• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.487-487
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• 2013

According to shrinkage of transistor, interface traps have been recognized as a major factor which limits the process development in manufacturing industry. The traps occur through spontaneous generation process, and spread into the forbidden band. There is a large change of current though a few traps are existed at the Si-SiO2 interface. Moreover, the increased temperature largely affects to the leakage current due to the interface trap. For this reason, we made an effort to find out the relationship between temperature and interface trap. The subthreshold swing (SS) was investigated to confirm the correlation. The simulated results show that the sphere of influence of trap is enlarged according to increase in temperature. To investigate the relationship between thermal energy and surface potential, we extracted the average surface potential and thermal energy (kT) according to the temperature. Despite an error rate of 6.5%, change rates of both thermal energy and average surface potential resemble each other in many ways. This allows that SS is affected by the trap within the range of the thermal energy from the surface energy.

• Journal of Korean Society for Geospatial Information Science
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• v.11 no.1 s.24
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• pp.29-37
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• 2003

The High-resolution satellite images are able to get the latest information of wide range area and to shorten updating cycle of digital map better than the aerial images. Especially, as high-resolution satellite images are opened to public recently and able to be used commercially, the studies that make ortho-images using them and apply to the digital mapping and the database of geo-spatial information system are having been progressed actively. Therefore, the purposes of this study are to establish the auto-extraction methods and to develop algorithms for automatically extracting buildings which are distributed very much in urban areas and which updating cycle needs to shorten, out of man-made structures in the IKONOS ortho-image with 1m spatial resolution. The result of this study, we can extract automatically extract 72% out of the whole buildings. And we could know that the methods and algorithms proposed in this study are good relatively analyzing the error trend by means of the comparison with ortho-image, digital map and hawing result.

• Journal of Korean Society for Geospatial Information Science
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• v.18 no.4
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• pp.3-10
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• 2010

In this study, the orbit-based sensor modeling is applied to the digital plotting and the accuracy of digital plotting is analyzed. The KOMPSAT-2 satellite image with orbit-attitude model is used for the analysis. The precise sensor modeling with various combination of parameters is performed for the stereo satellite image. In addition, we analyze the error range of ground control points by applying the result of stereo modeling to digital survey system. According to the result, it is possible to produce digital map using stereo image with a small number of GCPs when the orbit-based sensor modeling for KOMPSAT-2 is applied. This means that it is suitable for the generation of digital map on a scale of 1/5,000 to 1/25,000 considering the resolution of KOMPSAT-2 image.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.2
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• pp.131-135
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• 2006

The purposes of this study is examining a wearing tendency of a progressive multifocal lens. We measured refractive error values using subjective and objective refraction method with subjects in 40-65 ages. Also, we investigated and analyzed distribution of addition power and wearing tendency of progressive multifocal lens. Detected addition powers were ranged of +0.75D - +3.00D. In case of average addition, they were detected with +1.18D in 40's, +1.55D - +1.97D in 50's and +2.38D in above 61's age. The distributions of visual ability at a distant were measured that the hyperopia and hyperopic astigmatism 43%, the myopia and myopic astigmatism characteristic astigmatism 7% appeared highly with 36%. The male who uses the interior aspect multi focal lens with the short-range work were appeared the male 20%, the woman 19%.

• The Journal of Korean Society for Radiation Therapy
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• v.16 no.1
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• pp.21-27
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• 2004

An isotope Ir-192, which is used in brachytherapy depends on import in whole quantities. There are a few ways for its activity. measurement using Welltype chamber or the way to rely on authentic decay table of manufacturer. In-air dosimetry using Farmer Chamber, etc. In this paper, let me introduce the way using Farmer chamber which is easier and simple. With the Farmer chamber and source calibration jig, take a measurement the activity of an isotope Ir-192 and compare the value with the value from decay table of manufacturer and check the activity of source. The result of measurement, compared the value from decay table, by ${\pm}2.1\%$. (which belongs to recommendable value for AAPM ${\pm}5\%$ as difference of error range) It is possible to use on clinical medicine. With the increase in use of brachytherapy, the increase of import is essential. And an accurate activity check of source is compulsory. For the activity check of source, it was possible to use Farmer chamber and source calibration jig without additional purchase of Well type chamber.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.7
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• pp.712-718
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• 2005

Stepwise reductions of glucose and Orange II concentration were observed from the experiment of both white-rot fungi such as T. versicolor and P. chrysosporium. As a result, typical removal patterns in those dual substrate system were categorized through several distinctive steps: initial lag period, primary and secondary carbon consumption periods. Also, based on the total removal amounts of Orange II, COD and Color during the experimental period, similar removal extent were observed from both species experiments, within the maximal error range of 5%. However, it was refereed that the internal steps of Orange II removal on enzymatic level should be different between two species: Enzyme Lac showed good affinity for Orange II removal in T. versicolor, however in P. chrysosporium enzyme LiP represented more close affinity to the similar experimental condition. Thus, even though the superficial removal amount of calcitrant Orange II at different fungal species was merely similar, removal pathway of enzymatic levels and intermediates produced during the fungal decomposition would be different.

• Journal of the Institute of Convergence Signal Processing
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• v.9 no.1
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• pp.89-97
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• 2008

Chaotic behavior in motor systems is undesired dynamics in real-time implementation since the speed is oscillated in a wide range and the torque is changed by a random manner. We present an adaptive control approach for time-varying permanent-magnet synchronous motors (PMSM) with chaotic phenomenon. We consider that its parameters are changed randomly within certain bounds. First, a nonlinear system model of a PMSM is transformed to derive a nominal linear control strategy. Then, an auxiliary control for compensating real-time control error occurred by system perturbation due to parameter change is designed by using Lyapunov stability theory. Numerical simulation is accomplished for evaluating its efficiency and reliability comparing with the traditional control method. Additionally, we test our control method in real-time motor experiment including a PSoC based drive system to demonstrate its practical applicability.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.6
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• pp.831-836
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• 2010

In real system application, the path planning and following system for the coordinated control of heterogeneous marine robots based on the underwater acoustic communication has the following problems: surface and underwater robots have different maneuvering properties, an underwater robot requires more effective operating, it has a limited communication range because of the transmission loss (TL) of acoustic wave, it has a communication error because of the Doppler distortion of acoustic wave, and further, it requires an easy design procedure in terms of its structures and parameters. To solve these problems, an intelligent path planning algorithm using the evolution strategy (ES) and the fuzzy logic controller (FLC) based on system modeling, is proposed. To verify the performance of the proposed algorithm, the path planning and following of an underwater robot is performed according to the maneuvering of a surface robot. Simulation results show that the proposed algorithm effectively solves the problems.

• YAKHAK HOEJI
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• v.42 no.5
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• pp.473-479
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• 1998

Lovastatin (LOVA), a fungal metabolite isolated from cultures of Aspergillus terreus, is a competitive HMG-CoA reductase inhibitor used for the treatment of primary hyper cholesterolemia, and has also been shown to suppress growth in a variety of non-glioma tumor cell lines. A sensitive reversed-phase high-perfonnance liquid chromatographic method with ultraviolet (UV) absorbance detection has been developed to quantitate LOVA in human plasma and urine samples using liquid-liquid extraction procedure. Baseline separation of LOVA and internal standard, simvastatin was achieved on a Novapak $C_{18}$ analytical column with a mobile phase containing 0.025M $NaH_2PO_4$: CAN (35:65, v/v%), adjusted pH to 4.5. The flow rate was set at 1.5ml/min, and the column effluent was monitored by a UV detection at 238nm. The limit of quantification was determined to be 0.5${\mu}$g/ml while extraction efficiency of LOVA ranged from 73.4-82.9% at LOVA concentrations of 0.5 to 10${\mu}$g/ml. Good linearity with correlation coefficients greater than 0.999 was obtained in the range of LOVA concentrations from 0.5 to 10${\mu}$g/ml. The accuracy and the precision were proven excellent with relative standard deviation (RSD, %) and relative error (RE, %) of less than 4.2 and 4.0, respectively. Intraday precision, evaluated at five LOVA concentrations (0.5, 1, 2, 5, 10${\mu}$g/ml) and expressed as RSD ranged from 0-1.82% while the interday precision at the same concentrations ranged from 0.7-10.5%. The analytical method described was then successfully employed for the determination of LOVA concentrations in plasma samples obtained during a phase II clinical trial using high doses of LOVA (30-40mg/kg/day). This method could be further utilized for the ongoing pharmacolkinetic studies and therapeutic drug monitoring of the high-dose LOVA therapy in adenocarcinoma patients.

• YAKHAK HOEJI
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• v.52 no.2
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• pp.93-100
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• 2008

A liquid chromatographic method with tandom spectrometric detection (LC/MS/MS) for the simultaneous determination of doxifluridine and its active metabolite, 5-fluorouracil (5-FU) was developed over the concentration range of $5{\sim}2000$ ng/ml, respectively. Doxifluridine, 5-FU and internal standard, 5-chlorouracil (5-CU), were extracted from liver and intestine tissue via protein precipitation. Acetonitrile was used as the extraction solvent and the supernatant was evaporated and reconstructed in mobile phase. Optimum chromatographic separation was achieved on a Agilent Zorbax $C_{18}$ ($100\;mm{\times}2.1\;mm$, $3.5\;{\mu}m$) column with mobile phase run in isocratic with methanol : water (20 : 80, v/v). The flow rate was 0.2 ml/min with total cycle time of 5 min. The lower limit of quantification was validated at 5.0 ng/ml of liver and intestine tissue, for both doxifluridine and 5-FU, respectively. The intra-day and inter-day precision and accuracy of quality control (QC) samples were <11% coefficient of variation and <7% relative error from theoretical concentration for both analytes. In addition, the special designed stability study was performed, because the metabolism of doxifluridine occurs spontaneously even in ice bath for monkey liver. The stability of doxifluridine in liver and intestine of monkey and beagle dog was compared. It was found that bioanalytical validation could not be performed for the monkey liver; however, beagle dog's liver has relatively low speed of metabolism compared to monkey liver and instead of monkey liver, beagle dog's liver could be used for the validation. Bioanalytical validation could be performed in monkey intestine. Eventually, this developed method for liver and intestine will be useful in support of the toxicokinetic and pharmacokinetic studies of doxifluridine and 5-FU.