• Molecules and Cells
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• v.37 no.8
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• pp.569-574
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• 2014

As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail.

• Journal of the Korea Furniture Society
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• v.13 no.1
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• pp.49-59
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• 2002

The studio furniture movement that expanded in the United States after the Second World War was truly American creation representing highly sophisticated individualism versus industrial anonymity. The studio furniture movement can be traced back to the 1930s in terms of its influences and emergences. Based on the ideals of Arts and Crafts movements from the earlier decades, studio furniture movement emerged in the 1950s in reaction to Bauhaus inspired industrially produced furniture. Studio furniture has represented an alternative for people who wanted individual objects in their homes rather than industrially produced products. Opposed to plastics and industrial materials, artists in studio furniture mainly focused on one natural material, emphasizing its singular beauty. There were significant roles and influences of craft education along with Scandinavian influences in terms of spreading out the movement. A historical examination of furniture from the 1930s until the 1960s illustrates how this significant movement began in the mid-century.

• Proceedings of the KSR Conference
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• 2005.11a
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• pp.494-499
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• 2005

Transportation routes by land like a human being blood vessel should exist for economic and trade exchange in Northeast Asia. Thinking from this point of view. I believe that TSR(Trans Siberian Railroad) and TCR(Trans Chinese Railroad). which will be connected with I would like to talk about .not only the effects of various international railroads and their connections but also economic activation TKR(Trans Korean Railroad). can play important roles. In this study, and effects in Northeast Asia which will be resulted from various international railroads construction. I tried to figure out comparative superiority and comparative advantage of the trade structure and industries in South and North Korea to find out the possibility of economic unification in East Asia. especial1y in Northeast Asia. This study also includes the effort to find out how trade exchange between South and North Korea can be expanded as a result of being a member of East Asia economic zone.

• IMMUNE NETWORK
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• v.13 no.1
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• pp.1-9
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• 2013

Autophagy is a fundamental cellular process in eukaryotic cells for maintaining homeostasis by degrading cellular proteins and organelles. Recently, the roles of autophagy have been expanded to immune systems, which in turn modulate innate immune responses. More specifically, autophagy acts as a direct effector for protection against pathogens, as well as a modulator of pathogen recognition and downstream signaling in innate immune responses. In addition, autophagy controls autoimmunity and inflammatory disorders by negative regulation of immune signaling. In this review, we focus on recent advances in the role of autophagy in innate immune systems.

• Hwankyungkyoyuk
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• v.11 no.1
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• pp.251-274
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• 1998

The purpose of this study was to investigate the current status and problems in environmental education by schools which was newly established in the 6th curriculum and to propose the future agendas for environmental education. Then, we have investigated teachers' consciousness about environmental education and analysed the 6th curriculum and textbooks at primary and secondary school levels. The result of this study was as follows. 1. Most teachers thought of 'participation' as important goal of environmental education, but they actually could not practice it because of various preventing factors. 2. Most teachers thought that there were no efforts to reform textbook system and school conditions. 3. The content and goal of environmental education was duplicated and vague in each subject. The suggestions for the improvement of the environmental education based on these conclusions were as follows. 1. The systematic goal strategy of environmental education must be established. 2. We must allot appropriate roles to each environment related subjects for efficient environmental education 3. The opportunity for pre-service and in-service for teachers of environmental education must be expanded.

• Molecules and Cells
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• v.45 no.11
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• pp.771-780
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• 2022

The field of extracellular vesicles (EVs) has expanded tremendously over the last decade. The role of cell-to-cell communication in neighboring or distant cells has been increasingly ascribed to EVs generated by various cells. Initially, EVs were thought to a means of cellular debris or disposal system of unwanted cellular materials that provided an alternative to autolysis in lysosomes. Intercellular exchange of information has been considered to be achieved by well-known systems such as hormones, cytokines, and nervous networks. However, most research in this field has searched for and found evidence to support paracrine or endocrine roles of EV, which inevitably leads to a new concept that EVs are synthesized to achieve their paracrine or endocrine purposes. Here, we attempted to verify the endocrine role of EV production and their contents, such as RNAs and bioactive proteins, from the regulation of biogenesis, secretion, and action mechanisms while discussing the current technical limitations. It will also be important to discuss how blood EV concentrations are regulated as if EVs are humoral endocrine machinery.

• Journal of Species Research
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• v.12 no.1
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• pp.48-54
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• 2023

Foraminifera are unicellular eukaryotes widely distributed in marine and transitional marine environments. They play important roles in marine food webs and geochemical cycles and have physiological properties like the formation of calcareous tests and nitrogen respiration. Research on species diversity, distribution and endemism are essential in biogeography and biodiversity conservation. Here, we report three unrecorded species of foraminifera (Hemirotalia foraminulosa, Planispirillina denticulogranulata and Oolina brevisolenia) collected from Jeju Island and the South Sea (Korea). Planispirillina denticulogranulata is the second Planispirillina species recorded in Korea, which can be distinguished from congeners by its tubercles on the ventral side and grooves on the spiral suture. Hemirotalia foraminulosa is differentiated from the only congener H. calvifacta by multiple-scattered pits on the umbilicus, and it is the first report of Hemirotalia from Korean water. Oolina brevisolenia has specific bifurcating costae that characterize it from other congeners. This study contributes to documentation of the foraminiferal biodiversity in Korea, moreover, provides an essential basis for the expanded studies on modern foraminifera.

• Development and Reproduction
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• v.15 no.1
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• pp.17-24
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• 2011

Lipid metabolites involved in cellular regulation as signaling mediators. Prostaglandins (PGs), metabolites of lipid are involved to pregnancy at the time of implantation but the functional roles of PGs on embryo development are still controversy and largely unknown. In previous report, the levels of $PGE_2$ and $PGF_{2a}$ at embryos of morula stage and blastocyst stage were explored (Cheon et al., 1998). In this study, the previous suggestion was confirmed and the possible downstream mediator of prostaglandin $E_2$ and prostaglandin $F_{2a}$ on the expansion and hatching of mouse embryo was examined. As expected, developmental rate of the blastocyst to expanded stage was a concentration-response curve that showed the highest expansion rate at 10 ${\mu}M$ $PGE_2$, but at 100 ${\mu}M$ $PGE_2$, the rate was decreased. In contrast to the $PGE_2$, $PGF_{2a}$ stimulated expansion without toxicity at highest concentration. Cotreatment of PGs with indomethacin overcame the inhibitory effects of indomethacin in expansion. Exogenous PGs also improved the development of expanded embryos to the hatching stage. Besides, PGs receptors' transcripts detected at blastocyst. $PGE_2$ was caused of calcium fluctuation in the blastocyst but $PGF_{2a}$ did not. The changes of intracellular calcium concentration were different between indomethacin pretreated embryos and non-treated embryos. Based on these results it is suggested that PGs work as paracrine and/or autocrine factors through calcium and the others which were not identified in this study.

• Journal of Science of Art and Design
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• v.8
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• pp.267-296
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• 2005

Typography, as the median for communication, has expanded its roles according the attributes of the media where it Is used, and the change of media follwing the change of times is presenting new directions to the field of typography. The attempts of 20C experimental typography prioritize visual formativeness, free typography and language started to appear on printed matters and different kinds of prints put pep in magazines. Thus, experiments in the aspects of effective delivery of inpormation that letters have and aesthetic side of shapes of letter are continuing. Today with the appearance of multimedia, development of visual colture and rapid development of digital technology, the range of experimental typography has expanded even wider and therefore, different kinds of expressions became possible. As seen above, unlike the existing static printed media that carries linguistic information only, letters in the multimedia environment is shown in the movie titles, TV or web not only as a basic visual media such as type and image, but as a dynamic and complex factor that contains additional information of motion and sound factor. This study will attempt to find the historic context of focus of moment from the kinetic art and define the moving letters as kinetic typography. Therefore, this paper will have an understanding on kinetic typography's background, concept and characteristics following the change of communication environment in the multimedia era and tried to study the basic theories of kinetic typography and the information delivery and imagery function of letters. Also, this paper attempted to carry out a study on whether kinetic typography is delivering information smoothly from the aspect of communication through the image role as delivering information by studying major works of artists who have influenced kinetic typography. Based on this study, I would like to suggest new direction for effective delivery of information and value of use.

• Archives of design research
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• v.11 no.2
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• pp.242-248
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• 1998

Rapid increasing number of the internet web site enables the users receives information prepared with multimedia techniques as an exchanging gateway to the world. It is also realized that we are living in information society connected by the flooding number of the web sites. Consequently, setting up the identity in developing a homepage is critical since clear distinction from other sites is required for the homepage in which a random user can delivers the ideas from the message offered by the provider. In this paper, in order to establish the identity for a homepage, what kinds of components of the identity should be discussed and how the identity is reflected in the existing homepage are analyzed with the selected sample web sites. The design process in developing the identity for Ssamzie homepage (www ssarnzie eo.kr) is reviewed for comparing with others of the selected sites as a case study. These will explain that the roles of the designers in a homepage preparation will not be limited to the graphic expressions but will be expanded to the contribution to provide the reasonable distinction in terms of the establishing identity of the web sites. Moreover, the phase of the designer can be reevaluated by emphasizing the roles and the established identity.