• The Journal of the Acoustical Society of Korea
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• v.30 no.4
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• pp.181-189
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• 2011

According to developments of digital signal processing, 3D sound come into focus on multimedia systems. Many studies on 3d sound have proposed lots of clues to create realistic sounds. But these clues are only focused on binaural systems which two ears are normal. If we make the 3d sound using those clues at monaural systems, the performance goes down dramatically. In order to use the clues for monaural systems, we have studies algorithms such as duplex theory. In duplex theory, the sounds that we listen are affected by human's body, pinna and shoulder. So, we can enhance sound localization performances using its characteristics. In this paper, we propose a new method to use psychoacoustic theory that creates realistic 3D audio at monaural systems. To improve 3d sound, we calculate the excitation energy rates of each symmetric HRTF and extract the weights in each bark range. Finally, they are applied to emphasize the characteristics related to each direction. Informal listening tests show that the proposed method improves sound localization performances much better than the conventional methods.

• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.17-29
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• 1988

The author examined the effects of lidocaine on the veratrine-or potassium-induced release of neurotransmitters to determine the possible role of amino acid neurotransmitters in lidocaine-induced convulsion. The examined transmitters were gamma-aminobutyric acid (GABA), aspartic acid, glutamic acid and norepinephrine which are released from the synaptosomes. Furthermore, the effects of lidocaine on the binding to receptors and synaptosomal uptake of the two transmitters, GABA and glutamic acid, were determined in crude synaptic membranes and synaptosomes. In addition, the effects of propranolol, norepinephrine and serotonin on the release of amino acid neurotransmitters were also examined. The veratrine-induced release of GABA was most severely inhibited by lidocaine and propranolol, while norepinephrine and serotonin reduced the release of aspartic acid and glutamic acid more than the GABA release. Generally the potassium-induced release was much more resistant to the lidocaine action than the veratrine-induced release. Among the neurotransmitters examined, the aspartic acid release was most prone to the lidocaine action, while the GABA release was most resistant. Concentrations of lidocaine below 1 mM did not significantly change the GABA and glutamic acid receptor binding and uptake. These results indicate that the blocking of sodium channels by lidocaine can result in the selective depression of the GABA release. This may result in unlimited excitation of the central nervous system.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.24 no.6
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• pp.397-404
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• 1991

The steady state and decay characteristics of primary fluorescenece of phytoplanktons including Cyanophyceae and Cryptophyceae were investigated in vivo. At 580-640 nm region, fluorescence emission spectra were obtained from all algae examined. The observed fluorescence emission maxima were similiar$(\pm3\;nm)$ except Synechocorcus sp. (SYN). Considered $\lambda_{max}$ of emission spectra of phycobiliproteins and the excitation spectra with $\lambda_{max}=540-560nm$, it seems to be originated from biliproteins. Fluorescence lifetimes $(\tau)$ and decay curves were compared with standard solution of candidate organic compounds, b-phycoerythrin. The $\tau$ values obtained for phytoplankton with $\lambda_{max}=580nm$ were different depending upon the species of algae. The observed $\tau$ values were ranged from 1.39 ns to 1.95 ns. These are considerably shorter than $\tau(3.23\;us)$ for standard solution of b-phycoerythrin. The reduction of $\tau$ for phycoerythrin in vivo seems to be originated from effective energy transfer system between Chl. a and phycobiliprotein in intact cell. There are subtantial differences in fluorsecence spectra and lifetimes at the class level. At the species level, differences seems to be much smaller. The result of experiment suggests that measurement of fluorescence lifetimes may be helpful in the rapid characterization of algae. Direct application will likely be found in combination with the measurement of other luminescence parameters.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.3
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• pp.303-313
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• 1997

The role of the lower esophageal sphincter(LES) is characterized by the ability to maintain tone and to relax allowing the passage of a bolus. It is known that LES relaxation during swallowing may be induced by the cessation of the tonic neural excitation and the activation of non-adrenergic, non-cholinergic(NANC) inhibitory neurons. Furthermore, it is generally accepted that the relaxation of the smooth muscle is mediated primarily by the elaboration of adenosine 3',5'-cyclic monophosphate(cyclic AMP) and guanosine 3',5'-cyclic mono-phosphate(cyclic GMP) via activation of adenylate cyclase and guanylate cyclase, respectively. It is thus possible that cyclic nucleotides might be a second messenger involved in neural stimulation-induced relaxation of LES, although a relationship between relaxation and changes in cyclic nucleotides after neural stimulation has not been established. The present study was performed to define the participation of cyclic nucleotides in the relaxation of LES of dog in response to neural stimulation. Electrical field stimulation(EFS) caused relaxation of the canine isolated LES strips in a frequency-dependent manner, which was eliminated by pretreatment with tetrodotoxin$(1{\mu}M)$, but not by atropine$(100{\mu}M)$, guanethidine$(100{\mu}M)$ and indomethacin$(10{\mu}M)$. The nitric oxide synthase inhibitors, $N^G-nitro-L-arginine$, $N^G-nitro-L-arginine$ methyl ester and $N^G-monomethyl-L-arginine$ inhibited EFS-induced relaxation. Additions of sodium nitroprusside, a nitrovasodilator and forskolin, a direct adenylate cyclase stimulant, caused a dose-dependent relaxation of LES smooth muscle. Effects of sodium nitroprusside and forskolin were selectively blocked by the corresponding inhibitors, methylene blue for guanylate cyclase and N-ethylmaleimide(NEM) for adenylate cyclase, respectively. Dibutyryl cyclic AMP and dibutyryl cyclic GMP caused a concentration-dependent relaxation of the LES smooth muscle tone, which was not blocked by NEM or methylene blue, respectively. However, both NEM and methylene blue caused significant antagonism of the relaxation in LES tone in response to EFS. EFS increased the tissue cyclic GMP content by 124%, whereas it did not affect the tissue level of cyclic AMP. Based on these results, it is suggested that one of the components of canine LES smooth muscle relaxation in response to neural stimulation is mediated by an increase of cyclic GMP via the activation of guanylate cyclase. Additionally, an activation of cyclic AMP generation system was, in part, involved in the EFS-induced relaxation.

• Journal of Internet Computing and Services
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• v.18 no.5
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• pp.17-22
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• 2017

In a MPC coding using excitation source of voiced and unvoiced, it would be a distortion of speech waveform. This is caused by normalization of synthesis speech waveform of voiced in the process of restoration the multi-pulses of representation section. This paper present PCFBD-MPC( Position Compensation Frequency Band Division-Multi Pulse Coding ) used V/UV/S( Voiced / Unvoiced / Silence ) switching, position compensation in a multi-pulses each pitch interval and Unvoiced approximate-synthesis by using specific frequency in order to reduce distortion of synthesis waveform. Also, I was implemented that the PCFBD-MPC( Position Compensation Frequency Band Division-Multi Pulse Coding ) system and evaluate the SNRseg of PCFBD-MPC in coding condition of 8kbps. As a result, SNRseg of PCFBD-MPC was 13.4dB for female voice and 13.8dB for male voice respectively. In the future, I will study the evaluation of the sound quality of 8kbps speech coding method that simultaneously compensation the amplitude and position of multi-pulse source. These methods are expected to be applied to a method of speech coding using sound source in a low bit rate such as a cellular phone or a smart phone.

• Journal of the Korea institute for structural maintenance and inspection
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• v.17 no.6
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• pp.61-69
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• 2013

This research is aimed to evaluate characteristics and dynamic modeling of MR damper for semi-active vibration control. A MR damper of semi-active type was designed and made for the purpose of controlling the vibration of a real-size model structure. Usually a semi-active control system equipped with a MR damper requires a dynamic model which expresses numerical data about the damping capacity and dynamic characteristics generated by a MR damper. To fulfil the requirement, a Power model and a Bingham model were particularly employed among many dynamic models of MR damper. Those models being contrasted with other ones, a dynamic test was carried out on the developed MR damper. In the test, excitation frequencies were conditioned to be 0.15 Hz, 1.0 Hz, and 2.0 Hz, and three different currents were adopted for each frequency. From these test results, it was found that displacement affected control capacity of the MR damper. The test results led to the identification of model variables for each dynamic model, on the basis of which a force-speed relation curve and expected damping force were derived and contrasted to those of the developed MR damper. Therefore, it was proven that the MR damper designed and made in this research was effective as a semi-active controller, and also that displacement of 2mm at minimum was found to be secured for vibration control, through the test using various displacements.

• Journal of the Earthquake Engineering Society of Korea
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• v.14 no.6
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• pp.1-9
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• 2010

Most of shear wall structures require openings in shear walls and thus shear walls are linked by floor slabs or coupling beams resulting in the coupled shear wall structures. When these structures are subjected to seismic excitations, excessive shear forces are induced in coupling beams. Accordingly, brittle failure of coupling beams may occur or shear walls may yield first. To avoid this problem, damping devices can be installed in coupling beams. It can increase the vibration control effect and improve the seismic resistance performance of the coupled shear wall structure by avoiding stress concentration and the brittle failure of coupling beams. Based on this background research, an LRB (lead rubber bearing) was introduced in the middle of the coupling beam in this study and the authors investigated the seismic response control effect and stress distribution of the proposed system. To this end, a modeling technique that can effectively predict the structural behavior of coupled shear wall structures has been proposed. With this proposed technique, time history analyses of the example coupled shear wall structure subjected to seismic excitation were performed and the vibration control effects of the seismic responses were investigated.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.3
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• pp.186-191
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• 2016

The effects of $Eu^{3+}$ doping on the structural, morphological, and optical properties of $MgMoO_4:Dy^{3+},Eu^{3+}$ phosphors prepared by solid-state reaction technique were investigated. XRD patterns exhibited that all the synthesized phosphors showed a monoclinic system with a dominant (220) diffraction peak, irrespective of the content of $Eu^{3+}$ ions. The surface morphology of $MgMoO_4:Dy^{3+},Eu^{3+}$ phosphors was studied using scanning electron microscopy and the grains showed a tendency to agglomerate as the content of $Eu^{3+}$ ions increased. The excitation spectra of the phosphor powders were composed of a strong charge transfer band centered at 294 nm in the range of 230~340 nm and two intense peaks at 354 and 389 nm, respectively, arising from the $^6H_{15/2}{\rightarrow}^6P_{7/2}$ and $^6H_{15/2}{\rightarrow}^4M_{21/2}$ transitions of $Dy^{3+}$ ions. The emission spectra of the $Mg_{0.85}MoO_4$:10 mol% $Dy^{3+}$ phosphors without incorporating $Eu^{3+}$ ions revealed a strong yellow band centered at 573 nm resulting from the $^4F_{9/2}{\rightarrow}^6H_{13/2}$ transition of $Dy^{3+}$. As the content of $Eu^{3+}$ was increased, the intensity of the yellow emission was gradually decreased, while that of red emission band located at 614 nm began to appear, approached a maximum value at 10 mol%, and then decreased at 15 mol% of $Eu^{3+}$. These results indicated that white light emission could be achieved by controlling the contents of the $Dy^{3+}$ and $Eu^{3+}$ ions incorporated into the $MgMoO_4$ host crystal.

• Journal of the Earthquake Engineering Society of Korea
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• v.11 no.5
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• pp.33-47
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• 2007

In a practical engineering, the equivalent static analysis (E.S.A) and the response spectrum analysis (R.S.A) are generally used for the seismic analysis. The base shears obtained from the E.S.A are invariable no matter how the principal axes of building structures are specified on an analysis program while those from the R.S.A are variable. Accordingly, the designed member size may be changed by how an engineer specify the principal axes of a structure when the R.S.A is used. Moreover, the base shears in the normal direction to the excitation axis are sometimes produced even when an engineer performs a response spectrum analysis in only one direction. This tendency makes the base shear, which is used to calculate the scale-up factor, relatively small. Therefore the scale-up factor becomes larger and it results in uneconomical member sizes. To overcome these disadvantages of the R.S.A, an alternative has been proposed in this study. Three types of example structures were adapted in this study, i.e. bi-direction symmetric structure, one-direction antisymmetric structure and bi-direction antisymmetric structure. The seismic analyses were performed by rotating the principal axes of the example structures with respect to the global coordinate system. The design member forces calculated with the scale-up factor used in the practice were compared with those obtained by using the scale-up factor proposed in this study. It can be seen from this study that the proposed method for the scale-up factor can provide reliable and economical results regardless of the orientation of the principal axes of the structures.

• Microbiology and Biotechnology Letters
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• v.40 no.3
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• pp.274-277
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• 2012

Cytokinesis is the final stage of cell division, dividing one mother cell into two daughter cells. For the cutting of a plasma membrane during bacterial cytokinesis, a tubulin homolog FtsZ protein is recruited from the cytoplasm to the division site. FtsZ protein polymerizes in a GTP-dependent manner and its N-terminal domain has a GTPase activity. In this study, we have begun to characterize FtsZ from Staphylococcus aureus (SA). Full-length SA FtsZ was cloned into pRSFDuet-1 vector and the clone was transformed into a BL21 (DE3) star cell. The recombinant SA FtsZ protein was purified using Ni-NTA affinity chromatography and dialysis. Using a spectrofluorometer, we showed that SA FtsZ undergoes a GTP-dependant polymerization in vitro. The polymer of the SA FtsZ protein disappeared after a few minutes, suggesting that the polymer is degraded as the GTP is consumed. This assay system may well be applied for inhibitor screening targeting S. aureus FtsZ.