• Title/Summary/Keyword: evaluation analysis

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Identification and evaluation of fragmentation pathways of PDE-5 inhibitor analogues using LC-QTOF-MS (LC-QTOF-MS를 이용한 발기부전치료제 유사물질의 fragmentation pathway 분석)

  • Do, Jung-Ah;Noh, Eunyoung;Yoon, Soon-Byung;Park, Hyoung-Joon;Cho, Sooyeul;Park, Sung-Kwan;Yoon, Chang-Yong
    • Analytical Science and Technology
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    • v.28 no.4
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    • pp.278-287
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    • 2015
  • Phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) are used in the treatment of erectile dysfunction. In recent years, a number of reports have been conducted on dietary supplements contaminated with PDE-5 analogues. In this study, 58 analogues of PDE-5 inhibitors were sorted into five groups: tadalafil, sildenafil, hongdenafil, vardenafil, and other analogues. These analogues were then evaluated using a liquid chromatography-quadrupole-time of flight mass spectrometry (LC-QTOF-MS) electrospray ionization mass method. Each compound has a unique fragmentation ion, which can be easily analyzed qualitatively. The fragmentation pathways of the analogues were elucidated based on the QTOF-MS and MS/MS data. Common ions were confirmed for each group by analyzing the structural characteristics and fragmentation pathways. Specifically, common ions were observed at m/z 169.08 and 135.04 (tadalafil analogues), m/z 311.15 and 283.12 (sildenafil analogues and hongdenafil analogues), and m/z 312.16 and 151.09 (vardenafil analogues). The advantage of this method is that the structure of unknown components can be determined by interpreting the product ions. Hence, the developed method can be used for the identification of unknown compounds. Fragmentation pathways may also aid in the detection and identification of PDE-5 inhibitor analogues.

A New Model for Effectiveness Analysis of Government- supported R&D Institutes Evaluation System (정부출연연구기관 기관평가시스템 유효성 분석 모형: 유효성 분석을 위한 새로운 접근방법)

  • 이민형
    • Journal of Technology Innovation
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    • v.13 no.3
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    • pp.175-196
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    • 2005
  • This Paper examines analytic studies of the evaluation system used for evaluating government-supported R&D Institutes (GSRIs), and designs a new model for analyzing the evaluation system's effectiveness. The analytic models in existing studies use the meta evaluation and balanced scorecard (BSC) models. However, theses studies focused on the structure and elements of the evaluation system for examples, the appropriateness of the elements within the evaluation system and the balance of the evaluation index. Accordingly, the effectiveness of the GSRI evaluation system, that is, the evaluation's influence on GSRI performance improvement was not analyzed. This study uses the institution theory and contingency theory perspectives as related to government organization management to develop an analytical model of GSRI evaluation system effectiveness. The new model proposes an analytical approach for improving the effectiveness of the GSRI evaluation system in an institutionalized environment.

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A Study on User's Value Consciousness toward Products and Patterns of Design Evaluation (제품에 대한 사용자의 가치의식에 따른 디자인 평가의 유형에 관한 연구)

  • Shong, Chang-Ho;Choi, Myoung-Sik
    • Archives of design research
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    • v.19 no.5 s.67
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    • pp.255-268
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    • 2006
  • This study raised a question about 'how user's psychological value consciousness influences design evaluation and evaluated 14 product samples. Three main categories were chosen to be analyzed; product evaluation by step, value consciousness toward products, and creation of shape image and design evaluation. In order to obtain results, four research hypotheses were established a and case study was conducted as part of 'conclusive research' for verification. 120 university students in their 20s majoring in product design were chosen as testees in a bid to increase the accuracy of data. With data collected, the whole flow was analyzed by simple tabulation and further analysis was carried out in three evaluation items. An analysis method was mainly quantitative, focusing on multivariate analysis like factor analysis, cluster analysis, etc. The empirical analysis of this study was verified at P<.05 significance level and SPSSWIN 12.0 program was used for statistic process. As a result, four conclusions were gained regarding 'user's value consciousness toward products and pattern of design evaluation'.

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A Scheme of the defence project analysis and evaluation using a systems engineering process (시스템 엔지니어링 프로세스를 적용한 사전/사후분석 방안)

  • Min, Seong-Gi;Gwon, Yong-Su;Lee, Im-Su
    • 시스템엔지니어링워크숍
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    • s.1
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    • pp.32-39
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    • 2003
  • This work describes a study of analysis and evaluation activities applied systems engineering approach. It is presented technique of derivation and management requirement. A scheme of the defence project analysis and evaluation using a systems engineering process is described.

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The Economic Evaluation of Experimental Fishing Grounds in the North Pacific Midway Ocean Under Uncertainty : Focusing on Tuna Longline Fishing Grounds (불확실성하에서 북태평양 미드웨이 시험어장의 경제성 평가 : 다랑어연승 어장을 중심으로)

  • Moon, Seong-Ju;Jin, Sang-Dae;An, Young-Su;Kim, Yeong-Seung;Hwang, Seon-Jae
    • The Journal of Fisheries Business Administration
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    • v.40 no.1
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    • pp.153-172
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    • 2009
  • Developing foreign fishing ground executed in various uncertainty such as fishing price, oil price, exchange rate. But traditional economic evaluation method, CVP(Cost-Volume-Profit) analysis doesn't consider uncertainty of foreign fishing ground. So we need new approach about economic evaluation that can take into account uncertainty. This study focus on the economic evaluation about experimental survey of tuna fishing grounds in the north pacific ocean by sensitive analysis and simulation. The results of the economic evaluation can be summarized as follows. First, when we take it for granted that the other uncertainty factors except for each fishing price, oil price, and exchange rate are constant. CVP gross sales has positive relation to the increasing rate of oil price, exchange rate(W/$) and negative relation to the increasing rate of fishing price and exchange rate(W/${\yen}$). Second, when we are supposing that fishing price, oil price, and exchange rate are followed. the probability of less than CVP gross sales is A ship(48.87%), B ship(49.64%), C ship(50.55%). Consequently, the economic evaluation by sensitive analysis and simulation is more useful tool than CVP(Cost-Volume-Profit) analysis under uncertainty.

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Attitude toward Uniform and Evaluation Criteria toward Uniform according to Individualism-collectivism of Middle and High School Girls (여자 중·고등학생의 개인주의-집단주의에 따른 교복태도와 교복선택기준)

  • Park, Eun-Hee
    • Journal of the Korea Fashion and Costume Design Association
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    • v.17 no.3
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    • pp.45-60
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    • 2015
  • The purpose of this study is to classify individualism-collectivism into groups and analyze the difference of attitude toward uniform and evaluation criteria toward uniform. Questionnaires are being administered to 369 middle and high school girls in Deagu province. The Frequency, factor analysis, reliability analysis, cluster analysis, correlation analysis, ANOVA, Duncan-test, and t-test are used for data analysis. Individualism-collectivism factors are found to be other focus, individuality focus, competition consciousness, love of family, and self-esteem. Attitude toward uniform are categorized into fashion pursuit, symbol of role, conformity, color, and neatness. Evaluation criteria toward uniform is categorized into 7 factors: practicality, care, promotion, aesthetics, service, brand focus, and regulation focus. Individualism-collectivism are classify into three groups such as high individualism-collectivism, low individuality, and high individuality. Individualism-collectivism shows a significant correlation with the sub-variable attitude toward uniform and evaluation criteria toward uniform. The groups show a significant difference in the attitude toward uniform and evaluation criteria toward uniform. There is a significant difference among individualism-collectivism, attitude toward uniform, and evaluation criteria toward uniform by the middle and high school girls.

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A Priority Analysis on Influential Factors for Software Bid Evaluation in Public Sectors based on Analytic Hierarchy Process(AHP) (AHP 기법을 활용한 소프트웨어 제안평가요인의 상대적 중요도에 관한 연구 : 발주자와 수주자 비교를 중심으로)

  • Kim, Hong Jin;Jo, Dong Hyuk;Ahn, Tae Ho
    • Journal of Information Technology Services
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    • v.16 no.1
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    • pp.41-53
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    • 2017
  • Recently, due to the economic recession and increase of ITO (IT Outsourcing), bidding in software industry has been recognized as more competitive and the importance of software bid evaluation for corporate selection is being increased. This study aims to analyze and prioritize influential factors in the software bid evaluation criteria which is adopted as the main evaluation model of national software businesses by Ministry of Science. The priority was developed by AHP (Analytic Hierarchy Process) through pair-wise comparison. For the analysis, this study developed analysis model for AHP and conducted survey of experts who have work experience for more than 10 years in the IT industry. As the result of analysis, weighted factors in the evaluation criteria were deduced and differences of priority factors between purchaser and bidder were investigated. The analysis showed differences of view point in the bidding process. With these results, this study suggests how to write a proposal strategically and effectively in perspective of the purchaser. It is expected that priority factors will be adopted in strategic proposals in both bidder and purchaser. For purchaser, the priority will be adopted to select reliable bidder. So, we expect that the priority factors will be used to get more values for both bidder and purchaser in their business atmosphere.

Risk Based Accidental Limit State Evaluation on Explosion Accident at Shale Shaker Room of Semi-Submersible Drilling Rig (반잠수식 시추선의 Shale Shaker Room 폭발 사고에 대한 위험도 기반 사고한계상태 평가)

  • Yoo, Seung-Jae;Kim, Han-Byul;Park, Jin-Hoo;Won, Sun-Il;Choi, Byung-Ki
    • Special Issue of the Society of Naval Architects of Korea
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    • 2015.09a
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    • pp.69-73
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    • 2015
  • An evaluation of the accidental limit state (ALS) for design of a semi-submersible drilling rig is one of the essential design requirements as well as ultimate limit state (ULS) and fatigue limit state (FLS). This paper describes the ALS evaluation on the explosion accident at shale shaker room of semi-submersible drilling rig. There are three steps for the ALS evaluation such as structural analysis at concept design, risk based safety design and structural analysis at detailed design. For the ALS evaluation at concept design, conceptual explosion overpressure from the Rule guided by the classification society was used in the structural analysis that was carried out using LS-DYNA. To set up the design accidental load (DAL), explosion analysis was carried out using FLACS taking safety barriers into consideration. Then, the structural analysis was carried out applying DAL for the ALS evaluation at detailed design. Through the ALS evaluation on the explosion at shale shaker room, the importance of the risk based safety design was described.

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Evaluation of e-Learning Satisfaction (e-Learning 만족도 평가)

  • Lee, Dong-Hoo;Hwang, Seung-Gook
    • Proceedings of the Korean Institute of Intelligent Systems Conference
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    • 2005.11a
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    • pp.345-348
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    • 2005
  • In this paper, we suggested an evaluation model for satisfaction of e-Learning. This model was composed decision of evaluation criteria, analysis of consciousness structure for evaluation factors using the Fuzzy Structural Modeling method, decision of weights for evaluation factors considering intersectional dependence relations and evaluation of satisfaction of e-Learning. The case study of this model was done for comparative analysis between teachers and students of e-Learning in high school.

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