• 전기학회논문지P
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• 제66권3호
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• pp.129-134
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• 2017

We investigated theoretically the quantum optical transition properties of Si, in quasi 2-Dimensinal Landau splitting system, based on quantum transport theory. We apply the quantum transport theory (QTR) to the system in the confinement of electrons by square well confinement potential under linearly polarized oscillating field. We use the projected Liouville equation method with Equilibrium Average Projection Scheme (EAPS). In order to analyze the quantum transition, we compare the temperature and the magnetic field dependencies of the QTLW and the QTLS on four transition processes, namely, the intra-leval transition process, the inter-leval transition process, the phonon emission transition process and the phonon absorption transition process.

• Molecules and Cells
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• 제44권8호
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• pp.569-579
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• 2021

Cyclase-associated protein 2 (CAP2) has been addressed as a candidate biomarker in various cancer types. Previously, we have shown that CAP2 is expressed during multi-step hepatocarcinogenesis; however, its underlying mechanisms in liver cancer cells are not fully elucidated yet. Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. We also found that the ER stress-induced CAP2 expression is mediated through activation of protein kinase C epsilon (PKCε) and the promotor binding of activating transcription factor 2 (ATF2). In addition, we further demonstrated that CAP2 expression promoted epithelial-mesenchymal transition (EMT) through activation of Rac1 and ERK. In conclusion, we suggest that ER stress induces CAP2 expression promoting EMT in liver cancer cells. Our results shed light on the novel functions of CAP2 in the metastatic process of liver cancer cells.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2000년도 유체기계 연구개발 발표회 논문집
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• pp.337-344
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• 2000

A modified k-$\epsilon$ model is proposed for calculation of transitional boundary layer flows. In order to develop the eddy viscosity model for the problem, the flow is divided into three regions; namely, pre-transition region, transition region and fully turbulent region. The pre-transition eddy-viscosity is formulated by extending the mixing Length concept. In the transition region, the eddy-viscosity model employs two length scales, i.e., pre-transition length scale and turbulent length scale pertaining to the regions upstream and the downstream, respectively, and a university model of stream-wise intermittency variation is used as a function bridging the pre-transition region and the fully turbulent region. The proposed model is applied to calculate three benchmark cases of the transitional boundary layer flows with different free-stream turbulent intensity ( $1\%{\~}6\%$ ) under zero-pressure gradient. It was found that the profiles of mom velocity and turbulent intensity, local maximum of velocity fluctuations, their locations as well as the stream-wise variation of integral properties such as skin friction, shape factor and maximum velocity fluctuations are very satisfactorily Predicted throughout the flow regions.

• 대한간호학회지
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• 제47권5호
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• pp.589-599
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• 2017

Purpose: The purpose of this study was to develop a scale to assess the transition shock experienced by newly graduated nurses, and test the validity and reliability of the scale. Methods: The initial items were identified through a review of literature and in-depth interviews with nine newly graduated nurses. Content validation of the items was evaluated by five nurse professors and three nurses. Participants were 269 newly graduated nurses who worked at six acute care hospitals in Busan, Ulsan, and Yangsan, South Korea. Data were analyzed using item analysis, exploratory and confirmatory factor analysis, criterion related validity, and internal consistency. Results: The final scale consisted of 18 items and six factors (conflict between theory and practice, overwhelming workload, loss of social support, shrinking relationship with co-workers, confusion in professional nursing values, and incongruity in work and personal life), which explained 71.3% of the total variance. The six subscale model was validated by confirmatory factor analysis. Cronbach's alpha for the total items was. 89. Convergent validity was evaluated by analyzing total correlation with burnout (r=.71, p<.001) and turnover intention (t=5.84, p<.001). Conclusion: This scale can be used in the development of nursing interventions to reduce the transition shock experienced by newly graduated nurses.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2006년 제4회 한국유체공학학술대회 논문집
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• pp.235-238
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• 2006

This paper is about the code that realizes the $e^N$-Method for boundary-layer transition prediction. The $e^N$-Method based on the linear stability theory is applied to predicting boundary-layer transition frequently. This paper deals with the construction of code, stability analysis and the calculation of N-factor. The results of transition prediction using the $e^N$-Method for flat plate/cone compressible boundary-layers are presented.

• 한국가스학회지
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• 제6권1호
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• pp.81-85
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• 2002

탱크와 연결된 배관에서 원하지 않은 사고로 인해 액체 위험물질의 누출이 발생할 경우 천이영역에서의 누출속도 계산방법을 제시하였다. 배관에서의 액누출에 관한 누출속도는 층류와 난류영역에서 Crowl and Louvar 등이 제시한 모델식을 이용하여 프로그램 또는 직접계산에 의해 이루어지고 있으나, 천이영역에 대한 모델식은 없었다. 따라서 본 논문에서는 Lap-Mou Tam 등이 실험한 천이영역에서 레이놀즈수에 따른 마찰계수 실험값을 이용하여 천이영역에 대한 누출속도 값을 계산하였고 이 값을 층류와 난류에 관한 모델식을 사용한 값과의 비교를 통해 천이영역에서 일반적으로 사용할 수 있는 모델식으로 난류에 관한 모델식으로 계산한 값에 안전율 $30\%$를 추가한 값을 위험평가에 사용할 수 있음을 보였다.

• Journal of Power Electronics
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• 제7권1호
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• pp.55-63
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• 2007

This paper proposes a simple unity power factor zero-voltage-transition (ZVT) pulse-width-modulated (PWM) single-phase rectifier, which features reduced switching and conduction losses. The switching loss reduction is achieved by a simple auxiliary commutation circuit, and the conduction loss reduction is achieved by employing a single-stage converter, rather than a typical double-stage converter comprising of a front-end rectifier and a boost rectifier. Furthermore, thanks to good features such as a simple PWM control at constant frequency, low switch stress, low Var rating of commutation circuits, and simple power circuit structure, it is suitable for high power applications. The principles of operation are explained in detail, and a major characteristics analysis and the experimental results of the new converter are also included in this paper.

• The Korean Journal of Physiology and Pharmacology
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• 제28권1호
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• pp.83-91
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• 2024

Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor activated under hypoxic conditions, and it plays a crucial role in cellular stress regulation. While HIF-1α activity is essential in normal tissues, its presence in the tumor microenvironment represents a significant risk factor as it can induce angiogenesis and confer resistance to anti-cancer drugs, thereby contributing to poor prognoses. Typically, HIF-1α undergoes rapid degradation in normoxic conditions via oxygen-dependent degradation mechanisms. However, certain cancer cells can express HIF-1α even under normoxia. In this study, we observed an inclination toward increased normoxic HIF-1α expression in cancer cell lines exhibiting increased HDAC6 expression, which prompted the hypothesis that HDAC6 may modulate HIF-1α stability in normoxic conditions. To prove this hypothesis, several cancer cells with relatively higher HIF-1α levels under normoxic conditions were treated with ACY-241, a selective HDAC6 inhibitor, and small interfering RNAs for HDAC6 knockdown. Our data revealed a significant reduction in HIF-1α expression upon HDAC6 inhibition. Moreover, the downregulation of HIF-1α under normoxic conditions decreased zinc finger E-box-binding homeobox 1 expression and increased E-cadherin levels in lung cancer H1975 cells, consequently suppressing cell invasion and migration. ACY-241 treatment also demonstrated an inhibitory effect on cell invasion and migration by reducing HIF-1α level. This study confirms that HDAC6 knockdown and ACY-241 treatment effectively decrease HIF-1α expression under normoxia, thereby suppressing the epithelial-mesenchymal transition. These findings highlight the potential of selective HDAC6 inhibition as an innovative therapeutic strategy for lung cancer.

• 한국농공학회논문집
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• 제50권5호
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• pp.39-50
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• 2008

This study are decided the mix proportion method of latex modified concrete for agricultural concrete structures from the results of workability and strength test with mix proportion factor. For mix proportion factor, this study are selected the water-cement ratio, unit cement amount and latex content. Also, this study were performed the slump, compressive strength test and microstructure analysis using the scanning electron microscope(SEM). The strength and slump of LMC are dependent with unit cement amount, latex content, and water-cement ratio. Especially, the strength of LMC are not controlled by single mix proportion factor but effected by combined mix proportion factor. Microstructure investigation are showed the LMC are reduced the internal pore volume and enhanced the transition zone between cement paste and aggregate interface. This effect get by consist of latex films in the concrete. Also, this study were recommended the mix proportion method for LMC. These mix proportions method are estimated the mix design for satisfied the target performance which are applied the agricultural concrete structure.

• Bulletin of the Korean Chemical Society
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• 제4권1호
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• pp.36-41
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• 1983

An equation is derived which correlates the unperturbed dimensions $_0$ of polypeptides with the helical contents in the helix-coil transition region by using a simple model of a polypeptide chain. The model is a chain of connected balls which represent the repeating units, -CO-NH-CHR-, based on the fact that the repeating unit has a plane structure. The changing trend of the expansion factor ${\alpha}_{\eta}$ in the transition region is connected with the helical content $f_H$. The intrinsic viscosities [${\eta}$] of polypeptides are calculated from the unperturbed dimensions and the ${\alpha}_{\eta}$ factors. The above calculated results concerning $_0$ and [${\eta}$] are compared with other authors' theoretical and experimental results. From the comparison, we concluded that our theory explains better the chain dimensional behavior of polypeptides in the helix-coil transition region than others.