Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Family History Attributes and Risk Factors for Breast Cancer in Turkey

  • Gokdemir-Yazar, Ozden (Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University) ;
  • Yaprak, Seval (Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University) ;
  • Colak, Muhteber (Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University) ;
  • Yildirim, Ediz (Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University) ;
  • Guldal, Dilek (Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University)
  • Published : 2014.03.30
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Abstract

Background: When dealing with breast cancer, early detection is closely associated with determining and closely monitoring high risk groups. The aim of this study was to determine the preventable risk factors that are specific for our country, and to understand which risk factors were most predominant. Materials and Methods: The study was planned as a case-control design. Women diagnosed with breast cancer who visited the Surgery, Obstetrics and Gynaecology, and Radiation Oncology outpatient clinics of the Izmir Dokuz Eylul University (DEU) School of Medicine were accepted as the case group. Then a control group matched for age was established among females who visited the outpatient clinics on the same days. A questionnaire prepared by the researchers was implemented using a face-to-face interview technique. The Mann-Whitney U test was used in the comparisons of the group averages, and the Pearson chi-square test in the comparisons between groups. In order to determine the dominant risk factors, binary logistical regression test was implemented. Results: A total of 138 patients, 69 cases and 69 controls, were included in the study. A significant difference can be detected between the groups in terms of BMI, smoking, breast cancer prevalence among first degree family members, presence of breast cancer among distant family members, existence of other types of cancers among family members and the age of onset of menopause (p<0.05). Logistical regression analysis revealed that the presence of breast cancer among first degree relatives increased the risk of developing breast cancer 5.7 times. Conclusions: Although some results of this study are compatible with findings in the literature, some are not. In order to determine unique risk factors, there is a clear need for large-scale studies.

Keywords

References

  1. Althuis MD, Fergenbaum JH, Garcia-Closas M, et al (2004). Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev, 13, 1558-68.
  2. Bagnardi V, Rota M, Botteri E, et al (2013). Light alcohol drinking and cancer: a meta-analysis. Ann Oncol, 24, 301-8. https://doi.org/10.1093/annonc/mds337
  3. Breast cancer: prevention and control. Introduction. [homepage on the Internet]. [cited 2013 Nov 21].
  4. Cannata D, Fierz Y, Vijayakumar A, LeRoith D (2010). Type 2 diabetes and cancer: what is the connection? Mt Sinai J Med,77, 97-213.
  5. Ceber E , Mermer G, Okcin F, et al (2013). Breast cancer risk and early diagnosis applications in Turkish women aged 50 and over. Asian Pac J Cancer Prev, 14, 5877-82. https://doi.org/10.7314/APJCP.2013.14.10.5877
  6. da Cunha PA, de Carlos Back LK, Sereia AF, et al (2013). Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk. MolBiol Rep, 40, 6657-64.
  7. De Bruijn KM, Arends LR, Hansen BE, et al (2013). Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer. Br J Surg, 100, 1421-9. https://doi.org/10.1002/bjs.9229
  8. Devolli-Disha E, Manxhuka-Kerliu S, Ymeri H, Kutllovci A (2009). Comparative accuracy of mammography and ultrasound in women with breast symptoms according to age and breast density. Bosn J Basic Med Sci, 9, 131-6.
  9. Domchek SM, Bradbury A, Garber JE, Offit K, Robson ME (2013).Multiplexgenetictesting for cancersusceptibility: out on the high wire without a net? J ClinOncol, 31,1267-70. https://doi.org/10.1200/JCO.2012.46.9403
  10. Esposito K, Capuano A, Giugliano D (2013). Metabolic syndrome and cancer: holistic or reductionist? Endocrine, 45,362-4
  11. Gadeyne S, Deboosere P, Vandenheede H, Neels K (2012). Does birth history account for educational differences in breast cancer mortality? A comparison of premenopausal and postmenopausal women in Belgium. Int J Cancer, 131, 2878-85. https://doi.org/10.1002/ijc.27538
  12. Global Database on Body Mass Index.[homepage on the Internet]. [cited 2013 Oct 21].
  13. Hall AE, Chowdhury S, Hallowell N, et al (2013). Implementing risk-stratified screening for common cancers: a review of potential ethical, legal and social issues. J Public Health. [Epub ahead of print]
  14. Hamajima N, Hirose K, Tajima K, et al (2002). Alcohol, tobacco and breast cancer-collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer, 18, 1234-45.
  15. Hardmann AE, Stensel DJ, editors. Physical activity and health: the evidence explained, second edition, page 23. Routledge; 2009.
  16. Harman O. Variance of risk factors of the patients who have breast cancer applied to medical oncology department of medical faculty of hacettepe university [Turkish] (Unpublished thesis of master degree). Ankara; 2007.
  17. Hartz AJ, He T (2013). Cohort study of risk factors for breast cancer in postmenopausal women. Epidemiol Health, 35, 2013003. https://doi.org/10.4178/epih/e2013003
  18. Health Quality Ontario (2007). Screening mammography for women aged 40 to 49 years at average risk for breast cancer: an evidence-based analysis. Ont Health Technol Assess Ser, 7, 1-32.
  19. Health Quality Ontario (2010). Cancer screening with digital mammography for women at average risk for breast cancer, magnetic resonance imaging (MRI) for women at high risk, an evidence-based analysis. Ont Health Technol Assess Ser, 10, 1-55.
  20. Houssami N, Irwig L, Ciatto S (2012). Radiological surveillance of interval breast cancers in screening programmes. Lancet Oncol, 7, 259-65.
  21. Hunter CP (2000). Epidemiology, stage at diagnosis, and tumor biology of breast carcinoma in multiracial and multiethnic populations. Cancer, 88, 1193-202. https://doi.org/10.1002/(SICI)1097-0142(20000301)88:5+<1193::AID-CNCR3>3.0.CO;2-D
  22. IARC Handbooks of Cancer Prevention. Vol.7, chapter 3: breast cancer screening (2002). [homepage on the Internet]. [cited 2013Feb13].
  23. Kohut K, D'Mello L, Bancroft EK, et al (2012). Implications for cancer genetics practice of pro-actively assessing family history in a general practice cohort in north west London. Fam Cancer, 11, 107-13. https://doi.org/10.1007/s10689-011-9482-6
  24. Korde LA, Calzone KA, Zujewski J (2004). Assessing breast cancer risk: genetic factors are not the whole story. Postgrad Med, 116, 6-20.
  25. Korpraphong P, Limsuwarn P, Tangcharoensathien W, et al (2013). Improving breast cancer detection using ultrasonography in asymptomatic women with non-fatty breast density. ActaRadiol. [Epub ahead of print].
  26. Kutanzi K, Kovalchuk O (2013). Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats. Cancer BiolTher, 14, 564-73.
  27. Lee IM, Cook NR, Rexrode KM, Buring JE (2001). Lifetime physical activity and risk of breast cancer. Br J Cancer, 85962-5.
  28. Lee IM (2003). Physical activity and cancer prevention-data from epidemiologic studies. Med Sci Sports Exerc, 35, 1823-7. https://doi.org/10.1249/01.MSS.0000093620.27893.23
  29. Li CI, Moe RE, Daling JR (2003). Risk of mortality by histologic type of breast cancer among women aged 50 to 79 years. Arch Intern Med, 163, 2149-53. https://doi.org/10.1001/archinte.163.18.2149
  30. Li CI, Chlebowski RT, Freiberg M, et al (2010). Alcohol consumption and risk of postmenopausal breast cancer by subtype: the women's health initiative observational study. J Natl Cancer Inst, 102, 1422-31. https://doi.org/10.1093/jnci/djq316
  31. Lin Y, Shao N, Zhang YJ, et al (2012). Risk assessment of breast cancer in Guangdong, China: a community-based survey. Asian Pac J Cancer Prev, 13, 2759-63. https://doi.org/10.7314/APJCP.2012.13.6.2759
  32. Luo J, Marqolis KL, Wactawski-Wende J, et al (2011). Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ, 342, 1016. https://doi.org/10.1136/bmj.d1016
  33. McTiernan A (2003). Behavioral risk factors in breast cancer: can risk be modified? Oncologist, 8, 326-34. https://doi.org/10.1634/theoncologist.8-4-326
  34. Muller I, Pinchera A, Fiore E, et al (2011). High prevalence of breast cancer in patients with benign thyroid diseases. J Endocrinol Invest, 34, 349-52. https://doi.org/10.1007/BF03347458
  35. National Cancer Institute. Breast cancer risk assessment tool [homepage on the Internet]. [cited 2013 Nov 12].
  36. Ogrodnik A, Hudon TW, Nadkarni PM, Chandawarkar RY (2013). Radiation exposure and breast cancer: lessons from Chernobyl. Conn Med, 77, 227-34.
  37. Onitilo AA, Stankowski RV, Berg RL, et al (2014). Type 2 diabetes mellitus, glycemic control, and cancer risk. Eur J Cancer Prev, 23, 134-40. https://doi.org/10.1097/CEJ.0b013e3283656394
  38. Orio F, Muscogiuri G, Ascione A, et al (2013). Effects of physical exercise on the female reproductive system. Minerva Endocrinol, 38, 305-19.
  39. Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  40. Parkin DM, Fernandez LM (2006). Use of statistics to assess the global burden of breast cancer. Breast J, 1, 70-80.
  41. Pfeiffer RM, Park Y, Kreimer AR, et al (2013). Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50 y or older: derivation and validation from population-based cohort studies. PLoS Med, 10, 1001492. https://doi.org/10.1371/journal.pmed.1001492
  42. Porter P (2008). Westernizing women's risk? Breast cancer in lower income countries. NEng J Med, 358, 213-6. https://doi.org/10.1056/NEJMp0708307
  43. Rosenberg L, Boggs DA, Bethea TN, et al (2013). A prospective study of smoking and breast cancer risk among African- American women. Cancer Causes Control, 24, 2207-15. https://doi.org/10.1007/s10552-013-0298-6
  44. Scoccianti C, Straif K, Romieu I (2013). Recent evidence on alcohol and cancer epidemiology. Future Oncol, 9, 1315-22. https://doi.org/10.2217/fon.13.94
  45. SEER Cancer Statistics Review, 1975-2000. [homepage on the Internet]. [cited 2012Mar10].
  46. Sezer H, Yilmaz M, Gurler H, Koyuncu A (2011). Breast cancer risk factors in Turkey: a hospital-based case-control study. Asian Pac J Cancer Prev, 12, 2317-22.
  47. Shamsi U, Khan S, Usman S, Soomro S, Azam I (2013). A multicenter matched case control study of breast cancer risk factors among women in Karachi, Pakistan. Asian Pac J Cancer Prev, 14, 183-8. https://doi.org/10.7314/APJCP.2013.14.1.183
  48. Siegel R, Ward E, Brawley O, Jemal A (2011). Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin, 61, 212-36. https://doi.org/10.3322/caac.20121
  49. Szychta P, Szychta W, Gesing A, Lewinski A, Karbownik- Lewinska M (2013). TSH receptor antibodies have predictive value for breast cancer-retrospective analysis. Thyroid Res, 6, 8. https://doi.org/10.1186/1756-6614-6-8
  50. TriaTirona M (2013). Breast cancer screening update. AmFam Physician, 87, 274-8.
  51. Thune I, Brenn T, Lund E, Gaard M (1997). Physical activity and the risk of breast cancer. N Engl J Med, 336, 1269-75. https://doi.org/10.1056/NEJM199705013361801
  52. TurkStat, Turkey in Statistics, 2012. Turkish Statistical Institute, Printing Division, Ankara. ISBN 978-975-19-5660-6
  53. Walsh MD, Buchanan DD, Cummings MC, et al (2010). Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry. Clin Cancer Res, 16, 2214-24. https://doi.org/10.1158/1078-0432.CCR-09-3058
  54. Warner ET, Colditz GA, Palmer JR, et al (2013). Reproductive factors and risk of premenopausal breast cancer by age at diagnosis: are there differences before and after age 40? Breast Cancer Res Treat, 142, 165-75. https://doi.org/10.1007/s10549-013-2721-9
  55. What are the key statistics about breast cancer?[homepage on the Internet]. [cited 2013Oct20].
  56. Wong CA, Jim MA, King J, et al (2011). Impact of hysterectomy and bilateral oophorectomy prevalence on rates of cervical, uterine, and ovarian cancer among American Indian and Alaska Native women, 1999-2004. Cancer Causes Control, 22, 1681-9. https://doi.org/10.1007/s10552-011-9844-2

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