• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.17
• /
• pp.7689-7694
• /
• 2015

Background: Bone tumors are neoplasias with a high overall mortality; one of the main factors that reduce survival is their high capacity to develop metastases. It has been reported that finding lung metastases at diagnosis of osteosarcoma (OS), chondrosarcoma (CS) and giant cell tumor of bone (GCTb) is quite common. In this study, we inquire the relationship of metastases caused by these tumors with different clinical and pathological aspects, in order to guide medical personnel in the diagnosis and opportune treatment of metastases or micro metastases. Materials and Methods: We collected data of 384 patients with clinical, radiological and histopathological diagnosis of OS, GCTb and CS that attended the National Rehabilitation Institute (INR) during 2006 to 2014. Chi-square and Fisher's exact tests were performed for data analysis. Results: In the three tumor types, the presence of metastases at diagnosis was variable (p=0.0001). Frequency of metastases was 36.7%, 31.7% and 13.2% for OS, CS and GCTb respectively. The average age had no significant difference (p>0.05) in relation to metastases, even so, patients with OS and GCTb and metastases, were older while patients with CS and metastases were younger, in comparison to patients without metastases. Males had a higher frequency of metastases (68.2%, p = 0.09) in contrast to CS and GCTb, in which the metastases was more frequent in women with 51.9% (p = 0.44) and 57.9% (p = 0.56) respectively. Broadly, metastasis was associated with primary tumors located in the femur (44.4%), followed by the tibia (15.6%); metastases was more frequent when primary tumor of GCTb and OS were in the same bones, but were located in the hip (26.3%) for CS. Conclusions: The frequency of metastases in OS, GCTb and CS is high in our population and is determined by different clinicopathological variables related to the kind of tumor. Further studies are needed in order to evaluate metastases subsequent to diagnosis and associations with survival and clinicopathological factors, as well as to determine the sensitivity and specificity of current methods of detection.

• Journal of IKEEE
• /
• v.24 no.2
• /
• pp.654-660
• /
• 2020

Through the output of brain waves during muscle operation, this paper checks whether it is possible to find characteristic vectors of brain waves that are capable of dividing left and right movements by extracting brain waves in specific areas of muscle signal output that include the motion of the left and right muscles or the will of the user within EEG signals, where uncertainties exist considerably. A typical surface EMG and noninvasive brain wave extraction method does not exist to distinguish whether the signal is a motion through the degree of ionization by internal neurotransmitter and the magnitude of electrical conductivity. In the case of joint and motor control through normal robot control systems or electrical signals, signals that can be controlled by the transmission and feedback control of specific signals can be identified. However, the human body lacks evidence to find the exact protocols between the brain and the muscles. Therefore, in this paper, efficiency is verified by utilizing the results of application of CSP (Common Spatial Pattern) filter to verify that the left-hand and right-hand signals can be extracted through brainwave analysis when the subject's behavior is performed. In addition, we propose ways to obtain data through experimental design for verification, to verify the change in results with or without filter application, and to increase the accuracy of the classification.

• Development and Reproduction
• /
• v.18 no.3
• /
• pp.161-166
• /
• 2014

Previously, we demonstrated that the shift and/or restriction of feeding time during relatively short-term period (4 weeks) could alter the pituitary gonadotropin expression and the weights of seminal vesicle and prostate in rats. We also found that the reverse feeding (RF) schedule (up to 8 weeks) might induce an adaptable metabolic stress and cause impairment of androgen-dependent reproductive tissues. In the present study, we extended the RF time regimen up to 12 weeks, and measured the reproductive tissue weights. After 4 and 8 weeks of RF, the weights of epididymis were not significantly different. After 12 weeks, however, epididymis weights of RF animals were significantly different (CON 12W : RF 12W = $48.26{\pm}0.62mg$ : $44.05{\pm}1.57mg$, p<0.05). After 4 and 12 weeks of feeding, seminal vesicle weights of RF animals were significantly decreased (CON 4W : RF 4W = $79.36{\pm}8.34mg$ : $46.28{\pm}2.43mg$, p<0.001; CON 12W : RF 12W = $72.04{\pm}3.76mg$ : $46.71{\pm}2.27mg$, p<0.001, respectively). Prostate weights were not changed by RF. Kidney and spleen weights of RF animals were significantly different on weeks 4 and 12 (Kidney, CON 4W : RF 4W = $249.72{\pm}4.20mg$ : $228.41{\pm}3.03mg$, p<0.001; CON 12W : RF 12W = $309.15{\pm}7.49mg$ : $250.72{\pm}6.13mg$, p<0.001, respectively, Spleen, CON 4W : RF 4W = $111.26{\pm}3.76mg$ : $96.88{\pm}4.69mg$, p<0.05; CON 12W : RF 12W = $123.93{\pm}10.72mg$ : $94.68{\pm}5.65mg$, p<0.05, respectively). Histology analysis of seminal vesicle revealed that the thinner epithelial cell layers, reduced complexities of swollen papilla folding in the exocrine glands on weeks 4 and 12 of RF. There was no histological difference between control and RF group on week 8. The present study indicates that up to 12 weeks RF induced differential changes in tissue weights of male mice. In particular, seminal vesicle, kidney and spleen seemed to temporarily adapted to the RF-induced metabolic stress on week 8 of feeding schedule. These results confirmed the our previous study that the RF might induce an adaptable metabolic stress and cause impairment of androgen-dependent reproductive tissues such as epididymis and seminal vesicle as well as non-reproductive tissues such as kidney and spleen. Further studies will be needed to achieve a better understanding of the how does mealtime shift affect the reproductive function and exact nature of adaptation.

• Journal of the Korean Society of Radiology
• /
• v.14 no.5
• /
• pp.503-510
• /
• 2020

Concrete is one of the most widely used materials as the shielding structures of a nuclear facilities. It is also the most generated radioactive waste in quantity while dismantling facilities. Since the concrete captures neutrons and generates various radionuclides, radiation measurement and analysis of the sample was fulfilled prior to dismantle facilities. An HPGe detector is used in general for the radiation measurement, and effective correction factors such as geometrical correction factor, self-absorption correction, and absolute detector efficiency have to be applied to the measured data to decide exact radioactivity of the sample. Correction factors are obtained by measuring data using a standard source with the same geometry and chemical states as the sample under the same measurement conditions. However, it is very difficult to prepare standard concrete sources because concrete is limited in pretreatment due to various constituent materials and high density. In addition, the concrete sample obtained by core drill is a volumetric source, which requires geometric correction for sample diameter and self absorption correction for sample density. Therefore in recent years, many researchers are working on the calculation of effective correction factors using Monte carlo simulation instead of measuring them using a standard source. In this study we calculated, using Geant4, one of the Monte carlo codes, the correction factors for the various diameter and density of the concrete core sample at the gamma ray energy emitted from the nuclides ¹⁵²Eu and ⁶⁰Co, which are the most generated in radioactive concrete.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.37 no.1
• /
• pp.44-51
• /
• 2000

We have analyzed optical matched filters considering the third order signals in the optical code division multiple access (CDMA) system based on optical series coupler access encoder (SCAE) and series coupler access decoder (SCAD). In previous studies, the performance evaluation of the optical CDMA system using SCAE and SCAD was not sufficiently accurate because they analyzed system performance only considering the first order signals. Since optical SCAE and SCAD intrinsically have high order signals of various patterns as the number of coupler increases, they change auto- and cross-correlation intensities. Thus, it is necessary to investigate properties of the third order signals so that we may analyze the exact performance of system. In this paper, we mathematically interpret the optical signals up to the third order, and analyzed the effects of th third order signals on auto- and cross-correlation intensities. In result, as ${\alpha}$(coupling coefficient) value increases, the intensity of the third order signals increases. It is found that the peak to side-lobe ratio considering the third order signals is degraded by 3.75 dB at N(coupler number)=5 and ${\alpha}$=0.5. Also if threshold value in receiver is set by main-lobe peak of the first order signals, it is found that the number of users in an optical CDMA system is limited because the intensity peak of side-lobes is raised by the third order signals.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.27 no.6
• /
• pp.566-576
• /
• 2016

Inverse synthetic aperture radar(ISAR) image generated from bistatic radar(Bi-ISAR) represents two-dimensional scattering distribution of a target, and the Bi-ISAR can be used for bistatic target identification. However, Bi-ISAR has large variability in scattering mechanisms depending on bistatic configurations and do not represent exact range-Doppler information of a target due to inherent distortion. Thus, an efficient training DB construction is the most important factor in target identification using Bi-ISARs. Recently, a database construction method based on realistic flight scenarios of a target, which provides a reliable identification performance for the monostatic target identification, was applied to target identification using high resolution range profiles(HRRPs) generated from bistatic radar(Bi-HRRPs), to construct efficient training DB under bistatic configurations. Consequently, high identification performance was achieved using only small amount of training Bi-HRRPs, when the target is a considerable distance away from the bistatic radar. Thus, flight scenarios based training DB construction is applied to target identification using Bi-ISARs. Then, the capability and efficiency of the method is analyzed.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.13
• /
• pp.5171-5174
• /
• 2014

Background: The increase in breast cancer awareness and widespread use of mammographic screening has led to an increased detection of (non-palpable) breast cancers that cannot be discovered through physical examination. One of the methods used in the diagnosis of these cancers is vacuum-assisted core biopsy, which prevents a considerable number of patients from undergoing surgical procedures. The aim of this study was to present the results of stereotactic vacuum-assisted core biopsy for suspicious breast lesions. Materials and Methods: Files were retrospectively scanned and data on demographic, radiological and pathological findings were recorded for patients who underwent stereotactic vacuum-assisted core biopsy due to suspicious mammographic findings at the Interventional Radiology Centre of the Florence Nightingale Hospital between January 2010, and April 2013. Statistical analysis was carried out using Pearson's Chi-square, continuity correction, and Fisher's exact tests. Results: The mean age of the patients was 47 years (range: 36-70). Biopsies were performed due to BIRADS 3 lesions in 8 patients, BIRADS 4 lesions in 77 patients, and BIRADS 5 lesions in 3 patients. Mammography elucidated clusters of microcalcifications in 73 patients (83%) and focal lesions (asymmetrical density, distortion) in 15 patients (17%). In terms of complications, 1 patient had a hematoma, and 2 patients had ecchymoses (3/88; 3.3%). The histopathologic results revealed benign lesions in 63 patients (71.6%) and malignant lesions in 25 patients (28.4%). The mean duration of the procedure was 37 minutes (range: 18-55). Although all of the BIRADS 3 lesions were benign, 22 (28.6%) of the BIRADS 4 lesions and all of the BIRADS 5 lesions were malignant. Among the malignant cases, 80% were in situ, and 20% were invasive carcinomas. These patients underwent surgery. Conclusions: In cases where non-palpable breast lesions are considered to be suspicious in mammography scans, the vacuum-assisted core biopsy method provides an accurate histopathologic diagnosis thus preventing a significant number of patients undergoing unnecessary surgical procedures.

• Atmosphere
• /
• v.24 no.4
• /
• pp.481-489
• /
• 2014

The Chugugi and Wootaek data of Gyeongsang-do (Dagu, Jinju, Goseong) were restored from "Gaksadeungnok", the governmental documents reported by the local government to the central during the Joseon Dynasty, and analyzed. The duration of the restored data represents 6 years for Daegu (1863, 1872, 1890, 1897, 1898, and 1902), 3 years for Jinju (1897, 1898, and 1900), and 2 years for Goseong (1871 and 1873). Total number of the restored data was 134, including 83 in Daegu, 25 in Jinju, and 26 in Goseong with the period ranging from March to September. The summer data from June to August accounts for approximately 50% (73 data), while the April data also shows relatively high number of 22, followed by September and March. Most data was collected from March to October, while this time winter data was not found even in October. The rainfall patterns using Chugugi data were investigated. First, the number of days with rainfall by annual mean showed 41 days in Daegu, 39 in Jinju, 33 in Goseong, respectively. In terms of the time series distribution of daily rainfall, the ratio between the number of occurrences with over 40 mm of heavy rainfall and the number of rainy days showed 14 times (8%) in Daegu, 24 (39%) in Jinju, and 4 (6%) in Goseong, respectively. The maximum daily rainfall during the period was recorded with 80mm in Jinju on August 24, 1900. The result of analyzing monthly amount of rainfall clearly indicated more precipitation in summer (June, July and August) with the relatively high records of 284 mm and 422 mm in April, 1872 and July, 1902, respectively, in Daegu, while Jinju recorded the highest value of 506 mm in June, 1898. When comparing the data with those observed by Chugugi in Seoul during the same period from "Seungjeongwonilgi", the monthly rainfall patterns in Daegu and Seoul were quite similar except for the year of 1890 and 1897 in which many data were missing. In particular, in June 1898 the rainfall amount of Jinju recorded as much as 506 mm, almost 4 times of that of Seoul (134 mm). Based on this, it is possible to presume that there was a large amount of the precipitation in the southern region during 1898. According to the calculated result of Wootaek data based on Chugugi observations, the unit of 1 'Ri' and 1 'Seo' in Daegu can be interpreted into 18.6 mm and 7.8 mm. When taking into consideration with the previous result found in Gyeonggi-do (Cho et al., 2013), 1 'Ri' and 1 'Seo' may be close to 20.5 mm and 8.1 mm, however, more future investigations and studies will be essential to verify the exact values.

• Korean Journal of Cognitive Science
• /
• v.4 no.1
• /
• pp.213-242
• /
• 1993

During the past decades,several automatic indexing systems have been developed such as single term indexing.phrase indexing and thesaurus basedidndexing systems.Among these systems,single term indexing has been known as superior to others despte its simpicity of extracting meaningful terms.On the other hand,thesaurus based one has been conceived as producing low retrival rate ,mainly because thesauri do not usually have enough index terms.so that much of text data fail to be indexed if they do not match with any of index terms in thesauri.This paper develops a thesaurus based indexing system THINS that yields higher retrieval rate than other systems.by doing syntactic analysis of text data and matching them with index terms in thesauri partially.First,the system analyzes the input text syntactically by using the machine translation suystem MATES/EK and extracts noun phrases.After deleting stop words from noun phrases and stemming the remaining ones.it tries to index these with similar index terms in the thesaurus as much as possible. We conduct an experiment with CACM data set that measures the retrieval effectiveness with CACM data set that measures the retrieval effectuvenss of THINS with single term based one under HYKIS-a thesaurus based information retrieval system.It turns out that THINS yields about 10 percent higher precision than single term based one.while shows 8to9 percent lower recall.This retrieval rate shows that THINS improves much better than privious ones that only yields 25 or 30 percent lower precision than single term based one.We also argue that the relatively lower recall is cause by that CRCS-the thesaurus included in CACM datea set is very incomplete one,having only more than one thousand terms,thus THINS is expected to produce much higher rate if it is associated with currently available large thesaurus.

• Biomedical Science Letters
• /
• v.11 no.2
• /
• pp.175-183
• /
• 2005

The two major isoflavones in soy, genistein and daidzein, are well known to prevent hormone-dependent cancers by their anti estrogenic activity. The exact molecular mechanisms for the protective action are, however, not provided yet. It has been reported that genistein and daidzein have a potential anticancer activity through their antiproliferative effect in many hormone-dependent cancer cell lines. Transforming growth $factor-\beta1(TGF-\beta1)$ has also been found to have cell growth inhibitory effect, especially in mammary epithelial cells. This knowledge led to a hypothetical mechanism that the soy isoflavones-induced growth inhibitory effect can be derived from the regulation of $TGF-\beta1$ and $TGF-\beta$ receptors. In order to test this hypothesis, the effects of the soy isoflavones at various concentrations and periods on the expression of $TGF-\beta1$and $TGF-\beta$ receptors were investigated by using Northern blot analysis in human breast carcinoma epithelial cell lines, an estrogen receptor positive cell line (MCF-7) and an estrogen receptor negative cell line (MDA-MB-231). As a result, only genistein has shown a profound dose-dependent effect on $TGF-\beta1$ expression in the $ER^+$ cell line within the range of doses tested, and the expression levels are correspondent to their inhibitory activities of cell growth. Moreover, daidzein showed down-regulated $TGF-\beta1$ expression at a low dose, the cell growth proliferation was promoted at the same condition. Therefore, antiproliferative activity of the soy isoflavones can be mediated by $TGF-\beta1$ expression, and the effects are mainly, if not all, occurred by ER dependent pathway. The expression of $TGF-\beta$ receptors was induced at a lower dose than the one for $TGF-{\beta}1$ induction regardless of the presence of ER, and the expression patterns are similar to those of the cell growth inhibition. These results indicated that the regulation of $TGF-\beta$ receptor expression as well, prior to $TGF-\beta1$ expression, may be involved in the antiproliferative activity of soy isoflavones. Little or no expression of $TGF-\beta$ receptors was found in the MCF-7 and MDA-MB-231 cells, suggesting refractory properties of the cells to growth inhibitory effect of the $TGF-\beta$. The soy isoflavones can seemingly restore the sensitivity of growth inhibitory responses to $TGF-\beta1$ by re-inducing $TGF-\beta$ receptors expression. In conclusions, our findings presented in this study show that the antitumorigenic activity of the soy isoflavones could be mediated by not only $TGF-\beta1$induction but $TGF-\beta$ receptor restoration. Thus, soy isoflavones could be good model molecules to develop new nonsteroidal antiestrogenic chemopreventive agents, associated with, regulation of $TGF-\beta$ and its receptors.