• Journal of Korean Neurosurgical Society
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• v.65 no.6
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• pp.779-789
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• 2022

Objective : To analyze the effects of the number and shape of fenestrations on the mechanical strength of pedicle screws and the effects of bone cement augmentation (BCA) on the pull-out strength (POS) of screws used in conventional BCA. Methods : For the control group, a conventional screw was defined as C1, a screw with cannulated end-holes was defined as C2, a C2 screw with six pinholes was defined as C3, and the control group type was set. Among the experimental screws, T1 was designed using symmetrically placed thru-hole type fenestrations with an elliptical shape, while T2 was designed with half-moon (HM)-shaped asymmetrical fenestrations. T3 and T4 were designed with single HM-shaped fenestrations covering three pitches and five pitches, respectively. T5 and T6 were designed with 0.6-mm and 1-mm wider fenestrations than T3. BCA was performed by injecting 3 mL of commercial bone cement in the screw, and mechanical strength and POS tests were performed according to ASTM F1717 and ASTM F543 standards. Synthetic bone (model #1522-505) made of polyurethane foam was used as a model of osteoporotic bone, and radiographic examinations were performed using computed tomography and fluoroscopy. Results : In the fatigue test, at 75% ultimate load, fractures occurred 7781 and 9189 times; at 50%, they occurred 36122 and 82067 times; and at 25%, no fractures occurred. The mean ultimate load for each screw type was 219.1±52.39 N for T1, 234.74±15.9 N for T2, 220.70±59.23 N for T3, 216.45±32.4 N for T4, 181.55±54.78 N for T5, and 216.47±29.25 N for T6. In comparison with C1, T1, T2, T3, T4, and T6 showed significantly different ultimate load values (p<0.05). However, when the values for C2 and the fenestrated screws were evaluated with an unpaired t test, the ultimate load value of C2 significantly differed only from that of T2 (p=0.025). The ultimate load value of C3 differed significantly from those of T1 and T2 (C3 vs. T1 : p=0.048; C3 vs. T2 : p<0.001). Linear correlation analysis revealed a significant correlation between the fenestration area and the volume of bone cement (Pearson's correlation coefficient r=0.288, p=0.036). The bone cement volume and ultimate load significantly correlated with each other in linear correlation analysis (r=0.403, p=0.003). Conclusion : Fenestration yielded a superior ultimate load in comparison with standard BCA using a conventional screw. In T2 screws with asymmetrical two-way fenestrations showed the maximal increase in ultimate load. The fenestrated screws can be expected to show a stable position for the formation of the cement mass.

• Asia Marketing Journal
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• v.15 no.3
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• pp.159-172
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• 2013

In the present study, we apply the multiple cue probability learning (MCPL) paradigm to examine consumer learning from feedback in repeated trials. This paradigm is useful in investigating consumer learning, especially learning the relationships between the overall quality and attributes. With this paradigm, we can analyze what people learn from repeated trials by using the lens model, i.e., whether it is knowledge or consistency. In addition to introducing this paradigm, we aim to demonstrate that knowledge people gain from repeated trials with feedback is robust enough to weaken one of the most often examined contextual effects, the asymmetric dominance effect. The experiment consists of learning session and a choice task and stimuli are sport rafting boats with motor engines. During the learning session, the participants are shown an option with three attributes and are asked to evaluate its overall quality and type in a number between 0 and 100. Then an expert's evaluation, a number between 0 and 100, is provided as feedback. This trial is repeated fifteen times with different sets of attributes, which comprises one learning session. Depending on the conditions, the participants do one (low) or three (high) learning sessions or do not go through any learning session (no learning). After learning session, the participants then are provided with either a core or an extended choice set to make a choice to examine if learning from feedback would weaken the asymmetric dominance effect. The experiment uses a between-subjects experimental design (2 × 3; core set vs. extended set; no vs. low vs. high learning). The results show that the participants evaluate the overall qualities more accurately with learning. They learn the true trade-off rule between attributes (increase in knowledge) and become more consistent in their evaluations. Regarding the choice task, there is a significant decrease in the percentage of choosing the target option in the extended sets with learning, which clearly demonstrates that learning decreases the magnitude of the asymmetric dominance effect. However, these results are significant only when no learning condition is compared either to low or high learning condition. There is no significant result between low and high learning conditions, which may be due to fatigue or reflect the characteristics of learning curve. The present study introduces the MCPL paradigm in examining consumer learning and demonstrates that learning from feedback increases both knowledge and consistency and weakens the asymmetric dominance effect. The latter result may suggest that the previous demonstrations of the asymmetric dominance effect are somewhat exaggerated. In a single choice setting, people do not have enough information or experience about the stimuli, which may lead them to depend mostly on the contextual structure among options. In the future, more realistic stimuli and real experts' judgments can be used to increase the external validity of study results. In addition, consumers often learn through repeated choices in real consumer settings. Therefore, what consumers learn from feedback in repeated choices would be an interesting topic to investigate.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2004.05a
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• pp.408-413
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• 2004

High speed planning boats also have been required more and more the rational strength analysis and evaluation for the optimal structural design in respect of the structural lightness according to the high speed trend. Even though the suggestion of the simple type equation for the equivalent dynamic pressure is reasonable to design the scantling of ship structure conveniently, many research activities for more reasonable improvement of the simple design pressure, have been continued to suggest the more accurate equivalent static description of tire structural response such as the deflection and stress of hull structure. In this research, we focus on the aluminum bottom stiffened plate structure in which structural scantling is mainly depend on the local loads such as dynamic or impact pressure without other load effects and structural response for the simple dynamic equivalent pressure was investigated through the structural analysis. In order to investigate the structural response of the bottom stiffened plate structure subjected to the dynamic equivalent design pressure, linear and nonlinear structural analysis of the bottom stiffened plate structure of 4.3 ton aluminum planning boat was performed based on the equivalent static applied loads which were derived from the KR regulation and representative one among various dynamic equivalent pressure equations. From above analysis results, we found that the response such as deflection and stress of plate member was similar with the response results of one plate member model with fixed boundary, which was published previous paper and in case of KR design loading, all response of stiffened plate structure were within elastic limit. Through the nonlinear analysis, nearly elastic behavior including the slight geometrical nonlinear response was dominant but plastic local zone was appeared at $85\%$ limit load. Therefore, we can say that through tire linear and nonlinear analysis, this stiffened plate member has no structural strength problem based on the yield criteria in case within $60\%$ limit load except the other strength point of view such as the fatigue and buckling problem.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.8
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• pp.1035-1041
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• 2013

To evaluate the structural integrity and dynamic characteristic of the knuckle part of a KTX anti-roll bar, an experimental and a numerical approach were used in this study. In the experimental approach, the acceleration and strain data for the knuckle parts of the KTX and KTX-SANCHUN anti-roll bar were respectively measured to evaluate and compare its structural dynamic characteristics under the operating environments of the Honam line. In the numerical approach, the evaluation of its structural integrity was conducted using LS-DYNA 3D, and then, the reliability of the finite element model used was ensured by a comparative evaluation with the experiment. The numerical results showed that the stress and velocity field of the knuckle part composed of a layered structure of a thin steel plate and rubber were more moderate than those of the knuckle part made of only a thick steel block owing to the reduction of relative contact between the knuckle and the connecting rod. It was found that the knuckle part made of a thin steel plate and rubber was recommended as the best solution to improve its structural integrity resulting from the elastic behavior of the KTX anti-roll bar being enabled under a repeating external force.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.6
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• pp.498-507
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• 2017

Electronic equipments comprised of high density components with various packaging types have been recently applied to a satellite. Therefore, to guarantee high reliability of electrical equipment, a design approach, which can reduce the development period and cost through an early diagnosis in potential risks of failure, should be established. In the previous research, the reliability assesment of the electronic equipments have based on Steinberg's fatigue failure theory. However, this theory was not enough for further investigation of life prediction and reliability of the electronic equipments comprised of various sizes and packaging types due to its theoretical limitations and analysis results sensitivity with regard to different modeling technic. In that case, if detailed finite element model is established, aforementioned problems can be readily solved. However, this approach might arise disadvantage of spending much time. In this paper, to establish strategy for high reliability design of electronic equipment, we performed mechanical reliability evaluation of CCB (Camera Controller Box) at qualification level based on the approach using Sherlock unlike design techniques applied to existing business.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.662-675
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• 2018

Objective: The aim of this study was to establish the developmental history of hospice palliative care (HPC) with Korean medicine (KM). Methods: We compared the developmental history of HPC in Korea with that of Britain, the United States, Taiwan, Japan, and China. The articles in English or Korean published until Feb. 2017 were searched using 'Hospice' or 'Palliative care' with the name of each nation in the PubMed, MEDLINE, ScienceDirect, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases for foreign articles and OASIS (Oriental Medicine Advanced Searching Integrated System) for domestic articles. Books and gray literature were searched on the same databases and websites of the Ministry of Health and Welfare and related organizations in each country. Results: Modern palliative care began with the hospice movement led by Dr. Cicely Saunders. HPC in Korea started earlier than in other countries but it took considerable time for social consensus, so Korean policies have only been published recently. In this process, KM was excluded from HPC. For this reason, western medicine in Korea does not fully accept the spirit of HPC, the government does not take an aggressive stance with KM, and the institutes of KM do not have any interest in HPC. The World Health Organization recommends the establishment of policies and programs connected with a country's own health care system. In 2015, the Korean government made the third comprehensive plan for the development of KM. It included critical pathway guidelines about cancer-related fatigue and anorexia. More effort is required to set up HPC than other care types because Korea has two medical systems. Conclusions: Each nation has been trying to improve systems of HPC. We need to overcome the problems and bring out the best by making our own model of HPC with KM.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.10
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• pp.1185-1191
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• 2014

Gas turbine blades that have complex geometry of the cooling holes and cooling passages are usually subjected to cyclic and sustained thermal loads due to changes in the operating characteristic in combined power plants; these results in non-uniform temperature and stress distributions according to time to gas turbine blades. Those operation conditions cause creep or thermo-mechanical fatigue damage and reduce the lifetime of gas turbine blades. Thus, an accurate analysis of the stresses caused by various loading conditions is required to ensure the integrity and to ensure an accurate life assessment of the components of a gas turbine. It is well known that computational analysis such as cross-linking process including CFD, heat transfer and stress analysis is used as an alternative to demonstration test. In this paper, temperatures and stresses of gas turbine blade were calculated with fluid-structural analysis integrating fluid-thermal-solid analysis methodologies by considering actual operation conditions. Based on analysis results, additionally, the total lifetime was obtained using creep and thermo-mechanical damage model.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.528-533
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• 2004

The immune system acts to protect the host from infectious agents that exist in the environment and from other noxious insults. The immune system has two functional divisions: the innate and the acquired. Both components involve various factors such as cytokines. A number of methodologies exist to assess aspects of immune function. There are large inter-individual variations in many immune functions even among the healthy. Genetics, age, gender, smoking habits, habitual levels of exercise, alcohol consumption, diet, stage in the female menstrual cycle, stress, history of infections and vaccinations, and early life experiences are likely to be important contributors to the observed variation. While it is clear that individuals with immune responses significantly below 'normal' are more susceptible to infectious agents and exhibit increased infectious morbidity and mortality, it is not clear how the variation in immune function among healthy individuals relates to variation in susceptibility to infection. Oriental medicine is an important factor contributing to immune competence. The author investigated the immune enhancement effects of Bojungikkitanggami-bang (BITB). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. In the present study, the author investigated the effects of BITB on FST and blood biochemical parameters related to fatigue, glucose (Glc); blood urea nitrogen (BUN); lactate dehydrogenase (LDH); creatinine; and total protein (TP). The author found that BITB (1 g/kg) significantly reduced the immobility time in the FST compared to the control. In addition, the contents of Glc, LDH, BUN, TP in the blood serum were increased in BITB (1g/kg)-fed group. Also, the author investigated the effects of BITB on the production of cytokines in human T-cell line, MOLT-4 cells. BITB (1 mg/ml) significantly increased the interferon (IFN)-vproduction compared with media control (about 2.2-fold for IFN-γ) at 24 h. However, BITB has not affect the production of IL-2 and IL-4. In addition, BITB increased the protein expression level of IFN-γ in MOLT-4 cells. Thus, BITB may have therapeutic value in generating or enhancing immune function in a clinical setting.

• Journal of Pharmacopuncture
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• v.19 no.2
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• pp.122-128
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• 2016

Objectives: Cornu cervi pantotrichum (CCP) has been widely used in Korean and China, as an anti-fatigue, anti-aging, and tonic agent to enhance the functions of the reproductive and the immune systems. Because CCP has various growth factors that play important roles in the development of hair follicles, we examined whether CCP pharmacopuncture solution (CCPPS) was capable of promoting hair growth in an animal model. Methods: One day after hair depilation, CCPPS were topically applied to the dorsal skin of C57BL/6 mice once a day for 15 days. Hair growth activity was evaluated by using macro- and microscopic observations. Dorsal skin tissues were stained with hematoxylin and eosin. Expressions of bromodeoxyuridine (BrdU), proliferating cell nuclear antigen (PCNA), and fibroblast growth factor (FGF)-7 were examined by using immunohistochemical staining. A reverse transcription polymerase chain reaction (RT-PCR) analysis was also conducted to measure the messenger RNA (mRNA) expression of FGF-7. Results: CCPPS induced more active hair growth than normal saline. Histologic analysis showed enlargement of the dermal papilla, elongation of the hair shaft, and expansion of hair thickness in CCPPS treated mice, indicating that CCPPS effectively induced the development of anagen. CCPPS treatment markedly increased the expressions of BrdU and PCNA in the hair follicles of C57BL/6 mice. In addition, CCPPS up regulated the expression of FGF-7, which plays an important role in the development of hair follicles. Conclusion: These results reveal that CCPPS facilitates hair re-growth by proliferation of hair follicular cells and up-regulation of FGF-7 and suggest that CCPPS can potentially be applied as an alternative treatment for patients with alopecia.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.579-584
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• 2017

The damper oil seal of a high-speed railway vehicle is made from nitrile butadiene rubber (NBR) in order to prevent lubricant from leaking into the damper and to stop harmful contaminants from entering the external environment while in service. Oil leakage through the seal primarily occurs from fatigue failure of the damper. Cumulative damage of the seal occurs due to the contact force between the rod and the rubber during movement due to track irregularities and cants, among other factors. Thus, the design of the oil seal should minimize the maximum principal strain at weak points. In this study, the optimal cross section of the damper oil seal was found using the multi-island genetic algorithm method to improve the durability of the damper. The optimal shape of the oil seal was derived using process automation and design optimization software. Nonlinear material properties for finite element analysis (FEA) of the rubber were determined by Marlow's model. The nonlinear FEA confirmed that the maximum principal strain at the oil leakage point was decreased 24% between the initial design and the optimum design.