• BMB Reports
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• v.38 no.2
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• pp.121-127
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• 2005

Drosophila protects itself from infection by microbial organisms by means of its pivotal defense, the so-called innate immunity system. This is its sole defense as it lacks an adaptive immunity system such as is found in mammals. The strong conservation of innate immunity systems in organisms from Drosophila to mammals, and the ease with which Drosophila can be manipulated genetically, makes this fly a good model system for investigating the mechanisms of virulence of a number of medically important pathogens. Potentially damaging endogenous and/or exogenous challenges sensed by specific receptors initiate signals via the Toll and/or Imd signaling pathways. These in turn activate the transcription factors Dorsal, Dorsal-related immune factor (Dif) and Relish, culminating in transcription of genes involved in the production of antimicrobial peptides, melanization, phagocytosis, and the cytoskeletal rearrangement required for appropriate responses. Clarifying the regulatory interactions between the various pathways involved is very important for understanding the specificity and termination mechanism of the immune response.

• Biomedical Science Letters
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• v.23 no.4
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• pp.295-302
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• 2017

Mononuclear osteoclast precursors derived from hematopoietic progenitors fuse together and then become multinucleated mature osteoclasts by macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL). Especially, the binding of RANKL to its receptor RANK provides key signals for osteoclast differentiation and bone-resorbing function. RANK transduces intracellular signals by recruiting adaptor molecules such as TNFR-associated factors (TRAFs), which then activate mitogen activated protein kinases (MAPKs), Src/PI3K/Akt pathway, nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and finally amplify NFATc1 activation for the transcription and activation of osteoclast marker genes. This review will briefly describe RANKL-RANK signaling pathways and key molecules critical for osteoclast differentiation.

• Korean Journal of Clinical Laboratory Science
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• v.37 no.1
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• pp.41-46
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• 2005

It is known that mast cells (MCs) are increased in H. pylori-infected gastritis and its increase is mediated by stem cell factor (c-kit ligand). To determine the mechanism of mast cell recruitment and activation by stem cell factor, weinvestigated the expression of stem cell factor receptor (c-kit) in H. pylori-positive and -negative gastric mucosa. Biopsy specimens from 16 H. pylori-negative and 20 positive subjects were examined. H. pylori infection in gastric mucosa was examined by the Warthin-Starry method. MC and c-kit were identified by immunohistochemisty, using a monoclonal antihuman MC tryptase antibody and a polyclonal anti-human c-kit antibody. Densities of MC and c-kit positive cell were measured by a computerized image analysis system. MCs were detected in the lamina propria of both H. pylori-positive and -negative gastric mucosa. Densities of MC and c-kit positive cell were significantly greater in H. pylori-positive than -negative subjects. c-kit was located on the surface of MCs. These results indicate that stem cell factors may be one of the factors involved in mast cell increase and that they activate mast cells by binding with c-kit.

• Biomedical Science Letters
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• v.12 no.3
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• pp.217-224
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• 2006

It has been reported that the dysfunctions of podocytes are associated with the development of diabetic nephropathy. In addition, insulin-like growth factors (IGFs) are associated with the development of diabetic nephropathy. However, it is not yet known about the effect of high glucose on IGF-I, -II secretion, and IGF binding proteins (IGFBPs) expression in the podocytes. Thus, this study was conducted to examine the effect of high glucose on IGF system and its involvement of protein kinase C (PKC) and mitogen activated protein kinases (MAPKs) in podocytes. In this study, high glucose (25 mM) increased IGF-I and IGF-II secretion (P<0.05), which was blocked by SB 203580 (a p38 MAPK inhibitor) but not by PD 98059 (a p44/42 MAPK inhibitor). In addition, high glucose-induced stimulation of IGFs was blocked by bisindolylmaleimide I and staurosporine (protein kinase C inhibitors). High glucose also increased IGFBP-l expression, which was blocked by bisindolylmaleimide I and SB 203580. In conclusion, high glucose alters IGFs secretion and IGFBP expression via PKC and p38 MAPK pathways in podocytes.

• Journal of Digital Convergence
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• v.13 no.10
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• pp.41-50
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• 2015

This study targeted volunteers to identify the variables that affect the attitude for participating in the volunteer activities going forth, and their effect. The independent are consisted of personal characteristic variables, participation related variables, management process variables. As for the dependent variables, they included the will to participate continually and degree of participation. The major findings are as follows : First, volunteer work agency try to activate housewives' participants. Second, the volunteer work agency need to improve and develop the programs which are consisted of more 3-hours per participation and three times per month. Third, so the motivations are the most important variables affect the sustainability, volunteer programs must be established to realize effective experience learning and social participation. Forth, a systematic management for the volunteer programs must be established to activate more participation.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.1089-1095
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• 2023

Windows are essential and important architectural elements for the organization of architectural spaces, and they give character to the space and have a great impact on the reaction of users. Virtual windows are installed to activate architectural spaces such as underground spaces where windows cannot be installed, and to provide a sense of psychological security to users in hospital clinics, etc. In this study, we reviewed the literature and collected and analyzed the precedents of virtual windows to discuss the factors necessary to improve the realism of virtual windows. The factors that affect the realism of virtual windows are further grouped into five categories: 1. Use of reproduced images or videos for views, 2. Representation of temporality, 3. Responsiveness to changes in the observer's perspective, 4. Realistic reproduction of sunlight, and 5. Provision of non-visual sensory elements. Virtual windows are not just a replacement for traditional windows, but a way to realize a virtual environment using digital media, and it is necessary to expand the discussion to the realization of the virtual environment and the relationship with architectural elements.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.6
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• pp.100-109
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• 2015

The purpose of this study is to explore factors that influence the use of intercity-bus services by means of applying a structural equation model. The data were collected by a questionnaire survey based on personal interviews with intercity-bus users in Chungcheongnam-do province. Analysis results show that environmental attributes of the bus service are more important than operational attributes. In the case of men, the cleanliness of bus stops and the ease of transportation card recharging are likely to be the most crucial factors. However, women are likely to consider the cleanliness of the bus as the most important factor affecting their satisfaction about the intercity-bus service. Moreover, as people's satisfaction about the bus service increases, their willingness to recommend the use of intercity-bus to others will increase. Therefore, to improve the use of intercity-bus and to increase the satisfaction about the service, clean buses must be provided. These results could contribute to developing a policy to activate the use of intercity-bus.

• Korean Journal of Health Education and Promotion
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• v.25 no.1
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• pp.25-38
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• 2008

Objectives: This study identified the factors associated with successful smoking cessation for 6 months at a smoking-cessation clinic of a public health center in an urban area. Methods: The subjects of this study were 670 visitors to the smoking cessation clinic of Dongjak-Gu public health center in Seoul, from September 6, 2005 to March 24, 2006. The 274 visitors of them responded to the questionnaire with registration, which contained the information related to the study except that of registered card for the clinic. A dependent variable was success or failure in smoking cessation during the 6 month-smoking cessation program, measured the status of smoking cessation in each week by self-report. Independent variable included demographic information, the characteristics in using the clinic, health status and smoking related behaviour, exposure to other smokers in daily life and motivation. Multiple logistic regression model was used to find the factors associated with success of smoking cessation. Results: The success rate in smoking cessation for 6 months was 33.6%. Five pretreatment characteristics were identified as univariate predictors of continuous abstinence. Finally, age, job, and practice oriented motivation were associated significantly with the success of smoking cessation for 6 months from a multiple logistic regression analysis. The lower socio-economic smokers such as people having lower literacy level, lower income people, unskilled workers, and recipients by Medical Assistant Program were more likely to fail in continuous abstinence for 6 months. Conclusions: In order to increase the success rate in smoking cessation clinics of public centers, counselors should activate self confidence and practice oriented motivation of participants for smoking cessation.

• Journal of the Korea Fashion and Costume Design Association
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• v.25 no.1
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• pp.49-63
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• 2023

The purpose of this study is to investigate the current status and motives of buying second-hand clothing among university students and to suggest a plan to activate second-hand clothing transactions. In order to discover the effect of the buying motives on the purchasing of second-hand clothing, 112 university students who have purchased second-hand clothing over the past six months were surveyed and their responses were used for analysis. As a result of the analysis, it was found that design differentiation, habitual use, and economical factors had a meaningful effect on the purchase of second-hand clothes. Second-hand clothes have a positive environmental perception, but that perception did not impact the purchasing of second-hand clothes. It is necessary to raise the awareness and social movement around second-hand clothing and teach consumers the environmental benefits and sustainability of second-hand clothing. An activation plan for the second-hand clothing market is: 1. Proposes various market subdivisions that meet the characteristics and tastes of consumers that lead to the purchase of used clothing. In this study, two economic factors were found among the buying motives. The first is purchasing second-hand clothing at a very low price, and the second is finding luxurious expensive items or unique values at a lower price. Therefore, it is necessary to find various markets segments that suit consumer tastes by checking consumer characteristics and detailed factors. 2. Nurture second-hand clothing processing brands for the diversification of the second-hand clothing market. 3. There is an urgent need for quality classification, quality assurance, and the standardization of second-hand clothing. This study is meaningful in that it explored the possibility of having a positive effect on activating the second-hand clothing market.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.31 no.3
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• pp.191-211
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• 2020

The main purpose of this research is to identify limitations and problems in access to information using reading aids devices for the visually impaired and to suggest ways to activate the use of alternative materials using reading aids devices. A survey was conducted on adults with visual impairment in order to identify the factors of limitation in using reading aids devices. The analysis resulted in six aspects of limiting factors in activating the use of reading aids devices. The approaches for activating the use of reading aids devices were proposed by dividing them into policy and operational aspects, focusing on the limiting factors derived. Policy aspects suggested developing low-cost reading aids devices, increasing awareness of the devices, and complying with Web standard guidelines for improving the applicability of the devices, while operational aspects suggested reinforcing hearing-use functions, expanding information services related to reading aids devices, and enhancing portability of the devices.