• 대한원격탐사학회지
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• 제29권1호
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• pp.57-68
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• 2013

20세기 후반부터 유부도 주위에서 하구언 축조 등 비교적 큰 규모의 간척사업들이 진행되었다. 이러한 간척사업의 시작으로 인공구조물들이 연안에 축조됨에 따라 주변 해역의 해류, 조위 및 조류의 변화를 야기하여 퇴적 및 침식으로 인한 연안지형의 변화가 예상된다. 따라서 이 연구에서는 유부도 조간대를 포함하는 Landsat TM/ETM+자료를 1998년부터 2012년까지 획득한 후 waterline 기법을 적용하여 인공구조물 축조에 의한 지형변화를 탐지하였다. 그 결과 유부도의 동쪽, 북동쪽, 서쪽 조간대에서 주로 퇴적이 일어났으며 그 면적이 약 4.5 $km^2$ 이상 되었다. 한편, RADARSAT-2의 완전편파 SAR자료에 Freeman-Durden decomposition을 적용하여 퇴적이 뚜렷이 일어난 지역에 대한 산란특성을 분석하였다. 그 결과 동쪽 퇴적지역은 서쪽 및 북동쪽의 퇴적지역과는 다른 산란특징이 관찰되었으며, 이는 퇴적환경의 차이로 인해 다른 종류의 퇴적물이 퇴적되어 발생한 것으로 여겨진다.

• Journal of Pharmaceutical Investigation
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• 제35권6호
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• pp.453-460
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• 2005

4-Aminopyridine (AP) is a potassium channel blocker used in the treatment of neurological disorders such as multiple sclerosis and Alzheimer disease. AP‘s window of therapeutic effect appears to correlate with its plasma halflife (3.5 hours). It demonstrates pH-dependent solubility because of a weakly basic drug. In addition, the resulting release from conventional matrix tablets decreases with increasing pH-milieu of the gastrointestinal tract. The aim of this study is to design sustained release matrix tablet containing AP, overcoming this problem. $Eudragit^{\circledR}$ L 100 (EuL) and sodium alginate were used in an effort to achieve pH independent drug release. The effect of sodium alginate and EuL on drug release from matrix tablet was investigated. The drug release behavior from the different tablets was analyzed by $t_{20%},\;t_{40%},\;t_{60%}$, The exponential diffusion coefficient n, kinetic constant K were calculated according to the Korsmeyer-Peppas equation. The drug release from matrix tablets prepared with sodium alginate was decreased with increasing the content of sodium alginate in pH 7.4 while there is no significant difference in pH 1.2. The exponent n values were determined to be approximately 0.5 and 0.8 respectively, in both pH 1.2 and 7.4. These values indicate diffusion-based anomalous mechanism and erosion-based anomalous mechanism, respectively. The drug release from sodium alginate matrix tablets prepared with solid dispersion of EuL containing drug showed a slow drug release in an acidic medium and a more fast drug release in phosphate medium, compared with sodium alginate matrix tablets prepared with physical mixture. These results may be attributed to the gel forming ability of sodium alginate and pH dependent solubility of EuL. Therefore, sustained-release AP matrix tablets using sodium alginate and EuL were successfully prepared.

• 지질공학
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• 제27권2호
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• pp.143-152
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• 2017

최근 도심지에서 자주 발생하는 지반함몰 문제는 사회적 문제로 대두되고 있으며, 지반함몰에 대한 시민들의 우려는 증가하고 있다. 그에 비해 지반함몰 발생 메커니즘에 대한 이해는 부족한 실정이다. 따라서 본 연구에서는 모형실험을 통해 다양한 지하수 조건에서 지하수와 토사가 동시에 유실될 때의 지반함몰 발생 메커니즘을 평가하고자 한다. 실험을 통해서 밝혀진 지반함몰 메커니즘의 주요 인자는 지하수 흐름 방향, 유출부위 주변 수두차, 지중 공동 유지를 위한 지반 내 강도 등이다. 첫째로 지하수와 토사가 동시에 유실될 때 토사의 유실은 지하수 흐름 방향을 따라 발생하며 이는 지중 공동 생성 및 공동 확장 방향을 결정짓는 요소임을 확인했다. 둘째로 지하수 및 토사가 유실되는 위치 주변의 수두차가 높아질수록 지반함몰 발생 속도가 급격히 빨라지는 것이 실험적으로 확인되었다. 마지막으로 지중 공동 확장으로 인해 최종적으로 갑작스런 붕괴를 일으킬 수 있음이 확인되었다.

• 한국환경과학회지
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• 제15권2호
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• pp.177-183
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• 2006

The hydrolytic kinetics of biodegradable poly(l-lactide) (PLLA) have been studied by using two model systems, solution-grown single crystal (SC) and Langmuir monolayer techniques, for elucidating the mechanism for both alkaline and enzymatic degradations. The present study investigated the parameters such as degradation medium and time. The Langmuir mono layers of PLLA showed faster rates of hydrolysis when they were exposed to a basic subphase rather than they did when exposed to neutral subphase. Both degradation mediums had moderate concentrations to show a maximized activity, depending on their sizes. An alkaline degradation of SCs of PLLA showed the decrease of molecular weight of the remained crystals due to the erosion of chain-folding surface. However, the enzymatic degradation of SCs of PLLA occurred in the crystal edges thus the molecular weight of remained crystals was not changed. This behavior might be attributed to the size of enzymes which is much larger than that of alkaline ions; that is, the enzymes need larger contact area with monolayers to be activated.

• Journal of Korean Neurosurgical Society
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• 제56권6호
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• pp.517-520
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• 2014

Cauda equina syndrome (CES) associated with dural ectasia is a rare neurologic complication in patients with longstanding ankylosing spondylitis (AS). We report a 68-year-old male with a 30-year history of AS who presented a typical symptom and signs of progressive CES, urinary incontinence and neuropathic pain of the lumbosacral radiculopathy. Computed tomography (CT) and magnetic resonance imaging (MRI) findings showed the unique appearances of dural ectasia, multiple dural diverticula, erosion of posterior element of the lumbar spine, tethering of the conus medullaris and adhesion of the lumbosacral nerve roots to the posterior aspect of the dural ectasia. Considering the progressive worsening of the clinical signs, detethering of the conus medullaris through resection of the filum terminale was performed through a limited laminectomy. However, the urinary incontinence did not improve and there was a partial relief of the neuropathic leg pain only. The possible pathogenetic mechanism of CES-AS and the dural ectasia in this patient with longstanding AS are discussed with a literature review.

• Asian-Australasian Journal of Animal Sciences
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• 제20권5호
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• pp.802-810
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• 2007

Fibrobacter succinogenes, a Gram-negative, anaerobic ruminal bacterium is a major fibre digesting species in the rumen. It intensively degrades plant cell walls by an erosion type of mechanism, burrowing its way through the complex matrix of cellulose and hemicellulose with the release of digestible and undigested cell wall fragments. The enzymes involved in this process include a combination of glucanases, xylanases, arabinofuranosidase(s) and esterases. The genome of the bacterium has been sequenced and this has revealed in excess of 100 putative glycosyl hydrolase, pectate lyase and carbohydrate esterase genes, which is greater than the numbers reported present in other major cellulolytic organisms for which genomes have been sequenced. Modelling of the amino acid sequences of two glycanases, CedA and EGB, by reference to crystallized homologs has enabled prediction of the major features of their tertiary structures. Two dimensional gel electrophoresis in conjunction with mass spectroscopy has permitted the documentation of proteins over expressed in F. succinogenes grown on cellulose, and analysis of the cell surfaces of mutant strains unable to bind to cellulose has enabled the identification of candidate proteins with roles in adhesion to the plant cell wall substrate, the precursor to cellulose biodegradation.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.1
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• pp.370-373
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• 2003

As the integrated circuit device shrinks to the smaller dimension, the chemical mechanical polishing (CMP) process was required for the global planarization of inter-metal dielectric(IMD) layer with free-defect. However, as the IMD layer gets thinner, micro-scratches are becoming as major defects. Chemical-Mechanical Planarization(CMP) of conductors is a key process in Damascene patterning of advanced interconnect structure. The effect of alternative commerical slurries pads, and post-CMP cleaning alternatives are discuess, with removal rate, scratch dentisty, surface roughness, dishing, erosion and particulate density used as performance metrics. Electroplated copper depostion is a mature process from a historical point of view, but a very young process from a CMP persperspective. While copper electrodepostion has been used and stuidied for dacades, its application to Cu damascene wafer processing is only now ganing complete accptance in the semiconductor industry. The polishing mechanism of Cu CMP process has been reported as the repeated process of passive layer formation by oxidizer and abrasion action by slurry abrasives. however it is important to understand the effect of oxidizer on copper pasivation layer in order to obtain higher removal rate and non-uniformity during Cu-CMP process. In this paper, we investigated the effects of oxidizer on Cu-CMP process regarding the additional volume of oxidizer.

• Tribology and Lubricants
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• 제33권6호
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• pp.256-262
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• 2017

Molten zinc plating is a process in which zinc is thinly coated over a metallic or non-metallic surface. It is used in various industrial fields for corrosion resistance and decoration. During the process, a steel sheet is passed through a roll that rotates inside the molten zinc liquid in the temperature range of $460^{\circ}C$ to $680^{\circ}C$, and the plating liquid flows into the roll causing abrasion and erosion of the roll surface. This problem is known to accelerate the replacement cycle of the roll and cause considerable economic loss owing to production line stoppage. Here, we propose a mechanism that operates at high temperature and pressure with a labyrinth type seal design to resolve this problem. We theoretically investigate the flow of the plating solution inside the seal and compute the minimum rotation speed required to prevent the plating solution from entering the seal chamber. In addition, we calculate the thermal deformation of the seal during operation and display thermally deformed dimensions at high temperatures. To verify the theoretical results, we perform experiments using pilot test equipment working in the actual plating environment. The experimental results are in good agreement with theoretical results. We expect our results to contribute towards the extension of the roll's life span and thereby reduce the economic losses.

• The Korean Journal of Physiology and Pharmacology
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• 제2권4호
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• pp.511-519
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• 1998

This study investigated the role of nitric oxide on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion and its relation to mucus. Nitric oxide synthesis modulators such as L-arginine and $N^G-nitro-L-arginine$ methyl ester, and sodium nitroprusside, a nitric oxide donor, were injected intraperitoneally to the rats 30 min prior to ischemia/reperfusion which was induced by clamping the celiac artery and the superior mesenteric artery for 30 min and reperfusion for 1 h. Lipid peroxide production, the contents of glutathione and mucus, and glutathione peroxidase activities of gastric mucosa were determined. Histological observation of gastric mucosa was performed by using hematoxylin-eosin staining and scanning electron microscopy. The result showed that ischemia/reperfusion increased lipid peroxide production and decreased the contents of glutathione and mucus as well as glutathione peroxidase activities of gastric mucosa. Ischemia/reperfusion induced gastric erosion and gross epithelial disruption of gastric mucosa. Pretreatment of L-arginine, a substrate for nitric oxide synthase, and sodium nitroprusside prevented ischemia/reperfusion-induced alterations of gastric mucosa. However, $N^G-nitro-$ L- arginine methyl ester, a nitric oxide synthase inhibitor, deteriorated oxidative damage induced by ischemia/reperfusion. In conclusion, nitric oxide has an antioxidant defensive role on gastric mucosa by maintaining mucus, glutathione, and glutathione peroxidase of gastric mucosa.

• 대한한의학회지
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• 제37권4호
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• pp.10-21
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• 2016

Objectives: This study was to investigate the anti-oxidative and anti-inflammatory effect of Psoralea corylifolia water extract (PE) on ulcerative colitis which was induced by dextran sulfate sodium (DSS) in mice. Methods: Ulcerative colitis was induced by DSS in male BALB/c mice. The mice were divided into 3 groups. The control group (Ctrl) was not induced ulcerative colitis. The pathological group (CE) was induced the colitis. The experimental group (PT) was administered PE after inducing the colitis. The effects of the PE on ulcerative colitis were evaluated by morphological change in the colon tissue and cells, substance P production, activity of tumor necrosis factor $(TNF)-{\alpha}$ and nuclear factor $(NF)-{\kappa}B$, cyclooxygenase (COX)-2 production, and anti-oxidative activity. Results: In the PT group, PE alleviated hemorrhagic erosion in colon mucosa and infiltration of inflammatory cells in lamina propria mucosae. In the colon of the PT group, COX-2 production was inhibited via regulating the activity of $TNF-{\alpha}$ and $NF-{\kappa}B$ p65. PE also had an anti-oxidative effect via activating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Conclusions: In this study, we found the utility of treatment with PE and the potential of developing a medicine for ulcerative colitis by applying our results. Further investigations for the anti-inflammatory mechanism of PE may be needed.