• 한국산학기술학회논문지
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• 제17권2호
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• pp.620-626
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• 2016

구조물의 비선형 지진응답을 평가하는 것은 내진공학에 있어서 중요한 요소로 인식되고 있다. 비선형 정적해석은 이를 위한 대표적인 방법론의 하나이며, 특정 해석단계에서의 구조물 강성추정을 위한 다양한 수치해석적 방법론들이 제시, 적용되고 있다. 하지만, 이러한 방법론들은 상당한 해석시간을 요하거나 부정확한 간편법에 그치고 있어 실무적용에 많은 어려움이 존재한다. 이러한 이유로 본 연구에서는 비선형 정적해석 시 정확하고 효과적인 구조물 강성추정 방법론을 제시하고자 한다. 이를 위하여, 기존의 단계해석법에 대한 이론적 연구를 수행하였으며, 이를 바탕으로 이선형 재료모델 특성을 가진 구조물의 강성구성 알고리즘을 제시하였다. 최종적으로, 제시된 알고리즘을 적용한 컴퓨터 프로그램 sNs를 개발하였다.

• Journal of Microbiology and Biotechnology
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• 제30권11호
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• pp.1651-1658
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• 2020

Since Zika virus (ZIKV) was first detected in Uganda in 1947, serious outbreaks have occurred globally in Yap Island, French Polynesia and Brazil. Even though the number of infections and spread of ZIKV have risen sharply, the pathogenesis and replication mechanisms of ZIKV have not been well studied. ZIKV, a recently highlighted Flavivirus, is a mosquito-borne emerging virus causing microcephaly and the Guillain-Barre syndrome in fetuses and adults, respectively. ZIKV polyprotein consists of three structural proteins named C, prM and E and seven nonstructural proteins named NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 in an 11-kb single-stranded positive sense RNA genome. The function of individual ZIKV genes on the host innate immune response has barely been studied. In this study, we investigated the modulations of the NF-κB promoter activity induced by the MDA5/RIG-I signaling pathway. According to our results, two nonstructural proteins, NS2A and NS4A, dramatically suppressed the NF-κB promoter activity by inhibiting signaling factors involved in the MDA5/RIG-I signaling pathway. Interestingly, NS2A suppressed all components of MDA5/RIG-I signaling pathway, but NS4A inhibited most signaling molecules, except IKKε and IRF3-5D. In addition, both NS2A and NS4A downregulated MDA5-induced NF-κB promoter activity in a dosedependent manner. Taken together, our results suggest that NS2A and NS4A signifcantly antagonize MDA5/RIG-I-mediated NF-κB production, and these proteins seem to be controlled by different mechanisms. This study could help understand the mechanisms of how ZIKV controls innate immune responses and may also assist in the development of ZIKV-specific therapeutics.

• Steel and Composite Structures
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• 제19권2호
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• pp.369-384
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• 2015

This work presents a free vibration analysis of functionally graded metal-ceramic (FG) beams with considering porosities that may possibly occur inside the functionally graded materials (FGMs) during their fabrication. For this purpose, a simple displacement field based on higher order shear deformation theory is implemented. The proposed theory is based on the assumption that the transverse displacements consist of bending and shear components in which the bending components do not contribute toward shear forces and, likewise, the shear components do not contribute toward bending moments. The most interesting feature of this theory is that it accounts for a quadratic variation of the transverse shear strains across the thickness, and satisfies the zero traction boundary conditions on the top and bottom surfaces of the beam without using shear correction factors. In addition, it has strong similarities with Euler-Bernoulli beam theory in some aspects such as equations of motion, boundary conditions, and stress resultant expressions. The rule of mixture is modified to describe and approximate material properties of the FG beams with porosity phases. By employing the Hamilton's principle, governing equations of motion for coupled axial-shear-flexural response are determined. The validity of the present theory is investigated by comparing some of the present results with those of the first-order and the other higher-order theories reported in the literature. Illustrative examples are given also to show the effects of varying gradients, porosity volume fraction, aspect ratios, and thickness to length ratios on the free vibration of the FG beams.

• Steel and Composite Structures
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• 제25권2호
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• pp.157-175
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• 2017

The novelty of this work is the use of a new displacement field that includes undetermined integral terms for analyzing thermal buckling response of functionally graded (FG) sandwich plates. The proposed kinematic uses only four variables, which is even less than the first shear deformation theory (FSDT) and the conventional higher shear deformation theories (HSDTs). The theory considers a trigonometric variation of transverse shear stress and verifies the traction free boundary conditions without employing the shear correction factors. Material properties of the sandwich plate faces are considered to be graded in the thickness direction according to a simple power-law variation in terms of the volume fractions of the constituents. The core layer is still homogeneous and made of an isotropic material. The thermal loads are assumed as uniform, linear and non-linear temperature rises within the thickness direction. An energy based variational principle is employed to derive the governing equations as an eigenvalue problem. The validation of the present work is checked by comparing the obtained results the available ones in the literature. The influences of aspect and thickness ratios, material index, loading type, and sandwich plate type on the critical buckling are all discussed.

• Restorative Dentistry and Endodontics
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• 제43권4호
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• pp.36.1-36.12
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• 2018

Objectives: Direct pulp capping is a treatment for mechanically exposed pulp in which a biocompatible capping material is used to preserve pulpal vitality. Biocompatibility tests in animal studies have used a variety of experimental protocols, particularly with regard to the exposure site. In this study, pulp exposure on the occlusal and mesial surfaces of molar teeth was investigated in a rat model. Materials and Methods: A total of 58 maxillary first molars of Wistar rats were used. Forty molars were mechanically exposed and randomly assigned according to 3 factors: 1) the exposure site (occlusal or mesial), 2) the pulp-capping material (ProRoot White MTA or Bio-MA), and 3) 2 follow-up periods (1 day or 7 days) (n = 5 each). The pulp of 6 intact molars served as negative controls. The pulp of 12 molars was exposed without a capping material (n = 3 per exposure site for each period) and served as positive controls. Inflammatory cell infiltration and reparative dentin formation were histologically evaluated at 1 and 7 days using grading scores. Results: At 1 day, localized mild inflammation was detected in most teeth in all experimental groups. At 7 days, continuous/discontinuous calcified bridges were formed at exposure sites with no or few inflammatory cells. No significant differences in pulpal response according to the exposure site or calcium-silicate cement were observed. Conclusions: The location of the exposure site had no effect on rat pulpal healing. However, mesial exposures could be performed easily, with more consistent results. The pulpal responses were not significantly different between the 2 capping materials.

• 한국재난정보학회 논문집
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• 제15권2호
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• pp.223-238
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• 2019

연구목적: 본 논문은 재난의 복잡다단한 맥락을 구성하는 정치 경제 사회의 다양한 이해관계자들이 생성해내는 담론과 사회적 실천의 함의를 파악하여 국내의 효율적 재난대응 방안 모색을 위한 기초자료를 제공하고자 한다. 연구방법: 페어클로(Fairclough)의 비판적 담론분석(Critical Discourse Analysis) 모델을 적용하여 국내 대표적인 세 일간지에 실린 2017년 11월 포항지진 관련 신문기사를 분석하였다. 연구결과: 담론분석 결과, 첫째, 세 언론사에서는 지진 발생 이후 대응의 측면에서 재난대응 매뉴얼과 대피훈련의 낮은 실효성을 지적하였다. 둘째, 지진피해 복구 측면에서 대피소 서비스 강화와 이재민 지원 확대의 필요성을 강조하였다. 셋째, 내진설계 강화 및 문자알림 서비스 질 향상 등 향후 피해를 미연에 방지하기 위한 실천 노력을 제시하였다. 결론: 본 연구에서는 효과적인 국내 재난대응을 위하여 재난 예방 대책의 현실성 실효성 제고, 유기적이고 통합적인 재난대응체계 마련, 시민의 역할과 참여 강조, 전문가 집단의 책임감 및 이에 대한 견제, 재난대응 관련 건전한 담론형성을 위한 미디어의 역할을 제안하였다.

• 한국지진공학회논문집
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• 제9권3호
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• pp.1-8
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• 2005

본 연구는 지진으로 인하여 발생한 건물의 피해액을 보다 객관적으로 예측 평가할 수 있는 ACM(Advanced Component Method) 개발 방법에 관한 것이다. ACM은 지금까지의 재래식 손실 평가방법에 사용된 구조 기술자들의 주관적인 관점과 전문가적 견해에서 탈피하여, 지진의 크기에 따른 구조형식이 각기 다른 건물들의 내진 성글 평가 기술에 바탕을 둔 지진 손실 평가 방법이다. 그 과정을 살펴보면 먼저 선별된 전형적인 건축 구조물에 대하여 비선형 정적 내진 해석인 pushover 해석을 실행하여 그들의 건물 능력도와 각 부재의 비선형 응답을 계산한다. 지진하중은 ADRS(Acceleration-Displacement Response Spectrum)의 응답 가속도와 응답 변위의 형태로 표현하여 이를 건물 능력도와 함께 능력 스펙트럼법(Capacity Spectrum Method) 기법을 이용하여 건물의 내진 성능점을 찾는다. 또한 전체 건물을 주요 구조체인 기둥, 보, 슬래브 등과 비구조체인 비내력 벽판, 외벽 장식용 요소 등을 각각 분리하여 건물 각 부재들의 지진 응답 변위에 따른 피해율을 산출한다. 이들 각 부재들의 피해는 그 부재들의 특성에 따른 적절한 보수보강기법과 그에 따른 비용산정 모델을 이용하여 각 부재의 금전적인 피해액으로 전환한다. 마지막으로 Monte Carlo기법을 이용하여 지금까지 얻은 건물의 응답과 각 부재들의 지진에 따른 피해율, 그리고 그 부재들의 비용산정 모델을 종합하여 전체 건물의 최종의 피해율을 얻는다. 특히, 현존하는 건물에 사용된 재료와 설계 가정 하중의 가변성에 따른 건물 거동에 대한 불확실성 등을 고려하기 위하여 Latin Hypercube 추출 기법을 사용하며, 마지막으로 본 연구의 사례평가를 위하여 과거 일어났던 지진 피해정보와 손실 자료들을 바탕으로 ACM방법과 재래식 방법을 이용한 건물 손실 평가 방법을 비교 분석하였다.

• 국제초고층학회논문집
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• 제5권3호
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• pp.233-241
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• 2016

This paper describes the structural solution for the design of a 29-story high-rise tower, which features a large office space above the Kabukiza Theatre. Kabuki is a type of Japanese traditional drama, and Kabukiza is the home building of Kabuki. GINZA KABUKIZA is the fifth generation of the Kabukiza Theatre, the first of which was built in 1889. In order to support 23 stories of office space above the theater - featuring a large void in plan - two 13-meter-deep mega-trusses, spanning 38.4 meters, are installed at the fifth floor of the building. Steelwork is used as a primary material for the structure above-ground, and a hybrid response control system using a buckling-restrained brace and oil damper is adopted in order to achieve a high seismic performance. This paper also describes the erection process of installing hydraulic jacks directly above the mega-truss at column bases, in order to keep the structure above the truss level during construction. The temple architecture of the previous Kabukiza is carefully restored by incorporating contemporary light-weight materials supported by steelwork.

• 전산구조공학
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• 제4권3호
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• pp.79-88
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• 1991

내진설계를 하고 있는 나라들이 채택하고 있는 내진해석방법중 가장 일반적인 응답스펙트럽법(Response Spectrum Method)은 지진하중을 정적 수평하중으로 치환하여 정적해석하는 것을 기본으로 하고 있다. 여기서 계산된 대치수평하중은 구조물의 소성화에 따른 비선형거동으로 부터 오는 에너지분산현상 및 감쇠(damping)현상 등을 고려하기 위하여 소위 반응수정계수(behavior factor)란 일정수로 나누어 준다. 응답스펙트럼법에 의한 내진설계의 정확도를 좌우하는 지금까지 사용되어지고 있는 반응수정계수는 정확한 계산값들이 아닌 경험적인 값들이다. 반응수정계수를 해석적으로 결정하기 위해서는 구조물의 극한상태에 대한 정의가 선결되어져야 한다. 본 논문에서는 지진하중하에서 강구조물의 한계상태를 기하학적측면과 사용성 측면 및 재료공학적 측면에서 검토하였고 3가지 형태의 구조물을 모델로 하여 반응수정계수를 계산하였다.

• 대한두경부종양학회지
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• 제14권1호
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• pp.61-69
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• 1998

Objectives: The response rate of the radioactive iodine(RI) therapy with low dose was variable. Only a few studies reported the response and complication rate with high dose. The goal of this study was to access the ablation and complication rate after high dose of RI therapy (more than 100mCi) and to evaluate the factors affect the results. Material and Methods: During a period of 12 years, 225 patients received high dose of RI from 100 to 200mCi depending on the RI uptake in the whole body after total thyroidectomy. 100mCi of RI was given to 123 patients for ablation who showed the uptake only in the thyroid bed. 150mCi was given to another 84 patients for ablation who had uptake confined to the neck. The other 21 patients took more than 200mCi of RI because the whole body scan showed distant metastasis. Among these patients, the ablation and the complication rate was investigated. Results: Elevated level of the serum thyroglobulin(Tg) decreased less than 5ng/ml after RI therapy in all patients except two in the first group. The second group showed reduction of the serum Tg in 93%. Eighteen of the 21 patients in the third group are still alive after RI therapy. There were no fatal complications after high dose RI therapy and most of the complications were minimal and transient. The complication rate was not related with the dose of RI, age, sex, DNA flowcytometry, serum thyroglobulin level and the extent of node dissection. Conclusion: We concluded that RI therapy with high dose was very effective for thyroid ablation after operation and it also showed excellent results with minimal complications for treatment of metastatic lesions.