• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5007-5010
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• 2013

Heat shock proteins are molecular chaperones that may be constitutively present in cells protecting them from various stresses, such as extreme temperature, anoxia or chemical agents. Cervical cancer is the second most prevalent malignancy of women. In this study, we analyzed the expression of Hsp27 by immunohistochemistry in cervical intraepithelial lesions of Brazilian women, along with samples from non neoplasic lesions (NN). Cervical intraepithelial neoplasia I (CIN I), II (CIN II) and III (CIN III)/in situ carcinoma and squamous cell carcinoma (SCC) were included. Immunostaining was observed in 30 (100%) samples of NN, 46 (92%) in CIN I, 50 (100%) in CIN II, 52 (98.11%) in CIN III/CIS, and 46 (98.11%) in SCC. In group NN Hsp27 immunostaining was heterogeneous, more intense in basal and parabasal layers of the epithelium and less or absent in the intermediate and superficial layer. The majority of the samples of CIS and SCC presented strong staining in all epithelial layers. Metaplasic cells, when present, were strongly stained. In this study, Hsp27 protein was found to be commonly expressed in cervical epithelial cells.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.8
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• pp.1-7
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• 2016

A range of techniques have been being developed to remove the volatile organic compounds from paining processes. High temperature decomposition of harmful VOCs using arc plasma has recently been proposed, and this work analyzed the extreme hot process by computer-aided fluid dynamics prior to the reactor design. Numerical simulations utilized the conservation equations of mass and momentum. The simulation showed that the fluid flowed down along the inner surface of the centrifugal reactor by forming intensive spiral trajectories. Although the high temperature gas generated by plasma influences the bottom of the reactor, no heat transfer in radial direction appeared. The decomposition efficiency of a typical VOCs, toluene, was found to be a maximum of 67% across the reactor, which was similar to the value (approximately 70%) for the lab-scale test.

• Applied Biological Chemistry
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• v.31 no.3
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• pp.274-283
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• 1988

Aqualysin I is an alkaline serine protease which is secretet into the culture medium by Thermus aquaticus YT-1, an extreme thermophile. Aqualysin I was purified, and its partial amino acid sequence was determined. The gene encoding aqualysin I was cloned into E. coli using synthetic oligodeoxyribonucleotides as hybridization probes. The nucleotide sequence of the cloned DNA was determined. The primary structure of aqualysin I, deduced from the nucleotide sequenc, agreed with the determid amino acid sequences, including the $NH_2-$ and COOH terminal sequence of the tryptides derived from aqualysin I. Aqualysin I comprised 281 amino acid residues and its molecular mass was determined to be 28350. On alignment of the whole amino acid sequence, aqualysin I showed high sequence homology with the subtilisin type serine protease, and 43% identity with proteinase K, 37-30% with subtilisins and 34% with thermitase. Extremely high sequence identity was observed in the regions containing the active-site residues, corresponding to Asp32, His64 and Ser221 of subtilisin BPN'. Aqualysin I contains two disulfide bonds, Cys67-Cys99 and Cys163-Cys194, and these disulfide bonds seem to contribute to the heat stability of the enzyme. The determined positions of the twe disulfide bonds of aqualysin I agreed with those predicted previously on the basis of computer graphics of the crystallographic data for subtilisin BPN'. Therefore, these findings sugests that the three-dimensional structure of aqualysin I is similar to that of subtilisin BPN' Aqualysin I is produced as a lage precursor, which contains $NH_2-$ and COOH- terminal portions besides the mature protease sequence.

• Journal of Biosystems Engineering
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• v.31 no.3 s.116
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• pp.175-181
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• 2006

Nursery pig building is imperative to provide environmental conditions favorable to maintenance of piglet health and the efficiency of growth rate. To meet the ultimate goal, it is necessary to apply proper ventilation design and construction to a confinement livestock building. This study was conducted to investigate the performance of a modified ventilation system in terms of devised slot-inlet (modification I) and exhaust fan (modification II) to improve air change rate in a confined nursery pig building, with dimension of 5.9 m(W) ${\times}$ 12.6 m(L) ${\times}$ 2.2 m(H) in an Darby Genetic Station. The experiment was carried out in August, especially when the outdoor peak temperature were above $30^{\circ}C$ and the measured indoor environmental factors were temperature, air velocity, humidity and ammonia concentration which have been known to affect the piglet health and growth. There was no difference in indoor temperature between the original and modified ventilation systems, however the air velocity and ammonia concentration in confined nursery pig building with modified ventilation system were, in most cases, better performance than original ventilation system. Therefore, it was concluded that the slot-inlet system that kept indoor environmental factors pertinent and had an economic advantage, should be considered as a ventilation system for decreasing sensible heat from piglet in confined nursery pig building during extreme summer season.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.5
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• pp.474-480
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• 2011

Space Imaging Sensor operated on LEO is affected from the Earth IR and Albedo as well as the Sun Radiation. The Imaging Sensor exposed to extreme environment needs thermal control subsystem to be maintained in operating/non-operating allowable temperature. Generally, units are periodically dissipated on spacecraft panel, which is designed as radiator. Because thermal design of the imaging sensor inside a spacecraft is isolated, heat pipes connected to radiators on the panel efficiently transfer dissipation of the units. First of all, preliminary thermal design of radiating area and heater power is performed through steady energy balance equation. Based on preliminary thermal design, on-orbit thermal analysis is calculated by SINDA, so calculation for thermal design could be easy and rapid. Radiators are designed to rib-type in order to maintain radiating performance and reduce mass. After on-orbit thermal analysis, thermal requirements for Space Imaging Sensor are verified.

• Aerospace Engineering and Technology
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• v.3 no.1
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• pp.155-169
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• 2004

Space launch vehicles and reentry vehicles are exposed to extreme heating conditions due to high aerodynamic heating while flying at high Mach numbers in the atmosphere. To protect the vehicle itself or the payload from the aerodynamic heating, the thermal load imposed on the surface should be exactly predicted and proper thermal protection should be applied based on the prediction results. But this requires rigorous thermal analysis and testing to prevent loss of payload capacity caused by excessive heat shielding, and the amount of thermal protection material to be applied is determined through aerodynamic heating tests. Various design points to be considered to upgrade the prototype aerodynamic thermal simulation facility(ATSF) used for the KSR-series sounding rocket development to the one suitable for the KSLV(Korean Space Launch Vehicle)-series launch vehicle are considered in this research. The need and limitation for the facility are first considered, and the functions required for KSLV testing are determined. The specifications of the upgraded facility are briefly suggested and these results will be used for the future fabrication and installation of the facility.

• Korean Journal of Food Science and Technology
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• v.37 no.6
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• pp.951-956
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• 2005

Selection of oxygen-tolerant strains and elucidation of their oxygen tolerance mechanism were crucial for effective use of bifidobacteria. Oxygen-tolerant bifidobacteria were able to significantly remove environmental oxygen (oxygen removal activity) as compared to oxygen-sensitive strains. Most oxygen removal activity was inhibited by heat treatment and exposure to extreme pH (2.0) of bifidobacterial cell. NADH oxidase was major enzyme related to oxygen removal activity. Oxygen-tolerant bifidobacteria possessed high NADH peroxidase activity level to detoxify $H_2O_2$ formed from reaction of NADH oxidase. Addition of oxygen to anaerobic culture broth significantly increased activities of HADH oxidase and NADH peroxidase within 1hr and rapid increment of oxygen concentration was prevented. Results showed NADH oxidase and NADH peroxidase of oxygen-tolerant bifidobacteria played important roles in elimination of oxygen and oxygen metabolite $(H_2O_2)$.

• Journal of Integrative Natural Science
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• v.13 no.1
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• pp.27-33
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• 2020

The unsustainable human activities like increased use of automobiles, heavy industrialization and the use of large volumes of fertilizers, chemicals and pesticides in the agricultural land cause climate change problems in one way or another. Under normal circumstances, the heat radiations from the sun will be reflected back. An excessive volume of GHGs in the atmosphere would prevent these radiations from reflecting back. East Asia is facing severe climate change issues in recent times. A lot of climate change problems such as hurricanes and floods have been reported from this region in the last couple of decades. The study aimed at investigating the climate change in East Asia with changing Sea Surface Temperature (SST). The study adopted a quantitative research method with a case study research design where a deliberate focus was made on the East Asia Region. Secondary data was gathered and analyzed to yield both descriptive and inferential statistics. The study concluded that the impact of East Asia Climate variability was significant mainly for some extreme events. Also, the study concluded that there was a significant link between the change of the East Asia climate variability and that of the sea surface temperature. Further, the study concluded that a linear relationship existed between the sea surface temperature and the climate of East Asia. Hence, a linear regression was a significant predictor of the East Asia Climate (EAC) based on changing sea surface temperature. The model revealed that 37.4% of the variations in the climate change index were explained by the changes in the sea surface temperature. The climate was expected to change with a value of 49.48 for a unit change in the sea surface temperature.

• Journal of the Korean Geotechnical Society
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• v.36 no.8
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• pp.49-60
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• 2020

A fully coupled thermo-hydro-mechanical model is established to evaluate frost heave behaviour of saturated frost-susceptible soils. The method is based on mass conservation, energy conservation, and force equilibrium equations, which are fully coupled with each other. These equations consider various physical phenomena during one-dimensional soil freezing such as latent heat of phase change, thermal conductivity changes, pore water migration, and the accompanying mechanical deformation. Using the thermo-hydro-mechanical model, a sensitivity analysis study is conducted to examine the effects of the geotechnical parameters and external conditions on the amount of frost heave and frost heaving rate. According to the results of the sensitivity analysis, initial void ratio significantly affects each objective as an individual parameter, whereas soil particle thermal conductivity and temperature gradient affect frost heave behaviour to a greater degree when applied simultaneously. The factors considered in this study are the main factors affecting the frost heaving amount and rate, which may be used to determine the frostbite sensitivity of a new sample.

• Journal of the Korea Furniture Society
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• v.20 no.5
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• pp.467-479
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• 2009

The high-tech computer technology developments have greatly affected the area of design education. Starting from the mid 80s, innovations in visual presentation methods have heightened with 2D computer graphic programs, CAD & 3D modeling, and Rapid Prototype that allows dimensional generation. The specialty and quality in design studio education have advanced due to the development in presentation methods such as Power Point and Keynote. But there are many problems with the current method of presenting the visual outcome in a data format using beam projectors, which is a vertical presenting method compared to the old studio study method of conducting discussions and reviews based on the substantial outcome. The essence of studio study that allows for comparisons and analysis by horizontally opening up the various work outcomes is being offset. Also the requirement for manual idea sketching work that plays an important role in the initial design phase continuing to decrease due to the digital working process dependence and cumbersome procedures in the presentation. In order to resolve this problem, the CALM system (Class Applied LCD Modular System) has been developed that replaces the method of attaching the sketches or renderings on the wall with a digital multi-display system. In a nutshell, individuals will upload the outcomes online and display them on the CALM system studio that is composed of 32 LCD (Columns: 4 $\times$ Rows: 8) monitors that are 19 inches in size so that various personnel can openly study the design outcomes. Also the central 42 inch PDP monitor that offers touch pad capability allows each design outcome to be described and examined by expanding. The concept phase of this development process has elevated to the production of an operating prototype that is being reviewed of its practicality. It is considered that the development of this system will decrease the extreme tendency of depending on digital operation but achieve revitalization of a more realistic and opened studio study environment compared to the individual consulting method of the old study approach.