• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.19
• /
• pp.8351-8359
• /
• 2014

Background: Recent epidemiological data have implicated human papilloma virus (HPV) infection in the pathogenesis of head and neck cancers, especially oropharyngeal cancers. Although, HPV has been detected in varied amounts in persons with oral dysplasia, leukoplakias and malignancies, its involvement in oral tongue carcinogenesis remains ambiguous. Materials and Methods: HPV DNA prevalence was assessed by PCR with formalin fixed paraffin embedded sections (n=167) of oral tongue squamous cell carcinoma patients and the physical status of the HPV16 DNA was assessed by qPCR. Immunohistochemistry was conducted for p16 evaluation. Results: We found the HPV prevalence in tongue cancers to be 51.2%, HPV 16 being present in 85.2% of the positive cases. A notable finding was a very poor concordance between HPV 16 DNA and p16 IHC findings (kappa<0.2). Further molecular classification of patients based on HPV16 DNA prevalence and p16 overexpression showed that patients with tumours showing p16 overexpression had increased hazard of death (HR=2.395; p=0.005) and disease recurrence (HR=2.581; p=0.002) irrespective of their HPV 16 DNA status. Conclusions: Our study has brought out several key facets which can potentially redefine our understanding of tongue cancer tumorigenesis. It has emphatically shown p16 overexpression to be a single important prognostic variable in defining a high risk group and depicting a poorer prognosis, thus highlighting the need for its routine assessment in tongue cancers. Another significant finding was a very poor concordance between p16 expression and HPV infection suggesting that p16 expression should possibly not be used as a surrogate marker for HPV infection in tongue cancers. Interestingly, the prognostic significance of p16 overexpression is different from that reported in oropharyngeal cancers. The mechanism of HPV independent p16 over expression in oral tongue cancers is possibly a distinct entity and needs to be further studied.

• Journal of the Korean Society for information Management
• /
• v.27 no.1
• /
• pp.41-60
• /
• 2010

This study aims to analyze the properties of the tags used in the fiction genre, the structural aspect of the patterns and the contents of the tags by utilizing LibraryThing, where the tags are assigned in work units of FRBR. A comparative analysis was conducted in terms of the level of association between the descriptive terms in bibliography and LCSH terms. The study also examined the sources of the tags not included in the bibliographic descriptions or LCSHs, what aspects of work they represented, and the terms used as tags in relation to the work. By restricting the study to a single genre, a number of tags that reflected the characteristics of fiction (three elements of the fiction which are theme, plot, style and three elements of the fiction composition which are character, event, setting) were extracted. This study finds out the role of the tag making up the taxonomy and proposes a new direction for the tagging system by demonstrating the possibility of using tags as facets in information organization and retrieval.

• Journal of Korean Society of Rural Planning
• /
• v.23 no.2
• /
• pp.19-28
• /
• 2017

While the significance and need of landscape assessment for rural area has been recognised, an appropriate method has not been established due to the lack of statutory ground and policy status in Korea. For that reason, current studies have been limited to dominantly amenity field survey in specific rural areas and stayed in academic. In particular, the majority of research on rural landscape amenity or character assessment methodologies so far has been attempted with quantitative processes. Such quantitative methods produced sometimes, heavily overlapped, conflicted, and not much meaningful characterisation and classification. Moreover, such results could not only have been reflected to policy implementation but provide vision for rural areas. Therefore, this study offers new facets for landscape character assessment methods through the lens of practitioners' qualitative survey methods and moreover, seek a policy implementation of newly developed methodologies. In order to carry out such analysis, the study employed a case study of England's Landscape Character Assessment and survey location was Gateshead Council, Northeast of England. The study suggests meaningful qualitative landscape character assessment method and review of its policy implementation.

• Management & Information Systems Review
• /
• v.39 no.1
• /
• pp.93-114
• /
• 2020

Platform is considered as an alternative strategy to the traditional linear pipeline based business. Moreover, in the 4th industrial revolution period, efficiency driven pipeline business model needs to be changed to platform business. We have such success stories about platform as Apple, Google, Amazon, Uber, and so on. However, for those smaller corporations, it is not easy to find out the transformation strategy. The essence of platform business is to leverage network effect in management. Thus platform based management can be rephrased as network management across the business functions. Research on platform business is popular and related to diverse facets. But few scholars cover what the research trend of the domain is. The main purpose of this paper is to identify the research trend on platform business in Korea. To do that we first propose the analytical model for platform architecture whose components are consumers, suppliers, artifacts, and IT platform system. We conjecture that mapping of the research work on platform to the components of the model will make us understand the hidden domain of platform research. We propose three hypotheses regarding the characteristics of research and one proposition for the transitional path from pipeline to platform business model. The mapping is based on the research articles filtered from the Korea Citation Index, using keyword search. Research papers are searched through the keywords provided by authors using the word of "platform". The filtered articles are summarized in terms of the attributes such as major component of platform considered, platform type, main purpose of the research, and research method. Using the filtered data, we test the hypotheses in exploratory ways. The contribution of our research is as follows: First, based on the findings, scholars can find the areas of research on the domain: areas where research has been matured and territory where future research is actively sought. Second, the proposition provided can give business practitioners the guideline for changing their strategy from pipeline to platform oriented. This research needs to be considered as exploratory not inferential since subjective judgments are involved in data collection, classification, and interpretation of research articles.