• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1049-1052
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• 2016

Background: Myelodysplastic syndrome (MDS) is a clonal disorder of hemopoeitic stem cells, characterized by infective hematopoiesis, peripheral cytopenias along with hypercellularity of marrow and marked dysplastic features. Our aim was to study the spectrum of the WHO classification in adult Pakistani patients with MDS at disease presentation. Materials and Methods: This retrospective descriptive study was conducted at Liaquat National Hospital and Medical College, extending from January 2010 to December 2014. Patient data were retrieved from the maintained archives. Results: Overall, 45 patients were diagnosed at our institution with de novo MDS during the study period. There were 28 males and 17 females. Age ranged between 18 and 95 years with a mean of $57.6{\pm}17.4years$. The male to female ratio was 1.7:1. According to the WHO classification, 53.3% had refractory cytopenia with multilineage dysplasia, 22.2% had refractory cytopenia with unilineage dysplasia, 4.4% each had refractory anemia with excess of blasts-1 and II and 15.5% had MDS unclassified. The main presenting complaints were generalized fatigue (60%), fever (33.3%), dyspnea (15.5%), bleeding (13.3%) and weight loss (11.1%). Physical examination revealed pallor in 37.7%, followed by petechial and purpuric rashes in 20% of patients. Hemoglobin was <10 g/dl in 41 (91.1%). Pancytopenia and bicytopenia were noted in 18 (40%) and 14 (31.1%) respectively. Conclusions: MDS in our patients presents at a relatively young age. Refractory c ytopenia with multilineage dysplasia was the dominant disease variant in our setting.

• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.146-176
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• 1996

Through the study of successive literatures from the Han-dynasty(漢代) when ${\\ll}$Keumkweyeuliak(金궤要略)${\gg}$ was written to modern age, we inspected many types of Onkyuatgtang(溫經湯) and prescriptions including the term of 'Okywg(溫湯)' or 'Chokyung(調經), and look into their composition and symptoms respond to administration of this medicine, The results of this study were as follows; 1. The medicine which makes up Onkyuatgtang was 38kinds from the Han-dynasty to the Ching-dynasty(淸代), and up to the present it summed into 43kinds. 2. Onkywgtang which was composed of different kinds of medicine was 10types from the Hun-dynasty to the Chung-dynasty and added 11types in modern days. Therefore it sumed up into 21types. 3. No Onkyuatgtang is seen more common than that of the same composition as in ${\\ll}$Keumkweyeuliak${\gg}$ in successive literature. The next is the same constituents as in ${\\ll}$Buinyangbangdaejeun(婦人良方大全)${\gg}$ Others were rare. 4. Onkywgtang in ${\\ll}$Keumkweyeuliak${\gg}$ was used to treat cold syndrome of the penetration and conception vessles or uterus of deficiency type(衛任 胞宮의 虛寒) and that in Buinyangbangdaejeun was for cold syndrome of the penetration and conception vessels or uterus of excess type(衛任 胞宮의 虛寒). 5. Other names of Ohylmgtang in ${\\ll}$Keumkweyeuliak${\gg}$ were Daeonrkyungtang(大溫經湯), Chokyungsan(調經散), Chokyungtang(調經湯), Chunkeumchokyungtang(千金調經湯), Chunkeumchokyungsan(千金調經散) and Soonkyungtang(小溫經湯), And the prescription in the same constitution was also called Chokyungonkyungtang(仲景溫經湯), Keumkweonkyungtang(千궤溫經湯) and Sibbionkyunghwan(十二溫經丸). 6. Onkywgtang in ${\\ll}$Buinyangbongdaejeun${\gg}$ of Yangbangonkyungtang(良方溫經湯), Jimionkyungtang(指迷溫經湯), Kyunkwionkyungtang(穹歸溫經湯) and Jinssionkyungtang(陣氏溫經湯).

• Korean Journal of Veterinary Research
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• v.62 no.3
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• pp.25.1-25.9
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• 2022

Canine cognitive dysfunction syndrome (CDS) is a neurodegenerative disease that causes cognitive and behavioral disorders and reduces the quality of life in dogs and their guardians. This study reviewed the complementary and alternative medicine (CAM) for CDS and compared the diagnosis and therapy of CAM between CDS in canines and dementia in humans. The evaluation tools for the diagnosis of CDS and dementia were similar in the neurological and neuropsychiatric examinations, daily life activity, cognitive tests, and neuroimaging, but the evaluation for dementia was further subdivided. In CAM, pattern identification is a diagnostic method for accurate, personalized treatment, such as herbal medicine. For herbal medicine treatment of cognitive impairment in canines and humans, a similar pattern identification classified as deficiency (Qi, blood, and Yin) and Excess (phlegm, Qi stagnation, and blood stasis) is being used. However, the veterinary clinical basis for verifying the efficacy and safety of CAM therapies for CDS is limited. Therefore, based on CAM evidence in dementia, it is necessary to establish CDS-targeted CAM diagnostic methods and therapeutic techniques considering the anatomical, physiological, and pathological characteristics of dogs.

• Clinical and Experimental Pediatrics
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• v.65 no.2
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• pp.85-89
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• 2022

Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Purpose: Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Methods: Three main English databases were searched for articles published through December 2020. The Newcastle-Ottawa Scale was used to assess study quality. Study heterogeneity was determined using I² statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model. Results: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (I²=0.0%, P=0.588) and RR (I²=0.0%, P=0.878). Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.

• Journal of Acupuncture Research
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• v.21 no.4
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• pp.149-157
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• 2004

Objective : The purpose of this study is to research whether Inyeong Chon spot pulse(人迎氣口脈) could be used on application of Ohaeng-acupuncture(五行鍼法). Methods : I research ${\ll}$Naegyeong${\gg}$(內經) and annotations were excerpted and record that notied the Inyeong Chon spot pulse(人迎氣口脈). Results : Comparison of Inyeong Chon spot pulse and Deficiency Excess syndrome of meridian system is useful to use Zheng Ge(正格) and Sheng Ge(勝格) of Ohaeng-acupuncture(五行鍼法) but in application of Han Ge(寒格) and Re Ge(熱格), Inyeong Chon spot pulse(人迎氣口脈) is not useful.

• Journal of Korean Medical classics
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• v.22 no.2
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• pp.349-362
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• 2009

Jangseoksun(張錫純), a noted doctor of China in the early 20th century, has influenced the establishment of Contemporary Chinese Medicine greatly. , which is an accumulation of Jang's lectures and publications, contains the essence of his medical spirit to fuse his theory and experience of Traditional Medicine and the newly imported Western Medicine knowledge of his time. is especially important, presenting the core of Jang's academic theory. In this book he gives full play of his unique experience of treating the Eum(陰, Yin) Deficiency Syndrome which is presented as excess in the upper and deficiency in the lower[上盛下虛]. He also shows the importance of merging theory and practice, the pliability to collaborate the Sanghan(傷寒, Damage from Cold) theory and Onbyeong(溫病, Epidemic Febrile Disease) theory and the study of the blended affect of external and internal pathogens.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.1
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• pp.177-197
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• 2002

The result were achived from 29 kinds of the medical literature of many generation is like this. 1. Oriental medical expressions of Xerophthalmia are "Baksab(白澁)", "Kunsabhonhwa(乾澁昏花)", "Sinsoojanggo(神水將枯)", "Donginkunkyul(瞳人乾缺)", "Taljung(奪精)", etc. "Baksab(白澁)" is very close to Xerophthalmia. 2. The cause of Xerophthalmia is Wind, Wind-heat Pathogen, Damp-heat of spleen and lung, DefIciency of body fluid, Yin-deficiency of liver and kidney, Liver deficiency syndrome, Deficiency of blood, Fire, Fire of deficiency type, Liver heat, etc. 3. In the frequency of prescription used Xerophthalmia are "Sangbakpi-Tang(桑白皮湯)", "Eunkyosan(銀翹散)", etc as Excess type, "Kikookjihwang-Tang(杞菊地黃湯)", "Samooloja hwan(四物五子丸)", etc as Deficiency type. 4. In the frequency of medical herbs of Xerophthalmia use much Rehmannia root nourishing Yin and clearing away heat and Divaricate Saposhnikovia root(expelling pathogenic wind.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.630-636
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• 2002

After The Yellow Emperor's Canon of Internal Medicine, The text researches of pathologic change to the liver disease concluded the next, 1, The category of liver-disease(肝病) include the Symptoms of abnormality due to vital energy and blood motion, emotion and intention, muscular and reproductive function, and legions around descending liver channel. 2. In the theory that Liver-Yang energy(肝陽氣) is always overproducing, Liver-Yin blood(肝陰血) is always lacking, pathologic characteristics for liver disease is functional change of malfunction of the use of body(體用失調), So nourishing the liver and kidney is used for the principal aspects of a disease. regulating and calm the liver is used for the secondary aspects of a disease as the treatment plan, 3. If malfunctioning of the functions of dispersion and discharge(疏泄), Iiver-energy(肝氣) is becoming degected, So overproduct and overflow of ascent and exhalation of liver-yang(肝陽) is becoming blood are ascending following energy. complete usage of Yin-blood(陰血) is responsible for some kinds of mass formed by blood stasis in the early stage of pathogenesis of liver disease syndrome of the energy system as the progession of disease extravasated blood is forming. the pathologic characteristics is appeared loss of control of the vital energy and blood(體用失調) at the liver disease. 4. Sthenia-syndrome of liver(肝實證) and liver-heat syndrome(肝熱證) is appered that overproducing and overflow of dispersion(疏泄太過) and discharge is responsible for overfunctioning of liver disease or some kinds of heat syndrome such as liver fire(肝火), Sthenia of liver-yang(肝陽上亢), the syndromes of sthenic liver heat(肝實熱) are appered. deficiency of the liver(肝虛證) and cold syndrome of liver(肝寒證) is classified pathologic characteristics of cold and heat, deficiency and excess that regression of sensory, motor, mental due to lack of dispersion and discharge(疏泄不及), or intruding of the cold miasma, are degected. 5. The liver is close relation of physiologic function and internal organ such as spleen, stomach, lung, heart, kidney, gall bladder by the meridian channels, because of property of wind Zang, rapid progession is classified by phthologic charateristics.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.13-24
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• 2008

This Chapter mentioned Terror and Palpitation due to Fright(驚悸) and Hemorrhagic disease(血證). Terror and Palpitation due to FrightAcctually Terror(驚) is different from Palpitation(悸). Terror(驚) is one of the seven emotions. But in this case, It refer to the Palpitation and the uneasiness of mind due to one's hearing a strange sound of seeing a strange. Tremulous Pulse can be appear. So Terror(驚) is caused by Exopathic Factors(外因) and belongs to Excess syndrome(實證). Palpitaion(悸) is the sensation of plamus, palpitation and unrest not because of being frightened. It is usurally caused by the deficiency of Ki(氣) and blood(血). So Deep, Thready and weak pulse can be appear. So Palpitaion(悸) is caused by Endopathic Factors and belongs to Deficiency Syndrome. In this Chapter, Terror and Palpitation due to Fright(驚悸) treat with the Kyeji-ke-jakyak-ka-chokchil-moryu-yongkol-kuyuk-tang(桂枝去芍藥加蜀漆牡蠣龍骨救逆湯) and Banha-mahwang-hwan(半夏麻黃丸). There are two type in Hemorrhagic disease(血證). One is bleeding(出血) and another is blood stasis(瘀血). The contents which relate with the Hemorrhagic disease(血證) are Hematemisis(吐血), Rhinorrhagia, Hemafecia(下血). In hemorrhage pathological mechanisms, there are two mechanisms. One is that Fire and Heat(火熱) pressure blood. Another is that cold and deficiency(虛寒) disable Ki(氣) from keeping blood flowing within vessels. Blood stasis(瘀血) can be called Extravasated Blood(惡血), Coagulated Blood, Blood retention(蓄血,積血), Dead Blood(死血) and Emaciation due to Blood disorder(乾血). It refer to a morbid state of unsmooth circulation and blood stagnancy often resulting from Ki(氣) stagnation, Ki(氣) deficiency and accumulation of pathogenic coldness. The symptom of Blood stasis are 'Fullness sensation in the chest, Lip Flaccidity, Cyonotic Tongue and Dryness of Mouth'. And the man who have Blood stasis, want to rinse his mouth with the water, but he can't drink the water because there isn't interior Heat of Excess Type. The symptom of Cyonotic Tongue(舌靑) had influence on diagnosing Blood stasis(瘀血) in offspring.

• Journal of Oriental Neuropsychiatry
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• v.15 no.1
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• pp.9-25
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• 2004

Behavioral characteristics of Attention Deficit Hyperactivity Disorder(ADHD) is one of the most common mental disorders among children.child psyachiatry. Inattention, Hyperactivity that is done by hyperkinesis or minimal brain dysfunction is major sypmton in ADHD, But etiology and pathological facor of ADHD is very much or unkown.. We brought to about a Study on the Oriental - medical pathologic Understanding about Inattention, Hyperactivity symptom in ADHD within Don yui bo gam Book are as follows. 1. Oriental medical pathologic concepts about Inattention, Hyperactivity are continuous with process of Yang Qi(陽氣), an unbalance of qi(氣) and shen ming(神明), excess of seven emotions(七情), pathology of Huo(火). 2. Immanent factors in inattention, Hyperactivity are improper diet, overtiredness and seven emotions, are continuous with pathological process of the heart, liver, gall bladder, spleen, stomach, kidneys. 3. In oriental medicine, considered as a child's qi of shao yang, dynamic physiological feature, excess and want of yin and yang, organs and bowels, immanently imbalance in growth rather than a child's mental disorder 4. Inattention, looseness in ADHD-PI type are continuous with forgetfulness, improper overtiredness, shortage of qi, the interior heat syndrome due to yin deficiency within Don yui bo gam Book 5. Hyperactivity, impulsive actions in ADHD-C type are continuous with sudden palpitation, severe palpitation, delirium, fidgeting due to deficiency, fidgetiness, hyperactivity of huo due to yin deficiency, fever, febrile disease with accumulation of blood.