• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.303-306
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• 2015

Purpose: This study was conducted to determine risk of developing of breast cancer among Turkish women. Materials and Methods: Using a descriptive and cross-sectional approach, data were collected from 231 women. Breast cancer risk was calculated using the National Cancer Institute's on-line verson of called as the Breast Cancer Risk Assessment Tool or the Gail Risk Assesment Tool. Results: The average age of women was $45.0{\pm}8.06$ years. It was revealed that 6.1% of participants reported having first degree relatives who had had breast cancer, with only four women having more than one first-degree relative affected (1.7%). The mean five-year breast cancer risk for all women was $0.88{\pm}0.91%$, and 7.4% of women had a five-year breast cancer risk >1.66% in this study. Mean lifetime breast cancer risk up to age 90 years was $9.3{\pm}5.2%$. Conclusions: The breast cancer risk assessment tool can help in the clinical management of patient seeking advice concerning screening and prevention. Healthcare providers in Turkey can use this approach to estimate an individual's probability of developing breast cancer.

• 가정과삶의질연구
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• 제27권4호
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• pp.81-101
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• 2009

This study examines married couples' forgiveness and forgiveness process in order to provide basic information related to married couples' forgiveness and to identify significant variables through analyzing socio-demographic characteristics affecting forgiveness and what influences the forgiveness process variables. Based on the study, the conclusions are as follows: First, men are affected by personal and intrinsic factors and women are affected by the other person's factor in the forgiveness. Married couples all expect that self-growth and the recovery of negative emotion occur through forgiveness. It indicates that the forgiveness contains a strong selfish character and not an altruistic character for others. Second, married couples experience hurt in the martial relationship due to problems caused by relationships with the husband's family, wife's family, and relatives. There is a significant difference between men and women in the period of problem occurrence, period of worry, seriousness degree of the problem, intention status of the problem, hurt degree, unfairness status of hurt, unfairness degree of hurt, and locus of control. Third, men's forgiveness level is higher in emotional forgiveness, cognitive forgiveness, and behavioral forgiveness. Among them, there is the biggest difference of cognitive forgiveness between men and women. Also, the variable affecting forgiveness is different between men and women.

• 디지털융복합연구
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• 제11권12호
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• pp.685-696
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• 2013

본 연구는 우리나라 교육계열 전공 여성 박사의 학교와 직장의 진로성취과정에서 겪는 진로개발 및 진로장애를 탐색하는데 그 목적이 있다. 연구의 목적을 수행하기 위하여 최근 5년 이내의 교육계열 전공 여성 박사 42명을 대상으로 질적 연구를 진행하였다. 그 결과 교육계열 여성 박사들은 교수와의 학술활동을 통해서 자신의 진로개발에 영향을 가장 많이 받고 있었으며 둘째, 직장 내에서 유리창효과를 경험한 것으로 나타났다. 셋째, 결혼이라는 것이 기혼 및 미혼 여성 박사 모두 진로개발 시 장애요인이라고 인식했다. 기혼은 자신의 가정과 육아에 대한 책임감과 미혼은 유교적 가치관 속에서 사회적 약자로 인식하고 있었다. 이러한 다양한 경험들은 여성 박사들에게 진로개발을 저해하는 요인으로 나타났지만 주변인의 지지와 자신의 자아실현에 대한 강한 목표의식은 진로장벽을 타계하는 방편으로 나타났다. 본 연구는 여성 박사의 진로개발에는 다양한 관점에서의 맥락이 여성의 진로개발에 영향을 주는 것으로 발견되었다. 여성 박사를 위한 진로지도는 학생들의 요구와 사회 변화에 따라 유동적이고 다각적인 방향에서 접근 하는 것이 필요하다.

• 수면정신생리
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• 제3권1호
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• pp.3-14
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• 1996

Eye movement dysfunction has been found in large numbers of schizophrenia patients and their first-degree relatives and can be studied without the interference of deficits in attention, motivation, clinical status and medication effects with relatively easy method. Eye movement dysfunction has been proposed as a useful way of expanding the schizophrenia phenotype in genetic studies. I review the literature on eye movement dysfunction with respect to syndrome and familial specificity and the quantitative assessment of eye tracking. I hope that the etiology and the pathophysiology of schizophrenia can be clarified through this eye movement study.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권1호
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• pp.41-49
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• 2019

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Several genetic defects that disturb intestinal epithelial barrier function or affect immune function have been noted in these patients from the young age groups. In incidence of pediatric IBD in Korea has been increasing since the early 2000s. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Children with "neonatal IBD" or "infantile-onset IBD" have higher rates of affected first-degree relatives, severe disease course, and a high rate of resistance to immunosuppressive treatment. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations in the genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typically presented with perianal fistulae, shows a poor response to medical management, and require early surgical interventions in the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majority of monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing could become an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severe disease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatric IBD.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7533-7537
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• 2014

Background: Breast cancer (BC) is the most frequent cancer type, and the leading cause of death from cancer among women in Israel. The Bedouin-Arab (BA) population in southern Israel is characterized by a high rate of consanguinity, common hereditary disorders, and transition from a semi-nomadic, traditional society to a more sedentary and urbanized society. In this hospital-based study, the demographic and the clinicopathological characteristics of BC in BA were compared with Jewish patients. Materials and Methods: 85 BA patients treated at the Soroka Medical Center, Beer Sheba, during the years 2004-2012, were studied and compared with 180 consecutive Jewish patients treated during the year 2007. Clinicopathological features compared included age, menopausal state, number of births, a history of BC in first-degree relatives, tumor size (T), extent of lymph-node involvement (N), distant metastases (M), stage, grade, estrogen and progesterone receptor (ER/PR), and Her2 status. Types of treatment, relapse rate and site, as well as outcome were also studied. Cox's regression models were applied for studying disease-free, and overall survival. Results: Compared with Jewish patients, BA patients were younger (average age $49{\pm}12$ yrs vs $59{\pm}13$, p<0.001), had a lower rate of BC in first-degree relatives (p<0.001), and a larger number of births ($6{\pm}4.2$ vs $2.5{\pm}1.9$, p<0.001). BA patients had larger tumors (p=0.02), more extensive lymph-node involvement (p=0.002), and more advanced stage (p=0.003). Grade, ER, PR, and Her2 status were similar in the two ethnic groups. Relapse type was most commonly systemic in BA patients (p=0.05), and loco-regional in Jewish patients (p=0.02). Median survival was 63, and 35 months for Jewish and BA patients, respectively (log-rank test, p=0.02). In Cox multivariate analysis, stage and PR status (HR-0.14, p<0.0001; HR-3.11, p=0.046), but not ethnicity, influenced overall survival. Conclusions: BC presents a decade earlier, and with more advanced disease in BA compared with Jewish patients. Biologic parameters including grade, ER, PR, and Her2 status were similar in both groups. Although prognosis was worse in BA than in Jewish patients, it was affected only by stage and PR status, but not by ethnicity.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2841-2846
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• 2014

Background: When dealing with breast cancer, early detection is closely associated with determining and closely monitoring high risk groups. The aim of this study was to determine the preventable risk factors that are specific for our country, and to understand which risk factors were most predominant. Materials and Methods: The study was planned as a case-control design. Women diagnosed with breast cancer who visited the Surgery, Obstetrics and Gynaecology, and Radiation Oncology outpatient clinics of the Izmir Dokuz Eylul University (DEU) School of Medicine were accepted as the case group. Then a control group matched for age was established among females who visited the outpatient clinics on the same days. A questionnaire prepared by the researchers was implemented using a face-to-face interview technique. The Mann-Whitney U test was used in the comparisons of the group averages, and the Pearson chi-square test in the comparisons between groups. In order to determine the dominant risk factors, binary logistical regression test was implemented. Results: A total of 138 patients, 69 cases and 69 controls, were included in the study. A significant difference can be detected between the groups in terms of BMI, smoking, breast cancer prevalence among first degree family members, presence of breast cancer among distant family members, existence of other types of cancers among family members and the age of onset of menopause (p<0.05). Logistical regression analysis revealed that the presence of breast cancer among first degree relatives increased the risk of developing breast cancer 5.7 times. Conclusions: Although some results of this study are compatible with findings in the literature, some are not. In order to determine unique risk factors, there is a clear need for large-scale studies.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3759-3762
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• 2016

Background: Breast cancer risk assessment is a helpful method for estimating development of breast cancer at the population level. Materials and Methods: In this cross-sectional study, participants consisted of a group of 3,847 volunteers ($mean{\pm}SD$ age: $463{\pm}7.59$ years) in a convenience sample of women referred to health centers affiliated to Tehran University of Medical Sciences in Tehran, Iran. The risk of breast cancer was estimated by applying the National Cancer Institute's online version of the Gail Risk Assessment Tool. Results: Some 24.9% of women reported having one first-degree female relative with breast cancer, with 8.05% of them having two or more first-degree relatives with breast cancer. The mean five-year risk of breast cancer for all participants was $1.61{\pm}0.73%$, and 9.36% of them had a five-year risk of breast cancer >1.66%. The mean lifetime risk of breast cancer was $11.7{\pm}3.91%$. Conclusions: The Gail model is useful for assessing probability of breast cancer in Iranian women. Based on the their breast cancer risk, women may decide to accept further screening services.

• 한국가족관계학회지
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• 제21권2호
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• pp.25-51
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• 2016

Objectives: This research started with the attempt to comprehend the relationship between household types and psychological stability by linking single-person households to the emotional index "depression." Method: For this purpose, we first compare to see if there is a difference in socio-demographic variables, social relationships, the degree of depression between single households and multi-person households, and to comprehend the relative influence that household types have on depression by taking other factors under consideration. Results: Then based on the results, we compare and analyze the factors that affect the degree of depression on single-person households and multi-person households, respectively. To summarize the results, first of all, residents in single-person households are somewhat older but show lower level of income, education, and health condition compared to peers inmulti-person households. They also had a consistently high level not only in the frequency of contact and emotional connection with families, relatives, and friends, but also in the degree of depression when compared to multi-person households. Secondly, for depression, considering the various factors targeting all the households, the following had a strong influence in the order of "health condition compared to peers," "emotional connection with family," "household types," "emotional connection with colleagues," "frequency of contact with neighbors," "gender," and "age."The degree of depression increases in the following conditions: if the health condition is worse, lower emotional connection with family, single-person household, lower emotional connection with colleagues, lower the frequency of contact with neighbors, female, and older the age. Thirdly, comparing the factors that affect depression by dividing single-person households and multi-person households, "health condition compared to peers" and "emotional connection with family" had the largest effect in common, respectively. In cases of living alone, regardless of other factors, the degree of depression increases with "health condition compared to peers" and "emotional connection with family." Conclusions: On the contrary, in multi-person households, "health condition compared to peers," "emotional connection with family," "emotional connection with colleagues," "income," and "gender" are important.

• Clinical and Experimental Pediatrics
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• 제57권2호
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• pp.67-71
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• 2014

Pediatric infection with Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate of H. pylori eradication. In pediatric patients with H. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended that H. pylori strains be eradicated. Antibiotic drug resistance to H. pylori, which has been reported to vary widely between geographic regions, is mainly associated with treatment failure in these patients. It is therefore imperative that the antibiotic resistance rates of H. pylori in children and adolescents be meticulously monitored across countries and throughout geographic regions. This paper particularly focuses on the antibiotic drug resistance of H. pylori and the thearpy of pediatric H. pylori infection cases.