• PNF and Movement
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• 제12권2호
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• pp.97-106
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• 2014

Purpose: The purpose of this study was to investigate changes in EEG through attention. Concentration training and performing tasks are important factors in the improvement of motor learning ability. Methods: In the experiment, 22 healthy people were divided into two groups: the trail making test (TMT) group and the computerized neurocognitive function test (CNT) group. A one-way Neuro Harmony M test to see whether there was a significant difference among the groups. Results: The TMT group showed a significant increase in ${\alpha}$ wave, ${\alpha}$ wave sequence, and ${\beta}$ wave sequence; however, there were no significant differences in SMR wave, SMR wave sequence, and ${\beta}$ wave. The CNT group showed increases in ${\alpha}$ wave, ${\alpha}$ wave sequence, SMR wave, SMR wave sequence, and ${\beta}$ wave sequence; however, there was no significant difference in ${\beta}$ wave. In EEGs before and after two performance tasks were changed, there were significant differences in ${\beta}$ wave, SMR wave, SMR wave sequence; however, there were no significant differences in ${\alpha}$ wave sequence, ${\beta}$ wave, and ${\beta}$ wave sequence. Conclusion: Attention training and concentration training offer feedback and repetition for constant stimulus and response. Moreover, attention training and concentration training can contribute to new studies and motivation by developing fast sensory and motor skills through acceptable visual and auditory stimulation.

• Animal Bioscience
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• 제34권1호
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• pp.143-153
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• 2021

Objective: To explore the molecular mechanisms of fatty liver hemorrhagic syndrome (FLHS) in laying hens, an experiment was conducted to reveal the differences in histopathological observation and gene expression between FLHS group and normal group. Methods: We compared the histopathological difference using hematoxylin and eosin staining and proceeded with RNA sequencing of adipose tissue to search differentially expressed genes and enriched biological processes and pathways. Then we validated the mRNA expression levels by real-time polymerase chain reaction and quantified protein levels in the circulation by enzyme-linked immunosorbent assay. Results: We identified 100 differentially expressed transcripts corresponding to 66 genes (DEGs) were identified between FLHS-affected group and normal group. Seven DEGs were significantly enriched in the immune response process and lipid metabolic process, including phospholipase A2 group V, WAP kunitz and netrin domain containing 2, delta 4-desaturase sphingolipid 2, perilipin 3, interleukin-6 (IL-6), ciliary neurotrophic factor (CNTF), and suppressor of cytokine signaling 3 (SOCS3). And these genes could be the targets of immune response and be involved in metabolic homeostasis during the process of FLHS in laying hens. Based on functional categories of the DEGs, we further proposed a model to explain the etiology and pathogenesis of FLHS. IL-6 and SOCS3 mediate inflammatory responses and the satiety hormone of leptin, induce dysfunction of Jak-STAT signaling pathway, leading to insulin resistance and lipid metabolic disorders. Conversely, CNTF may reduce tissue destruction during inflammatory attacks and confer protection from inflammation-induced insulin resistance in FLHS chickens. Conclusion: These findings highlight the therapeutic implications of targeting the JAK-STAT pathway. Inhibition of IL6 and SOCS3 and facilitation of CNTF could serve as a favorable strategy to enhance insulin action and improve glucose homoeostasis, which are of importance for treating obesity-related disorders for chickens.

• 디지털융복합연구
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• 제11권11호
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• pp.37-52
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• 2013

현재 정부는 본격적인 전력 스마트그리드 확대에 앞서 제주도 구좌읍 6,000호를 대상으로 스마트그리드 실증사업을 추진 중에 있다. 하지만, 관련 기업들은 정부와 한전 주도의 한국 전력시장의 한계, 기존 전력망의 높은 안정성 및 효율성, 신재생에너지 활용도 미흡, 전기요금 인상 우려 등을 이유로 스마트그리드 확산에 대한 부정적인 시각을 가지고 있다. 본 연구는 스마트그리드 시장을 활성화하기 위한 핵심 이슈들을 1) 이해관계자들의 대립 문제, 2) 실시간 요금제 도입에 따른 효과 문제, 3) 소비자들의 수요 반응 참여 부족, 4) 스마트그리드의 비즈니스 모델부재, 5) 스마트그리드 거점지구 확산 문제 등의 5가지로 분류하고, 이에 대한 전략적 방안을 제시하였다.

• PNF and Movement
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• 제19권2호
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• pp.225-231
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• 2021

Purpose: This study was conducted to investigate the type of physical therapist response work and its intensity, along with the prolonged prevalence of COVID-19, to determine the impact on physical therapists' occupational stress and occupational burnout. Methods: An online survey was conducted with 118 physiotherapists and collected the participants' gender, final educational background, clinical work experience, workplace type, additional workload, and fatigue associated with COVID-19. After excluding one participant who submitted an incomplete questionnaire, 117 respondents were included in the final data. Results: Additional COVID-19-related workloads and response reliability for fatigue, occupational burnout, and occupational stress were shown to have Cronbach's alpha measures of 0.76, 0.89, and 0.87, respectively. Groups who had experienced a new epidemic in the past showed higher fatigue levels (3.06±0.94) than those groups who had no such experience (2.49±0.84; p < 0.05). Correlation analysis of COVID-19 work fatigue and occupational burnout scales showed a positive correlation (r = 0.19; p < 0.05). The regression of occupational burnout and occupational stress showed a regression model of Y = 20.00+0.43X₁ (X₁: job stress; p< 0.05) and an explanatory power of 24.8% with an adj.R² = 0.25. Conclusion: Based on the results, it is suggested that various institutions, such as medical institutions, educational institutions, and physiotherapists' associations, should seek ways to manage and alleviate physiotherapists' stress.

• Journal of Radiation Protection and Research
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• 제22권2호
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• pp.85-95
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• 1997

전통적으로 개인방사선감시에 열형광선량계와 필름배지가 공식개인선량계로 이용되어 왔고 현재까지도 여전히 가장 보편적으로 사용되고 있지만, 최근에는 Si 다이오드와 G-M관을 이용한 능동형 전자개인선량계가 개발 보급되고 있다. 전자개인선량계는 누적선량을 곧바로 알 수 있다는 분명한 장점을 가지고 있을 뿐만 아니라 선량률에 관한 정보도 제공하므로 높은 비용부담에도 불구하고 피폭관리의 용이함으로 인해 주목을 받고 있다. 이에 세 종류의 전자개인선량계 즉, EPD2, STEPHEN6000, PD-3i에 대하여 재현성, 정확성, 선형성, 에너지와 방향 의존성, 반응시간을 포함하는 선량계의 전반적인 성능을 실험적으로 평가한 후 판단기준으로 IEC standard 그리고 Ontario Hydro standard와 비교함으로써 전자개인선량계가 방사선방호의 핵심인 개인선량측정에 충분한 신뢰도를 제공하여 공식선량계로 적합한가를 논의하였다. STEPHEN6000 및 PD-3i는 표층선량 측정능력의 보완이 필요하였다.

• 인지과학
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• 제23권1호
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• pp.109-132
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• 2012

최근 체화된 인지 접근에 따르면 행위의 이해는 추상적인 기호 처리가 아니라 그 행위와 관련된 감각-운동 정보의 심적 모사(mental simulation)를 통해 이루어진다고 주장되고 있다. 이 주장을 지지하는 증거로서 제시된 운동공명효과(motor resonance effect)는 관찰되는 행위와 현재 수행하는 행위 사이의 유사성에 의해 행위자의 운동 반응에 일어나는 간섭 혹은 촉진 효과를 말한다. 본 연구에서는 이러한 운동공명효과가 복잡한 사회적 행위를 지각하는 상황에서도 일어나는지 그리고 사회적 행위의 해석 관점에 따라 그 효과가 어떻게 달라지는 지를 알아보고자 하였다. 이를 위하여 어떤 행위자가 세 가지 신체 부위(팔, 발, 입)를 사용하여 다른 사람과 다투는 행위 장면을 그림으로 묘사하고, 각 그림을 행위자의 관점에서 기술하거나(예, 간호사가 의사를 때렸다/밟았다/물었다), 피행위자의 관점에서 기술하여(예, 의사가 간호사에게 맞았다/밟혔다/물렸다), 행위 사건 지각의 관점을 조절하였다. 실험 1에서는 실험참가자로 하여금 제시된 그림과 문장이 일치하면 페달을 밟거나 혹은 버튼을 누르는 행동 반응을 하도록 지시함으로써, 발 행위의 운동공명효과를 측정하였고, 실험 2에서는 마이크와 버튼을 이용하여 입 행위에 대한 운동공명효과를 측정하였다. 실험 1의 결과, 페달을 밟는 발 행동 반응이 발 행위 장면을 행위자의 관점에서 능동적으로 해석한 경우 다른 행위 지각 조건에 비해 빨라졌으며, 피행위자 관점에서 수동적으로 해석한 경우에는 오히려 느려졌다. 이와 유사하게, 실험 2에서는 마이크에 '합'이라는 소리를 내는 입 행동 반응이 입 행위 장면을 행위자가 상대방을 무는 행위로 능동적으로 해석한 경우 빨라졌으며, 같은 장면이라도 피행위자 관점에서 기술하였을 때는 오히려 느려졌다. 본 연구의 결과는 일상생활에서 사회적 행위를 지각하는 과정에서도 운동공명효과는 일어날 수 있다는 것과, 그러나 그 효과 또한 행위 사건을 해석하는 관점에 따라 조절될 수 있다는 점을 시사한다.

• 한국해양바이오학회지
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• 제13권2호
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• pp.86-93
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• 2021

A high salt diet contributes to kidney damage by causing hypoxia and oxidative stress. Recently, an increase in dietary salt has been reported to induce an inflammatory phenotype in immune cells, further contributing to kidney damage. However, studies on the exact mechanism and role of a high salt diet on the inflammatory response in the kidneys are still insufficient. In this study, a cisplatin-induced acute kidney injury model using C57BL/6 mice was used to analyze the effect of salt intake on kidney injury. Results showed that high salt administration aggravated kidney edema in mice induced by treatment with cisplatin. Moreover, the indicators of kidney and liver function impairment were significantly increased in the group cotreated with high salt compared with that treated with cisplatin alone. Furthermore, the exacerbation of kidney damage by high salt administration was also associated with a decrease in the number of cells in the immune regulatory system. Additionally, high salt administration further decreased renal perfusion functions along with increased cisplatin-induced damage to proximal tubules. This was accompanied by increased expression of T cell immunoglobulin, mucin domain 1 (a biomarker of kidney injury), and Bax (a pro-apoptotic factor). Moreover, cisplatin-induced expression of proinflammatory mediators and cytokines, including cyclooxygenase-2 and tumor necrosis factor-α in kidney tissue, was further increased by high salt intake. Therefore, these results indicate that the kidney's inflammatory response by high salt treatment can further promote kidney damage caused by various pathological factors.

• The Korean Journal of Physiology and Pharmacology
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• 제5권1호
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• pp.27-32
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• 2001

We have characterized the aftereffects of impulse activities on the transmission of afferent sensory to the primary somatosensory (SI) cortex of the anesthetized rats (n=22). Following conditioning stimulation (CS, 10 sec, either 5 Hz or 200 Hz) to the receptive field (RF), quantitative determination of the changes of afferent sensory transmission was done by generating post-stimulus time histogram of unit response to the testing stimulation (TS, at 0.5 Hz) to the RF center (RFC) for 60 min. In one group of experiments, CS was delivered to the RF center (RFC). In another group of experiments, CSs were simultaneously given to both RFC and RF outside (RFO, either forepaw or hindpaw). CS of 5 Hz to RFC exerted irreversible facilitation of sensory transmissions evoked by TS. Simultaneous CSs of 5 Hz to RFC and hindpaw RFO exerted reversible suppression of afferent transmission. However, CSs of 5 Hz to RFC and forepaw RFO did not significantly altered afferent sensory transmission to SI cortex neurons. CS of 200 Hz to RFC exerted irreversible suppression of sensory transmissions up to 60 min of experimental period. Simultaneous CSs of 200 Hz to RFC and RFO did not significantly altered afferent sensory transmission to SI cortex neurons. The profiles of CS-induced modulation of afferent sensory transmission were significantly different between two CS conditions. Thus, this study suggests that activity-dependent modulation of afferent transmission from a RF center to the SI cortex may be significantly altered when remote body part was simultaneously activated.

• 보건행정학회지
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• 제15권3호
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• pp.1-16
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• 2005

This study was planned to investigate the relationship between development levels of learning organization and organization effectiveness in Hospital. Data were collected from 285 respondents who have participated in 'Learning Organization Project'(response rate =$50.5\%$). Structured questionnaire were applied by self administrated survey for two weeks since 2003 May. Main results were as follows; In the result of factor analysis, four factor were created and almost questionnaire items were classified into as same categories as theoretical concepts. Cronbach's a coefficient also showed over 0.7 in all categories. This result means that measurement tool to evaluate the development level of learning organization is valid and reliable. In the comparison of the development level of learning organization by participants' specialties, managerial workers perceived the lowest construction level, while medical technicians evaluated it as the highest level. In regression analysis, the perception levels of work environment, task and human aspect showed positive relationship with job competency significantly. For job satisfaction, levels of task and human aspects had positive relationship significantly. In addition, for organizational commitement, levels of organization and human aspect were positive predictors. Finally, for the satisfaction about experience of learning organization project, levels of environment, task and hmm aspects were related positively. We concluded from these result that the positive relationship between construction levels of learning organization and organization effectiveness was extended to hospital, besides industrial fields. We recommend the introduction and facilitation of learning organization project in various settings to improve the competency of knowledge management in individual and organizational levels.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.91-97
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• 2017

Hyperglycemia is associated with an increased risk of cardiovascular diseases. It has been demonstrated that chronic exposure to high glucose impaired endothelial functions. However, specific effects of short-term exposure to high glucose on vascular reactivity are controversial. Moreover, the combined effects of other metabolic substrates such as free fatty acids (FFA) on vascular reactivity remain poorly understood. Here we investigate the effects of short-term exposure to high glucose with or without other metabolic substrates including FFAs termed "nutrition full" (NF) solution, on mesenteric (MA) and deep femoral arteries (DFA) of rats. Arterial ring segments were mounted in a double-wire myograph. Contraction in response to phenylephrine (PhE) was determined in control (5 mM) and high glucose (23 mM, HG) environments over a 30 min period. In both arteries, PhE-inducedvasocontraction was enhanced by pre-incubation of HG solution. A combined incubation with HG and palmitic acid ($100{\mu}M$) induced similar sensitization of PhE-contractions in both arteries. In contrast, high $K^+$-induced contractions were not affected by HG. Interestingly, pre-incubation with NF solution decreased PhE-induced contraction in MA but increased the contraction in DFA. In NF solution, the HG-induced facilitation of PhE-contraction was not observed in MA. Furthermore, the PhE-induced contraction of DFA was attenuated by HG in NF solution. Our results demonstrate that the sensitization of PhE-induced arterial contraction by HG is differentially affected by other metabolic substrates. The conversation of skeletal arterial contractility by HG in NF solution requires careful interpretation of the previous in vitro studies where only glucose is included in physiological salt solutions. Further studies are required to elucidate the mechanism underlying the inconsistent effect of NF solution on MA and DFA.