• 대한영상의학회지
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• 제85권1호
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• pp.240-246
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• 2024

상피상 혈관육종은 혈관에 생기는 육종 중 드문 변이이다. 이 종양은 대개 연부조직에서 발생하고, 뼈에서 발생하는 경우는 특히 드물다. 다발성으로 발생한 경우 이 종양은 이차성 골전이와 혼동될 수 있으며, 매우 치명적인 임상 진행을 보일 수 있다. 우리는 61세의 남성에서 다발성으로 발생한 상피상 혈관육종의 증례를 보고하고자 한다. 이 종양은 혈관성 파종으로 인해 발생한 것으로 추정된다. 엑스선 단순 촬영, CT 및 MRI에서 양쪽 하지 장골에 여러 개의 골융해성 병변이 관찰되었다. 이 중 일부는 골피질을 파괴하면서 연조직성 병변도 동반되었다. 초기 영상의학적 검사 결과로는 전이성 암종이 의심되어, PET-CT를 촬영하였다. 흥미롭게도, PET-CT에서는 이러한 병변들이 양쪽 하지 뼈의 반골, 장골, 경골을 따라 분포하고 있어, 혈관을 따라 파종할 가능성이 있는 혈관육종의 가능성도 확인되었다. 병리학적 소견에서 또한 처음에는 전이성 암종의 가능성을 고려하여 추가적인 면역 화학 염색 검사를 시행하였다. 그러나, 혈관성 표지자인 CD31, ERG 등의 검사 결과 강한 양성 소견을 보여 최종적으로 이 병변은 상피상 혈관육종으로 진단되었다. 이번 증례를 통해 뼈에 일차성으로 발생한 상피상 혈관육종에 대한 임상적, 영상의학적 특징을 정리하여, 진단적 혼동을 줄이고 더 나은 치료 방법을 제공하는데 도움이 될 것이다.

• 대한수의학회지
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• 제24권2호
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• pp.137-147
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• 1984

가토 자궁 근충에서 분리한 상피세포를 10% 송아지혈청, 3mM glutamine이 함유한 Basal Eagle 배지에서 배양한 결과 세포 성장 시간은 53시간이 소요되었고, estrogen에 insulin을 첨가했을 때는 40시간으로 감소하였다. Creatine kinase 활성 단위는 단백질 mg당 0.019 unit이었다. 활성의 30%가 이온상태가 높은 완충액에서 추출되었고, plasminogen 활성 인자는 세포 백만당 140 CTA unit였다.

• 대한예방한의학회지
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• 제13권2호
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• pp.39-50
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• 2009

Objectives : In order to evaluate the cytotoxicity of 3,4,5-trihydroxybenzoic acid and related compounds on the growth of normal cell lines and human oral epithelioid cell line, cell viability, cell adhesion ability, and morphological changes of cells were examined. Methods : We measured the cytotoxicity of 3,4,5-trihydroxybenzoic acid and related compounds with 3-[4,5-dimethyl-thiazol-2-yl]-2,5-diphenyltetrazolium bromide-[MTT), and 2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium -5-caboxanilide-[XTT) methods. Results : The cytotoxicity of 3,4,5-trihydroxybenzoic acid($IC_{50}$, $2,552.40\;{\mu}M$) was low according to the toxic criteria. Cytotoxic effect of 3,4,5-trihydroxybenzoic acid and related compounds against $IC_{50}$ value in cell morphology increased in a concentration-dependent manner. In light microscopy, $100\;{\mu}M$ 3,4,5-trihydroxy-benzoic acid showed th highest cytotoxic activity. Conclusions : These results suggest that 3,4,5-trihydroxybenzoic acid may have a potential anticancer activity.

• 대한세포병리학회지
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• 제4권1호
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• pp.35-40
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• 1993

We describe a case of fine needle aspiration cytology of metastatic nasopharyngeal carcinoma in the lymph node of the neck presenting a predominantly spindle cell pattern. A 36 year-old male patient complained of dysesthesia on the right face and a palpable neck mass. Fine needle aspiration was done on the neck mass. Tumor cells were present in syncytial groups or singly with mainly spindle shaped nuclei, vesicular chromatin, thin and regular nuclear membrane, occasional prominent nucleoli and a few fool of cellular cohesiveness. The cytoplasm was scant and pale with ill-defined borders. Mature lymphocytes were present in the background of aspirates and within the tumor cell clusters. Histologically, the tumor of nasopharynx showed several areas of spindle cell pattern. Because the tumor cells showed a predominantly spindle shape with vesicular nuclear chromatin, the differential diagnosis of spindle cell sarcoma or granuloma of epithelioid clils were considered, but the characteristic morphology of the nuclei with vesicular chromatin and prominent nucleoli, and cellular cohesiveness were important in making the diagnosis of nasopharyngeal carcinoma. The possibility of metastatic carcinoma should always be considered in fine needle aspiration cytology of the lymph node in the neck because the incidence of metastatic carcinoma, particularly of the nasopharyngeal carcinoma in the lymph nodes of the neck is relatively high.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.785-791
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• 2014

Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and ${\beta}$-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity.