• Toxicological Research
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• 제17권
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• pp.145-155
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• 2001

Cytochrome P4502C19 (CYP2C19) is one of human polymorphic xenobiotic-metabolizing enzymes. The enzyme has been reported to catalyze more than 70 substrates, involving more than 100 reactions. These include several classes of therapeutic agents (e.g. anti-microbial. cardiovascular, psycho-active, etc.), sex hormones and insecticides. Associations of the CYP2C19 genotype/phenotype with individual differences in drug efficacy (e.g. diazepam, omeprazole, proguanil) and toxicity (e.g. mephenytoin, barbiturates) have been documented by many investigators. At least 11 allelic variants of CYP2C19 gene were reported to date. Most of the mutant alleles found in the poor metabolizer (PM) led to the production of truncated and/or inactive proteins. Except for the exon 6, single-nucleotide mutations were reported in all nine exons of the gene. Genetic polymorphism of CYP2C19 shows marked interethnic variation with the population frequencies of PM phenotype ranging from 1∼2% up to more than 50%. The prevalence of CYP2C19 PM tends to be higher in Asian and certain Pacific Islanders than other race or ethnic specificity. Genotyping results of CYP2C19 also revealed that there are different proportions of individual mutant alleles among ethnic populations. This may, in part, explains the interethnic difference in the metabolism of certain drugs (i.e. diazepam), though they were from the same CYP2C19 phenotype. Recently, our research group has studied the genotype and phenotype of CYP2C19 and found that the PM frequency (7∼8%) in Thais is lower than other Asian populations. Molecular and clinical impacts of this finding warrant to further investigation.

• 한국환경성돌연변이발암원학회지
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• 제22권1호
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• pp.12-21
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• 2002

Genetic polymorphisms of the renin-angiotensin system (RAS) have been associated with hypertension in various ethnic groups, but no relation between these polymorphisms and hypertension has yet been systematically evaluated. To assess the relationship between allelic variation of RAS genes and hypertension, we performed the case-control studies using genetic markers in Korean normotensives and hypertensives. The allele and genotype frequencies of RAS genes in Korean population were not significantly different between normotensives and hypertensives. To investigate the distribution of allele frequencies among various populations, the data obtained in this study were compared to those in other ethnic groups studied previously. Except for T174M polymorphism of angiotensinogen (AGT) gene, allele frequencies of RAS genes were different among racial groups. The reason for these differences may be due to the difference in various genetic or environmental background or due to the effects by various sample size studied. In addition, it can be emphasized that carefully designed studies are required to minimize the ethnic heterogeneity of the case and control populations.

• Toxicological Research
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• 제18권3호
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• pp.233-240
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• 2002

In view of the effect of $\beta_2$-Adrenergic receptors ($\beta_2$-AR) as a risk factor for essential hypertension, we investigated the Fnu4HI and MnlI RFLPs of $\beta_2$ -AR gene in the Korean patients with essential hypertension and normal controls. There were no significant differences in the allele and genotype of these polymorphisms between normotensive and essential hypertensive subjects. In ethnic comparison, the allele frequencies of these three sites contained Nde I RFLP reported the association with essential hypertension in Korean population previously, were very different from those of other ethnic populations studied. The significant linkage disequilibrium was detected only in hypertensive group between Nde I and Fnu4HI sites. The Fnu4HI RFLP was also significantly associated with plasma triglyceride (TG) level. Therefore, our results suggest that the significant association between Fnu4HI variation in the human $\beta_2$-AR gene and plasma TG level may reflect the potential role of human $\beta_2$-AR gene as one of the genetic components for cardiovascular risk.

• 공연문화연구
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• 제22호
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• pp.185-221
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• 2011

본 연구는 해외교포사회에 북한춤이 전파되는 과정과 그 발전양상을 살펴보는데 목적을 둔 것으로, 해외에 거주하는 민족집단으로서의 재외동포들의 무용문화, 특히 재중, 재일조선인들의 무용문화에 대한 관심과 연구의 필요성을 생각해보았다. 문헌연구 중심으로 살펴본 논점의 결과, 재일조선인사회와 중국조선족자치구의 무용문화의 출발점엔 공통적으로 최승희춤이 있었으며, 두 민족집단은 최승희로부터 직접·간접적으로 춤을 배우거나 작품을 전수받았으며, 최승희가 정리한 조선무용기본을 기초훈련으로 하여 무용을 습득했다. 또한 무용전수 및 훈련기관은 재일조선인사회의 경우 북한의 체계와 같이 무용소조를 따로 두고 그곳에서 무용훈련을 통해 재능있는 인재를 배출하여, 전문예술단에서 활동하게 하는 시스템을 유지해 왔다. 이에 반해 중국조선족자치구는 연변대학과 중앙민족대학내에 무용학과가 배치되어 있어 그곳에서 조선춤을 전수 교육함으로써 재능있는 무용인재들을 배출해 왔으며, 한국의 무용교육체계와 유사한 면을 볼 수 있다. 무용기초훈련과 작품의 경향면에서는 재일조선인사회에서는 북한에서 실천하고 있는 무용기초훈련과 기본훈련을 그대로 전수하고 있으며, 작품도 북한춤을 대표하는 명무나 민속무용을 그대로 전수받아 공연하고 있다. 그러나 중국조선족자치구에서는 최승희가 정리한 조선무용의 기초와 작품을 그녀로부터 직접 훈련받거나 전수받았으나, 최승희의 제자들은 그녀가 세운 무용기초를 발전시켜 중국소수민족의 춤기법 등을 접수하면서 중국조선족만의 무용훈련체계를 세워나가면서 한국춤과의 교류도 성사시켜 북한춤보다는 자유롭게 창작성을 가미한 중국조선족 무용문화를 형성하게 되었다. 전수된 시기로 보면, 재일조선인사회는 1960년대부터 시작되어 1970년대에 들어서는 직접적인 평양방문을 통해 전수와 교육을 받았고, 1990년대에는 북한무용가를 직접 일본으로 초청하여 무용기초훈련을 교육받음으로써 북한춤에서 볼 수 있는 스펙터클한 양상을 그대로 재현하고 있다하겠으나, 중국조선족자치구에서는 1950년대에 평양과 북경에서 최승희로부터 직접적인 지도를 받았고, 이후에는 북한무용가들로부터의 직접적인 지도보다는 북한예술단의 중국방문을 계기로 무용영향을 받는 한편, 1990년대 이후부터는 한국춤을 흡수하기 시작하면서 중국조선족만의 색다른 무용문화를 창조해 왔다. 같은 민족이면서도 살아가는 지역과 그 지역을 구성하는 민족집단의 구성체계 및 정치체제에 따라 북한춤의 전수과정 및 발전양상도 유사하지만 각각의 아이덴티티를 보장하는 독자적인 특색을 지닌 무용문화를 형성하며 발전시켜 왔음을 알 수 있으며, 재일조선인사회의 무용문화는 조총련의 통제하 강제적 문화접변에 의한 무용문화의 변동을, 중국조선족자치구의 무용문화는 자발적 문화접변에 의한 자유로운 차용과 발전으로의 변동을 살필 수 있었다.

• 문화기술의 융합
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• 제7권1호
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• pp.234-239
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• 2021

본 연구는 언어의 본질인 언어변이의 주된 방향성을 탐색하고 언어변이의 결과로 나타나는 영어의 모든 방언들, 즉 세계영어들을 연구하는 것이다. 특정지역에서 사용되는 지역적, 사회적 방언의 연구인 언어변이의 특성을 규명하기 위하여 하이브리드 언어변이모델을 제안한다. 사회적 거리두기, 대면과 비대면 소통모드, 그리고 언어적 다양성이라는 세 가지 상호영향자의 관점에서 하이브리드 언어변이모델을 제안하고 언어변이의 결과로 나타나는 세계적 영어방언 현상인 세계영어들의 다양성 특질을 연구한다. 세계영어들의 문맥에서 지역화 목적으로 영어가 어떻게 사용되는가를 살펴보면, 사회적 거리두기가 높은 비대면의 상황에서는 다양성이 감소하여 좀 더 표준적이며 글로벌한 영어가 사용되며 변이가 줄어 세계영어들의 확장 속도가 완만해진다. 동시에 지역적인 사용이 줄어들어 의사소통의 오류도 줄어든다. 반면 사회적 거리두기가 낮은 대면의 상황에서는 세계영어들의 확장 속도가 빨라지고 변이의 형태가 다양해지며 의사소통의 오류 또한 증가한다. 이러한 영어변이 현상의 특성을 살펴보기 위하여 세계영어들의 핵심 원이라고 할 수 있는 영국영어, 미국영어, 그리고 캐나다영어의 언어적, 사회적 변이의 사례를 비교 분석한다.

• 복식
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• 제51권2호
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• pp.149-167
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• 2001

Today, every culture has taken on the compromise form by means of the cultural difference, variety, and pluralism according to the internationalization and the advance so that it has been developed toward the half-blooded and multilayered the aspect. In accordance with this current of the times, this thesis observed the feminism found in the multiculturism of the end of the 20th century, the third world, and technology with the side of the tendency of modern fashion, considered the hybride phenomenon which is pulling down the wall between culture and genre due to the social diversification. and predicted the fashion trend do 21st century serf on it. Multiculturism is the movement that began to arise in the academic world of America and the literary world form the close of 1980's in accepting the variety of culture and regarding the culture with the more balanced and wide view and just as it is, it means the attitude of accepting one or more cultures of variely and the position of taking interest in the culture of minority race not the culture of a governing race. It is the fashion of feminism adapts dualism like unisex, androgynous look, etc of bisexual lendency in the 1980's, it shows new style with crossover of liberal sense because there is not the difference of sex in fashion. The eco-feminism pursues the natural sexuality not being instrumental and dismantling and expressed it in the Gender expression of an integrated human being. The trend of ethnic fashion in the close of 20th century is that the element of hippie is working so strongly. By adding embroidery of Oriental style, accessories of Indian style, feathers, beads, a hempen hood to the ethnic costumes of Asia and Latin, is shows the figure of ethnic hippie. As the cycler fashion is the future clothes through technology of computer, it uses a cool glass material bringing up the image of a spacesuit in order to expresses cyber image through artificial color combination of sheen colors, Though this techno-color fashion has established the fresh stimulation and the innovative aspect with ultramodern materials and image of futurism, it transmits a hope of estranged people and the natural elements. Hybride means a cross and mixture of animal and plant in Korean and is also called fusion. The phenomenon of hybrid predicts to comes the period of a cross and variation because something completely new comes into the world by contamination, mixture and compromise through meeting something different each other and it has on advantage of developing something existing to one more stage. It is prospected that in the society of 21st century, the borderline of traditional gender will be disappeared, variety and individuality will determine the individual behavior, and the masculine value will be substituted by feminine value. In the society giving priority to feminine value, a fashion stuck closely to women is what must reflect lives of woman under the proposition of woman's beauty, being on original function. So, it is considered that a fashion with added convenience and practicality having the function which is easy to put on, comfortable to act, able to express solves so much, and able to show various appearances according to T.P.O will get into the spotlight.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5721-5726
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• 2015

Lung cancer is the leading contributor to cancer deaths in the developing world. Within countries, significant variability exists in the prevalence of lung cancer risk, yet limited information is available whether some of the observed variability is associated with differences in the consumption pattern of local tobacco products with differing potency. We recruited 606 lung cancer cases and 606 controls from the B.P. Koirala Memorial Cancer Hospital in Nepal from 2009-2012. We estimated odds ratios (ORs) and 95% confidence intervals (CI) for lung cancer risk associated with different tobacco products, using unconditional logistic regression. Unfiltered cigarettes tended to be the most frequently used products across ethnic subgroup with about 53.7% of Brahmins, 60.1% of Chettris, and 52.3% of Rai/Limbu/Magar/others. In contrast, about 39.9% of Madishe/Tharu smokers reported using bidi compared with only 27.7% who smoked unfiltered cigarettes. Among those who only smoked one type of product, choor/kankat smokers had the highest lung cancer risk (OR 10.2; 95% CI 6.2-16.6), followed by bidi smokers (OR 5.6; 95% CI 3.6-8.7), unfiltered cigarettes (OR 4.9; 95% CI 3.4-7.2), and filtered cigarettes (OR 3.4; 95% CI 2.2-5.3). A clear dose-response relationship was observed between increased frequency of smoking and lung cancer risk across all ethnic subgroups. These results highlight the important role of traditional tobacco products on lung cancer risk in the low income countries.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6059-6064
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• 2014

Background: Colorectal cancer is the second most frequent cancer in Malaysia. Nevertheless, there is little information on treatment and outcomes nationally. We aimed to determine the demographic, clinical and treatment characteristics of colorectal cancer patients treated at the University Malaya Medical Centre (UMMC) as part of a larger project on survival and quality of life outcomes. Materials and Methods: Medical records of 1,212 patients undergoing treatment in UMMC between January 2001 and December 2010 were reviewed. A retrospective-prospective cohort study design was used. Research tools included the National Cancer Patient Registration form. Statistical analysis included means, standard deviations (SD), proportions, chi square, t-test/ANOVA. P-value significance was set at 0.05. Results: The male: female ratio was 1.2:1. The mean age was 62.1 (SD12.4) years. Patients were predominantly Chinese (67%), then Malays (18%), Indians (13%) and others (2%). Malays were younger than Chinese and Indians (mean age 57 versus 62 versus 62 years, p<0.001). More females (56%) had colon cancers compared to males (44%) (p=0.022). Malays (57%) had more rectal cancer compared to Chinese (45%) and Indians (49%) (p=0.004). Dukes' stage data weres available in 67%, with Dukes' C and D accounting for 64%. Stage was not affected by age, gender, ethnicity or tumor site. Treatment modalities included surgery alone (40%), surgery and chemo/radiotherapy 32%, chemo and radiotherapy (8%) and others (20%). Conclusions: Significant ethnic differences in age and site distribution, if verified in population-based settings, would support implementation of preventive measures targeting those with the greatest need, at the right age.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2035-2038
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• 2014

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important protein involved in the regulation of the immune system. The +49 G/A polymorphism is the only genetic variation in the CTLA-4 gene that causes an amino acid change in the resulting protein. It is therefore the most extensively studied polymorphism among all CTLA-4 genetic variants and contributions to increasing the likelihood of developing cancer are well known in various populations, especially Asians. However, there have hiterto been no data with respect to the effect of this polymorphism on breast cancer susceptibility in our North Indian population. We therefore assayed genomic DNA of 250 breast cancer subjects and an equal number of age-, sex- and ethnicity-matched healthy controls for the CTLA-4 +49 G/A polymorphism but no significant differences in either the gene or allele frequency were found. Thus the CTLA-4 +49 G/A polymorphism may be associated with breast cancer in other Asians, but it appears to have no such effect in North Indians. The study also highlights the importance of conducting genetic association studies in different ethnic populations.

• Archives of Pharmacal Research
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• 제27권5호
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• pp.576-580
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• 2004

Primaquine is used for relapses caused by vivax malaria hypnozoites. No studies on the pharmacokinetics of primaquine (PMQ) has been reported in Korean patients. In our study, thirty vivax malaria patients were given 15 mg primaquine daily for 14 days after 3 days of chloroquine treatment. Plasma samples were taken at intervals after each daily dose of PMQ for 3 days. Plasma concentrations of PMQ and carboxyprimaquine (CPMQ), the major metabolite of primaquine, were measured by HPLC. The PMQ concentrations reached a maximum of 0.28$\pm$0.18 $\mu\textrm{g}$/mL at 1.5 h after the first dose. The maximum concentration of CPMQ was 0.32$\pm$0.13 $\mu\textrm{g}$/mL at 4 h. Higher drug concentrations with repeated dosing were observed for CPMQ, but not for the parent drug, PMQ. The elimination half-life was 3.76$\pm$1.8 hand 15.7$\pm$12.2 h, for PMQ and CPMQ, respectively. Large variation in the plasma concentrations of both drugs was observed. Overall, PMQ is absorbed and metabolized rapidly after oral administration. It was noted that the mean peak plasma concentration of PMQ was significantly higher and that of CPMQ was lower in our patients compared to other studies. This suggests a potential difference of inter-ethnic groups, which warrants further investigations.