• 품질경영학회지
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• 제23권3호
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• pp.93-101
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• 1995

We present a brief survey concerning the relations between mean residual life and failure rate. Change points of mean residual life and failure rate are known to be different in general and we explore such situations in this paper. A few parametric models which show bathtub-shaped failure rate are examined in details, including the shape of its corresponding mean residual life function. We give some graphical comparisons of trend changes of mean residual life and failure rate for various choices of parameters for each parametric model.

• Journal of Pharmaceutical Investigation
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• 제20권4호
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• pp.199-203
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• 1990

The pharmacokinetics of propranolol administered orally (10 me/kg) was investgated in the rabbits of carbon tetrachloride induced hepatic failure. The plasma concentration and relative bioavailability of propranolol were increased significantly in hepatic failure rabbits, compared with those of normal rabbits. There were significant relationship between GOT, GPT value and bioavailability parameters of propranolol. In short, dosage regimen of propranolol is considered to be adjusted in dose size and dosing interval using GOT or GPT an index.

• Communications for Statistical Applications and Methods
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• 제23권6호
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• pp.467-478
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• 2016

The accelerated failure time model or accelerated life model relates the logarithm of the failure time linearly to the covariates. The parameters in the model provides a direct interpretation. In this paper, we review some newly developed practically useful estimation and inference methods for the model in the analysis of right censored data.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 추계학술발표대회 논문집
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• pp.73-77
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• 2004

Failure predictions of composite single-lap bonded joints were performed considering both of composite adherend failure and bondline failure. An elastic-perfectly plastic model of adhesive and a delamination failure criterion are used. The failure prediction results such as failure mode and strength have very good agreements with the test results of joint specimens with various bonding methods and parameters. The influence of variations in the effective strength (that is, adhesion performance) and plastic behavior of adhesive on the failure characteristics of composite bonded joints are investigated numerically. The numerical results show that optimal joint strength is archived when adhesive and delamination failure occur in the same time.

• Smart Structures and Systems
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• 제22권6호
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• pp.643-662
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• 2018

One of the methods for investigation of mechanical behavior of materials is numerical simulation. For simulation, its need to model behavior is close to real condition. PFC is one of the rock mechanics software that needs calibration for models simulation. The calibration was performed based on simulation of unconfined compression test and Brazilian test. Indeed the micro parameter of models change so that the UCS and Brazilian test results in numerical simulation be close to experimental one. In this paper, the effect of four micro parameters has been investigated on the uniaxial compression test and Brazilian test. These micro parameters are friction angle, Accumulation factor, expansion coefficient and disc distance. The results show that these micro parameters affect the failure pattern in UCS and Brazilian test. Also compressive strength and tensile strength are controlled by failure pattern.

• 한국정보전자통신기술학회논문지
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• 제9권6호
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• pp.566-572
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• 2016

소프트웨어 개발과정에서 소프트웨어 신뢰성은 매우 중요한 문제 중에 하나이다. 소프트웨어 고장현상을 분석하기 위하여 비동질적인 포아송과정에서 고장 발생 추이를 의미하는 위험함수가 고장시간에 독립적으로 일정하거나, 종속적인 경우, 즉 비-증가 또는, 비-감소하는 속성을 가질 수 있다. 본 연구에서는 소프트웨어 제품 테스팅 과정에서 고장 수명분포로서 어랑분포의 다양한 형상모수를 고려한 소프트웨어 개발 비용 분석에 대하여 연구되었다. 소프트웨어 고장현상을 분석하기 위하여 모수추정은 최우추정법이 사용되었다. 따라서 본 논문에서는 어랑분포의 형상모수를 고려한 소프트웨어 개발비용모형 분석을 위하여 소프트웨어 고장간격 시간자료를 이용하여 비교 및 평가하였다. 그 결과 형상모수에 따른 비용곡선을 비교 하였을 때 형상모형이 작을수록 비용이 많고 소프트웨어 최적 방출시간이 지연 됨을 알 수 있었다. 이 연구를 통하여 소프트웨어 개발자들에게 소프트웨어 형상모수에 따른 개발 비용을 탐색하는데, 기본적으로 도움을 줄 수 있는 사전정보의 역할을 할 수 있을 것으로 판단된다.

• 한국터널지하공간학회 논문집
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• 제9권3호
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• pp.263-273
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• 2007

일반적으로 고심도에 건설되는 암반구조물의 경우 높은 현지응력과 공동의 굴착에 따른 유도응력으로 인하여 공동 경계면에서 스폴링(spatting)이나 슬래빙(slabbing)과 같은 취성파괴가 발생할 수 있다. Hoek-Brown과 Mohr-Coulomb 파괴기준과 같은 전통적인 파괴기준을 적용한 결과 취성파괴현상과 파괴심도 등을 예측할 수 없는 것으로 나타나 취성파괴를 예측하기 위한 여러 모델이 제안되었으며, 그 중 CWFS 모델이 적합한 것으로 알려져 있다. 본 연구에서는 모형실험에서 얻어진 원형공동주변의 취성파괴현상을 모델링하기위하여 CWFS 모델을 적용하였으며, 입력자료의 산정을 위해 암석의 손상정도와 손상에 따른 물성의 변화를 측정하는 손상제어시험을 수행하였다. CWFS 모델에 의해 예측된 파괴양상을 전통적인 파괴기준에 의한 해석결과 및 모형실험결과와 비교하여 취성파괴모델링의 적용성을 평가하였다.

• 한국지반공학회논문집
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• 제32권3호
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• pp.15-27
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• 2016

본 연구에서는 제주도 북동부 육해상, 남동부 해상 및 북서부 해상에서 채취한 현무암 암석에 대하여 삼축압축시험을 수행하였으며, 그 결과로부터 산정된 Hoek-Brown 파괴기준의 파라미터인 암석 계수 $m_i$의 특성을 살펴보았다. 그리고 Hoek-Brown 파괴기준으로부터 추정된 점착력 및 내부 마찰각과 Mohr-Coulomb 파괴기준으로부터 산정된 점착 력 및 내부 마찰각을 각각 비교 분석하였다. 그 결과 제주도 현무암 암석에 대한 Hoek-Brown 파괴기준의 암석 계수 $m_i$는 암석의 내부 마찰각과 밀접하게 연관되어 있었으며, 내부 마찰각이 증가함에 따라 급격하게 증가하였다. Hoek-Brown 파괴기준으로부터 추정된 점착력은 Mohr-Coulomb 파괴기준으로부터 산정된 점착력보다 평균적으로 약 24% 정도 과대하게 추정되고 있으며, Hoek-Brown 파괴기준으로부터 추정된 내부 마찰각은 Mohr-Coulomb 파괴기준의 내부 마찰각과 비슷한 값을 나타내고 있음을 알 수 있었다.

• Clinical and Experimental Reproductive Medicine
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• 제50권3호
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• pp.185-191
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• 2023

Objective: Although intracytoplasmic sperm injection (ICSI) is a way to deal with in vitro fertilization failure, 3% of couples still experience repeated fertilization failure after attempted ICSI, despite having sperm within normal parameters. These patients are a challenging group whose sperm cannot fertilize the egg during ICSI. Unfortunately, no test can predict the risk of fertilization failure. Phospholipase C zeta (PLCζ) and transition nuclear proteins (TNPs) are essential factors for chromatin packaging during sperm maturation. This study aimed to assess PLCζ1 and TNP1 expression in the sperm of patients with fertilization failure and the correlations among the DNA fragmentation index, PLCζ1 and TNP1 gene and protein expression, and the risk of fertilization failure. Methods: In this study, 12 infertile couples with low fertilization rates (<25%) and complete failure of fertilization in their prior ICSI cycles despite normal sperm parameters were chosen as the case group. Fifteen individuals who underwent ICSI for the first time served as the control group. After sperm analysis and DNA fragmentation assays, quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and Western blot analyses were performed to compare the gene and protein expression of PLCζ and TNP1 in both groups. Results: DNA fragmentation was significantly higher in the fertilization failure group. The qRT-PCR and Western blot results demonstrated significantly lower PLCζ and TNP1 gene and protein expression in these patients than in controls. Conclusion: The present study showed that fertilization failure in normozoospermic men was probably due to deficient DNA packaging and expression of TNP1.

• Structural Monitoring and Maintenance
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• 제1권1호
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• pp.111-130
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• 2014

The increased use of carbon fiber reinforced polymer (CFRP) in retrofitting reinforced concrete (RC) members has led to the need to develop non-destructive techniques that can monitor and characterize the unique damage mechanisms exhibited by such structural systems. This paper presented the damage characterization results of six CFRP retrofitted RC beam specimens tested in the laboratory and monitored using acoustic emission (AE). The focus of this study was to continuously monitor the change in AE parameters and analyze them both qualitatively and quantitatively, when brittle failure modes such as debonding occur in these beams. Although deterioration of structural integrity was traceable and can be quantified by monitoring the AE data, individual failure mode characteristics could not be identified due to the complexity of the system failure modes. In all, AE was an effective non-destructive monitoring tool that can trace the failure progression in RC beams retrofitted with CFRP. It would be advantageous to isolate signals originating from the CFRP and concrete, leading to a more clear understanding of the progression of the brittle damage mechanism involved in such a structural system. For practical applications, future studies should focus on spectral analysis of AE data from broadband sensors and automated pattern recognition tools to classify and better correlate AE parameters to failure modes observed.