• 대한의용생체공학회:의공학회지
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• 제34권3호
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• pp.111-116
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• 2013

Finite element analysis(FEA) has been extensively applied in the analyses of biomechanical properties of stents. Geometrically, a closed-cell stent is an assembly of a number of repeated unit cells and exhibits periodicity in both longitudinal and circumferential directions. This study concentrates on various parameters of the FEA models for the analysis of drug-eluting biodegradable polymeric stents for application to the treatment of coronary artery disease. In order to determine the mechanical characteristics of biodegradable polymeric stents, FEA was used to model two different types of stents: tubular stents(TS) and helicoidal stents(HS). For this modeling, epigallocatechin-3-O-gallate (EGCG)-eluting poly[(L-lactide-co-${\varepsilon}$-caprolactone), PLCL] (E-PLCL) was chosen as drug-eluting stent materials. E-PLCL was prepared by blending PLCL with 5% EGCG as previously described. In addition, the effects of EGCG blending on the mechanical properties of PLCL were investigated for both types of stent models. EGCG did not affect tensile strength at break, but significantly increased elastic modulus of PLCL. It is suggested that FEA is a cost-effective method to improve the design of drug-eluting biodegradable polymeric stents.

• 한국식품영양학회지
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• 제30권1호
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• pp.9-18
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• 2017

As an indicator of skin health, acidified skin surface pH ranging from 5 to 7 is crucial for maintaining skin barrier. In this study, we evaluated the relationship between skin pH and dietary pattern (DP) as well as nutrient or food intake in 48 healthy middle aged adults. Skin pH was measured in the skin surface of the inner arm, and blood lipid profile was analyzed. Dietary intake data were obtained using 1 day 24 hour recall method, and DP was extracted using factor analysis. Results revealed that skin pH ranged from 5.15 to 6.88 in all subjects. There was no significant difference in skin pH between males and females. When subjects were grouped by tertile of skin pH, the food intake of fruit, and the nutrient intake of omega 6 fatty acid, potassium, vitamin A, vitamin C, ${\beta}$-carotene, and riboflavin in the first tertile group with skin pH ranging from 5.15 to 5.68 were significantly higher than in the third tertile group with skin pH ranging from 6.26 to 6.88. There was no difference in blood lipid profile between the first and the third tertile group. Among 5 DP extracted by factor analysis, DP5 characterized by a high intake of nuts and fruits as well as a low intake of beverages and alcohol was inversely correlated with skin pH after adjusting for gender and age. DP5 was positively correlated with nutrient intake of carbohydrate, fiber, potassium, iron, vitamin A, vitamin C, ${\beta}$-carotene, thiamine, and riboflavin but negatively correlated with sodium after adjusting for gender, age, smoking, and energy intake. Therefore, acidified skin pH could be maintained by these DP and nutrients.

• Composites Research
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• 제17권3호
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• pp.29-37
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• 2004

본 연구에서는 대변형 보이론을 이용하여 정지 비행 시 복합재 무베어링 로우터 시스템의 공력탄성학적 안정성 해석을 수행하였다. 무베어링 로우터 시스템은 유연보, 토오크 튜브, 피치 링크, 그리고 메인 블레이드로 구성된다. 유연보, 토오크 튜브, 그리고 메인 블레이드를 각각 플랩 굽힘, 리드-래그 굽힘, 비틀림 그리고 축 방향 변형의 탄성 운동을 하는 보로 가정하고, 1차원 보 요소로 모델링을 하였다. 또한, 유연보를 복합재료 적층판으로 구성된 비틀림에 유연한 직사각형 단면을 갖는 보로 모델링 하여, 1차원 보 해석에 필요한 유효 단면 상수를 얻었다. 외력으로는 2차원 준-정상 공기력 모델을 적용하였으며, 보의 유한 요소 지배방정식은 헤밀턴 원리(Hamilton's principle)를 이용하여 얻었다. 공력 탄성학적 안정성 해석을 수행하기 위하여 p-k 방법을 이용하였으며, 유연보의 적층각과 적층 순서에 따른 구조적 연성이 무베어링 로우터 시스템의 공란성 안정성에 미치는 영향을 알아보았다.

• Steel and Composite Structures
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• 제29권4호
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• pp.527-544
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• 2018

The paper presents the study on a change in modal parameters and structural stiffness of cable-stayed Fiberline Bridge made entirely of Glass Fiber Reinforced Polymer (GFRP) composite used for 20 years in the fjord area of Kolding, Denmark. Due to this specific location the bridge structure was subjected to natural aging in harsh environmental conditions. The flexural properties of the pultruded GFRP profiles acquired from the analyzed footbridge in 1997 and 2012 were determined through three-point bending tests. It was found that the Young's modulus increased by approximately 9%. Moreover, the influence of the temperature on the storage and loss modulus of GFRP material acquired from the Fiberline Bridge was studied by the dynamic mechanical analysis. The good thermal stability in potential real temperatures was found. The natural vibration frequencies and mode shapes of the bridge for its original state were evaluated through the application of the Finite Element (FE) method. The initial FE model was created using the real geometrical and material data obtained from both the design data and flexural test results performed in 1997 for the intact composite GFRP material. Full scale experimental investigations of the free-decay response under human jumping for the experimental state were carried out applying accelerometers. Seven natural frequencies, corresponding mode shapes and damping ratios were identified. The numerical and experimental results were compared. Based on the difference in the fundamental natural frequency it was again confirmed that the structural stiffness of the bridge increased by about 9% after 20 years of service life. Data collected from this study were used to validate the assumed FE model. It can be concluded that the updated FE model accurately reproduces the dynamic behavior of the bridge and can be used as a proper baseline model for the long-term monitoring to evaluate the overall structural response under service loads. The obtained results provided a relevant data for the structural health monitoring of all-GFRP bridge.

• 대한후두음성언어의학회지
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• 제31권2호
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• pp.66-70
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• 2020

Background and Objectives Presbyphonia is characterized by hoarse, breathy, weak vocal intensity. Extracellular matrix (ECM) in lamina propria (LP) of the vocal folds play an important role in voice production, and change of ECM according to the aging leads to the presbyphonia. The aim of this study was to investigate the histologic analysis of aging vocal fold of rat. Materials and Method Six and twenty two months old Sprague-Dawley rats (n=8, each group) were used and classified into young (six months old rats) and old (twenty two months old rats) group. Histologic analysis and immunohistochemical staining for ECM of LP were performed. Results Overall cellular density was significantly decreased in old rat group. Elastin fibers of LP were significantly decreased in old rat group. Type I collagen was significantly increased in old rat group. Type III collagen did not show significant difference. Hyaluronic acids did not show significant difference in Alcian blue staining and immunohistochemical staining. Conclusion Decreased general cellular density and elastin fiber and increased type I collagen were observed in the LP of vocal folds of aging rats. These ECM changes might to contribute the aging voice.

• 한국항공우주학회지
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• 제49권7호
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• pp.549-555
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• 2021

원공이 있는 복합재 적층판의 강도는 복합재 항공기기 설계 시 충격하중이 가해지는 부위의 설계 허용치로 사용된다. 일반적으로 BVID (Barely Visible Impact Damage)에 의한 강도저하는 24.0 mm 폭의 시편에 6.0 mm 지름의 원공이 있는 시편의 강도로 가정한다. 본 연구에서는 원공이 있는 복합재 적층판의 강도에 적층각이 미치는 영향을 조사하기 위해 잔류강도 시험을 수행하였다. 원공이 있는 적층판의 강도를 예측하기 위해 특성길이를 이용한 점응력 파손기준을 사용하였고, 이론해를 검증하기 위하여 유한요소해석을 수행하였다. 실험결과로부터 특성길이는 0°, ±45°와 90°층의 비율과 관련이 있음을 보였다. 또한 회귀분석을 통하여 임의의 적층 패턴에 대한 특성길이와 원공이 없는 시편의 강도를 결정하였다.

• 디지털융복합연구
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• 제20권4호
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• pp.459-468
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• 2022

의료 현장에서는 매우 고해상도의 이미지를 사용하고 있으며, 이는 손실에 매우 민감한 정보이다. 이에 따라 높은 대역폭뿐만 아니라 고신뢰성 전송을 제공할 수 있는 광 인터넷의 활용이 요구되고 있다. 그러나 인터넷의 특성상 다양한 종류의 데이터가 동일한 대역폭을 활용하게 되고, 이를 효과적으로 차별화할 수 있는 수단이 요구되고 있다. 이를 위해 광 지연 라인 버퍼가 많이 활용되고 있다. 그러나, 이러한 버퍼는 제공 부하, 측정된 데이터 버스트 크기, 기본 지연 유닛 등과 같은 최적값을 이용해 구성된다. 광 버퍼는 한 번 설정되면 변경할 수 없다. 그러므로 데이터 버스트 크기를 동적으로 변경시키는 방법이 활용되고 있다. 그러나 동적으로 버스트의 길이를 변화시키는 것은 상당한 불안정성을 내포하고 있다. 이에 본 논문에서는 안정적인 동작을 보장할 수 있는 동작 조건을 분석하고자 한다. 본 논문의 기법을 활용해 높은 우선순위의 고해상도 의료 데이터를 손실 없이 안정적으로 전송할 수 있다.

• 천문학회지
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• 제56권1호
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• pp.59-73
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• 2023

The second generation of stars in the globular clusters (GCs) of the Milky Way (MW) exhibit unusually high N, Na, or Al, compared to typical Galactic halo stars at similar metallicities. The halo field stars enhanced with such elements are believed to have originated in disrupted GCs or escaped from existing GCs. We identify such stars in the metallicity range -3.0 < [Fe/H] < 0.0 from a sample of ~36,800 giant stars observed in the Sloan Digital Sky Survey and Large Sky Area Multi-Object Fiber Spectroscopic Telescope survey, and present their dynamical properties. The N-rich population (NRP) and N-normal population (NNP) among our giant sample do not exhibit similarities in either in their metallicity distribution function (MDF) or dynamical properties. We find that, even though the MDF of the NRP looks similar to that of the MW's GCs in the range of [Fe/H] < -1.0, our analysis of the dynamical properties does not indicate similarities between them in the same metallicity range, implying that the escaped members from existing GCs may account for a small fraction of our N-rich stars, or the orbits of the present GCs have been altered by the dynamical friction of the MW. We also find a significant increase in the fraction of N-rich stars in the halo field in the very metal-poor (VMP; [Fe/H] < -2.0) regime, comprising up to ~20% of the fraction of the N-rich stars below [Fe/H] = -2.5, hinting that partially or fully destroyed VMP GCs may have in some degree contributed to the Galactic halo. A more detailed dynamical analysis of the NRP reveals that our sample of N-rich stars do not share a single common origin. Although a substantial fraction of the N-rich stars seem to originate from the GCs formed in situ, more than 60% of them are not associated with those of typical Galactic populations, but probably have extragalactic origins associated with Gaia Sausage/Enceladus, Sequoia, and Sagittarius dwarf galaxies, as well as with presently unrecognized progenitors.

• 생태와환경
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• 제54권3호
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• pp.199-208
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• 2021

메타바코딩을 이용한 환경 DNA 분석은 검출 감도가 높아 어류의 생물다양성 평가 및 멸종위기종의 검출에 유용한 기술이다. 이번 연구는 메타바코딩을 이용해 우리나라 담수어류를 대상으로 높은 검출 효율을 보일 수 있는 적합한 분석방법을 확인하기 위해 4가지 분석조건별, 즉 필터(cellulose nitrate filter, glass fiber filter), 추출 키트(DNeasy^® Blood & Tissue Kit, DNeasy^® PowerWater Kit), 프라이머 조합(12S rDNA, 16S rDNA) 그리고 PCR 방법(conventional PCR, touchdown PCR)로 나타나는 Operational Taxonomic Units(OTUs) 수와 종 조성을 비교하였다. Glass fiber filter와 DNeasy^® Tissue & Blood Kit를 이용해 추출한 시료는 12S rDNA와 16S rDNA 프라이머 조합에서 담수어류 OTUs가 가장 많이 검출되었다. 모든 분석조건 중 프라이머 조합에서만 조기어강(Class Actinopterygii) 평균 OTUs 수에서 통계적으로 유의한 차이를 보였고(Non-parametric Wilcoxon Signed Ranks Test, p=0.005), 담수어류 평균 OTUs 수는 유의하지 않았다. 종 조성 비교 결과 역시 프라이머 조합에서 유의한 차이를 보였고(PERMANOVA, Pseudo-F=6.9489, p=0.006), 나머지 분석조건에서는 유의한 차이를 보이지 않았다. NMDS 분석 결과 종 조성은 유사도 65% 기준에서 프라이머 조합에 따라 묶였고, 16S rDNA 프라이머 세트는 주로 멸종위기종인 모래주사(Microphysogobio koreensis), 꼬치동자개(Pseudogobio brevicorpus)가 기여하였고, 12S rDNA 프라이머 세트는 주로 일반종인 피라미(Zacco platypus), 꺽지(Coreoperca herzi) 등이 기여한 것으로 나타났다. 본 연구는 국내 하천에서 채취한 시료에 대한 메타바코딩을 이용한 종 다양성 분석의 기초정보를 제공한다.

• 한국초지조사료학회지
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• 제35권3호
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• pp.257-263
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• 2015

This study was conducted to assess the potential of using NIRS to accurately determine the chemical composition and fermentation parameters in fresh coarse sorghum and sudangrass silage. Near Infrared Spectroscopy (NIRS) has been increasingly used as a rapid and accurate method to analyze the quality of cereals and dried animal forage. However, silage analysis by NIRS has a limitation in analyzing dried and ground samples in farm-scale applications because the fermentative products are lost during the drying process. Fresh coarse silage samples were scanned at 1 nm intervals over the wavelength range of 680~2500 nm, and the optical data were obtained as log 1/Reflectance (log 1/R). The spectral data were regressed, using partial least squares (PLS) multivariate analysis in conjunction with first and second order derivatization, with a scatter correction procedure (standard normal variate and detrend (SNV&D)) to reduce the effect of extraneous noise. The optimum calibrations were selected on the basis of minimizing the standard error of cross validation (SECV). The results of this study showed that NIRS predicted the chemical constituents with a high degree of accuracy (i.e. the correlation coefficient of cross validation ($R^2{_{cv}}$) ranged from 0.86~0.96), except for crude ash which had an $R^2{_{cv}}$ of 0.68. Comparison of the mathematical treatments for raw spectra showed that the second-order derivatization procedure produced the best result for all the treatments, except for neutral detergent fiber (NDF). The best mathematical treatment for moisture, acid detergent fiber (ADF), crude protein (CP) and pH was 2,16,16 respectively while the best mathematical treatment for crude ash, lactic acid and total acid was 2,8,8 respectively. The calibrations of fermentation products produced poorer calibrations (RPD < 2.5) with acetic and butyric acid. The pH, lactic acid and total acids were predicted with considerable accuracy at $R^2{_{cv}}$ 0.72~0.77. This study indicated that NIRS calibrations based on fresh coarse sorghum and sudangrass silage spectra have the capability of assessing the forage quality control