• Child Health Nursing Research
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• v.27 no.3
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• pp.256-265
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• 2021

Purpose: This study presents a translation, cultural adaptation, and psychometric evaluation of two instruments of the Fertility Awareness and Attitudes Towards Parenthood (FAAP) questionnaire (Conditions and Life changes) for use in South Korea. Methods: This methodological study included 166 university students for psychometric evaluation in the sixth step. The first five steps included forward translation, backward translation, committee review, assessment of content validity, and a pre-test. In the sixth step, psychometric properties, including internal consistency, construct validity, and criterion validity, were evaluated. Exploratory factor analysis and confirmatory factor analysis were conducted to identify the structure of the tool and to assess its validity. Results: The Korean version showed acceptable internal consistency. Cronbach's α was .73 for FAAP-Conditions and .83 for FAAP-Life changes. FAAP-Conditions showed a four-factor structure (social conditions, relationship with partner, external environment, and child-rearing support) and FAAP-Life changes had a two-factor structure (reward and burden). In the confirmatory analysis, CMIN/DF, TLI, IFI, SRMR, CFI, and RMSEA were satisfactory. Conclusion: This study provided preliminary evidence of the acceptability, reliability, and validity of the Korean version of the FAAP questionnaire in university students in South Korea. Nonetheless, further evaluation among Korean young adults is warranted to validate this instrument.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.83-91
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• 2024

Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor activated under hypoxic conditions, and it plays a crucial role in cellular stress regulation. While HIF-1α activity is essential in normal tissues, its presence in the tumor microenvironment represents a significant risk factor as it can induce angiogenesis and confer resistance to anti-cancer drugs, thereby contributing to poor prognoses. Typically, HIF-1α undergoes rapid degradation in normoxic conditions via oxygen-dependent degradation mechanisms. However, certain cancer cells can express HIF-1α even under normoxia. In this study, we observed an inclination toward increased normoxic HIF-1α expression in cancer cell lines exhibiting increased HDAC6 expression, which prompted the hypothesis that HDAC6 may modulate HIF-1α stability in normoxic conditions. To prove this hypothesis, several cancer cells with relatively higher HIF-1α levels under normoxic conditions were treated with ACY-241, a selective HDAC6 inhibitor, and small interfering RNAs for HDAC6 knockdown. Our data revealed a significant reduction in HIF-1α expression upon HDAC6 inhibition. Moreover, the downregulation of HIF-1α under normoxic conditions decreased zinc finger E-box-binding homeobox 1 expression and increased E-cadherin levels in lung cancer H1975 cells, consequently suppressing cell invasion and migration. ACY-241 treatment also demonstrated an inhibitory effect on cell invasion and migration by reducing HIF-1α level. This study confirms that HDAC6 knockdown and ACY-241 treatment effectively decrease HIF-1α expression under normoxia, thereby suppressing the epithelial-mesenchymal transition. These findings highlight the potential of selective HDAC6 inhibition as an innovative therapeutic strategy for lung cancer.

• East Asian Journal of Business Economics (EAJBE)
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• v.11 no.4
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• pp.19-28
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• 2023

Purpose - research the main methods of financial analysis of corporation in the condition of inflationary processes: the analysis of financial sustainability, liquidity, profitability and etc. Research design, Data, and methodology - the main methodical aspects of financial analysis of operations in the conditions of inflation, their efficiency are presented in the theses. Also the main financial indicators are generalized and systematized with the factor of inflation. The general scheme of adjusting the analysis of financial stability for the factor of inflation is presented. Result - The specifics of adjusting the company's assets and liabilities for the factor of inflation during the analysis of prospective financial stability are details revealed in the article. The features of a comprehensive prospective assessment of liquidity and the financial stability are determined. Conclusion - The account of factor of inflations in the financial operations enable reduce the losses, to identify the price of price strategy on the market, to analyze the problematic situations and develop scenarios for the development of the organization's activities in these conditions. The article the limitations and recommendations for adjusting for the factor of inflation are presented, including the necessary to clearly define the levels of their detail, since the study may be overloaded with calculations.

• The Journal of Fisheries Business Administration
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• v.17 no.1
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• pp.1-17
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• 1986

Since the middle of the 70s, the countries with the marine resources declared the exclusive water zone of two hundred miles. As a result, our country lacked many foreign fishing grounds. This awakened our perception of fishing grounds. The fishing ground is an important factor in the economical effectiveness of fisheries. The fishing ground must have the following basic conditions. 1. It must be the place the fishery resources inhabit and wander. 2. Their catching or aquaculturing must be possible by the technical methods. 3. It must have economic worth in the management. The fishing ground that achieves the above basic conditions is affected by the following factors. This is the factor of the fishing ground location. A. Natural factor 1). Suitable climate 2).Abundant resources 3). Good quality of the sea-bottom 4). Not to be pollutted area B, Economic factor 1). Be adjacent to fishing port and fisheries market 2). Good working conditions 3). Be abundant of economical resources C. Social factor 1). Be possible to work legally 2). Be permitted in the political relations 3). Be acquainted with the customs of foreign countries The fishing ground location is mainly affected by the natural factor of the above factors. The abundance of resources depends on the natural resources. The resources in the fishing ground have the cycle of developing period, maturing period, and decaying period according to the fishing efforts. The point that we sustainably yield the maximum of fishery resources is the changing point of maturing period and decaying period. We call this point MSY, so the resources of fishing ground should be managed by the MSY. Therefore, when we select the fishing ground location. We should judge the natural factor, the economic factor and the social factor synthetically according to the situation and environment, so we can achieve the efficient management.

• Journal of Microbiology and Biotechnology
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• v.30 no.10
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• pp.1597-1606
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• 2020

Transcription factor engineering to regulate multiple genes has shown promise in the field of microalgae genetic engineering. Here, we report the first use of transcription factor engineering in Chlorella sp. HS2, thought to have potential for producing biofuels and bioproducts. We identified seven endogenous bZIP transcription factors in Chlorella sp. HS2 and named them HSbZIP1 through HSbZIP7. We overexpressed HSbZIP1, a C-type bZIP transcription factor, in Chlorella sp. HS2 with the goal of enhancing lipid production. Phenotype screening under heterotrophic conditions showed that all transformants exhibited increased fatty acid production. In particular, HSbZIP1 37 and 58 showed fatty acid methyl ester (FAME) yields of 859 and 1,052 mg/l, respectively, at day 10 of growth under heterotrophic conditions, and these yields were 74% and 113% higher, respectively, than that of WT. To elucidate the mechanism underlying the improved phenotypes, we identified candidate HSbZIP1-regulated genes via transcription factor binding site analysis. We then selected three genes involved in fatty acid synthesis and investigated mRNA expression levels of the genes by qRT-PCR. The result revealed that the possible HSbZIP1-regulated genes involved in fatty acid synthesis were upregulated in the HSbZIP1 transformants. Taken together, our results demonstrate that HSbZIP1 can be utilized to improve lipid production in Chlorella sp. HS2 under heterotrophic conditions.

• Journal of Fashion Business
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• v.18 no.6
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• pp.67-85
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• 2014

This study compares and analyzes the fashion industry of Korea with that of China and Japan, the two countries geographically and culturally adjacent to Korea, by applying the generalized double diamond model to find useful measures to strengthen the global competitiveness of the Korean fashion industry. The fashion industries of Korea, China and Japan were first compared in terms of the four determinants of the double diamond model: thereafter, the double diamond model of Korea, China and Japan were compared. In this, study 31 sub-variables were extracted to measure the eight determinants and secondary data were collected from selected sources between January 2013 and May 2014. The results of comparing the domestic diamond models showed that: China is considerably better than Korea and Japan in terms of demand conditions, firm strategy, organization, and competition conditions while Japan is superior in terms of demand conditions and Korea shows better related and supporting industries conditions. When comparing and analyzing the international diamond models, Japan is superior in terms of factor conditions and China has better demand conditions, while Korea has failed to lead in any of the four determinants. When comparing and analyzing the comprehensive diamond model per country, China show superior demand conditions and firm strategy, organization, and competition conditions, Japan has better factor conditions, and Korea shows superior related and supporting industries conditions.

• Transactions of Materials Processing
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• v.10 no.4
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• pp.319-328
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• 2001

Quantitative evaluation of the tribological conditions at the tool-workpiece interface in metal forming is usually accomplished by the ring compression test. This paper describes an experimental investigation into friction factor under warm forming conditions according to the lubricants and the lubricating methods using the ring compression test. Four different lubricants, two water based graphite and two oil based graphite lubricants, and three different lubricating methods were applied in the experiments. Calibration curves with the friction shear factor were obtained using FEM analysis and verified by the experimental results. The influence of lubricant and lubricating methods on friction are discussed. In the ring compression test, the lower friction factor got to spray the oil based lubricant on die and billet in warm forging temperature.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.18 no.2
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• pp.121-136
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• 2014

Objectives For the excellent differentiation of syndromes, we study on the individual characteristic factor by the inspection of body shape. Methods To the subject of diagnosis special books and diagnostics textbook of korean medicine, we arrange the individual characteristic factor by the four methods of diagnosis. Results The individual characteristic factor analyzed by the inspection of the body shape in the "Huangdineijing 黃帝內經" and "Donguisusebowon 東醫壽世保元" was observed stereotyped. The inspection of the body shape means to diagnose the patient by examining the individual physical conditions of the patient. The body depends on visceral essence to nourish, while the functions of the viscera and the conditions of visceral essence may be reflected by the body. The inspection of individual physical strength and weakness may enable one to know the functions of the viscera and the conditions of ki(氣) and blood. And also the inspection of local regions is used to closely examine some regional areas to obtain necessary clinical data on the individual characteristic factor. Conclusion As the results, the individual characteristic factor by the inspection of body shape is very important item of the four methods of diagnosis(四診) and the differentiation of syndromes(辨證). And therefore the process on four methods of diagnosis and differentiation of syndromesis is necessary to divide the signs of individual characteristic factor and the signs of disease.

• KCID journal
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• v.18 no.2
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• pp.66-75
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• 2011

Multivariate statistical analysis was applied to 110 dam heightening reservoir to classify the building conditions for waterfront centered around cultivated area using data of land cover, landscape, additional water quantity, local economic, tourism resources, and accessibility related variables. Five factors were extracted through factor analysis based on eigen value criteria of more than one. These five factors together account for 68.2% of the total variance. Characteristics of five factors for the downstream of dam heightening reservoirs are building conditions of waterfront, economic conditions, additional water quantity, eco-tours, and accessibility of tourism resources respectively. Five clusters were classified through cluster analysis based on factor score. The classified result shows that third cluster has remunerative terms for building waterfront.

• Journal of the Korean Solar Energy Society
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• v.30 no.4
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• pp.43-48
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• 2010

The performance of photovoltaic systems could be affected by various factors including installing conditions of modules, and their own efficiencies of solar cells and inverters. The installing conditions of a photovoltaic system including array types, tilting angles, azimuth, locations, quantities of sunshine, optimum angles of inclination and separated distance are analyzed using the SolarPro & Minitep SW simulation program, inorder to set up the installing conditions for improving system performance. The result from the simulation of the 500kWp PV system of Kochang with optimal installing conditions compared with normal conditions shows that the capacity factor has been increased from 11.02% to 12.06%.