• 대한간호학회지
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• 제35권1호
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• pp.186-194
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• 2005

Purpose: The purpose of this study was to investigate the effect of aromatherapy on pain, depression, and feelings of satisfaction in life of arthritis patients. Method: This study used a quasi-experimental design with a non-equivalent control group, pre-and post-test. The sample consisted of 40 patients, enrolled in the Rheumatics Center, Kangnam St. Mary's Hospital, South Korea. The essential oils used were lavender, marjoram, eucalyptus, rosemary, and peppermint blended in proportions of 2:1:2:1:1. They were mixed with a carrier oil composed of almond (45%), apricot(45%), and jojoba oil(10%) and they were diluted to 1.5% after blending. The data were analyzed using an 2-test, Fisher's exact test, t-test and paired t-test. Result: Aromatherapy significantly decreased both the pain score and the depression score of the experimental group compared with the control group. However, aromatherapy didn't increase the feeling of satisfaction in life of the experimental group compared with the control group. Conclusion: The result of this study clearly shows that aromatherapy has major effects on decreasing pain and depression levels. Based on our experiment's findings, we suggest that aromatherapy can be a useful nursing intervention for arthritis patients.

• Food Science and Biotechnology
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• 제16권1호
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• pp.37-42
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• 2007

The biotransformation of monoterpenic agro-industrial wastes (turpentine oil and essential orange oil) was studied. More than 40 fungal strains were isolated from Brazilian tropical fruits and eucalyptus trees and screened for biotransformation of the waste substrates. Solid phase microextraction was used to monitor the presence of volatile compounds in the headspaces of sporulated surface cultures. The selected strains were submitted to submerged liquid culture. The biotransformation of R-(+)-limonene and ${\alpha},\;{\beta}-$ pinenes from the oils resulted in ${\alpha}-terpineol$ and perillyl alcohol, and verbenol and verbenone, respectively, as the main products. The selected strains were also placed in contact with ${\alpha}-$ and ${\beta}-$ pinenes standards. It was confirmed that verbenol, verbenone, and ${\alpha}-terpineol$ were biotransformation products from the terpenes. A concentration of 90 mg/L of verbenone was achieved by Penicillium sp. 2360 after 3 days of biotransformation.

• 대한통합의학회지
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• 제10권4호
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• pp.103-111
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• 2022

Purpose : In recent years, essential oils have been produced using natural extracts for various uses. Their functionality is currently being tested not only for cosmetics and perfumes but also for other categories of products. Therefore, this study verified their antibacterial effects on S. mutans, P. gingivalis, and L. gasseri which are the representative strains that cause oral diseases. Methods : Eighteen types of natural essential oils were made at a concentration of 50 % (v/v) using Tween 20, and their antibacterial effects were verified by applying S. mutans, P. gingivalis, and L. gasseri. The antibacterial effects were measured with the disc diffusion method. All the experiments were repeated three times, and the mean value of three measurement values for each variable was used for data analysis. A one-way analysis of variance was conducted using these mean values. Results : Of the eighteen types of essential oils tested, sixteen types showed antibacterial effects on S. mutans, and sixteen and fifteen types exhibited antibacterial effects on P. gingivalis and L. gasseri respectively. The types of essential oils with high-level antibacterial activities were geranium, may chang, and bergamot for S. mutans, lemongrass, bergamot, and eucalyptus for P. gingivalis, and lemongrass, machan, and geranium for L. gasseri in order of antibacterial effect. This result was statistically significant (p<.001). In addition, in the case of mandarin oil, it was found that there was no antibacterial activity in all three strains. Conclusion : This study proved the antibacterial activities of essential oils, which are used for various purposes in daily life, against dental caries and periodontal diseases. The study results will likely be applied to different prevention programs for oral health and broadly used to develop products such as oral care items and dentifrices.

• 한국미생물·생명공학회지
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• 제38권1호
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• pp.93-104
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• 2010

프랑킨센스 에센셜 오일(BSEO)이 알러지성 천식 생쥐 모델의 폐, BALF 및 PBMC 내 면역세포 변화에 미치는 영향을 조사하였다. 본 연구는 Balb/c 생쥐를 이용하여 실험 1일에 $100\;{\mu}g$ ovalbumin (OVA)을 복강 내 투여하고, 실험 14일에 $50\;{\mu}g$ OVA를 기도 내 투여하여 감작시킨 후 OVA를 반복 흡입시켜 천식을 유발하였다. 천식 유발 생쥐군에 0.3% BSEO를 8주간, 1주에 3회, 1회에 30분간 nebulizer로 흡입시켰고, 실험일로부터 총 12주 후에 살처분시켜 폐, 기관지 폐포 세척액 (bronchoalveolar lavage fluid; BALF), 말초혈액단핵세포 (peripheral blood mononuc1ear cell; PBMC)를 분리하여 조직 내의 면역세포 변화를 관찰하였다. 본 연구 결과 알러지성 천식 유발 생쥐에서 기관지 수축제에 대한 기도 과민성반응이 천연 아로마 에센셜 오일군인 Bergamot군, Eucalyptus군, Chamomile군, Marjoram군, 및 Frankincense군 중 Frankincense군에서 효과적으로 억제됨을 확인하였다. 또한 알러지성 천식유발로 증가한 폐무게, 총폐포수, BALF수, MNL, DLN수가 억제됨을 확인하였다. BSEO는 알러지성 천적 모델 생쥐의 폐 조직 내의 $CD3e^+/CD19^-$, $B220^+/CD23^+$, $CD11b^+/Gr-1^+$ 세포 비율을 억제하였으며 BALF 내의 $CD4^+/CD8^-$, $B220^+/CD23^+$, $CD3e^+/CCR3^+$ 세포비율을 억제하였다. 또한 PBMC내 $CD3e^+/CD19^-$, $CD3^+/CD69^+$, $B220^+/CD23^+$ 세포비율을 억제하였다. 이러한 결과는 BSEO가 각 조직내의 면역세포의 활성 억제를 통한 면역조절작용으로 알러지성 천식의 치료에 효과적일 것으로 사료되었다.