• Korean Journal of Veterinary Service
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• v.23 no.1
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• pp.9-17
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• 2000

Epidemic malaria is prevalent in the demilitarized zone and the northern area of Kyonggi province in Korea. Malaria has broken out in Gangwha-Gun since 1997 due to geographical condition. The results obtained from an epidemiological surveillance for the malaria that happened in 1999 were as follows ; Anopheles sinensis collected in UV-light traps in the barn in Wolgogri and Dangsanri of Songhaemyon showed the distribution of 27,156 of 49,280 figures, corresponding to 55.1%, between July and August. The numbers of patients with malaria were 48(32.4%) in July, 36(24.3%) in August, and 38(25.7%) in September with a prevalence with the ages of the twenties to the seventies. Of a total 154 patients, the male were 86(58.1%) and the female were 68(41.8%). The annual parasite index(API) were 6.44, 5.89 and 4.45 in Songhaemyon, Yangsamyon and Kyodongmyon, respectively. A high infection rate was found Particularly in the areas within 2km from the Han river. By the immunofluorescence assays(IFA), 26 cases were positive with an antibody titers of $\geq$ 1 : 32, of 220 residents in Songhaemyon and 336 ones with a potential case and contacted with the patients. By the blood test, there was no significance in alkaline phosphatase, alanine aminotransferase, total cholesterol, glucose, hemoglobin, hematocrit, white blood cell, red blood cell, and platelet between residents with an antibody titers of $\geq$ 1 : 32 and < 1 : 32 in Songhaemyon.

• Journal of Preventive Medicine and Public Health
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• v.20 no.1 s.21
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• pp.137-146
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• 1987

The following facts have been identified as a result of epidemiological trend and characteristic of Japanese Encephalitis in Korea for the last 20 years. First: The Epidemiological period which was ten-year and three-year in the past has been disappeared following the start of immunization program at 1970. Second: The Incidence rate was much higher in the south and West areas than northeast area of Korea. City and Province with the highest incidence rate was Chungcheong Nam Province and Cholla Buk Province. Third: Regardless of scope of prevalence, the main season that 90 percent of total incidence occurrs in one month from mid-August through mid-September. Fourth: The number of case by age was that 80 percent of total patients is children aged $3{\sim}15$. Recently there is an increase in the number of patients who are elderly people. Fifth: The study on the ecological conditions of mosquito including wintering and effectiveness of immunization for Japanese Encephalitis and duration on antibody should be done. Sixth: There has been no case of Japanese Encephalitis for the last three years since 1984 mainly due to disinfecting to eradicate mosquitos, immunization for vulnerable group of people aged $3{\sim}15$, individual precaution not to be bitten by mosquito, improvement of environment sanitation. While there has been no case of Japanese Encephalitis during last three years, there is possibility that Japanese Encephalitis becomes prevalent again anytime since its virus has been isolated continuously from the natural reservoirs.

• The Korean Journal of Applied Statistics
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• v.28 no.2
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• pp.295-308
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• 2015

We have experienced a substantial improvement in and cost-drop for genotyping that enables genetic epidemiological studies with large-scale genetic data. Genome-wide association studies have identified more than ten thousand causal variants. Many statistical methods based on linear mixed models have been developed for various goals such as estimating heritability and identifying disease susceptibility locus. Empirical results also repeatedly stress the importance of linear mixed models. Therefore, we review the statistical methods related with to linear mixed models and illustrate the meaning of their estimates.

• Journal of Radiation Protection and Research
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• v.31 no.2
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• pp.69-89
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• 2006

Biological mechanisms for ionizing radiation effects are different at low doses than at high doses. Radiation hormesis involves low-dose-induced protection and high-dose-induced harm. The protective component is associated with a reduction in the incidence of cancer below the spontaneous frequency, brought about by activation of defensive and repair processes. The Linear No-Threshold (LNT) hypothesis advocated by the International Commission on Radiological Protection (ICRP) and the Biological Effects of ionizing Radiation (BEIR) Report VII for cancer risk estimations Ignores hormesis and the presence of a threshold. Cancer incidences significantly less than expected have been found in a large number of epidemiological studies including, airline flight personnel, inhabitants of high radiation backgrounds, shipyard workers, nuclear site workers in scores of locations throughout the world, nuclear power utility workers, plutonium workers, military nuclear test site Participants, Japanese A-bomb survivors, residents contaminated by major nuclear accidents, residents of Taiwan living in $^{60}Co$ contaminated buildings, fluoroscopy and mammography patients, radium dial painters, and those exposed to indoor radon. Significantly increased cancer was not found at doses <200 $mSv^*$. Evidence for radiation hormesis was seen in both sexes for acute or chronic exposures, low or high LET radiations, external whole- or partial body exposures, and for internal radionuclides. The ubiquitous nature of the Healthy Worker Effect (HWE)-like responses in cellular, animal and epidemiological studies negates the HWE as an explanation for radiation hormesis. The LNT hypothesis is wrong and does not represent the true nature of the dose-response relationship, since low doses or dose-rates commonly result in thresholds and reduce cancer incidences below the spontaneous rate. Radiation protection organizations should seriously consider the cost and health implications of radiation hormesis.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.30 no.3
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• pp.270-279
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• 2020

Objective: The aim of this study was to propose revision of the occupational exposure limit(OEL) for 1-Bromopropane(1-BP) following a review of the appropriateness of the standard in light of increasing epidemiological data and handling risk. Materials and Methods: The results of toxicity and epidemiologic investigations for 1-BP and agencies' OELs were compared and reviewed through a literature review. In order to investigate the status of 1-BP handling in South Korea, data from work environment actual condition survey results and work environment measurement results were used. Results: The toxicity of 1-BP, such as central nervous system(CNS) damage, peripheral neuropathy, hematological adverse effects, and developmental and reproductive toxicity(male and female) has been reported. ACGIH recommends 0.1 ppm as a TLV-TWA value, but the OEL of South Korea stands at 25 ppm, which is 250 times higher than the TLV-TWA. Although 1-BP is a specially managed substance under the Industrial Safety and Health Law, the currently applied OEL cannot be said to be a safe level based on the results of epidemiological studies to date. In a work environment measurement in 2017, the total number of samples was 626, which were derived from 78 industries, and the average concentration was 1.173 ppm(standard deviation 2.88). Conclusions: To protect the health of workers handling 1-BP, estimated to be 780 in South Korea, it is necessary to strengthen the OEL(TWA) to a level of 0.3 ppm(lower than the 0.34 ppm with known toxic effects), which is believed to be safe as a result of epidemiological investigation. "Skin" notation should be recommended.

• Journal of Preventive Medicine and Public Health
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• v.38 no.2
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• pp.163-169
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• 2005

Objectives: Pedestrian traffic injuries have been an important cause of childhood mortality and morbidity for decades. The aim of this study was to describe the epidemiological characteristics of child pedestrian traffic injuries that occurred during 2000 in one metropolitan city and its school-zones, and to determine the factors associated with those accidents. Methods: A cross-sectional study was performed in 2001. Police records were used to identify the cases of pedestrian injury. Children aged between 6 and 15 years, injured during road walking, were included in this study. A direct survey of the environmental factors within the school-zones in study area (n=116) was also performed. Self-administered questionnaires, via mail and telephone surveys, were used to assess the safety education programmes. The schools were divided into two groups according to the occurrence of pedestrian traffic injuries in their school-zone. Results: Pedestrian injuries (n=597) were found to account for 3.2% of all traffic injuries in the subject area. The epidemiological characteristics were not significantly different between genders. There were some significant risk factors within the environmental factors, such as local road (OR: 2.3, 95% CI=1.05-5.35), heavy traffic volume (OR: 2.2, 95% CI=1.00-5.04), poor visibility of speed-limit signs (OR: 2.8, 95% CI=1.25-6.42), no separation of pedestrian routes from cars (OR: 2.6, 95% CI=1.02-6.75) and barriers on the pedestrian routes (OR: 2.2, 95% CI=1.01-5.08). Only one factor, that of education in a safety-park (OR: 0.3, 95% CI=0.09-0.96), was significantly associated in the traffic and pedestrian safety education factors. Conclusion: Significant associations with pedestrian injury risk were identified in some of the modifiable environmental factors than in the educational factors.

• Korean Journal of Clinical Laboratory Science
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• v.40 no.2
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• pp.80-85
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• 2008

Microsporum gypseum is a geophilic fungus abundant in soil throughout the world. M. gypseum has been identified for the first time in Korea at 1976. The purpose of this study was to investigate epidemiologic aspects of M. gypseum. We performed the epidemiologic study an 198 patients with M. gypseum infections in from January 1976 to December 2005. From 100,012 patients, dermatophytes were isolated as follows; Trichophyton rubrum was isolated from 86,553 (86.5%), T. interdigitale 3,991 (4.0%), Epidermophyton floccosum 1.021 (0.1%), T. tonsurans 141 (0.1%). T. mentagrophytes 3.930 (3.9%), T. verrucosum 220 (0.2%), Microsporum canis 3.879 (3.9%), and M. gypseum 198 (0.2%). Number of patients with M. gypseum by site and age were as follows; most patients infected with tinea corporis were young people under 10 years. M. gypseum were most frequently isolated in summer and autumn.

• Biomedical Science Letters
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• v.10 no.4
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• pp.473-477
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• 2004

Methicillin-Resistant Staphylococcus aureus (MRSA) strains are resistant to a wide range of antibiotics and are a major cause of nosocomial infections. Accurate and rapid typing of MRSA is needed to implement effective infection control measures. Arbitrarily Primed PCR (AP-PCR) is a very useful method in rapid typing. AP-PCR is not necessary information about target DNA sequence because this is basically DNA amplification and could be useful in epidemiological typing by classified band pattern. In this study, MRSA were isolated and identified from ICU, Neu, IM and Ped environments and investigated molecular typing by AP-PCR. Ped, the MRSA pattern determines the la, IIa type, 1M is Ib type, Neu is IIa type and ICU determines the IIa, lIb types. All MRSA in this study were typeable by AP-PCR, which was easy to perform and reproduce with evidence of MRSA for purposes of nosocomial infection control.

• Korean Journal of Veterinary Service
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• v.45 no.3
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• pp.201-209
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• 2022

An epidemiological study was conducted to investigate five diarrhea-causing pathogens (coronavirus, rotavirus, E. coli, Cryptosporidium, Giardia) using a rapid diagnostic kit in Hanwoo calves with diarrhea in Chungcheongbuk-do, Korea, from 2018 to 2021. A total of 22,417 fecal samples were collected from calves under 1 year of age; of those, 13,518 (60.3%) were positive for five bovine diarrhea antigens. The antigen positivity rates for rotavirus, coronavirus, E. coli, Giardia, and Cryptosporidium were 34.5%, 11.0%, 8.2%, 4.7%, and 2.0%, respectively. The prevalence of the five pathogens in calves was statistically higher in autumn and winter. The highest prevalence of the pathogens was observed in the under 1 month age group, and the incidence of diarrhea decreased with age. Rotavirus was a major pathogen in calves under 1 month of age, whereas the prevalence of E. coli increased with age. This study provides epidemiological evidence of the prevalence of calf diarrheal pathogens in Chungcheongbuk-do, Korea, which will facilitate early diagnosis and development of measures against calf diarrhea.

• The Journal of the Korean dental association
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• v.13 no.5
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• pp.463-469
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• 1975