• YAKHAK HOEJI
• /
• v.35 no.3
• /
• pp.231-235
• /
• 1991

Compounds of the structure of -4,9-dione are known to have an antibacterial activity against Gram-positive bacteria. New kinds of 2-amino-$\alpha$-cyano-$\alpha$-ethoxycarbonyl-niethyl)-1,4-naphthoquino ne was reacted with some alkylamines(methylamine, ethylamine, ethanolarnine, isopropylamine, cyclohexylamine, benzylamine) to yield 2-amino-3-ethoxycarbonyl-N-alkyl-4,9-diones.

• The KIPS Transactions:PartC
• /
• v.9C no.4
• /
• pp.573-580
• /
• 2002

Within the security architecture of the 3GPP system there is a standardised integrity algorithm f9. The integrity algorithm f9 computes a MAC to authenticate the data integrity and data origin of signalling data over a radio access link of W-CDMA IMT-2000. f9 is a variant of the standard CBC MAC based on the block cipher KASUMI. In this paper we provide the provable security of f9 We prove that f9 is secure by giving concrete bound on an adversary's inability to forge in terms of her inability to distinguish the underlying block cipher from a pseudorandom permutation.

• The Korean Journal of Zoology
• /
• v.33 no.4
• /
• pp.446-453
• /
• 1990

In order to investigate the retinoic acid indticed-differentiation of F9 teratocarcinoma stem cell, we have analyzed the change of cell morphology and laminin expression after exposure to retinoic add and cyclic AMP. It is shown that undifferentiated F9 stem cells grow as closely packed colonies, and it is difficult to distinguish cell-cell boundaries. After retinoic add and dibutyryl cyclic AMP treatment, F9 cells assume a flat morphology characterized by perinuclear granules and arrest growth. According to Northern blot analysis, laminin expression was increased markedly after retinoic acid treatment. Laminin Bi gene expression was increased at least 30-fold and laminin B2 gene expression was increased approximately 20-fold during differentiation process. Employing immunofluoresence analysis, it was proved that the synthesis of laminin protein was low level in F9 stem cell whereas it became high level in retinoic acid treated F9 cell and the laminin protein was largely accumulated in the cell surface. Our results suggest that induction of laminin Bi and B2 genes m F9 cells is retinoic acid-mediated control, and morphological change and differentiation of F9 cells might be associated with laminin gene expression.

• Journal of Life Science
• /
• v.8 no.1
• /
• pp.51-59
• /
• 1998

The apoptosis-inducing activity of ursolic acid (UA) was examined in mouse F9 teratocarcinoma cells on the bases of biochemical and morphological characteeristics. UA, pentacyclic trierpene acid, exhibits antitumor activities including inhibition of skin tumorigenesis, induction of tumor cell differentiation and antitumor promotion. Treatment with UA showed that the decrease of cell viability was dose-dependent. UA also induced genomic DNA fragmetation, a hallmark of apoptosis, indicating that the mechanism of UA-induced F9 cell death was through apoptosis. When the morphology of the F9 cells was examined by electron microscopy, the cells treated with UA showed the charcteristic morphological features of apoptosis such as chromatin condensation and nuclear fragmentation. DNA fragmentations by UA were inhibired by cycloheximide, which suggest that de novo protein synthesis was required for DNA fragmentation by UA. Inaddition, the expression of c-jun was increased, but those of c-myc and laminin B1 were decreased during apoptosis induced by UA in F9 cells. These results suggest that UA causes an apoptosis in F9 cells. Further, the increased expression of c-jun may be involved in the UA-induced apoptosis of f9 cells.

• Proceedings of the Korean Magnestics Society Conference
• /
• 1994.10a
• /
• pp.9-9
• /
• 1994

• Archives of Pharmacal Research
• /
• v.15 no.2
• /
• pp.138-141
• /
• 1992

The new N-aryl-benz[f]-indole-4, 9-dione derivatives were synthesized via in tramolecular cyclization when triethylamine was employed as a base for the reaction of 2-chloro-3-$(\alpha$-cyano-$\alpha$-ethoxycarbonyl-methyl)-1, 4-naphthoquinone and arylamines.

• Journal of Korean Academy of Nursing Administration
• /
• v.6 no.2
• /
• pp.227-243
• /
• 2000

The purpose of this study was to identify the relationship between nursing organizational climate and job satisfaction of nurses in general hospitals and also the factors which had influences in the nursing organizational climate and job satisfaction of nurses. Data were collected from 200 nursing managers and 800 nurses with structured questionnaires at 11 general hospitals in Taegu and Kyungbuk-area, from June 1 to June 30, 1999. Data were analyed with SPSS 7.5 using program such as t-test, ANOVA and stepwise multiple regression. The results were as follows: 1) In the nursing organizational climate there were significant differences by age(F=9.246, p=.000), religion(f=5.658, p=.001), educational level(F=4.660, p=.010), position(F=27.016, p=.000), and the total length of service(F=7.274, p=.000). Also there were significant differences by subsidiary school(F=11.224, p=.000), the number of beds(F=9.893, p=.000), the number of nurses(F=6.365, p=.000), and kind of medical agency(F=5.251, p=.000) in the hospitals. 2) In the nurses' job satisfaction there were significant differences by age(f=11.528, p=.000), religion(F=3.003, p=.000), position(F=22.485, p=.000), career the department of the present service(F=5.157, p=.000), total career of service(F=9.243, p=.000), and salary(F=5.507, p=.000). Also there were significant differences by religious background(F=4.779, p=.009), subsidiary school(F=7.039, p=.000), the number of beds(F=7.039, p=.000), and kind of medical agency(F=2.778, p=.006) in the hospitals 3) There was significant correlation between nursing organizational climate and job satisfaction of nurses(r=.686). 4) The nursing organizational climate was explained 21.8% by salary 9.5%, position 7.4%, religious background of hospital 4.1%, and subsidiary school of hospital 0.8%. 5) The nurses' job satisfaction was explained 70.9% by nursing organizational climate 46.7%, salary 21.9%, kind of medical agency 1.4%, position 0.3%, religious background of hospital 0.3%, religion 0.3%.

• YAKHAK HOEJI
• /
• v.43 no.3
• /
• pp.378-384
• /
• 1999

Retinoic acid (RA) and dibutyryl cyclic AMP (dbcAMP) induce the differentiation of the multipotent embryonic carcinoma cell line, F9 cells, into parietal endoderm like cell. The F9 cells are highly proliferative doubling approximately 12 hourse. S Phase is predominant, lasting 10 hours and G2/M phase occupies most of the remaining cycle (2 hours) and G1 phase is nearly non-existent. In this study, we showed the effect of RA and dbcAMPon the cell cycle associated molecules (especially around G1 phase) during F9 cell differentiation. Differentiation of F9 cells was induced by the combined addition of RA ($10^{-7}M$) and dbcAMP (0.5mM), and cells were harvested daily up to 4 days. Flow cytometric analysis showed the prolongation of G1 phase around 30 hours after induction. Western blot analysis revealed that the amount of cyclin D1 and cdk2 were increased at day 4. However, histone H1 kinase activity of cdk2 was decreased. These data strongly suggest that RA and dbcAMP induce the growth arrest of F9 cells at G1 phase by decreasing the activity of cdk2, although they have increased the protein contents of cyclin D1 and cdk2. The reason for the discrepancy between the H1 kinase activity and protein contents are not clear yet.

• YAKHAK HOEJI
• /
• v.34 no.1
• /
• pp.15-21
• /
• 1990

-4,9-dione derivatives were prepared from $2-chloro-3-({\alpha}-accetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ and 2-chloro-3-N-phenylamino-1,4-naphthoquinone. $2-Chloro-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ was reacted with amines to give $2-amino-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ derivatives. Subsequent treatment of $2-amino-3-({\alpha}-acetyl-{\alpha}-ethoxycarbonyl-methyl)-1,4-naphthoquinone$ with sodium ethoxide gave -4,9-dione derivatives. When 2-chloro-3-N-phenylamino-1,4-naphthoquinone reacted with sodium ${\alpha}-cyano$ ethyl acetate, 2-amino-3-ethoxycarbonyl-N-phenyl--4,9-dione was obtained. However, with sodium diethyl malonate, not -4,9-dione but 2-chloro-3-bis-(methoxycarbonyl)-methyl-2H-3-N-phenylamino-1,4-naphthoquinone was obtained.

• Journal of the Korean Mathematical Society
• /
• v.59 no.2
• /
• pp.353-365
• /
• 2022

Let 𝓐 be the collection of analytic functions f defined in 𝔻 := {ξ ∈ ℂ : |ξ| < 1} such that f(0) = f'(0) - 1 = 0. Using the concept of subordination (≺), we define $$S^*_{\ell}\;:=\;\{f{\in}A:\;\frac{{\xi}f^{\prime}({\xi})}{f({\xi})}{\prec}{\Phi}_{\ell}(\xi)=1+{\sqrt{2}{\xi}}+{\frac{{\xi}^2}{2}},\;{\xi}{\in}{\mathbb{D}}\}$$, where the function 𝚽_ℓ(ξ) maps 𝔻 univalently onto the region Ω_ℓ bounded by the limacon curve (9u² + 9v² - 18u + 5)² - 16(9u² + 9v² - 6u + 1) = 0. For 0 < r < 1, let 𝔻_r := {ξ ∈ ℂ : |ξ| < r} and 𝒢 be some geometrically defined subfamily of 𝓐. In this paper, we find the largest number 𝜌 ∈ (0, 1) and some function f₀ ∈ 𝒢 such that for each f ∈ 𝒢 𝓛_f (𝔻_r) ⊂ Ω_ℓ for every 0 < r ≤ 𝜌, and $${\mathcal{L} _{f_0}}({\partial}{\mathbb{D}_{\rho})\;{\cap}\;{\partial}{\Omega}_{\ell}\;{\not=}\;{\emptyset}$$, where the function 𝓛_f : 𝔻 → ℂ is given by $${\mathcal{L}}_f({\xi})\;:=\;{\frac{{\xi}f^{\prime}(\xi)}{f(\xi)}},\;f{\in}{\mathcal{A}}$$. Moreover, certain graphical illustrations are provided in support of the results discussed in this paper.