• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10577-10583
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• 2015

Background: Triple-negative breast cancer (TNBC), characterized by the lack of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2, is typically associated with a poor prognosis. The majority of TNBCs show the expression of basal markers on gene expression profiling and most authors accept TNBC as basal-like (BL) breast cancer. However, a smaller fraction lacks a BL phenotype despite being TNBC. The literature is silent on non-basal-like (NBL) type of TNBC. The present study was aimed at defining behavioral differences between BL and NBL phenotypes. Objectives: i) Identify the TNBCs and categorize them into BL and NBL breast cancer. ii) Examine the behavioral differences between two subtypes. iii) Observe the pattern of treatment failure among TNBCs. Materials and Methods: All TNBC cases during January 2009-December 2010 were retrieved. The subjects fitting the inclusion criteria of study were differentiated into BL and NBL phenotypes using surrogate immunohistochemistry with three basal markers $34{\beta}E12$, c-Kit and EGFR as per the algorithm defined by Nielsen et al. The detailed data of subjects were collated from clinical records. The comparison of clinicopathological features between two subgroups was done using statistical analyses. The pattern of treatment failure along with its association with prognostic factors was assessed. Results: TNBC constituted 18% of breast cancer cases considered in the study. The BL and NBL subtypes accounted for 81% and 19% respectively of the TNBC group. No statistically significant association was seen between prognostic parameters and two phenotypes. Among patients with treatment failure, 19% were with BL and 15% were with NBL phenotype. The mean disease free survival (DFS) in groups BL and NBL was 30.0 and 37.9 months respectively, while mean overall survival (OS) was 31.93 and 38.5 months respectively. Treatment failure was significantly associated with stage (p=.023) among prognostic factors. Conclusions: Disease stage at presentation is an important prognostic factor influencing the treatment failure and survival among TNBCs. Increasing tumor size is related to lymph node positivity. BL tumors have a more aggressive clinical course than that of NBL as shown by shorter DFS and OS, despite having no statistically significant difference between prognostic parameters. New therapeutic alternatives should be explored for patients with this subtype of breast cancer.

• Journal of the Korean Magnetic Resonance Society
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• v.5 no.2
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• pp.99-109
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• 2001

Authors investigated neuronal changes of local cellular metabolism in the cerebral lesions of Parkinsonian symptomatic side between before and after stereotactic neurosurgery by follow-up 1H magnetic resonance spectroscopy (MRS). Patients with Parkinson's disease (PD) (n = 15) and age-matched normal controls (n = 15) underwen MRS examinations using a stimulated echo acquisition mode (STEAM) pulse sequence that provided 2${\times}$2${\times}$2 ㎤ (8ml) volume of interest in the regions of substantia nigra, thalamus, and lentiform nucleus. Spectral parameters were 20 ms TE, 2000 ms TR, 128 averages,2500 Hz spectral width, and 2048 data points. Raw data were processed by the SAGE data analysis package (GE Medical Systems). Peak areas of N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho), inositols (Ins), and the sum (Glx) of glutamate and GABA were calculated by means of fitting the spectrum to a summation of Lorentzian curves using Marquardt algorithm. After blindly processed, we evaluated neuronal alterations of observable metabolite ratios between before and after stereotactic neurosurgery using Pearson product-moment analysis (SPSS, Ver. 6.0). A significant reduction of NAA/Cho ratio was observed in the cerebral lesion in substantia nigra of PD patient related to the symptomatic side after neurosurgery (P : 0.03). In thalamus, NAA/Cho ratio was also significantly decreased in the cerebral lesion including the electrode-surgical region (P : 0.03). A significant reduction of NAA/Cho ratio in lentiform nucleus was not oberved, but tended toward significant reduction after neurosurgery (P = 0.08). In particular, remarkable lactate signal was noted from the surgical thalamic lesions of 6 among 8 patients and internal segments of globus pallidus of 6 among 7 patients, respectively. Significant metabolic alterations of NAA/Cho ratio might reflect functional changes of neuropathological processes in the lesion of substantia nigra, thalamus, and lentiform nucleus, and could be a valuable finding fur evaluation of Parkinson's disease after neurosurgery. Increase of lactate signals, being remarkable in surgical lesions, could be consistent with a common consequence of neurosurgical necrosis. Thus, IH MRS could be a useful modality to evaluate the diagnostic and prognostic implications fur Parkinsons disease after functional neurosurgery.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.29-29
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• 2011

SWAT (Soil and Water Assessment Tool) 모형은 물리적 기반의 준분포형 강우-유출 모형으로서, 대규모의 복잡한 유역에서 장기간에 걸친 다양한 종류의 토양과 토지이용 및 토지관리 상태에 따른 유출과 유사 및 오염물질의 거동에 대한 토지관리 방법의 영향을 예측이 가능하여, 수자원 관리 계획 및 유역관리를 위한 의사결정 지원 등 그 적용 범위가 매우 광범위하다. 이러한 모형의 적용성 검증을 위해서는 매개변수 민감도 분석 및 검 보정, 예측 불확실성 분석을 필요로 한다. 최근 수문 모델의 불확실성을 분석하기 위한 다양한 기법들이 개발 되었는데, 본 연구는 충주댐 유역(6,581.1 m)을 대상으로 유역출구점의 실측 일 유출량 자료(1998~2003)를 바탕으로 SWAT 모형의 유출관련 매개변수(총 18개)에 대한 불확실성 분석을 실시하였다. 이때 사용된 분석 기법으로는 SUFI2 (Sequential Uncertainty FItting algorithm 2), GLUE (Generalized Likelihood Uncertainty Estimation), ParaSol (Parameter Solution)등을 적용 하였다. 이러한 기법은 모두 SWAT-CUP (SWAT-Calibration Uncertainty Program, Abbaspour, 2007) 모형에 탑재되어있으며, 모형의 결과로써 검 보정, 매개변수의 민감도 분석, 각종 목적 함수 및 불확실성의 범위 등이 자동으로 산출 되므로 모형의 사용자가 불확실성 평가 기법의 분석 및 비교를 손쉽게 할 수 있다. 그 결과 대표적인 목적 함수인 결정 계수( $^2$)와 NSE (Nash-Sutcliffe Model Efficiency)는 모두 0.65에서 0.92사이의 값을 나타내어 대체적으로 모의가 잘 이루어졌음을 알 수 있었다. 그러나 불확실성의 범위를 나타내는 지표인 p-factor 및 r-factor에서는 평가 기법 별로 그 차이가 확연하게 드러났다. 여기서 p-factor는 불확실성 범위에 실측치가 포함되는 비율이며, r-factor는 불확실성의 상대적인 범위로 각각 1과 0에 가까울수록 모의 기법의 성능이 우수함을 의미한다. 세 가지 알고리듬 중에서 SUFI2의 p-factor가 약 0.51로 가장 높게 나타났으며, ParaSol의 r-factor가 0.00으로 가장 작게 나타났다. 여기서 p-factor는 불확실성 범위에 실측치가 포함되는 비율이며, r-factor는 불확실성의 상대적인 범위를 의미한다. 본 연구의 결과는 SWAT 모형을 이용한 수문모델링에서 수문분석에 따른 예측결과의 불확실성을 정량적으로 평가함으로서, 모형의 적용성 평가 및 모의결과의 신뢰성 확보에 근거자료로 활용이 가능할 것으로 판단된다.

• Journal of Korea Water Resources Association
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• v.31 no.1
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• pp.13-25
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• 1998

It is necessary to develop methodologies for the application of artificial neural network into hydrologic rainfall-runoff process, although there is so much applicability by using the functions of associative memory based on recognition for the relationships between causes and effects and the excellent fitting capacity for the nonlinear phenomenon. In this study, some problems are presented in the application procedures of artificial neural networks and the simulation of runoff hydrograph experiences are reviewed with nonlinear functional approximator by artificial neural network for rainfall-runoff relationships in a watershed. which is regarded as hydrdologic black box model. The neural network models are constructed by organizing input and output patterns with the deserved rainfall and runoff data in Pyoungchang river basin under the assumption that the rainfall data is the input pattern and runoff hydrograph is the output patterns. Analyzed with the results. it is possible to simulate the runoff hydrograph with processing element of artificial neural network with any hydrologic concepts and the weight among processing elements are well-adapted as model parameters with the assumed model structure during learning process. Based upon these results. it is expected that neural network theory can be utilized as an efficient approach to simulate runoff hydrograph and identify the relationship between rainfall and runoff as hydrosystems which is necessary to develop and manage water resources.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.49 no.1
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• pp.29-38
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• 2012

The noise generated in the process of obtaining the medical image acts as the element obstructing the image interpretation and diagnosis. To restore the true image from the image polluted from the noise, the total variation optimization algorithm was proposed by the R.O. F (L.Rudin, S Osher, E. Fatemi). This method removes the noise by fitting the balance of the regularity and fidelity. However, the blurring phenomenon of the border area generated in the process of performing the iterative operation cannot be avoided. In this paper, we propose the adaptive total variation method by mapping the control parameter to the proposed transfer function for minimizing boundary error. The proposed transfer function is determined by the noise variance and the local property of the image. The proposed method was applied to 464 tooth images. To evaluate proposed method performance, PSNR which is a indicator of signal and noise's signal power ratio was used. The experimental results show that the proposed method has better performance than other methods.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.6
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• pp.699-710
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• 2009

If a country has her geoid model, it could be determine accurate orthometric height because the geoid model could provide continuous equi-gravity potential surface. And it is possible to improve the coordinates accuracy of national control points through geodetic network adjustment considering geoidal heights. This study aims to find the best way to develop geoid model in Philippines which have similar topographic conditions as like Malaysia and Indonesia in Eastsouth asia. So, in this study, it is surveyed the general theories of geoid determination and development cases of geoid model in Asia and it is computed that the geoidal heights and gravity anomalies by spherical harmonic analysis using EGM2008, the latest earth geopotential model. The results show that first, the development of gravimetric geoid model based on airborne gravimetry is needed and second, about 200 GPS surveying data at national benchmark is needed. It is concluded that it is the most reasonable way to develop the hybrid geoid model through fitting geometric geoid by GPS/leveling data to gravimetric geoid. Also, it is proposed that four band spherical Fast fourier transformation(FFT) method for evaluation of Stokes integration and remove and restore technique using EGM2008 and SRTM for calculation of gravimetric geoid model and least square collocation algorithm for calculation of hybrid geoid model.

• Journal of Korean Society for Geospatial Information Science
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• v.24 no.1
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• pp.89-98
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• 2016

In this paper, we proposed an automated areal feature matching method based on geometric similarity without user intervention and is applied into areal features of many-to-many relation, for confusion of spatial data-sets of different scale and updating cycle. Firstly, areal feature(node) that a value of inclusion function is more than 0.4 was connected as an edge in adjacency matrix and candidate corresponding areal features included many-to-many relation was identified by multiplication of adjacency matrix. For geometrical matching, these multiple candidates corresponding areal features were transformed into an aggregated polygon as a convex hull generated by a curve-fitting algorithm. Secondly, we defined matching criteria to measure geometrical quality, and these criteria were changed into normalized values, similarity, by similarity function. Next, shape similarity is defined as a weighted linear combination of these similarities and weights which are calculated by Criteria Importance Through Intercriteria Correlation(CRITIC) method. Finally, in training data, we identified Equal Error Rate(EER) which is trade-off value in a plot of precision versus recall for all threshold values(PR curve) as a threshold and decided if these candidate pairs are corresponding pairs or not. To the result of applying the proposed method in a digital topographic map and a base map of address system(KAIS), we confirmed that some many-to-many areal features were mis-detected in visual evaluation and precision, recall and F-Measure was highly 0.951, 0.906, 0.928, respectively in statistical evaluation. These means that accuracy of the automated matching between different spatial data-sets by the proposed method is highly. However, we should do a research on an inclusion function and a detail matching criterion to exactly quantify many-to-many areal features in future.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.25 no.4
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• pp.327-336
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• 2007

The 3D building modeling is one of crucial components in building 3D geospatial information. The existing methods for 3D building modeling depend mainly on manual photogrammetric processes by stereoplotter compiler, which indeed take great amount of time and efforts. In addition, some automatic methods that were proposed in research papers and experimental trials have limitations of describing the details of buildings with lack of geometric accuracy. It is essential in automatic fashion that the boundary and shape of buildings should be drawn effortlessly by a sophisticated algorithm. In recent years, airborne LiDAR data representing earth surface in 3D has been utilized in many different fields. However, it is still in technical difficulties for clean and correct boundary extraction without human intervention. The usage of airborne LiDAR data will be much feasible to reconstruct the roof tops of buildings whose boundary lines could be taken out from existing digital maps. The paper proposed a method to reconstruct the roof tops of buildings using airborne LiDAR data with building boundary lines from digital map. The primary process is to perform octree-based segmentation to airborne LiDAR data recursively in 3D space till there are no more airborne LiDAR points to be segmented. Once the octree-based segmentation has been completed, each segmented patch is thereafter merged based on geometric spatial characteristics. The experimental results showed that the proposed method were capable of extracting various building roof components such as plane, gable, polyhedric and curved surface.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.10
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• pp.713-722
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• 2013

This paper proposes a method of using depth information to detect the hand region in real-time based on the cascade method. In order to ensure stable and speedy detection of the hand region even under conditions of lighting changes in the test environment, this study uses only features based on depth information, and proposes a method of detecting the hand region by means of a classifier that uses boosting and cascading methods. First, in order to extract features using only depth information, we calculate the difference between the depth value at the center of the input image and the average of depth value within the segmented block, and to ensure that hand regions of all sizes will be detected, we use the central depth value and the second order linear model to predict the size of the hand region. The cascade method is applied to implement training and recognition by extracting features from the hand region. The classifier proposed in this paper maintains accuracy and enhances speed by composing each stage into a single weak classifier and obtaining the threshold value that satisfies the detection rate while exhibiting the lowest error rate to perform over-fitting training. The trained classifier is used to classify the hand region, and detects the final hand region in the final merger stage. Lastly, to verify performance, we perform quantitative and qualitative comparative analyses with various conventional AdaBoost algorithms to confirm the efficiency of the hand region detection algorithm proposed in this paper.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3B
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• pp.279-289
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• 2006

The reconstruction of low dimension nonlinear behavior from the hydrologic time series has been an active area of research in the last decade. In this study, we present the applications of a powerful state space reconstruction methodology using the method of Support Vector Machines (SVM) to the Great Salt Lake (GSL) volume. SVMs are machine learning systems that use a hypothesis space of linear functions in a Kernel induced higher dimensional feature space. SVMs are optimized by minimizing a bound on a generalized error (risk) measure, rather than just the mean square error over a training set. The utility of this SVM regression approach is demonstrated through applications to the short term forecasts of the biweekly GSL volume. The SVM based reconstruction is used to develop time series forecasts for multiple lead times ranging from the period of two weeks to several months. The reliability of the algorithm in learning and forecasting the dynamics is tested using split sample sensitivity analyses, with a particular interest in forecasting extreme states. Unlike previously reported methodologies, SVMs are able to extract the dynamics using only a few past observed data points (Support Vectors, SV) out of the training examples. Considering statistical measures, the prediction model based on SVM demonstrated encouraging and promising results in a short-term prediction. Thus, the SVM method presented in this study suggests a competitive methodology for the forecast of hydrologic time series.