• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.4
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• pp.52-58
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• 2016

Recently, interest in structural stability has increased due to earthquakes. Isolation systems can improve seismic ability without harming the functions and appearance of existing and new constructions, and they have established efficiency in foreign country that have experienced earthquakes. In this study, an isolation system is suggested using a natural rubber bearing (NRB) on a stainless water tank for stability assurance in an earthquake. A shaking table test was carried out to evaluate the seismic capacity of a non-isolated water tank and an isolated tank. Displacement meters in the water tank measured the behavior characteristics of the tanks, which were compared using artificial seismic waves of 0.154 g, 0.231 g, 0.341 g, and 0.348 g with water levels of 0.0 m, 1.5 m, and 2.5 m. At 2.5 m, a decrement effect was generally shown in the isolated water tank, and a bigger displacement occurred in the non-isolated water tank than in the isolated one at water levels of 0.0 m and 1.5 m. It is interpreted that the weight of different water levels affects the decrement effect. If seismic reinforcement is done, the isolated bearing should be designed while considering the fluid storage level.

• Journal of the Korean Society of Food Culture
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• v.9 no.1
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• pp.71-77
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• 1994

This study was undertaken to investigate the physicochemical properties of chitosans produced from chitins which were prepared from shrimp shell under the 4 different conditions(HCl concentration : 1 N, 4 N and reaction temperature $0^{\circ}C,\;20^{\circ}C$). The effects of chitosan on the properties of Kakdugi during storage also were examined. Viscosity of chitosan was markedly different$(313.1{\sim}98.8\;cps)$ depending on the production conditon. Chitosan solution showed pseudoplastic property. The infrared(IR) spectrums of chitosans prepared under the conditions of this study were very simillar, and the degree of deacetylation of chitosan was relatively high$(92{\sim}96%)$ independent of the extraction conditions of chitin. As the storage period was extended, markedly lower pH and higher titratable acidity were resulted in all the groups. Throughout the storage period, pH and titratable acidity of kakdugies with chitosan were higher and lower, respectively than those of control. Viscosity of kakdugi juice was significantly different among the groups and as the storage period increased, the juice viscosity decreased. At the eighth day of storage, the juice of control group was more viscous than those of kakdugies containing chitosan. Throughout the storage period the numbers of total microorganisms and of microorgarnisms of Leuconostoc genus in control kakdugi tended to be higher and lower, respectively than those in kakdugies containing chitosan. The growth of Lac. plantarum was slightly lower in kakdugi containing chitosan C produced at low HCl concentration and high temperature compared to the others.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.4
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• pp.521-527
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• 1998

An important property of the intestine is the ability to secrete fluid. The intestinal secretion is regulated by a number of substances including vasoactive intestinal peptide (VIP), ATP and different inflammatory mediators. One of the most important secretagogues is adenosine during inflammation. However, the controversy concerning the underlying mechanism of adenosine-stimulated $Cl^-$ secretion in intestinal epithelial cells still continues. To investigate the effect of adenosine on $Cl^-$ secretion and its underlying mechanism in the rabbit colon mucosa, we measured short circuit current ($I_{SC}$) under automatic voltage clamp with DVC-1000 in a modified Ussing chamber. Adenosine, when added to the basolateral side of the muocsa, increased $I_{SC}$ in a dose-dependent manner. The adenosine-stimulated $I_{SC}$ response was abolished when $Cl^-$ in the bath solution was replaced completely with gluconate. In addition, the $I_{SC}$ response was inhibited by a basolateral Na-K-Cl cotransporter blocker, bumetanide, and by apical $Cl^-$ channel blockers, dephenylamine-2-carboxylate (DPC), 5-nitro-2-(3-phenyl-propylamino)-benzoate (NPPB), glibenclamide. Amiloride, an epithelial $Na^+$ channel blocker, and 4,4-diisothiocyanato-stilbene-2,2-disulphonate (DIDS), a $Ca^{2+}-activated$ $Cl^-$ channel blocker, had no effect. In the mucosa pre-stimulated with forskolin, adenosine did not show any additive effect, whereas carbachol resulted in a synergistic potentiation of the $I_{SC}$ response. The adenosine response was inhibited by 10 ${\mu}M$ H-89, an inhibitor of protein kinase A. These results suggest that the adenosine-stimulated $I_{SC}$ response is mediated by basolateral to apical $Cl^-$ secretion through a cAMP-dependent $Cl^-$ channel. The rank order of potencies of adenosine receptor agonists was $5'-(N-ethylcarboxamino)adenosine(NECA)＞N^6-(R-phenylisopropyl)adenosine(R-$ PIA)＞2-[p-(2-carbonylethyl)-phenyl-ethylamino]-5'-N-ethylcarboxaminoadenosine(CGS21680). From the above results, it can be concluded that adenosine interacts with the $A_{2b}$ adenosine receptor in the rabbit colon mucosa and a cAMP-dependent signalling mechanism underlies the stimulation of $Cl^-$ secretion.

• Korean Journal of Food Science and Technology
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• v.22 no.7
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• pp.852-857
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• 1990

The rheological properties and food functionality of the novel sugar derivatives, fructo-oligosaccharide, high maltose syrup(HMS), maltitol and sorbitol were examined and compared to those of sucrose. All samples tested showed Newtonian fluid property at the concentration range of 10% to the original concentrated products containing $69{\sim}81%w/w$ solid. HMS showed the highest viscosity. The viscosity increased(r=0.8038) as the average molecular weight of sugar derivatives were increased. The viscosity increased exponentially as the concentration increased, and sugar alcohols had lower value of the exponent compared to HMS and fructo-oligosaccharide. The viscosity of sugar derivatives solutions decreased by the increasing temperature following the Arrhenius equation. The flow activation energies of sorbitol and HMS were higer than that of sucrose. Substitution of sucrose with fructo-oligosaccharide in apple jam processing did not change the textural characteristics, but in redbean jelly(yanggaeng) it reduced the hardness, adhesiveness, springiness and cohesiveness. When sucrose was 100% replaced by HMS, the texture of apple jam and redbean jelly was not changed, but by mixing sucrose and HMS 1 : 1 ratio, the hardness decreased substantially The sugar alcohols reduced the hardness, adhesiveness, springiness of apple jam and redbean jelly significantly. Addition of fructo-oligosaccharide and HMS to sucrose did not influence the solidifying rate of candy, but sorbitol, even at 10% addition, retarded the candy moulding.

• Clean Technology
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• v.13 no.3
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• pp.195-200
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• 2007

This study investigated the flow rate changes of the heterogeneous rectangular microchannels which have different hydrophilic property on the bottom surface. The heterogeneous rectangular microchannel has three native PDMS (poly-dimethyl siloxane) surfaces which were patterned by the soft lithography. PDMS bottom surface was treated by the argon plasma and coated by the allyl alcohol (99%). The channel length was 10, 20 and 30 mm and the channel width was 100, 200 and $300\;{\mu}m$, respectively. Several external voltages were applied to make the fluid flow by the electroosmosis in the microchannel. For the same electric field strength and hydrophilicity of the bottom surface, the flow rate is almost same. This result is matched to the theoretical expectation and confirms that the experimental system is reliable. With increasing the channel width, the flow rate increased for the same hydrophilicity of the bottom surface. The flow rate of the microchannel of higher hydrophilicity was larger than that of the microchannel of lower hydrophilicity. This result implies that the hydrophilicity change of the bottom surface could be applied to control the flow rate in the microchannel.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.17 no.4
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• pp.418-425
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• 1988

Since conventional computer program is workable only with velocity boundary condition, in practical fluid passage such as clean room which usually have wide inlets and outlets, it is not easy to measure velocity itself because of its vector property. Furthermore a certain assumption of velocity at boundaries may lead to physically unreasonable results. From this motivation, we have developed a computer program to predict whole flow field imposed on pressure-based boundary condition which can be measured by relatively simple method. The only additional velocity boundary condition that should be imposed on to make the problem unique, are no slip condition at all walls and zero cross stream velocity at inlet. The result of present study was compared with that by Bernoulli equation being used practically. They were coincident well each other within 5%, therefore the validity of the present method is proved. In the present work, the flow field in a clean room subject to pressure-based boundary conditions at an inlet and two exits was predicted numerically. The pressure difference between the inlet and the left exit which keeps relatively low pressure among two exits is fixed as 150[Pa] and the pressure at the right exit is varied from zero to 150[Pa] by the increment of 25[Pa]. For each cases the flow characteristics in the clean room, the velocity profile at the inlet, and the flow rate through the two exits was predicted. The flow rate through the right exit imposed on relatively higher pressure than the left exit decreased linearly according to the increase of pressure of the right exit. When the pressure of the right exit is increased enough to cause back flow at the exit, the flow rate is rapidly decreased.

• Korean Chemical Engineering Research
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• v.57 no.5
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• pp.628-636
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• 2019

In various industrial processes, piping serves as a link between unit processes and is an essential installation for internal flow. Therefore, the optimum design of the piping system is very important in terms of safety and cost, which requires the estimation of the pressure drop, flow rate, pipe size, etc. in the piping system. In this study, we developed a software that determines pressure drop, flow rate, and pipe size when any two of these design variables are known. We categorized the flows into single phase, homogeneous two phase, and separated two phase flows, and applied suitable calculation models accordingly. We also constructed a system library for the calculation of the pipe material, relative roughness, fluid property, and friction coefficients to minimize user input. We further created a costing library according to the piping material for the calculation of the investment cost of the pipe per unit length. We implemented all these functions in an integrated environment using a graphical user interface for user convenience, and C # programming language. Finally, we verified the accuracy of the software using literature data and examples from an industrial process with obtained deviations of 1% and 8.8% for the single phase and two-phase models.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.84-91
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• 2021

In the 21st century, a number of storm and flood disasters caused by rapidly changing climate change is increasing, and the number of flood accidents at construction sites is also increasing. However, no specific reduction measures have been presented and thereby safety management to prevent flood accident need to be improved. Therefore, in this study, the inundation pattern by downpour at the excavation site was interpreted and the inundation risk quantification method was used to classify the risk magnitude. Finally, using the fish-bone diagram, we derived the major reasons of inundation accident at construction site systematically. The simulation results showed that the inundation depths of small-scale excavation sites and excavation sites exceeded 3 m due to the fluid flowing through the excavation surface. In addition, depending on the excavation site, a high velocity temporarily observed and decreased due to the storage effect, or high velocity surpassing 10 m/s continued. Since this type of flooding can pose a risk to most or all workers, if proper management measures are insufficient, fatal damage to life and property could occur. Consideration of the roots of these disasters is judged to be helpful in understanding the causes of inundation accidents that result in casualties and presenting accident reduction measures.

• Applied Chemistry for Engineering
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• v.34 no.1
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• pp.23-29
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• 2023

Microfluidic reactors have been made to achieve significant development for the generation of new functional materials to apply in a variety of fields. Over the last decade, microfluidic reactors have attracted attention as a user-friendly approach that is enabled to control physicochemical parameters such as size, shape, composition, and surface property. Here, we develop a centrifugal microfluidic reactor that can control the flow of fluid based on centrifugal force and generate multifunctional particles of various sizes and compositions. A centrifugal microfluidic reactor is fabricated by combining microneedles, micro- centrifuge tubes, and conical tubes, which are easily obtained in the laboratory. Depending on the experimental control param- eters, including centrifuge rotation speed, alginate concentration, calcium ion concentration, and distance from the needle to the calcium aqueous solution, this strategy not only enables the generation of size-controlled microparticles in a simple and reproducible manner but also achieves scalable production without the use of complicated skills or advanced equipment. Therefore, we believe that this simple strategy could serve as an on-demand platform for a wide range of industrial and academic applications, particularly for the development of advanced smart materials with new functionalities in biomedical engineering.

• Microbiology and Biotechnology Letters
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• v.50 no.4
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• pp.574-583
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• 2022

Ficus vasculosa Wall. ex Miq. (FV) has been used as a herbal medicine in Southeast Asia and its antioxidant activity has been shown in previous studies. However, it has not yet been elucidated whether FV exerts anti-inflammatory effects on activated-macrophages. Thus, we aimed to evaluate the ameliorative property of FV methanol extract (FM) on lipopolysaccharide (LPS)-induced inflammatory responses and the underlying molecular mechanisms in RAW264.7 macrophages. The experimental results indicated that FM decreased the production of inflammatory mediators (NO/PGE2) and the mRNA/protein expression of iNOS and COX-2 in LPS-stimulated RAW264.7 cells. FM also reduced the secretion of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and monocyte chemoattractant protein (MCP)-1 in LPS-stimulated RAW264.7 cells. Results also demonstrated that FM improved inflammatory response in LPS-stimulated A549 airway epithelial cells by inhibiting the production of cytokines, such as IL-1β, IL-6 and TNF-α. In addition, FM suppressed MAPK activation and NF-κB nuclear translocation induced by LPS. FM also upregulated the mRNA/protein expression levels of heme oxygenase-1 and the nuclear translocation of nuclear factor erythroid 2-related factor 2 in RAW264.7 cells. In an experimental animal model of LPS-induced acute lung injury, the increased levels of molecules in bronchoalveolar lavage (BAL) fluid were suppressed by FM administration. Collectively, it was founded that FM has anti-inflammatory properties on activated-macrophages by suppressing inflammatory molecules and regulating the activation of MAPK/NF-κB signaling.