• Asian Pacific Journal of Cancer Prevention
• /
• 제16권15호
• /
• pp.6365-6373
• /
• 2015

Background: Tobacco consumption has become pandemic, and is estimated to have killed 100 million people in the 20th century worldwide. Some 700,000 out of 5.4 million deaths due to tobacco use were from India. The era of global modernization has led to an increase in the involvement of women in tobacco consumption in the low income and middle-income countries. Tobacco consumption by females is known to have grave consequences. Objectives: To assess: (1) the tobacco use among urban and rural women; (2) the discrepancy in the knowledge, belief and behavior towards tobacco consumption among urban and rural women in Durg-Bhilai Metropolitan, Chhattisgarh, Central India. Materials and Methods: The study population consisted of 2,000 18-25 year old young women from Durg-Bhilai Metropolitan, Chhattisgarh, Central India, from both urban and rural areas. Data were collected using a pretested, anonymous, extensive face to face interview by a female investigator to assess the tobacco use among women and the discrepancy in the knowledge, belief and behavior towards tobacco consumption among urban and rural individuals. Results: The prevalence of tobacco use was found to be 47.2%. Tobacco consumption among rural women was 54.4% and in urban women was 40%. The majority of the women from urban areas (62.8%) were smokers whilst rural women (77.4%) showed preponderance toward smokeless tobacco use. Urban women had a better knowledge and attitude towards harms from tobacco and its use than the rural women. Women in rural areas had higher odds (1.335) of developing tobacco habit than the urban women. Conclusions: Increased tobacco use by women poses very severe hazards to their health, maternal and child health, and their family health and economic well-being. Due to the remarkably complex Indian picture of female tobacco use, an immediate and compulsory implementation of tobacco control policies laid down by t he WHO FCTC is the need of the hour.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권17호
• /
• pp.7467-7472
• /
• 2015

Background: Breast cancer is known to be one of the most prevalent cancers among women in both developing and developed countries. The incidence of breast cancer in Pakistan has increased dramatically within the last few years and is the second country after Israel in Asia to have highest proportional cases of breast cancer. However, there are limited data for breast cancer available in the literature from Pakistan. Objectives: The study was conducted to bring to light the common clinical presentation of breast cancer and to evaluate the frequency of established risk factors in breast carcinoma patients and furthermore to compare the findings between premenopausal and postmenopausal women in Pakistan. Materials and Methods: A 6 months (from July 2012 to Dec 2012) cross sectional survey was conducted in Surgical and Oncology Units of Civil Hospital, Karachi. Data were collected though a well developed questionnaire from 105 female patients diagnosed with carcinoma of breast and analyzed using SPSS version 17. Institutional ethical approval was obtained prior to data collection. Results: Out of 105 patients, 43 were premenopausal and 62 were postmenopausal, 99 being married. Mean age at diagnosis was $47.8{\pm}12.4years$. A painless lump was the most frequent symptom, notived by 77.1%(n=81). Some 55.2% (n=58) patients had a lump in the right breast and 44.8%(n=47) in the left breast. In the majority of cases, the lump was present in upper outer quadrant 41.9% (n=44). Mean period of delay from appearance of symptoms to consulting a doctor was $5.13{\pm}4.8months$, from the shortest 1 month to the longest 36 months. Long delay (> 3 months) was the most frequent figure 41.9%. Considering overall risk factors most frequent were first pregnancy after 20 years of age (41%), physical breast trauma (28.6%), lack of breast feeding(21.9%), and early menarche <11 years (19%), followed by null parity (16.2%), consumption of high fat diet (15.2%), family history of breast cancer or any other cancer in first degree relatives (9.5% and 13.3%, respectively). Some of the less common factors were late menopause >54 years (8.6%), use of oral contraceptive pills (10.5%), use of hormone replacement therapy (4.7%),smoking (4.7%) and radiation (0.96%). Significant differences (p<0.005) were observed between pre and post menopausal women regarding history of physical breast trauma, practice of breast feeding and parity. Conclusions: A painless lump was the most frequent clinical presentation noted. Overall age at first child > 20 years, physical breast trauma, lack of breast feeding, early menarche <11 were the most frequent risk factors. Physical breast trauma, lower parity, a trend for less breast feeding had more significant associations with pre-menopausal than post-menopausal onset. Increase opportunity of disease prevention can be obtained through better understanding of clinical presentation and risk factors important in the etiology of breast cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1419-1424
• /
• 2012

Objectives: To investigate in depth the use of complementary and alternative medicines (CAMs) by cancer patients at the end-of-life (EOL) and how they communicate with physicians about them. Design and location: In 17 hospitals in Korea between January and December 2004 we identified 4,042 families of cancer patients. Results: The prevalence of CAM use among cancer patients at the EOL was 37.0%, and 93.1% had used pharmacologic types of agents. The most frequent motive for CAM use was the recommendation of friends or a close relative (53.4%) or a physician (1.6%). Only 42.5% discussed CAM use with their physicians. Satisfaction with CAMS was recalled for 37.1%. The most common reason given for that satisfaction was improvement of emotional or physical well-being, while ineffectiveness was the most common reason given for dissatisfaction. The average cost of CAM during the last month of life was $US 900. CAM use was associated with longer disease periods, primary cancers other than liver, biliary, and pancreatic, and need of support from physicians or religion. Conclusions: CAM use among cancer patients at the EOL was common, not discussed with physicians, and associated with expectation of cure. Expectations were generally unmet while the treatments were a financial burden. Further studies evaluating the effects of CAM at the EOL and factors that enhance communication with the physician are needed.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권12호
• /
• pp.6155-6157
• /
• 2012

Background: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell proliferation. MKP - a dual specific phosphatase - interacts with activated ERK2 via the common docking (CD) domain of the later to inactivate (dephosphorylate) and effectively terminate further cell proliferation. A constitutively active form of ERK2 carrying a single point mutation - E322K in its CD domain, was earlier reported by our laboratory. In the present study, we investigated the prevalence of this CD domain E322K mutation in 88 well differentiated OSCC tissue samples. Materials and Method: Genomic DNA specimens isolated from 88 oral squamous cell carcinoma tissue samples were amplified with primers flanking the CD domain of the ERK2 gene. Subsequently, PCR amplicons were gel purified and subjected to direct sequencing to screen for mutations. Results: Direct sequencing of eighty eight OSCC samples identified an E322K CD domain mutation in only one (1.1%) OSCC sample. Conclusions: Our result indicates that mutation in the CD domain of ERK2 is rare in OSCC patients, which suggests the role of genetic alterations in other mitogenic genes in the development of carcinoma in the rest of the patients. Nevertheless, the finding is clinically significant, as the relatively rare prevalence of the E322K mutation in OSCC suggests that ERK2, being a common end point signal in the multi-hierarchical mitogen activated signaling pathway may be explored as a viable drug target in the treatment of OSCC.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권9호
• /
• pp.4259-4265
• /
• 2016

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20. Materials and Methods: Colorectal patients with a positive history of familial cancers were selected by evaluating medical records. Based on Amsterdam II criteria for Lynch syndrome 20 families were short listed. DNA was extracted from formalin fixed paraffin embedded tumour and adjacent normal tissues resected from the index case in each family. Extracted DNA was subjected to MT1XT20 mononucleotide marker analysis and assessment with a commercially available five marker MSI testing kit (Promega, USA). IHC also was performed on tissue sections and the results were compared with PCR based data. Results: Eight (40%), seven (35%) and five (25%) cases were MSI positive using with the Promega kit, IHC and MT1XT20, respectively. Among the markers included in Promega kit, BAT26 marker showed instability in all 8 samples. NR24 and NR21 markers showed instability in 7 (87.5%), and BAT25 and MONO 27 in 6 (75%) and 5 (62.5%). Conclusions: Although MT1XT20 was earlier reported as a valid standalone marker for MSI testing in CRC patients, we could not verify this in our Iranian patients. Instead BAT26 among the markers included in Promega MSI testing kit showed instability in all 8 MSI-H CRC samples. Therefore, it seems BAT26 could act well as a single marker for MSI testing in Iranian CRC patients.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2010년도 춘계학술대회 논문집
• /
• pp.49-49
• /
• 2010

The most commonly used numerical modelling techniques for acoustics and vibration are based on element based techniques, such as the nite element and boundary element method. Due to the huge computational eorts involved, the use of these deterministic techniques is practically restricted to low-frequency applications. For high-frequency modelling, probabilistic techniques such as SEA are well established. However, there is still a wide mid-frequency range, for which no adequate and mature prediction techniques are available. In this frequency range, the computational eorts of conventional element based techniques become prohibitively large, while the basic assumptions of the probabilistic techniques are not yet valid. In recent years, a vast amount of research has been initiated in a quest for an adequate solution for the current midfrequency problem. One family of research methods focuses on novel deterministic approaches with an enhanced convergence rate and computational eciency compared to the conventional element based methods in order to shift the practical frequency limitation towards the mid-frequency range. Amongst those techniques, a wave based prediction technique using an indirect Tretz approach is being developed at the K.U.Leuven - Noise and Vibration Research group. This paper starts with an outline of the major features of the mid-frequency modelling challenge and provides a short overview of the current research activities in response to this challenge. Next, the basic concepts of the wave based technique and its hybrid coupling with nite element schemes are described. Various validations on two- and threedimensional acoustic, elastic, poro-elastic and vibro-acoustic examples are given to illustrate the potential of the method and its benecial performance as compared to conventional element based methods. A closing part shares some views on the open issues and future research directions.

• 한국학교보건학회지
• /
• 제3권1호
• /
• pp.85-100
• /
• 1990

This study is an attempt to give basic information for sex maleducation, which is the integration of emotional, moral and social aspects as well as generative and physiological ones. It is concerned with both students and parents' sexual knowledge, attitude and need for sex education. The participants for this study are consisted of 193 parents, and 492 boys and girls high school students in Seoul. The main results of this study are as follows: 1. General Characteristics 66.5 percent of students is the girl and 38.8 percent of students is christian. Regarding parents age, 73.6 percent of them is 40~49 year old and 30.6 percent of them is Buddhist. 50.5 percent of them is graduated from high school, almost of them are keeping on being married(90.9%). 2. Sexual Knowledge: The boys score higher grade(average 8.98) than the girls. (average 7.51) (p<0.001) The Parents appear to record average 11.5, higher than the students' 8.01(p<0.01). However, there is no difference between them depending on their age, educational level or marital condition. 3. Sexual Attitude: The boys have more affirmative and positive feelings on the generative and physiological sides than girls. They also have a positive attitude to usual sides such as marriage, sexual intercourse and pregnancy, compared with girls. The girls have negative and irrecipient attitude to unusual sides like divorce, premarital sex or extramarital sex, while the boys are recipient(p<0.01). The parents' sexual attitude is positive feelings on the generative and physiological sides, and they also have a positive attitude to usual sides but they have a negative attitude to unusual sides. 4. Correlation between sexual knowledge and attitude Both the students and parents have positive correlation between sexual knowledge and attitude to generative and physiological sines and usual sides. The higher scores. of the sexual knowledge are, The more positive attitude they have. But parents only have positive carrelation between sexual knowledge and attitude to unusual sides. The lower scores of the sexual knowledge are, The more negative attitude they have. 5. More than half of the parents educate their high school children in sex: menstruation(75.0%), sexual hygiene (59.1%). intersexual fellowship(69.7%). marriage(62.0%) and chastity(51.9%) 6. Need for sexual education The students and the parents have almost the same opinions on this subject. Regarding pregnancy. delivery, family planning, dilatation and currettage and divorce, however, the students want to learn in high school. while the parents expect sex education later in high school.

• 지적과 국토정보
• /
• 제44권2호
• /
• pp.155-175
• /
• 2014

본 연구는 산업과 인구의 이동현상을 대상으로 한 공간적 패턴 분석의 필요성을 인지하고, 수도권에서 충남으로 이전한 가구의 가구특성 및 공간적 패턴을 파악한 후 종합적으로 지리적 가중 회귀분석을 통해 수도권 기업의 지방이전에 따른 인구이동의 관계성을 도출하는 것을 목표로 삼았다. 분석결과 수도권에서 충청남도로 전입하는 인구는 직업을 주 목적으로 예산과 아산을 중심으로 하여 1, 2인 가구가 주로 전입하고 있었으며, GWR을 통해 연구지역의 시 군별로 직업을 사유로 이동하는 인구의 이동 요인을 파악한 결과 경제적 요인 이외에도 인구 요인과 교통 요인, 주거환경 요인 등의 영향을 받고 있었다. 위와 같은 분석결과들을 공공기업의 지방이전 및 수도권 기업의 기업이전에 따른 도시조성과 연관시켜 생각함으로써 다음과 같은 정책적 시사점들을 이끌어 낼 수 있었다. 첫째로, 현재 충청남도의 탈 수도권인구의 이동에 있어 수도권 기업의 이전에 따른 영향이 직접적으로 미치는 지역은 '시'단위의 규모보다 '군'단위의 소도시에서 효과가 더욱 좋은 것을 볼 수 있었다. 그럼에도 수도권 유출인구가 천안시, 아산시, 당진시 같은 대형 '시'단위의 도시로 가장 많이 이주하는 것은 사람들이 거주지를 선택함에 있어서는 직장 외 다른 이유가 작용한다는 것을 시사해준다. 둘째로, 향후 직업을 사유로 이동하는 인구는 개인단위보다는 가족단위의 이동이 대두될 것이며 유년 고령인구 위주로 거주지를 선택하게 될 것이므로 유년층 혹은 고령층에 대비하여 정주환경을 개선할 필요가 있다.

• Journal of Applied Biological Chemistry
• /
• 제59권4호
• /
• pp.323-330
• /
• 2016

반하(Pinellia ternata Breitenbach)는 천남성과(Araceae)의 약용 식물로 동아시아 일대가 원산지이며, 유럽과 북아메리카 일부 지역에도 널리 분포하고 있는 식물이다. 반하의 괴경(tuber)은 약재로 사용되어 구토, 염증, 외상을 치료하는 목적으로 사용되고 있다. 보고된 약리학적 작용으로는 항경련, 항종양, 살충, 세포독성 등이 있는 것으로 알려져 있다. 반하는 약리학적으로 유용한 약용식물로 잘 알려져 있음에도 불구하고, 원산지를 판별할 수 있는 신뢰성이 있고 표준화된 방법이 없는 실정이다. 이를 위한 한국산과 중국산 반하를 판별할 수 있는 유의적인 화합물을 탐색하기 위해 UPLC-PDA와 QTof-MS에 기반을 둔 대사체 표지법을 이용하였다. 한국산으로부터 원산지 판별 화합물로 예상되는 화합물을 반복적인 역상 칼럼크로마토그래피에 기반을 둔 활성유도 분획법을 통해 분리하였다. 그리고, NMR과 MS를 포함한 물리화학적, 분광학적 정보의 결과를 토대로 [6]-gingerol이라는 화합물의 구조를 동정하였다. [6]-gingerol은 원산지를 판별할 수 있는 능력과 melanin 생합성 저해 활성을 지닌 기능성 화장품 소재로서 가치가 있다고 판단되어짐에 따라 유효성분 원산지 판별 화합물로 Fingerprint법에 의해 선정되었다. 더욱이, 한국산과 중국산 반하 유래 [6]-gingerol의 함량 비교를 위해, 유효성이 검증된 분석법을 이용하여 이에 대한 검량곡선을 작성하여 그 함량을 비교하였다. 이것은 한국산 반하판별을 위한 화합물 선정과 성공적인 유효성 검증을 다룬 최초의 보고이다.

• 한국가정과교육학회지
• /
• 제31권4호
• /
• pp.163-192
• /
• 2019

본 연구는 한국가정과교육학회 창립 30주년을 맞이하여 지금까지의 발자취를 성찰하고 앞으로 나아갈 방향을 모색하고자 하였다. 이러한 목적에 부합하도록 첫째, 30년 역사의 성과를 가정과교육의 현황, 한국가정과교육학회의 학술대회 주제와 가정과 교사의 사회적 기여를 통해 뒤돌아보았다. 지난 30년 역사를 통해 본 가정과교육 분야의 연구와 가정과교사의 수업은 가정과교육의 역할을 제고하여 사회적 요구에 부응하기 위해 노력하였음을 확인하였다. 둘째, 미래 가정과교육의 역할을 발전적으로 탐색하기 위하여 가정과교육의 비전과 사명을 도출하였다. 비전과 사명의 공유는 전문분야로서 가정과교육이 추구하는 이상적인 가치와 목표로 기능하여 우리가 나아가야 하는 과정으로 이끌어준다. 본 연구로부터 가정과교육의 비전과 사명의 실현은 자유로운 개인, 자유로운 사회, 지속가능한 환경으로 이끌 것이며, 궁극적으로 개인과 가족, 사회, 환경의 총체적 웰빙을 이루게 할 것이다. 이를 위한 가정과교육의 역할은 미래 사회에 더욱 지대해질 것이라는 결론에 도달할 수 있다.