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Isolation of $5{\alpha}-reductase$ Inhibitors from Euphorbia jolkinii  

Park, Sung-Hee (College of Pharmacy, Yeungnam University)
Kim, Jeong-Ah (College of Pharmacy, Yeungnam University)
Xu, Guang-Hua (College of Pharmacy, Yeungnam University)
Lee, Chong-Gu (College of Pharmacy, Yeungnam University)
Choi, Ji-Young (College of Pharmacy, Yeungnam University)
Oh, In-Suk (College of Pharmacy, Yeungnam University)
Son, Ae-Ryang (College of Pharmacy, Yeungnam University)
Chung, See-Ryun (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.1, 2005 , pp. 9-16 More about this Journal
Abstract
Twenty eight compounds were isolated from the whole plant of Euphorbia jolkinii and evaluated for inhibitory effect on $5{\alpha}-reductase$ activity. Among the tested compounds, 1-desgalloyl eugeniin, hippomanin A, euphorbin D, exocoecarianin, rugosin E, and pentagalloyl glucose showed potent inhibitory effect on the enzyme activity. The inhibitory potency of rugosin E and euphorbin D, which are dimeric ellagitannins on $5{\alpha}-reductase$ activity, was 7-to 8-fold stronger than that of ${\gamma}-linolenic$ acid.
Keywords
Euphorbia jolkinii; Euphorbiaceae; $5{\alpha}-reductase$ inhibitor; hydrolysable tannin; male pattern alopecia;
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