• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.3
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• pp.203-214
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• 2013

Objectives Yusanghan(類傷寒) means disease which chills and fever manifest like Cold damage(傷寒) but not Cold damage. However, study on Yussanghan is insignificant. The purpose of this study is to examine the origin and development process of Yusanghan. Methods: 1. Terms and disease related with Yusanghan was collected from books covering Cold damage of all time and analyzed. 2. The transition history was researched by analyzing collected terms. 3. Total appearance frequency of all time by collected disease was researched. Results: Yusanghan was appeared in Hwalinseo(活人書), which Ju Geong(朱肱) of the Song Dynasty wrote, for the first time and the definition and type were established. For the types of those, there are four diseases such as Phlegm-Fluid Retention(痰飮), Food Accumulation(食積), Vexation of Deficiency Type(虛煩), Beriberi(脚氣). Since then, the theory about Yusanghan had developed and the number of types had also increased until the Myung Dynasty. Conclusions: In early days, External Contraction Diseases(外感病) was not included in Yusanghan, but since the late Myung Dynasty, there were a lot of doctors who included External Contraction Diseases in Yusanghan, not in Cold damage. There are Summerheat Stroke, Wind-Dampness(風濕), and Warm Disease(溫病) etc. for included External Contraction Diseases. Because of this, the number of types of Yusanhan had significantly increased.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.4
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• pp.409-417
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• 2012

External pathogens such as wind, cold can easily invade the external parts of the body when host's external defense ability is not secure. Herein, we consider the underlying mechanisms against the external contraction at the body surface. During the early period after primary invasion, external defense mechanisms are gradually activated. The classic clinical manifestations are aversion to cold, fever, headache, generalized pain, and nasal congestion. This condition is called by invasion of external pathogen into the body surface. As the disease progress, lung qi is stagnated and thereby up-outward and downward movement action of lung become disturbed. Therefore, when doctor administrate formula to treat the exterior syndrome, doctor must keep in mind not only materia medica, but also underlying mechanisms through which many clinical symptoms appear.

• The Journal of Korean Medical History
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• v.33 no.1
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• pp.1-9
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• 2020

Pubescent Angelica is generally used in musculoskeletal diseases of lower extremity, itching, external contraction (外感) and furuncle, with the effect of dispelling wind, draining dampness, dispersing the external (解表) and stopping pain. The disease parts of Treasured Mirror of Eastern Medicine (東醫寶鑑) contain 121 examples of the usage of Pubescent Angelica. Cases of musculoskeletal diseases and itching are mainly in the External Bodily Elements section (外形篇), and those of external contraction and furuncle are mainly in the Miscellaneous Disorder section (雜病篇). Internal Bodily Elements section (內景篇) has 10 prescriptions that involve Pubescent Angelica, in Dreams (2), Voice (1), Uterus (4), Parasites (1), and Feces (2) chapters. Their specific symptoms are insomnia and sleep paralysis (Dreams), loss of voice due to external contraction (Voice), uterine hemorrhage (Uterus), phthisis (Parasites), and constipation and diarrhea (Feces). It is not easy for students beginning their clinical training to link the effects of Pubescent Angelica and its actual usage, especially in the area of internal medicine. By Analyzing the whole cases of Pubescent Angelica in the Treasured Mirror, we found various usages out of reach of basic knowledge of the herb. Such method can be utilized not only in developing herbal knowledge-based products, but also in improving Korean medicine education, by enhancing the occupational competency bridging basic and clinical knowledge.

• Journal of Korean Medical classics
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• v.36 no.2
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• pp.77-96
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• 2023

Objectives : The purpose and application method of the five kinds of Gagamjeong-gisan in the Onbyeongjobyeon were analyzed and their significance was examined. Methods : First, contents within medical texts on the Gwakhyangjeong-gisan, the original formula for the Gagamjeong-gisan were analyzed. Next, application, symptoms and pathogenic mechanism, treatment principle, composition of the Gagamjeong-gisan as written in the Onbyeongjobyeon were analyzed. Characteristics of each formula as deduced from this process were compared and examined. Results : The Gwakhyangjeong-gisan covers both external contraction and internal damage, applied regardless of external or internal symptoms. It restores the Yang qi of the Spleen and Stomach, balancing the Zheng qi to respond to the external qi. The Gagamjeong-gisan takes after the Gwakhyangjeong-gisan, reflecting such properties. However, the latter differs in that it excludes ingredients unfit for treating dampness-warmth, and uses different application methods according to the level of discharge of dampness pathogen. Conclusions : The Gagamjeong-gisan is modified from the Gwakhyangjeong-gisan, which is applied to cold damage and internal damage to better treat warm disease. It can be said to have acted as a bridge for warm disease scholars in composing formulas that deal with dampness-heat disease.

• Journal of Korean Medical classics
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• v.35 no.2
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• pp.99-120
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• 2022

Objectives : To analyze symptoms of olfactory dysfunction caused by COVID-19 from a Korean Medical Perspective. Methods : Previous studies dealing with olfactory dysfunction accompanying COVID-19 were studied and analyzed for general characterization. Physiology and pathology of olfactory functions within the classical texts of Korean Medicine were collected and analyzed, through which symptoms of olfactory dysfunction in COVID-19 were examined. Results : Olfactory dysfunction manifested in high ratios in the early stages of confirmed COVID-19 cases, at times independent of other nasal symptoms such as blockage or discharge. There was a high chance of loss of taste being accompanied, while mental problems such as a tendency to have difficulty concentrating were present as well. In most cases, recovery took one to two weeks. From a Korean Medical perspective, physiology of olfactory function is closely linked to the Lungs, Ancetral Qi[宗氣], and the Heart, while its dysfunction could be explained by pathological factors such as Wind-Cold, Fire stagnation, Qi deficiency, Wind stroke, etc. Conclusions : In the context of external contraction disease[外感病], olfactory dysfunction could be caused by problems in the Lungs and Stomach that are responsible for breathing, or the Heart which is involved in recognizing and differentiating scent. General characteristics of COVID-19 imply it to be closely related to the Heart. In clinical application, overall symptoms need to be considered in diagnosis and treatment planning, after which further approaches could made to determine the problem to be of the Lung and Stomach, or of the Heart.

• Journal of Korean Medical classics
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• v.26 no.2
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• pp.133-174
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• 2013

Objective : Malaria(瘧疾) is a disease that's main symptom is paroxysm - a cyclical occurrence of sudden coldness followed by rigor and then fever. Since the introduction of the cause and mechanism of malaria(瘧疾) in the "Suwen(素問)", including Cold malaria(寒瘧), Warm malaria(溫瘧), Heat malaria(癉瘧) and Wind malaria(風瘧), there has been over 20 different kinds of malaria, each of which are introduced in multiple medical texts. Method : Through comparison between "Suwen(素問)" and other medical texts, the categories, causes and mechanisms of malaria can be analysed and organized to overview the whole feature of it. Results & Conclusion : External pathogens of malaria(瘧疾) are wind(風), cold(寒), summerheat (暑), dampness(濕), miasmic toxin(瘴), pestilence(疫), ghost(鬼). Internal pathogens of malaria(瘧疾) are dietary irregularities(飮食不節), overexertion and fatigue(勞倦), phlegm(痰), seven emotion(七情). Malaria can be categorized into four groups according to the pathological mechanism that leads to paroxysm. They are latency of disease(伏氣), external contraction(外感), internal damage(內傷), and combination of disease(合病). Malaria-Paroxysm(瘧疾發作) occurs when the three following factors collide strongly : defense qi(衛氣), latent qi(伏邪) and external pathogen(新邪). When collision of the three factors takes place in the interior(裏), the body experiences chills. When it takes place in the exterior(表), the body experiences fever. The cyclical occurrence of Malaria-Paroxysm follows the circulation of defense qi.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1271-1278
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• 2023

Objective: The 19 Mechanisms of Disease were first described in Huangdi Neijing. When examining Yixuexinwu, three descriptions that were different from Huangdi Neijing were found. Methods and Results: After examining the two books, three differences in the description of the 19 Mechanisms of Disease were discovered: 1) The upper and lower locations of dyspnea (喘症) are reversed. 2) The ratio of provisions for "fire (火)" and "cold (寒)" is different. 3) The organ affiliation for pain is different. Conclusion: 1) The upper and lower locations of dyspnea (喘症) are reversed. : Regarding external contraction dyspnea (外感喘), Yixuexinwu used the disease of the upper location (lung 上, 肺) in the same way as in Huangdi Neijing. In terms of internal damage (內傷喘), it was separately classified as a disease of the lower location (kidney 下, 腎). 2) The ratio of provisions for "fire (火)" and "cold (寒)" is different. : Arithmetically, if you round off the number after calculating the fraction, the difference between the two ratios becomes the same. Theoretically, five provisions of "fire" are replaced by four provisions of "heat (熱)", and the difference in ratios is exactly the same. Empirically, it emphasizes that there are more illnesses from fire and heat than from cold. 3) The organ affiliation for pain is different. : Huangdi Neijing described general inflammatory pain, while the Yixuexinwu described only stress-related abdominal pain (肝木乘脾 腹痛).

• Biomedical Science Letters
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• v.27 no.4
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• pp.270-276
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• 2021

Physiological agents trigger a signaling process called "inside-out signaling" and activated platelets promote adhesion, granule release, and conformational changes of glycoprotein IIb/IIIa (αIIb/β₃). Activated αIIb/β₃ interacts with fibrinogen and initiates a second signaling step called "external signaling". These two signaling pathways can cause hemostasis or thrombosis, and thrombosis is a possible medical problem in arterial and venous vessels, and platelet-mediated thrombosis is a major cause of cardiovascular disease (CVD). Therefore, modulating platelet activity is important for platelet-mediated thrombosis and cardiovascular disease. Esculetin is a coumarin-based physiologically active 6,7-dihydroxy derivative known to have pharmacological activity against obesity, diabetes, renal failure and CVD. Although some studies have confirmed the effects of esculetin in human platelet activation and experimental mouse models, it is not clear how esculetin has antiplatelet and antithrombotic effects. We confirmed the effect and mechanism of action of escultein on human platelets induced by collagen. As a result, esculetin decreased Ca²⁺ recruitment through upregulation of inositol 1, 4, 5-triphosphate receptor. In addition, esculetin upregulates cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-dependent pathways and inhibits fibrinogen binding and thrombus contraction. Our results demonstrate the antiplatelet effect and antithrombotic effect of esculetin in human platelets. Therefore, we suggest that esculetin could be a potential phytochemical for the prevention of thrombus-mediated CVD.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.5 no.2
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• pp.35-45
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• 2007

The purpose of this study was to examine spiral way movement of a trunk exerts on the movement ability. The details established to achieve for this article. This examination confirmed the weight, weight/height2 index, ratio of lumbar to pelvic, musculoskeletal quantity, push up for 2 minute, pitch a ball and voluntary isometric contraction with flexion and extension of knee joint of the subjects with spiral direct movement. Healthy eighteen subjects who understand fully the significance of procedure, consented to a plan, without neuromuscular disease were participated in two groups of experiment. The group were a spiral movement(9), rectilinear movement(9). Trunk movement tested 2 sessions of a spiral movement and rectilinear movement with a push up for 2 minute, 5days per a week, for the 4 weeks. This experiment tested 3 times with a sufficient rest for fatigue limitation. An analysis of the results used a paired samples t-test for difference from before and after experiment. The following results were obtained; At an internal change of the body, the musculoskeletal quantity was increased significantly to spiral movement group, but the weight was increased significantly, the musculoskeletal quantity was not significant to rectilinear movement. The movement ability evaluation for a external change was increased significantly in a push up for 2 minute, pitch a ball, isometric contraction with extension of knee joint of a spiral movement group, but a push up for 2 minute was increased significantly in a push up for 2 minute on the abdominal muscle training of a rectilinear movement group. As compared with a rectilinear movement, a spiral movement was more effect by cooperation with nerve and musculoskeletal system and an increase in movement ability was caused by learning acknowledgment, muscular reeducation. These results lead us to the conclusion that a spiral movement of trunk was more effect than a rectilinear movement, the coordination of nerve and musculoskeletal system was of importance of Multi-direction movement. Therefore, A further studies concerning the therapeutic exercise intervention and active-dynamic analysis could enhance the development of the most effect on the trunk.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.5
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• pp.577-587
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• 2012

Warm disease: Any of various heat disease characterizer by rapid onset and shifts, pronounced heat signs, and a tendency to form dryness and damage yin. Exterior heat sign: exterior heat patterns are characterizer by pronounced heat signs, such as a red sore pharynx and a relatively red tongue with dry fur, the pulse is floating and rapid, cough and the production of thick white or yellow phlegm. If wind-heat evil exist in weifen, it becomes exterior syndrome, and a remedy about that is dispelling wind-heat but when wind-heat evil invades in nasal and throat part so the disease occurs, you need to add relieving sore throat worsens invades in lung it makes disharmony of diffuse in lungs. So a remedy about it is diffuse the lung. disharmony of diffuse in lungs makes metabolic disorder of qi and liquid and humor malfunction therefore it occurs cough and heat-phlegm syndrome. heat from weifen invades the whole of lungs and form lung heat. So a remedy about lung heat is clearing away lung heat, this lung heat makes inevitably bleed in lungs, therefore a remedy in this case is clearing the lung to stop bleeding, or moistening the lung. Exterior heat sign means that exterior syndrome coexists with heat syndrome and it means that a remedy of this syndrome need to mix prescriptions for relieving exterior syndrome and heat-clearing prescriptions to treat this syndrome.