• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제9권2호
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• pp.237-246
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• 1998

요 약：소아 ${\cdot}$ 청소년 병동에 입원하였던 전반적발달장애 소아 청소년 환자의 임상특성을 파악하기 위해 실시하였다. 방 법：최근 5년간 입원하였던 57명(남자 53명, 여자 4명)의 전반적발달장애 소아 청소년 환자를 대상으로 사회인구학적 특성, 진단, 아동초기 발달력, 공존 정신병리 및 신경심리학적 검사, 부모의 정신병리 및 가족력, 치료형태 및 경과 등을 조사하였다. 결 과：1) 입원시 평균연령은 $96{\pm}28.2$개월이었으며, 대상아동이 처음으로 전문기관을 방문했던 평균연령은 $52{\pm}26.6$개월이었다. 평균 입원기간은 $43.7{\pm}31.3$일이었다. 2) 진단은 ‘달리 분류되지 않은 전반적발달장애’가 27명(47.4%)으로 가장 많았고, 자폐장애 15명(26.3%), Asperger증후군 9명(15.8%), 소아기 붕괴성장애 2명(3.5%) 순이었다. 3) 임신기간 동안 문제를 보고한 환자모는 33명(57.9%)이었고, 이들 중 21명(36.8%)은 불안, 우울 등 심리적 문제를 보고하였다. 발달력상 특징적 소견으로, 34명(59.6%)에서 외인불안이 없었다 하였고, 30명(52.6%)에서 분리불안이 없었다고 하였다. 4) 공존병리로서는 13명(23.8%)에서 주의력결핍 ${\cdot}$ 과잉행동장애, 2명(3.5%)에서 틱장애, 3명(5.3%)에서 정신증이 있었다. 지능검사가 가능했던 28명의 평균 FSIQ는 $70{\pm}27.5$였으며, 이중 15명(53.6%)에서 70 이하였다. 벤더게스탈트검사(BGT)가 가능했던 28명 중 27명(96.4%)에서 이상소견을 보였다. 5) 뇌파검사를 시행하였던 52명 중 11명(21.2%)에서 이상소견을 보였으며, 뇌영상검사를 시행했던 37명중 8명(21.6%)에서 이상소견을 보였다. 6) 부모의 정신병리로는 환자모 8명(14%)에서 우울증을 보였다. 20명(35.1%)에서 정신과적 가족력이 있었으며, 이중 3명(5.3%)에서는 전반적발달장애의 가족력을 보였다. 7) 입원전의 치료형태를 살펴보면, 62.5%에서 조기교육을 포함한 특수치료를 받았다. 62.5%는 정신과 외래치료를 받았다. 결 론：전반적 발달장애의 경우 발달과정에서 문제가 발생하므로 더더욱 조기 진단 및 조기 치료의 필요성이 강조되야 한다. 치료시 다면적 접근이 필수적이므로 치료자간의 이해와 교류가 동반되야 한다.

• Toxicological Research
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• 제14권2호
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• pp.123-127
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• 1998

BRCA1 is a tumor suppresser gene in familial cases of breast cancer. It has been controversial whether the subcellular localization of BRCA1 is located in nuclei or cytoplasm in normal human breast cells. We found that a p220 protein was expressed in Type II Normal human breast epithelial cells (NHBEC) but not in Type I NHBEC in Western blot analysis using the 17F8 (3A2) antibody. Immunostaining using the same antibody revealed positive staining in nuclei, cytoplasm and perinuclei of Type II cells and negative staining in Type I NHBEC. The p220 protein, however, was expressed in SV40 immortalized Type I NHBEC and tumorigenic cells derived from them after x-ray and neu oncogene treatment. The subcelluar localization was mostly cytoplasmic and punctate in the nuclei. The breast carcinoma cell lines, MCF-7 and T47D, also expressed the p220 protein. Using RT-PCR, we observed the expression of BRCA1 mRNA in both Type I and Type II NHBEC. This result indicated that there might be mechanisms involved in post-translational or translational regulation of BRCA1 gene. It is speculated that the absence of BRCA1 protein expression in Type I NHBEC might playa role in their susceptibility to neoplastic transformation.

• 대한간호학회지
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• 제29권2호
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• pp.238-247
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• 1999

The purpose of this study was to describe the relationship between family stress and adaptation in families with a disabled child through literature review using McCubbin's Double ABCX family crisis framework. The literature review focused on (1) family stress and factors affecting family stress, (2) the critical individual, familial and social resources which families acquire and employ over time in managing crisis situation. (3) the changes in definition and meaning families develop in an effort to make sense out of their predicament. (4) the coping strategies families employ. and (5) the range of outcomes of these family efforts The results showed that families reported financial difficulties and the burden of care-giving demands as major family stressors. Siblings of disabled children manifested depressive symptoms and social isolation. but was not consistent study results. The parents' views of the cause of the disabling condition fundamentally affected their behavior toward their disabled child. Especially. the fathers' views of the child's characteristics made the greatest contribution to positive changes in the mothers' perceptions. The term perceived social support refers to the cognitive appraisal by individuals that they are cared for and valued, that significant others are available to them if needed, and that they are satisfied with their interpersonal relationships. The perceived social support was more protective than social support source. network size and network density. Parental adaptation was found to be related to the child's communication competence rather than family coping strategies proposed by Lazarus and Folkman. One study results showed that there was no difference in depressive symptoms and physical health between mothers with a disabled child and those without all though mothers with a disabled child had negative attitudes and perceived themselves as having significantly less social support and lower family functioning. But a longitudinal study revealed decreases in the negative impact of the child and increases in sibling and overall family adaptation.

• 대한간호학회지
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• 제30권6호
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• pp.1569-1579
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• 2000

The purpose of this study was to identify the level of grief experience, family hardiness and family resource for management after bereavement of a family member. The subjects of this study were 100 family members who had lost a family member from cancer within the past two years. The data was analyzed using the SPSS program for descriptive statistics, t-test, ANOVA, Duncan test, and Pearson correlation. The results were as follows. 1. The mean score for the level of grief was 2.84 $\pm$ 0.66. The mean score for the a family hardiness was 3.08 $\pm$ 0.39. The mean score for the level of family resource management was 2.70 $\pm$ 0.35. 2. The level of grief experience differed respondent's age was F=2.95, p=.02, and type of bereavement was t=2.01, p=.04. 3. The level of family hardiness was not significantly different according to respondent's and familial characteristics. 4. The level of family resource management differed according to monthly income of the family (F=3.98, p=.01). 5. There were negative correlations between grief experience and family hardiness (r= -.551, p<.001), grief experience and family resource for management (r=-.351, p<.001). Family hardiness was positively related with family resource for management (r=.709, p<.001). In conclusion, family hardiness and family resource management were identified as important variables that contributed to reduce the grief experience. Therefore, it is important to develop nursing intervention that enhances family hardiness and family resource for management for bereaved family.

• 가정과삶의질연구
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• 제33권6호
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• pp.115-128
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• 2015

This study aims to examine the general tendency of suicidal ideation in single person households and to analyse the differences and effects of related variables(sociodemographic variables, characteristics of single person households, happiness and depression) on suicidal ideation. For achieving these purposes, a survey was conducted using questionnaires, based on quota sampling that considers the distribution of population in each dong of one Gu in Gwangju. Finally, data of 686 single person households were used for analysis. The study findings were as follows. The average score of suicidal ideation in single person households was 6.47 points, it was somewhat higher as compared to prior research that was targeting general households. And the average score of happiness index was 4.17 points, depression was 33.11 points. The level of suicidal ideation in single person households was significantly different according to age, occupation, economic status, health status, period of single life, life satisfaction, and contact with family. In addition, the level of depression(${\beta}=.24$, p<.01) had the biggest effect on suicidal ideation in single person households and it was followed by happiness index(${\beta}=-.19$, p<.05) and family visit(${\beta}=-.15$, p<.05). The total explanatory power was 37%. These findings imply that it is important to find a high mental health risk group and treat it early, because there is a high possibility that single person households might have mental health problems by being isolated or alienated from society. In addition, diverse program and services designed to maintain familial bonds despite family members living separately are needed.

• Imaging Science in Dentistry
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• 제49권4호
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• pp.317-321
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• 2019

Steatocystoma multiplex is an uncommon benign skin disease, which typically manifests as numerous intradermal cysts that can be scattered anywhere on the body. Although usually asymptomatic, it can be significantly disfiguring. One type of steatocystoma multiplex is known to be associated with the autosomal dominant inheritance of a mutation in the gene coding for keratin 17 (KRT17). In such cases, it is often concurrent with other developmental abnormalities of the ectoderm-derived tissues, such as the nails, hair, and teeth. To the best of our knowledge, few cases have been reported of steatocystoma multiplex of the oral and maxillofacial region. This report describes a case of steatocystoma multiplex of both sides of the neck and multiple dental anomalies, with a focus on its clinical, radiological, and histopathological characteristics, as well as the possibility that the patient exhibited the familial type of this condition.

• 대한한방소아과학회지
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• 제24권2호
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• pp.1-12
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• 2010

Objectives Taking detailed patient history helps earlier diagnosis and treatment of developmental disability. In this study we analyzed the clinical questionnaire to find out the clinical characteristics of those with five-retardation, five-limpness, or five-stiffness. Methods The data was collected from 484 children under the age of six who have visited H oriental medicine clinic for developmental delay. The clinical questionnaire was filled out by their parents and the data was analyzed statistically. Results 436 children showed symptoms of five-retardation, 90 children suffered from five-stiffness, 54 children showed five-limpness and 7 children suffered from five-stiffness and five-limpness complex. Generally, boys had higher chance to show disease symptoms than the girls (2.32:1) and 40 children (8.26%) reported family history of developmental disability. Cerebral palsy ranks the most common familial disease, followed by developmental delay, mental retardation, autistic disorder and language disorder. Among the children we have studied, 285 children (63.19%) showed delayed unassisted walk while 192 children (42.57%) had language disorder. Also, 138 children (28.51%) had both walk and language disorders. The children in this study also showed delayed toilet training and half of them had little stranger anxiety when they were infants. It was also found that 120 children (24.79%) experienced epilepsy. This study reaffirmed that low birth weight, premature birth, and suffocation are major risks causing neurological damage. Conclusions They had history which including family history, problems at birth, epilepsy, face recognition, muscle tone disorder, delayed walking without assistance, language ability, and toilet training.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9649-9654
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• 2014

Background: Polyps are common lesions in the gastrointestinal (GI) tract. Colon cancer is mostly a result of progression from polyps. The present study aimed to evaluate demographic, clinical, and histological characteristics of colorectal polyps in Iran, particularly neoplastic and advanced types. Materials and Methods: Over a period of 10 years, specimens of all colorectal polyps obtained from colonoscopy were studied. The variables subjected to statistical analysis were age, sex, and the chief clinical complaint of the patients who underwent colonoscopy, their motivation, and the site, size, and histological types of detected polyps. The level of significance was set at p value <0.05. Results: Data were obtained from a total of 352 patients. No difference was seen between male and female patients regarding histological types. Only in nine patients was screening the reason for colonoscopy. Almost two-thirds (66.2%) of the polyps were neoplastic. Familial polyposis syndrome and inflammatory bowel disease were seen in 4.3% and 3.0% of the patients with neoplastic polyps, respectively. Sites of polyps were the sigmoid, rectum, and descending colon in 40.1%, 34.5%, and 17% of the cases, respectively. The advanced type made up 58.8% of neoplastic polyps. Only 3.6% of the patients undergoing colonoscopy in the study period had biopsied polyps. Discussion: No difference was observed between male and female patients in terms of overall incidence of polyps, histological and anatomical profiles, and mean age distribution. Anatomical and histological profiles agreed with the studies performed in areas with a low risk of colon cancer. The findings show that colonoscopy was not performed when it was necessary. A meaningful increase in the number polyp biopsy cases and a corresponding decrease in polyp size in the last few years of the study can be associated with the presence of more GI specialist clinicians in hospital centers, and this holds out much hope for the further improvement of the situation in the future.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4647-4652
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• 2015

Background: Colorectal cancer (CRC) is becoming one of the most complicated challenges of human health, particularly in developing countries like Iran. In this paper, we try to characterize CRC cases diagnosed < age 50 at-risk for Lynch syndrome within central Iran. Materials and Methods: We designed a descriptive retrospective study to screen all registered CRC patients within 2000-2013 in Poursina Hakim Research Center (PHRC), a referral gastroenterology clinic in central Iran, based on being early-onset (age at diagnosis ${\leq}50years$) and Amsterdam II criteria. We calculated frequencies and percentages by SPSS 19 software to describe clinical and family history characteristics of patients with early-onset CRC. Results: Overall 1,659 CRC patients were included in our study of which 413 (24.9%) were ${\leq}50years$ at diagnosis. Of 219/413 successful calls 67 persons (30.6%) were reported deceased. Family history was positive for 72/219 probands (32.9%) and 53 families (24.2%) were identified as familial colorectal cancer (FCC), with a history of at-least three affected members with any type of cancer in the family, of which 85% fulfilled the Amsterdam II Criteria as hereditary non-polyposis colorectal cancer (HNPCC) families (45/219 or 20.5%). Finally, 14 families were excluded due to proband tumor tissues being unavailable or unwillingness for incorporation. The most common HNPCC-associated extracolonic-cancer among both males and females of the families was stomach, at respectively 31.8 and 32.7 percent. The most common tumor locations among the 31 probands were rectum (32.3%), sigmoid (29.0%), and ascending colon (12.9%). Conclusions: Given the high prevalence of FCC (~1/4 of early-onset Iranian CRC patients), it is necessary to establish a comprehensive cancer genetic counseling and systematic screening program for early detection and to improve cancer prognosis among high risk families.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제8권1호
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• pp.43-49
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• 1997

본 연구는 아동의 기질특성이 신체발육에 영향을 주는가를 알아보기 위해 설계되었다. Thomas와 Chess에 의해 개발된 기질설문지의 한국 표준화 판을 이용하여 3세에서 7세 사이의 남녀 아동 395명의 기질을 측정하였다. 동시에 각 아동의 신장과 체중을 측정한 후 한국 소아 신체 발육 표준치에 근거하여 신장 및 체중 절대치를 백분율 값으로 전환하였다. 기질의 난이도 지수인 요인 A 점수 및 9가지 기질범주 점수와 신장 및 체중 백분율 값 및 신장에 따른 체중 백분율 값 사이에 상관분석을 실시하였다. 가족 평균 월 수입액에 따라 7단계로 분류한 가정 경제력을 통제변수로 하여 경제력을 통제하였다. 그 결과 기질적으로 어려운 아이일수록 동일 연령의 아동들에 비해 체중이 낮았으며, 동일한 신장을 갖는 아동들 중에서도 체중이 낮은쪽에 포함되었다. 이런 경향은 여자 아동들에서 두드러졌다. 이 결과는 기질특성이 심리적 발달뿐만 아니라 신체 성장과도 관련이 있음을 보여주는 것이다.