• Geotechnical Engineering
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• v.14 no.4
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• pp.177-204
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• 1998

In the present study, a method of quasi-three dimensional stability analysis is proposed for a systematic design of the GRS-RW(Geosynthetic-Reinforced Soil Retaining Wall) system based on the postulated three dimensional failure wedge. The proposed method could be applied to the analysis of the stability of both the straight-line and cove-shaped are. As with skew reinforcements. Maximum earth thrust expected to act on the rigid face wall is assumed to distribute along the depth, and wall displacements are predicted based on both the assumed compaction-induced earth pressures and one dimensional finite element method of analysis. For a verification of the procedure proposed in the present study, the predicted wall displacements are compared with chose obtained from the RMC tests in Canada and the FHWA tests in U.S.A. In these comparisons the wall displacements estimated by the methods of Christopher et at. and Chew & Mitchell are also included for further verification. Also, the predicted wall displacements for the convex-shaped zone reinforced with skew reinforcements are compared with those by $FLAC_{3D}$ program analyses. The assumed compaction-induced earth pressures evaluated on the basic of the proposed method of analysis are further compared with the measurements by the FHWA best wall. A parametric stduy is finally performed to investigate the effects of various design parameters for the stability of the GRS-RW system

• Biomolecules & Therapeutics
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• v.9 no.3
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• pp.167-175
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• 2001

Recent studies have shown that cytokines are capable of modulating cardiovascular function and that some drugs used in the treatment of heart failure variably modulate the production of cytokines. Hige- namine, a positive inotropic isoquinoline alkaloid, has been used traditionally as cardiac stimulant, and reported to reduce nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression in LPS- and/or cytokine-activated cells in vitro and in vivo. Therefore, we investigated whether higenamine modulates the production of proinflammatory cytokines in myocardial infarction. In addition, effects of higenamine on antioxidant action and antioxidant enzyme expression (MnSOD) were studied. Myocardial infarction (MI) was confirmed by measuring left ventricular (LV) pressure after occlusion of the left anterior descending coronary artery (LAD) for 5 weeks in rats. Treatment of higenamine (10 mg/kg/day) reduced infarct size about 35 %, which accompanied by reduction of production TNF-$\alpha$, IL-6, but not IFN-${\gamma}$ and IL-1$\beta$ in the myocardium. The expression of TNF-$\alpha$ mRNA in infracted myocardium was significantly reduced by higenamine. Although iNOS mRNA was not detected, nitrotyrosine staining was significantly increased in myocardium of Ml compared to higenamine-treated one, Indicating that peroxynitrite-induced damage is evident in MI. Cytochrome c oxidation by peroxynitrite was concentration-dependently reduced by higenamine, an effect which was almost compatible to glutathion. Higenamine treatment did not affect the expression of MnSOD mRNA in myocardial tissues in MI. Taken together, higenamine may be beneficial in oxidative stress conditions such as ischemic-reperfusion injury and MI due to antioxidant action as well as modulation of cytokines.

• Tunnel and Underground Space
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• v.17 no.5
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• pp.350-359
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• 2007

Most large cut slopes of open pit mines, roadways, and railways are steeply inclined and composed with rocks that do not contain soils. However, these rock slopes suffer both weathering and fragmentation. In the case of steep slopes, falling rock and collapse of a slope may often occur due to surface erosion. Cast-in place concrete and rubble work are the most widely used earth structure-based pressure supports that act as restraints against the collapse of the rock slope. In order to overcome the shortcomings of conventional retaining walls, a segmental grid retaining wall is being used with connects precasted segments to construct the wall. In this study, laboratory model test was conducted to estimate deformation behavior of segmental grid retaining wall with configuration of rear strecher, height and inclination of the wall. In order to examine the behavior characteristics of a segmental grid retaining wall, this research analyzes the aspects of spacial displacement through relative displacement according to change in the inclination of the wall. Also, the walls behavior according to the formation and status of the rear stretcher which serves the role of transferring the load from the header and the stretcher which make up the wall, the displacement of backfill materials in the wall, and the location of the maximum load were surveyed and the characteristics of displacement in the segmental grid retaining wall were observed. The test results of the segmental grid retaining wall showed that there was a sudden increase in failure load according to the decrease in the wall's height and the size of the in was greatly decreased. Furthermore, it revealed that with identical inclination and height, the structure of the rear stitcher did not greatly affect the starting point or size of maximum horizontal displacement, but rather had a stronger effect on the inclination of the wall.

• Tuberculosis and Respiratory Diseases
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• v.81 no.3
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• pp.247-255
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• 2018

Background: Patients with acute respiratory failure secondary to tuberculous destroyed lung (TDL) have a poor prognosis. The aim of the present retrospective study was to develop a mortality prediction model for TDL patients who require mechanical ventilation. Methods: Data from consecutive TDL patients who had received mechanical ventilation at a single university-affiliated tertiary care hospital in Korea were reviewed. Binary logistic regression was used to identify factors predicting intensive care unit (ICU) mortality. A TDL on mechanical Ventilation (TDL-Vent) score was calculated by assigning points to variables according to ${\beta}$ coefficient values. Results: Data from 125 patients were reviewed. A total of 36 patients (29%) died during ICU admission. On the basis of multivariate analysis, the following factors were included in the TDL-Vent score: age ${\geq}65$ years, vasopressor use, and arterial partial pressure of oxygen/fraction of inspired oxygen ratio <180. In a second regression model, a modified score was then calculated by adding brain natriuretic peptide. For TDL-Vent scores 0 to 3, the 60-day mortality rates were 11%, 27%, 30%, and 77%, respectively (p<0.001). For modified TDL-Vent scores 0 to ${\geq}3$, the 60-day mortality rates were 0%, 21%, 33%, and 57%, respectively (p=0.001). For both the TDL-Vent score and the modified TDL-Vent score, the areas under the receiver operating characteristic curve were larger than that of other illness severity scores. Conclusion: The TDL-Vent model identifies TDL patients on mechanical ventilation with a high risk of mortality. Prospective validation studies in larger cohorts are now warranted.

• Journal of the Korean Geotechnical Society
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• v.33 no.8
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• pp.5-16
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• 2017

When a lateral load is applied to a short pile whose embedded depth is relatively smaller than its diameter, an overturning failure occurs. To investigate the behavior of laterally loaded short piles, several model tests in laboratory scales had been carried out, however the behavior of large moment carrying piles for electric poles, traffic sign and road lamp, etc. have not been revealed yet. This paper deals with the real-scale load tests for 750 mm diameter short piles. To simulate the actual loading condition, very large moment was mobilized by applying lateral loads to the location 8 m away from the pile head. Three load tests changing the pile embedded lengths to 2.0 m, 2.5 m, and 3.0 m were carried out. The test piles overturned abruptly with very small displacement and rotation before the failures. These brittle failures are in contrast with the ductile failures shown in the former model tests with the relatively smaller moment to lateral load ratio. Comparisons of the test results with three existing methods for the estimation of the ultimate lateral capacity show that the method assuming the rotation point at pile tip matches well when the embedded depth is small, however, as the embedded depth increases the other two methods assuming the inversion of soil pressure with respect to rotation points in pile length match better.

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.4
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• pp.401-413
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• 2013

Slurry shield tunnelling ensures stability by pressurizing the tunnel face with the slurry contained in the chamber. It resists water and earth pressure in order to prevent the failure in the tunnel face during tunnel excavation. If the ground is relatively coarse, slurry can not clog the tunnel face and excessive slurry infiltration will occur. In this case chemical compounds or additives should be added to the slurry in order to improve the clogging phenomena at the tunnel face. In this study, the effect of the carbon dioxide gas as an additive to the slurry instead of chemical compounds on the capability of enhancing the clogging in the tunnel face is investigated. Bubbles arising from the carbonate-added slurry are trapped in the soil voids enhancing the clogging capability. This effect is studied in this paper by performing laboratory model tests simulating in-situ conditions, and by adopting the fine particle clogging theory. Tunnel face stability analysis was also performed and it was found that the effective size ($D_{10}$) of soils which can guarantee tunnel stability utilizing the carbonate-added slurry increased from 1.0 mm up to 2.6 mm. Moreover, Stability analysis showed that the tunnel face is stable if the ${\lambda}$(deposition coefficient) value is greater than $0.007sec^{-1}$.

• Journal of Yeungnam Medical Science
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• v.24 no.2
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• pp.232-242
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• 2007

Background : The safety and efficacy of trabeculectomy with Mitomycin C (MMC) for surgical treatment in aphakic and pseudophaic eyes were retrospectively evaluated. Materials and Methods : The authors reviewed 51 eyes of 45 patients who had been followed up for at least 6 months after trabeculectomy using MMC for aphakic and pseudophakic eyes. The success rate and complications were analyzed. The success criteria included intraocular pressures of 21 mmHg or less with or without glaucoma medications and no loss of light perception. Surgical failure was defined as a postoperative loss of light perception in patients with preoperative vision better than light perception, additional glaucoma surgery, or phthisis bulbi in patients with preoperative vision of no light perception. Results : The average follow up period was 27.7 months and the intraocular pressure was controlled under 21 mmHg in 36 eyes of 51 (70.6%) after the procedure with or without medication for glaucoma. Using the Kaplan-Meier survival analysis, the cumulative success rate at the 3-, 6-, 12-, 24- and 36-month intervals were 98.0%, 94.1%, 91.9%, 83.4% and 75.5%, respectively. The complications observed were hyphema (4 eyes), serous choroidal detachment (4 eyes), hypotony (3 eyes), and endophthalmitis (1 eye). Conclusion : Trabeculectomy using Mitomycin C for the treatment of aphakic and pseudophaic eyes was safe and effective.

• Journal of Nutrition and Health
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• v.12 no.1
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• pp.51-58
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• 1979

It is a general trend everywhere that the uses of vegetable oils are increasing due to the fact that they are effective in curing and preventing symptoms of high blood pressure and various heart failure conditions. At the same time the concept that oxidative rancidity is caused by the oxidation of unsaturated fatty acid moieties whose subsequent decomposition gives rise to various undesirable, sometimes toxic compounds is now well accepted. Linolenic acid (C, 18:3) is one of highly unsaturated and readily oxidizable fatty acid. The content of this essential polyunsaturated fatty acid in perilla seed oil (PSO) was found to be as high as 48% while only 1.5% in sesame seed oil (SSO). In this experiment the oxidative stability of PSO was compared with that of SSO. The experimental test group were as follows: A) Stored at different temperatures, namely $4^{\circ}C,\;30^{\circ}C,$ and $60^{\circ}C,$ B) Stored at room temperature $(20{\pm}5^{\circ}C)$ ; a. protected from sunlight and air, b. exposed to air without sunlight c. exposed to sunlight but protected front air, d. completely exposed to both air and sunlight. The following results were obtained; 1) It was found to be most stable against oxidation to store both PSO and SSO under the low temperature $(4^{\circ}C)$ condition. According to P.V. measurements it was found to be safe to keep both oils up to $30^{\circ}C$ for at least 8 weeks. When exposed to air, sunlight and high temperature $(60^{\circ}C)$, P.V. of PSO reached there peak values, which were much higher than those of SSO. This explains much of its instability as compared to SSO against oxidation. 2) The effect of high temperature $(60^{\circ}C)$ on A.V. was found to be more striking than those of all the other storage conditions. The condition of refrigeration was most effective in keeping A.V. low for both oils as was the case in P.V. 3) For both oils, I.V. decreased throughout the experimental period (8 weeks). The range of decrement was larger for PSO than SSO. 4) There was no significant change in the compositions of fatty acids of SSO caused by various experimental storage conditions. But for PSO the compositions of stearic, oleic and linoleic acid were decreased, whereas linolenic acid was increased proportionally.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.4C
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• pp.169-175
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• 2012

Soil water retention characteristics are influenced by factors of the confining stress and hysteresis in the variably saturated soil. In the description of effective stress based on hydraulic characteristics, the contribution of a matric suction to effective stress then varies with depth or is different between the processes of infiltration and evaporation. Unsaturated effective stress can be described based on suction stress characteristic curve, in which a representative soil water retention curve is required to evaluate. Pressure palate extractor tests under various confining stresses were performed and the hysteresis of drying and wetting process was also acquired. In the process of drying or wetting, a unique relationship has been estimated on the effective volumetric water content and the matric suction, which defines suction stress characteristic curve. In the unsaturated shear strength from triaxial tests, the suction stress and the effective stress were evaluated by matric suctions. The failure envelop by effective stress based on soil water retention characteristics was unique and the same as the saturated one. The measured suction stress from triaxial tests was similar to that from the soil water retention curve. Therefore it is verified that a representative soil water retention curve can be defined which is independent of the confining effect under wetting or drying process of the hysteresis.

• The Journal of Engineering Geology
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• v.23 no.3
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• pp.247-256
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• 2013

The carbonate sands of the Sabkha layer in the Middle East have very low shear strength. Therefore, instant settlement and time-dependent secondary settlement occur when inner voids are exposed, as in the case of particle crushing. We analyzed settlement of the Sabkha layer under a large-scale foundation by hydrotesting, and compared the field test results with the results of laboratory tests. With ongoing particle crushing, we observed the following stress-strain behaviors: strain-hardening (Sabkha GL-1.5 m), strain-perfect (Sabkha GL-7.0 m), and strain-softening (Sabkha GL-7.5 m). General shear failure occurred most frequently in dense sand and firm ground. Although the stress-strain behavior of Sabkha layer carbonate sand that of strain-softening, the particle crushing strength was low compared with the strain-hardening and strain-perfect behaviors. The stress-strain behaviors differ between carbonate sand and quartz sand. If the relative density of quartz sand is increased, the shear strength is also increased. Continuous secondary compression settlement occurred during the hydrotests, after the dissipation of porewater pressure. Particle crushing strength is relatively low in the Sabkha layer and its stress-strain behavior is strain-softening or strain-perfect. The particle crushing effect is dominant factor affecting foundation settlement in the Sabkha layer.