• Title/Summary/Keyword: experimental activity

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The effect of a physical activity on blood cholesterol in older adults (노인의 신체활동이 혈중지질에 미치는 영향)

  • Kim, Hyun-Sook;Um, Ki-Mai;Lim, In-Hyuk
    • Journal of Korean Physical Therapy Science
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    • v.13 no.3
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    • pp.7-14
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    • 2006
  • Despite well-known benefits of physical activity for older adults, most older adults remain significantly underactive. The purpose of this study was to examine the effects of a physical activity on blood cholesterol in older adults with an inclusive, choice-based physical activity promotion program to increase lifetime physical activity levels of seniors. A six-month comparison-group trial was conducted with 14 older adults(experimental group = 8, control group = 6) in community senior center. Changes in self-reported physical activity and blood cholesterol were evaluated using paired t-test. The intervention group increased estimated caloric expenditure by 858 calories/week in physical activities of any intensity (p=.050), total cholesterol(p=0.049), high density lipoprotein cholesterol(p=0.045). Control group changes were also negligible. The program led to meaningful physical activity increase. Individually tailored programs to encourage lifestyle changes in seniors may be effective and applicable to health care and community settings.

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Compilation of 104 Experimental Theses on the Antitumor and Immuno-activating therapies of Oriental Medicine (한의학의 항종양 면역치료에 관한 연구 -1990년 이후 발표된 실험논문을 중심으로-)

  • Kang Yeon Yee;Kim Tai Im;Park Jong Ho;Kim Sung Hoon;Park Jong Dai;Kim Dong Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.1-24
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    • 2003
  • This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.

Antioxidative Activity and Serum Lipid Composition of Wild Grape Seed Powder in Rats fed Hypercholesterolemic Diet (고콜레스테롤혈증 유발식이를 급여한 흰쥐에서 머루씨 분말첨가가 항산화활성과 혈액지질조성에 미치는 효과)

  • Won, Hyang-Rye
    • The Korean Journal of Community Living Science
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    • v.18 no.3
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    • pp.363-368
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    • 2007
  • This study is to find out the antioxidative effect and serum lipid composition of wild grape seed powder in vivo. 20 white Sprague Dawley rats of six weeks old were divided into 2 groups and AIN-93 basic diet, high fat and cholesterol were provided. And they were examined to know how wild grape seed powder worked for antioxidative effect and serum lipid composition. For the comparing group, wild grape seed powder consisting 5% of the diet weight was provided and the quantity of protein, fat, carbohydrate, and cellulose was controlled following the analysis of the ingredients. The rats were fed for four weeks with experimental diet. Serum lipid and the antioxidant enzyme activity in blood and liver microsome were measured after 4 weeks of experiment. The results are as follows; There was no difference between the experimental groups in the initial body weight, final body weight, weight gain and FER. Food intake was higher in the group wild grape seed powder was provided than in the control group(p<0.05). Serum total cholesterol in the control group was significantly higher than that in the group wild grape seed powder was provided.(p<0.05). There was no difference serum HDL cholesterol and LDL cholesterol between the groups. Serum triglyceride showed no significant difference between the groups. In blood, glutanthione peroxidase activity was higher in the group supplemented with wild grape seed powder than in the control group. The glutathione reductase activity of blood showed no difference between the groups. In liver, the glutanthione peroxidase activity was higher in the group supplemented with wild grape seed powder than in the control group(p<0.05). Glutathione reductase activity in liver showed no difference in accordance with the supplementation of wild grape seed powder.

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The Effects of the Task-Oriented Trunk Training on Muscle Strength and Muscle Activity of Trunk, Balance and Gait in Stroke Patients (뇌졸중 환자의 과제지향몸통훈련이 몸통 근력과 근활성도, 균형 및 보행에 미치는 효과)

  • Oh, Gkubin;Lee, Hyojung
    • Journal of The Korean Society of Integrative Medicine
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    • v.8 no.1
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    • pp.203-217
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    • 2020
  • Purpose : This study aimed to determine whether task-oriented trunk training can improve muscle strength, muscle activity, balance, and gait in stroke patients. Methods : A total of 27 stroke patients who agreed to participate in the study were randomly divided into the following two groups: (1) experimental group 1, task-oriented training applied to the proximal part (n=14) and (2) experimental group 2, task-oriented training applied to the distal part (n=13). Thereafter, task-oriented trunk training was accordingly applied in each group for 60 minutes per session, 5 times per week for 6 weeks. Muscle power, muscle activity, balance, and gait were assessed using a digital dynamometer, surface electromyograph, Timed Up and Go (TUG) test, and gait analyzer (G-WALK), respectively, before and after training. Results : Trunk muscle strength significantly increased in both groups after training (p<.05). and there was a significant difference between the groups. Muscle activity in the stance phase during gait significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. Muscle activity in the swing phase during gait significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. The TUG test values significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. Gait significantly increased in both groups after training (p<.05), and there was a significant difference between the groups. Conclusion : The results of this study show that task-oriented training can improve trunk muscle strength, muscle activity, balance, and gait in stroke patients.

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

  • Chen, Guangxin;Gao, Zhenhua;Chu, Wenhui;Cao, Zan;Li, Chunyi;Zhao, Haiping
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.4
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    • pp.569-575
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    • 2018
  • Objective: This experiment was conducted to investigate the effects of chromium picolinate (CrP) on fat deposition, genetic expression and enzymatic activity of lipid metabolism-related enzymes. Methods: Two hundred forty one-day-old Ross broilers were randomly divided into 5 groups with 4 replicates per group and 12 Ross broiler chicks per replicate. The normal control group was fed a basal diet, and the other groups fed the same basal diet supplemented with 0.1, 0.2, 0.4, and 0.8 mg/kg CrP respectively. The experiment lasted for 21 days. Results: Added CrP in the basal diet decreased the abdominal fat, had no effects on subcutaneous fat thickness and inter-muscular fat width; 0.2 mg/kg CrP significantly decreased the fatty acid synthase (FAS) enzymatic (p<0.05); acetyl-CoA carboxylase (ACC) enzymatic activity decreased in all CrP groups (p<0.05); hormone-sensitive lipase (HSL) enzymatic activity also decreased, but the change was not significant (p>0.05); 0.4 mg/kg CrP group significantly decreased the lipoprotein lipase (LPL) enzymatic activity. FAS mRNA expression increased in all experimental groups, and the LPL mRNA expression significantly increased in all experimental groups (p<0.05), but not 0.2 mg/kg CrP group. Conclusion: The results indicated that adding CrP in basal diet decreased the abdominal fat percentage, had no effects on subcutaneous fat thickness and inter-muscular fat width, decreased the enzymatic activity of FAS, ACC, LPL and HSL and increased the genetic expression levels of FAS and LPL.

An Effect of Inquiry Activity-based Environmental Education Class on Elementary School Students' Environmental Attitudes - Focusing on the Intelligent Life of the Second Grade - (기초 탐구 활동 중심 환경 수업이 초등학생들의 환경적 태도에 미치는 효과 - 초등학교 2학년 슬기로운 생활을 중심으로 -)

  • Cho, Won-Sil;Kim, Yong-Guen
    • Hwankyungkyoyuk
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    • v.22 no.3
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    • pp.83-96
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    • 2009
  • This article extracted feasible elements for an environmental education program from the 'Intelligent Life', an integrated subject of the 7th elementary school curriculum, and designed a program for second graders in the elementary school and applied it to them in order to examine how the students' environmental altitudes changed. In the controlled class, the instruction followed the lessons specified in the 7th national curriculum faithfully while for the experimental class 1, only the inquiry activity-based environmental education program was applied. Moreover, in experimental class 2, the inquiry activity-based environmental education program was implemented and wrap-up activity was performed as well with the products. To verify the program, questionnaires on the change of environmental altitudes were distributed and analyzed total three times in the pretest, posttest 1(right after the program), and posttest 2(30 days after the program). T-test was carried out with the SPSS 12 program to verify the effect of the applied program. To make up for the quantitative analysis, qualitative analysis was also conducted. The followings show the results gained after the program was implemented. First, This program showed a significant difference(p<.05) in the students' formation of environmental altitudes. Second, it was verified that the inquiry activity-based environmental education class that reorganized the second grade elementary students' 'Intelligent Life' subject had a more positive effect in the cultivation of environmental altitude than the class that followed the present curriculum as it was. It will be necessary to perform follow-up researches on the relativity between curricula for kindergarteners and lower grade elementary school students.

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Effect of Squat Exercise Combined with Whole Body Vibration Exercise on Muscle Activity and Muscle Fatigue of Quadriceps in Patients with Patellofemoral Pain Syndrome (전신 진동 운동을 병행한 스쿼트 운동이 무릎넙다리 통증 증후군 환자의 넙다리네갈래근의 근 활성도 및 피로도에 미치는 영향)

  • Kang, Jeong-Il;Moon, Young-Jun;Jeong, Dae-Keun
    • Journal of the Korean Society of Physical Medicine
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    • v.16 no.1
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    • pp.41-48
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    • 2021
  • PURPOSE: The purpose of this study was to provide fundamental clinical data to be used in therapeutic approach to patients with patellofemoral pain syndrome by administrating the squat exercise combined with whole body vibration exercise to them and investigating the effect of such exercise to leg muscle activity and muscle fatigue. METHODS: The patients with patellofemoral pain syndrome were randomly assigned to experimental group I (n = 9) where only squat exercise was administered and experimental group II (n = 9) where the squat exercise combined with whole body vibration exercise was provided. The intervention program was administered for two weeks, four days a week, one session a day, three set a session, and 20 reps a set. The pre- and post-test were performed to measure muscle activity and muscle fatigue of vastus medialis and vastus lateralis. RESULTS: The muscle activity significantly changed in both group (p < .05, p < .01, respectively) and the muscle fatigue showed significant change only in group I (p < .05). In addition, there was significant difference between groups in change of muscle fatigue of both muscles (p < .05) but not in change of muscle activity. CONCLUSION: The results showed that both exercise are effective in improving muscle activity, however, that the squat exercise combined with whole body vibration exercise is more effective in preventing muscle fatigue.

The Effects of Squat Exercises with Vertical Whole-Body Vibration on the Center of Pressure and Trunk Muscle Activity in Patients with Low Back Pain

  • Kang, Jeongil;Jeong, Daekeun;Choi, Hyunho
    • Journal of International Academy of Physical Therapy Research
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    • v.11 no.4
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    • pp.2253-2260
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    • 2020
  • Background: Patients with low back pain (LBP) experience misalignments in the center of pressure (COP) and muscle imbalances due to frequent onesided posture adjustments to avoid pain. Objectives: To identify the effects of Squat Exercises with Vertical Whole-Body Vibration on the Center of Pressure and Trunk Muscle Activity. Design: Randomized controlled trial. Methods: Thirty LBP patients with an imbalance in the COP were sampled and randomly assigned to an experimental group of 15 patients who under went an intervention involving squat exercises with vertical WBV and a control group of 15 patients who were treated via a walking intervention. As pretests before the interventions, the subjects' COP was identified by measuring their stability index (ST), and erector spinae, rectus abdominis, transverse abdominis, gluteus medius muscle activity was analyzed by determining the % reference voluntary contraction (%RVC) value using surface electromyography while sit to stand. After four weeks, a post test was conducted to remeasure the same variables using the same methods. Results: Statistically significant differences were found in the ST (P<.01) and trunk muscle (P<.05, P<.001) in the experimental group before and after the intervention. In terms of the differences between the left- and right-side (RL) muscle activity, only the transverse abdominis (TrA) and gluteus medius (GM) exhibited statistically significant increase (P<.05). A comparison of the groups showed statistically significant differences in the TrA with respect to muscle activity (P<.05) and in the RLTrA and RLGM in terms ofthe difference between left- and right-side muscle activity (P<.01). Conclusion: Squat exercises with vertical WBV produced effective changes in the COP of patients with LBP by reducing muscle imbalances through the delivery of a uniform force. In particular, strengthening the TrA and reducing an imbalance in the GM were determined to be important factors in improving the COP.

The Effects of IASTM Using Vibration Stimulation on Shoulder Muscle Activity, Flexibility and Pain of Chronic Shoulder Pain Patients (진동을 이용한 IASTM이 만성 어깨통증 환자의 어깨 근활성도, 유연성, 통증에 미치는 영향)

  • Kim, Jae-Woon;Yoo, Sung-Hoon;Kim, Sung-Su
    • Journal of The Korean Society of Integrative Medicine
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    • v.9 no.2
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    • pp.13-21
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    • 2021
  • Purpose : Instrument-assisted soft tissue mobilization (IASTM) has been widely used to improve pain and range of motion. However, research on IASTM using vibration stimulation is lacking. Therefore, this study investigates how IASTM using vibration stimulation affects chronic pain on muscle activity and flexibility of the shoulders. Methods : A total of 20 patients with chronic shoulder pain were divided into the experimental group and the control group. The experimental group (n=10) used vibration stimulus for IASTM, while the control group (n=10) used general IASTM. For six weeks, this training lasted for 30 min a day, twice a week. Muscle activity was evaluated using the surface electromyograph. The back and reach test was used to assess flexibility, the visual analogue scale to measure pain, and the paired t-test to compare the groups before and after the experiment. An independent ANCOVA was conducted to assess differences in the degree of transition between the two groups before and after the experiment. Results : Significant differences in muscle activity, flexibility, and pain in both groups before and after the experiment (p<0.05) were observed, as well as in the muscle activity of the pectoralis major and associated pain (p<0.05). however, muscle activity and flexibility of the upper trapezius and infraspinatus were not significantly different between groups (p>0.05). Conclusion : This study confirms the importance of IASTM using vibration. Design and manufacture of IASTM using vibration based on our results would be useful in the management of shoulder pain, Further clinical evidence are needed.

The Effect of Multimodal Intervention through Virtual Reality-Based Immersion Program on Cognitive Function and Brain activity in Patients with Mild Cognitive Impairment (가상현실 기반 몰입형 복합중재프로그램이 경도인지장애 환자의 인지기능 및 두뇌 활성에 미치는 영향)

  • Ye-Rim Im;Sun-Min Lee
    • Journal of the Korean Society of Physical Medicine
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    • v.18 no.1
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    • pp.87-97
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    • 2023
  • PURPOSE: The purpose of this study was to investigate the effect of multimodal intervention through VR (virtual reality)-based immersion program on the cognitive function and brain activity of patients with mild cognitive impairment. METHODS: The subjects of the study were 10 people in the experimental group who applied a complex intervention that performed cognitive tasks using the movement of the upper extremities through the VR program, and 10 people in the control group who received traditional occupational therapy. After the study intervention was applied 5 times a week, 30 minutes a day for a total of 8 weeks, LOTCA-G(Lowenstein Occupational Therapy Cognitive Assessment for Geriatric Population) and NIRSIT LITE were used to compare. RESULTS: Significant differences in cognitive function and brain activity were noted between the pre- test and post-test in the experimental group. Brain activity showed statistically significant differences in four channels of the working memory domain and one channel of the metacognitive domain (p < . 05). Comparative analysis of the difference between the two groups revealed statistically significant differences in cognitive function and brain activity. The brain activity showed statistically significant differences in three channels of the working memory domain and one channel of the metacognitive domain (p < .05). CONCLUSION: Through the results of this study, it was found that the complex intervention of performing cognitive tasks using upper extremity movements through the VR program had a positive effect on the cognitive function of patients with mild cognitive.