• The Korean Journal of Pain
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• v.26 no.2
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• pp.135-141
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• 2013

Background: Although paclitaxel is a widely used chemotherapeutic agent for the treatment of solid cancers, side effects such as neuropathic pain lead to poor compliance and discontinuation of the therapy. Ethyl pyruvate (EP) is known to have analgesic effects in several pain models and may inhibit apoptosis. The present study was designed to investigate the analgesic effects of EP on mechanical allodynia and apoptosis in dorsal root ganglion (DRG) cells after paclitaxel administration. Methods: Rats were randomly divided into 3 groups: 1) a control group, which received only vehicle; 2) a paclitaxel group, which received paclitaxel; and 3) an EP group, which received EP after paclitaxel administration. Mechanical allodynia was tested before and at 7 and 14 days after final paclitaxel administration. Fourteen days after paclitaxel treatment, DRG apoptosis was determined by activated caspase-3 immunoreactivity (IR). Results: Post-treatment with EP did not significantly affect paclitaxel-induced allodynia, although it tended to slightly reduce sensitivities to mechanical stimuli after paclitaxel administration. After paclitaxel administration, an increase in caspase-3 IR in DRG cells was observed, which was co-localized with NF200-positive myelinated neurons. Post-treatment with EP decreased the paclitaxel-induced caspase-3 IR. Paclitaxel administration or post-treatment with EP did not alter the glial fibrillary acidic protein IRs in DRG cells. Conclusions: Inhibition of apoptosis in DRG neurons by EP may not be critical in paclitaxel-induced mechanical allodynia.

• Journal of Fisheries and Marine Sciences Education
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• v.24 no.4
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• pp.602-608
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• 2012

This study was conducted to evaluate the effect of commercial extruded pellet (EP) diet on the growth and water quality compared with a raw fish moist pellet (MP) diet for flounder on field feeding experiments. Three replicate groups of 130 fish per each tank (initial weight of 380 g) were fed one of the EP and Moist pellet (MP) for 7 months. In field feeding experiment, no significant difference was observed in final mean weight of fish fed the experimental EP (1,233 g) and MP (1,237 g), and any noticeable problem caused by feeding the experimental EP was not found during the whole period of feeding trial. Feed efficiency of fish fed the experimental EP was higher than that of MP, and there was no significant difference in survival between the fish fed experimental EP and MP. The concentrations of SS, COD, TN and TP of seawater in tanks of MP groups were 1-5 times higher than those of EP groups. Therefore, these results strongly suggest that diet EP could be developed to replace MP diet for the marketable size of production for flounder without adverse effects on growth performance and water quality.

• East Asian mathematical journal
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• v.23 no.2
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• pp.207-212
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• 2007

We describe the class of invertible matrices T such that $TAT^{-1}$ is EPr, for a given EPr matrix A of order n. Necessary and sufficient condition is determined for $TAT^{-1}$ to be EP for an arbitrary matrix A of order n.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.11a
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• pp.154-159
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• 2005

The markers for Environmental Tobacco Smoke(ETS) a.e necessary to obtain, to interpretate and to provide the data of quantitative exposure assessment. The purpose of this research is to evaluate Indoor environment using the concentration of ETS and the correlations between markers(RSP, nicotine, 3-EP) and environmental conditions(smoking density, ventilation rate). The mean ACH(air change per hour) in smoking rooms showed non-compliance with ASHRAE standard value. The concentrations of RSP, 3-EP, nicotine showed log-normal distributions, and became different statistically depending on smoking condition(p<0.01). The geometric mean concentration of RSP in smoking room was 441.7 ${\mu}g/m^3$ that is far exceeded environmental standard(150 ${\mu}g/m^3$). The correlation coefficients between RSP and SI, 3-EP and SI, and Nicotine and SI were 0.67, 0.84, 0.74 respectively. The correlation coefficient between nicotine and 3-EP, Nicotine and RSP, and RSP and 3-EP were 0.76, 0.78, 0.57 respectively.

• Journal of Korean Society for Atmospheric Environment
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• v.10 no.1
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• pp.49-56
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• 1994

Electrostatic Precipitators( EP ) are widely used in industry for controlling the emission of particulate pollutant Recently, a number of researches have been conducted to solve performance and reliability problems of EP, As a result of researches in the laboratory and of pilot scale, a technology of wide-pitch-spacing has been successfully applied to full scale units. It has been known that the wide-pitch-spacing can reduce the capital cost of newly installed precipitators, and the cost of rebuilding existing uints. In this paper, a systematic study was performed to develop a wide-pitch electrostatic precipitator. The study includes experimental and numerical work on the following : Particle collection characteristics for a bench-scale unit; gas flow characteristics( temperature and velocity distributions): other EP operating variables such as electric Power supply/control. The results are applied directly to design of wide-pitch-spacing EP and the developed numerical model was found to be a good argreement with the experimental results. The EHD simulation program is necessary to design the high efficiency EP.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.265-268
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• 1995

Signal averaging technique to improve signal-to-noise ratio has widely been used in various fields, especially in electrophysiology. Estimation of the EP(evoked potential) signal using the conventional averaging method fails to correctly reconstruct the original signal under EEG(electroencephalogram) noise especial]y when the latency times of the evoked potential are not identical. Therefore, a technique based on the bispectrum averaging was proposed for recovering signal waveform from a set o noisy signals with variable signal dalay. In this paper an improved bispectrum estimation technique of the RP signal is proposed using a confidence thresholding of the EP signal in frequency domain in which energy distribution of the EP signal is usually not uniform. The suggested technique is coupled with the conventional bispectrum estimation technique such as least square method and recursive method. Some results with simulated data and real EP signal are shown.

• International Journal of Industrial Entomology and Biomaterials
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• v.15 no.2
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• pp.171-174
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• 2007

Sericin beads were prepared from ethanol-precipitated sericin. The addition of ethanol into hot-water extracted sericin solution induced precipitation of sericin and thereby some sericin could be fractionated. The ethanol-precipitated sericin (EpSS) had narrower molecular weight distribution than original sericin. The EpSS had mainly random coil structure with small portion of ${\beta}-sheet$ structure. With the EpSS, spherical beads could be prepared at lower concentration than with original sericin due to higher viscosity. The EpSS beads had better compressive strength than the original sericin beads and had rubber-like property. Our results suggest that EpSS is more compatible in the polymeric field, since it has better mechanical strength than original sericin.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2003.10a
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• pp.158-162
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• 2003

The PVDF(polyvinylidene fluoride) film sensor as one of smart sensors has good characteristics to detect the impact damages of composite structures. The capabilities of the PVDF film sensor for evaluating impact behaviors and damages of Gr/Ep laminates subjected to low-velocity impact were examined. From sensor signals, the specific wave-forms implying the damage were detected. The wavelet transform(WT) and Short Time Fourier Transform(STFT) were used to decompose the piezoelectric sensor signals in this study. The impact behaviors of Gr/Ep laminates were simulated and the impact forces were reconstructed using the sensor signals. Finally, the impact damages were predicted by finite element analysis with the reconstructed forces. For experimental verification, a series of low-velocity impact tests from low energy to damage-induced energy were carried-out. The extent of damage in each case was examined by means of ultrasonic C-scan and the measured damage areas were agreed well with the predicted areas by the F.E.A.

• Korean Journal of Pharmacognosy
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• v.22 no.3
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• pp.183-191
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• 1991

The effects of Ephedrae herba on cellular and humoral immune responses were investigated in mice. Group A and B of mice received intraperitoneal injection of methanol extracts, ether fraction(E), petroleum ether fraction(PE), ethyl acetate fraction(EA) and water fraction(W) for 5 days or 10 days before sensitization. The other group received i.p. injection of ephedrine (Ep) or pseudoephedrine $({\psi}\;Ep)$ for 1 day prior to sensitization. The change of body and spleen weights showed a tendency of decreasing but that of thymus showed increasing. Ear swelling was maximum at 48 hours after challenge and was significantly decreased in the groups treated with EA, W, Ep, and ${\psi}\;Ep$. HA titer was enhanced in EA, W and EP treated groups, HE titer being significantly decreased.

• Journal of the Korean Institute of Intelligent Systems
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• v.10 no.6
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• pp.542-547
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• 2000

진화프로그래밍(Evolutionary Programming : EP)은 최적화 문제에 있어서 매우 유용한 기법으로 자연선택의 원리를 모방한 탐색알고리즘이다. EP는 기존의 최적화 알고리즘에 비하여 여러해를 동시에 탐색하는 전역탐색(global search)방법이므로 국부수렴(local convergence)의 가능성이 줄어들고, 최적화 파라메터 영역의 연속성과 미분치의 존재성과 같은 조건이 필요 없는 장점을 갖는다. 이러한 장점에도 불구하고, EP의 탐색영역이 초기조건 및 최적화 파라메터들의 랜덤 생성 그리고 최적화에 필요한 전략적 파라메터들에 의하여 탐색 영역이 결정되고, 수렴성이 느린 단점을 갖는다. 이러한 문제를 해결하기 위하여, 본 연구에서는 빠른 수렴성과 다양성을 갖는 개선된 EP을 제안하고, 제안된 방향성 벡터를 갖는 개선된 EP를 함수 최적화 문제에 적용하여 그 성능의 유용성을 보이고자 한다.