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http://dx.doi.org/10.4062/biomolther.2013.015

Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease  

Kang, Dong Hoon (Division of Life and Pharmaceutical Science and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University)
Kang, Sang Won (Division of Life and Pharmaceutical Science and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University)
Publication Information
Biomolecules & Therapeutics / v.21, no.2, 2013 , pp. 89-96 More about this Journal
Abstract
Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerotic vascular disease. Intracellular redox status is tightly regulated by oxidant and antioxidant systems. Imbalance in these systems causes oxidative or reductive stress which triggers cellular damage or aberrant signaling, and leads to dysregulation. Paradoxically, large clinical trials have shown that non-specific ROS scavenging by antioxidant vitamins is ineffective or sometimes harmful. ROS production can be locally regulated by cellular antioxidant enzymes, such as superoxide dismutases, catalase, glutathione peroxidases and peroxiredoxins. Therapeutic approach targeting these antioxidant enzymes might prove beneficial for prevention of ROS-related atherosclerotic vascular disease. Conversely, the development of specific antioxidant enzyme-mimetics could contribute to the clinical effectiveness.
Keywords
Vascular disease; Atherosclerosis; Reactive oxygen species; Antioxidant enzymes; Antioxidant therapeutics;
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1 Toppo, S., Flohe, L., Ursini, F., Vanin, S. and Maiorino, M. (2009) Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme. Biochim. Biophys. Acta 1790, 1486-1500.   DOI   ScienceOn
2 Traber, M. G. and Atkinson, J. (2007) Vitamin E, antioxidant and nothing more. Free. Radic. Biol. Med. 43, 4-15.   DOI   ScienceOn
3 van Deel, E. D., Lu, Z., Xu, X., Zhu, G., Hu, X., Oury, T. D., Bache, R. J., Duncker, D. J., Chen, Y. (2008) Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free Radic. Biol. Med. 44, 1305-1313.   DOI   ScienceOn
4 van Empel. V. P., Bertrand, A. T., van Oort. R. J., van der, Nagel R., Engelen, M., van Rijen, H. V., Doevendans, P. A., Crijns, H. J., Ackerman, S. L., Sluiter, W. and De Windt, L. J. (2006) EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J. Am. Coll. Cardiol. 48, 824-832.   DOI   ScienceOn
5 Vernet, P., Rock, E., Mazur, A., Rayssiguier, Y., Dufaure, J. P. and Drevet, J. R. (1999) Selenium-independent epididymis-restricted glutathione peroxidase 5 protein (GPx5) can back up failing Se-dependent Gpxs in mice subjected to selenium deficiency. Mol. Reprod. Dev. 54, 362-370.   DOI
6 Watts, G. F. and Staels, B. (2004) Regulation of endothelial nitric oxide synthase by PPAR agonists: molecular and clinical perspectives. Arterioscler. Thromb. Vasc. Biol. 24, 619-621.   DOI   ScienceOn
7 Wei, Y., Liu, X. M., Peyton, K. J., Wang, H., Johnson, F. K., Johnson, R. A. and Durante, W. (2009) Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival. Am. J. Physiol. Cell Physiol. 297, C907-915.   DOI   ScienceOn
8 Wood, Z. A., Schroder, E., Robin Harris, J. and Poole, L. B. (2003) Structure, mechanism and regulation of peroxiredoxins. Trends. Biochem. Sci. 28, 32-40.   DOI   ScienceOn
9 Yan, W. and Chen, X. (2006) GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner. J. Biol. Chem. 281, 7856-7862.   DOI   ScienceOn
10 Yang, H., Roberts, L. J., Shi, M. J., Zhou, L. C., Ballard, B. R., Richardson, A. and Guo, Z. M. (2004) Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ. Res. 95, 1075-1081.   DOI   ScienceOn
11 Zhang, F., Strom, A., Fukada, K., Lee, S., Hayward, L. J. and Zhu, H. (2007) Interaction between Familial Amyotrophic Lateral Sclerosis (ALS)-linked SOD1 Mutants and the Dynein Complex. J. Biol. Chem. 282, 16691-16699.   DOI   ScienceOn
12 Stocker, R. and Keaney, J. F. Jr. (2004) Role of oxidative modifications in atherosclerosis. Physiol. Rev. 84, 1381-1478.   DOI   ScienceOn
13 Suh, Y. A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K. and Lambeth, J. D. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401, 79-82.   DOI   ScienceOn
14 Nishikawa, M., Tamada, A., Kumai, H., Yamashita, F. and Hashida, M. (2002) Inhibition of experimental pulmonary metastasis by controlling biodistribution of catalase in mice. Int. J. Cancer 99, 474-479.   DOI   ScienceOn
15 Ohara, Y., Peterson, T. E. and Harrison, D. G. (1993) Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 91, 2546-2551.   DOI   ScienceOn
16 Olson, G. E., Whitin, J. C., Hill, K. E., Winfrey, V. P., Motley, A.K., Austin, L. M., Deal, J., Cohen, H. J. and Burk, R. F. (2010) Extracellular glutathione peroxidase(Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells. Am. J. Physiol. Renal Physiol. 298, F1244-1253.   DOI   ScienceOn
17 Park, J. G., Yoo, J. Y., Jeong, S. J., Choi, J. H., Lee, M. R., Lee, M. N., Hwa, L. J., Kim, H. C., Jo, H., Yu, D. Y., Kang, S. W., Rhee, S. G., Lee, M. H. and Oh, G. T. (2011) Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice. Circ. Res. 109, 739-749.   DOI   ScienceOn
18 Rhee, S. G., Woo, H. A., Kil, I. S. and Bae, S. H. (2012) Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J. Biol. Chem. 287, 4403-4410.   DOI   ScienceOn
19 Rajagopalan, S., Kurz, S., Munzel, T., Tarpey, M., Freeman, B. A., Griendling, K. K. and Harrison, D. G. (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J. Clin. Invest. 97, 1916-1923.   DOI
20 Reddi, A. R., Jensen, L. T., Naranuntarat, A., Rosenfeld, L., Leung, E., Shah, R. and Culotta, V. C. (2009) The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection. Free Radic. Biol. Med. 46, 154-162.   DOI   ScienceOn
21 Ryter, S. W., Alam, J. and Choi, A. M. (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86, 583-650.   DOI   ScienceOn
22 Safo, M. K., Musayev, F. N., Wu, S. H., Abraham, D. J. and Ko, T. P. (2001) Structure of tetragonal crystals of human erythrocyte catalase. Acta Crystallogr. D. Biol. Crystallogr. 57, 1-7.
23 Sauer, H., Shah, A. M. and Laurindo, F. R. M. (2010) Studies on Cardiovascular Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York.
24 Sauer, H., Wartenberg, M. and Hescheler, J. (2001) Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 11, 173-186.   DOI   ScienceOn
25 Sentman, M. L., Brannstrom, T., Westerlund, S., Laukkanen, M. O., Yla-Herttuala, S., Basu, S. and Marklund, S. L. (2001) Extracellular superoxide dismutase deficiency and atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 21, 1477-1482.   DOI   ScienceOn
26 Lee, M. Y., Martin, A. S., Mehta, P. K., Dikalova, A. E., Garrido, A. M., Datla, S. R., Lyons E., Krause, K., Banfi, B., Lambeth J. D., Lassegue, B. and Griendling K. K. (2009) Mechanism of vascular smooth muscle NADPH Oxidase 1 contribution to injury-induced neointimal formation. Arterioscler. Thromb. Vasc. Biol. 29, 480-487.   DOI   ScienceOn
27 Sorescu, D., Weiss, D., Lassegue, B., Clempus, R. E., Szocs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., Taylor, W. R. and Griendling, K. K. (2002) Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 105, 1429-1435.   DOI   ScienceOn
28 Lassegue, B., Sorescu, D., Szocs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D. and Griendling, K. K. (2001) Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ. Res. 88, 888-894.   DOI   ScienceOn
29 Laukkanen, M. O., Leppanen, P., Turunen, P., Pokkala-Sarataho, E., Salonen, J. T. and Yla-Herttulala, S. (2001) Gene transfer of extracellular superoxide dismutase to atherosclerotic mice. Antioxid. Redox Signal. 3, 397-402.   DOI   ScienceOn
30 Li, C., Hossieny, P., Wu, B. J., Qawasmeh, A., Beck, K. and Stocker, R. (2007) Pharmacologic induction of heme oxygenase-1. Antioxid. Redox Signal. 9, 2227-2239.   DOI
31 Mayr, M., Chung, Y. L., Mayr, U., Yin, X., Ly, L., Troy, H., Fredericks, S., Hu, Y., Griffiths, J. R. and Xu, Q. (2005) Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscler. Thromb. Vasc. Biol. 25, 2135-2142.   DOI   ScienceOn
32 McCord, J. M. (2004) Therapeutic control of free radicals. Drug Discov. Today 9, 781-782.   DOI   ScienceOn
33 Milenkovic, M., De Deken, X., Jin, L., De Felice, M., Di Lauro, R., Dumont, J. E., Corvilain, B. and Miot, F. (2007) Duox expression and related $H_2O_2$ measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. J. Endocrinol. 192, 615-626.   DOI   ScienceOn
34 Forgione, M. A., Weiss, N., Heydrick, S., Cap, A., Klings, E. S., Bierl, C., Eberhardt, R. T., Farber, H. W. and Loscalzo, J. (2002) Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 282, H1255-1261.   DOI
35 Musset, B., Clark, R. A., DeCoursey, T. E., Petheo, G. L., Geiszt, M., Chen, Y., Cornell, J. E., Eddy, C. A., Brzyski, R. G. and El Jamali, A. (2012) NOX5 in human spermatozoa expression, function, and regulation. J. Biol. Chem. 287, 9376-9388.   DOI
36 Nguyen, V. D., Saaranen, M. J., Karala, A., Lappi, A., Wang, L., Raykhel, I. B., Alanen, H. I, Salo, K., Wang, C. and Ruddock, L. W. (2011) Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bind formation. J. Mol. Biol. 406, 503-515.   DOI   ScienceOn
37 Nishikawa, M., Hashida, M. and Takakura, Y. (2009) Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis. Adv. Drug Deliv. Rev. 61, 319-326.   DOI   ScienceOn
38 Fukai, T., Galis, Z. S., Meng, X. P., Parthasarathy, S. and Harrison, D. G. (1998) Vascular expression of extracellular superoxide dismutase in atherosclerosis. J. Clin. Invest. 101, 2101-2111.   DOI   ScienceOn
39 Gozzelino, R., Jeney, V. and Soares, M. P. (2010) Mechanisms of cell protection by heme oxygenase-1. Annu. Rev. Pharmacol. Toxicol. 50, 323-354.   DOI   ScienceOn
40 Griendling, K. K. (2005). ATVB in focus: redox mechanisms in blood vessels. Arterioscler. Thromb. Vasc. Biol. 25, 272-273.
41 Guo, X., Yamada, S., Tanimoto, A., Ding, Y., Wang, K. Y., Shimajiri, S., Murata, Y., Kimura, S., Tasaki, T., Nabeshima, A., Watanabe, T., Kohno, K. and Sasaguri, Y. (2012) Overexpression of peroxiredoxin 4 attenuates atherosclerosis in apolipoprotein E knockout mice. Antioxid. Redox Signal. 17, 1362-1375.   DOI   ScienceOn
42 Kisucka, J., Chauhan, A. K., Patten, I. S., Yesilaltay, A., Neumann, C., Van Etten, R. A., Krieger, M. and Wagner, D. D. (2008) Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis. Circ. Res. 103, 598-605.   DOI   ScienceOn
43 Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybylowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G. and Channon, K. M. (2006) Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 26, 333-339.
44 Imai, H. and Nakagawa, Y. (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med. 34, 145-169.   DOI   ScienceOn
45 Kang, S. W., Rhee, S. G., Chang, T. S., Jeong, W. and Choi, M. H. (2005) 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends. Mol. Med. 11, 571-578.   DOI   ScienceOn
46 Kokoszka, J. E., Coskun, P., Esposito, L. A. and Wallace, D. C. (2001) Increased mitochondrial oxidative stress in the Sod2(+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. U.S.A. 98, 2278-2283.   DOI   ScienceOn
47 Lambeth, J. D. (2004) NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4, 181-189.   DOI   ScienceOn
48 Landmesser, U., Cai, H., Dikalov, S., McCann, L., Hwang, J., Jo, H., Holland, S. M. and Harrison, D. G. (2002) Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 40, 511-515.   DOI   ScienceOn
49 Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E. and Harrison, D. G. (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J. Clin. Invest. 111, 1201-1209.   DOI   ScienceOn
50 Alp, N. J. and Channon, K. M. (2004) Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler. Thromb. Vasc. Biol. 24, 413-420.   DOI   ScienceOn
51 Bedard, K. and Krause, K. H. (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87, 245-313.   DOI   ScienceOn
52 Blankenberg, S., Rupprecht, H. J., Bickel, C., Torzewski, M., Hafner, G., Tiret, L., Smieja, M., Cambien, F., Meyer, J. and Lackner, K. J. (2003) Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N. Engl. J. Med. 349, 1605-1613.   DOI   ScienceOn
53 Bliznakov, E. G. (1999) Cardiovascular diseases, oxidative stress and antioxidants: the decisive role of coenzyme Q10. Cardiovasc. Res. 43, 248-249.   DOI   ScienceOn
54 Chang, T., Cho, C. Park, S., Yu, S. and Kang, S. W. (2004) Peroxiredoxin III, amitochindrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J. Biol. Chem. 279, 41975-41984.   DOI   ScienceOn
55 Chen, H., Yu, M., Li, M., Zhao, R., Zhu, Q., Zhou, W., Lu, M., Lu, Y., Zheng, T., Jiang, J., Zhao, W., Xiang, K., Jia, W. and Liu, L. (2012) Polymorphic variations in manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) contribute to elevated plasma triglyceride levels in Chinese patients with type 2 diabetes or diabetic cardiovascular disease. Mol. Cell Biochem. 363, 85-91.   DOI
56 Choi, H. J., Kang, S. W., Yang, C. H., Rhee, S. G. and Ryu, S. E. (1998) Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat. Struct. Biol. 5, 400-406.   DOI   ScienceOn
57 Choi, M. H., Lee, I. K., Kim, G. W., Kim, B. U., Han, Y. H., Yu, D. Y., Park, H. S., Kim, K. Y., Lee, J. S., Choi, C., Bae, Y. S., Lee, B. I., Rhee, S. G. and Kang, S. W. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435, 347-353.   DOI   ScienceOn
58 Day, B. J. (2004). Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov. Today 9, 557-566.   DOI   ScienceOn
59 Chu, F. F., Esworthy, R. S., Chu, P. G., Longmate, J. A., Huycke, M. M., Wilczynski, S. and Doroshow, J. H. (2004) Bacteria-induced intestinal cancer in mice with disrupted gpx1 and gpx2 genes. Cancer Res. 64, 962-968.   DOI   ScienceOn
60 Chu, Y., Iida, S., Lund, D. D., Weiss, R. M., DiBona, G. F., Watanabe, Y., Faraci, F. M. and Heistad, D. D. (2003) Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Circ. Res. 92, 461-468.   DOI   ScienceOn
61 Abreu, I. A. and Cabelli, D. E. (2010) Superoxide dismutases-a review of the metal-associated mechanistic variations. Biochim. Biophys. Acta 1804, 263-274.   DOI   ScienceOn