• Korean Journal of Pharmacognosy
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• v.27 no.2
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• pp.136-141
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• 1996

We have previously reported the isolation of nine hydrolisable tannins and five flavonoids from the aerial parts of Euphorbia ebracteolata. Further investigation about the same plant has led to the isolation of 5-O-caffeoyl quinic acid, kaempferol $3-O-(2'-O-galloyl-{\beta}-_D-glucoside)$ and euphorbin A.

• Korean Journal of Pharmacognosy
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• v.36 no.1 s.140
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• pp.9-16
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• 2005

Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on $5{\alpha}-reductase$ activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on $5{\alpha}-reductase$ activity, was 7-to 8-fold stronger than that of ${\gamma}-linolenic$ acid.