전자기파와 3배 발포분을 원료로 사용하였다. 유전가열방식이 스팀방식보다 내부 융착성에서 우수하였으며, 모분 온도 $105-110^{\circ}C$에서 내부 융착성이 가장 우수하였다.