• Journal of the Earthquake Engineering Society of Korea
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• v.22 no.3
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• pp.139-147
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• 2018

In the present study, effective hydrodynamic pressure modeling methods for three-dimensional earthquake safety analysis of a dam intake tower structure are investigated. Time history analysis results using the Westergaard added mass and Chopra added mass methods are compared with the one by the CASI (Coupled Acoustic Structural Interaction) method, which is accepted as giving almost exact solutions, to evaluate the difference in displacement response, stress and dynamic eccentricity. The 3D time history analysis of a realistic intake tower, which has the standard geometry widely used in Korea, shows that the Chopra added mass method gives similar results in displacement and stress and less conservative results in dynamic eccentricity to CASI ones, while the Westergaard added mass yields much more conservative results in all measures. This study suggests to use the CASI method directly for three-dimensional earthquake safety analysis of a dam intake tower, if computationally possible.

• Steel and Composite Structures
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• v.20 no.4
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• pp.813-832
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• 2016

This research deals with the behavior of Composite Box Girder Bridges (CBGBs) subjected to environmental effects such as solar radiation, atmospheric temperature, and wind speed. It is based on temperature and thermal stress results, which were recorded hourly from a full-scale experimental CBGB segment and Finite Element (FE) thermal analysis. The Hemi-cube method was adopted to achieve the accuracy in temperature distributions and variations in a composition system during the daily environmental variations. Analytical findings were compared with the experimental measurements, and a good agreement was found. On the other hand, parametric investigations are carried out to investigate the effect of the cross-section geometry and orientation of the longitudinal axis of CBGB on the thermal response and stress distributions. Based upon individual parametric investigations, some remarks related to the thermal loading parameters were submitted. Additionally, some observations about the CBGB configurations were identified, which must be taken into account in the design process. Finally, this research indicates that the design temperature distribution with a uniform differential between the concrete slab and the steel girder is inappropriate for describing the thermal impacts in design objective.

• Geomechanics and Engineering
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• v.17 no.5
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• pp.429-438
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• 2019

Microbially induced carbonate precipitation (MICP) is an innovative soil improvement approach utilizing metabolic activity of microbes to hydrolyze urea. In this paper, the shear response and the erodibility of MICP-treated sand under axial compression and submerged impinging jet were evaluated at a low confining stress range. Loose, poorly graded silica sand was used in testing. Specimens were cemented at low confining stresses until target shear wave velocities were achieved. Results indicated that the erodibility parameters of cemented specimens showed an increase in the critical shear stress by up to three orders of magnitude, while the erodibility coefficient decreased by up to four orders of magnitude. Such a trend was observed to be dependent on the level of cementation. The treated sand showed dilative behavior while the untreated sands showed contractive behavior. The shear modulus as a function of strain level, based on monitored shear wave velocity, indicated mineral debonding may commence at 0.05% axial strain. The peak strength was enhanced in terms of emerging cohesion parameter based on utilizing the Mohr-Coulomb failure criteria.

• Microbiology and Biotechnology Letters
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• v.50 no.4
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• pp.441-456
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• 2022

Shiga toxins (Stxs) are major virulence factors from the enterohemorrhagic Escherichia coli (EHEC), a subset of Stx-producing Escherichia coli. Stxs are multi-functional, ribosome-inactivating proteins that underpin the development of hemolytic uremic syndrome (HUS) and central nervous system (CNS) damage. Currently, therapeutic options for the treatment of diseases caused by Stxs are limited and unsatisfactory. Furthermore, the pathophysiological mechanisms underpinning toxin-induced inflammation remain unclear. Numerous works have demonstrated that the various host ribotoxic stress-induced targets including p38 mitogen-activated protein kinase, its downstream substrate Mitogen-activated protein kinase-activated protein kinase 2, and apoptotic signaling via ER-stress sensors are activated in many different susceptible cell types following the regular retrograde transportation of the Stxs, eventually leading to disturbing intercellular communication. Therapeutic options targeting host cellular pathways induced by Stxs may represent a promising strategy for intervention in Stx-mediated acute renal dysfunction, retinal damage, and CNS damage. This review aims at fostering an in-depth understanding of EHEC Stxs-mediated pathogenesis through the toxin-host interactions.

• Microbiology and Biotechnology Letters
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• v.25 no.3
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• pp.240-247
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• 1997

Bacillary is the most common form of H. pylori observed during human infection. However, it is known that the morphology change of H. pylori from bacillary to coccoid can be occurred with a response to the environmental stresses such as the nutrient depletion, accumulation of toxic metabolites, pH alteration, and exposure to antimicrobial agents. The coccoid form of H. pylori, which is viable but non-culturable in vitro, seems to be the major cause of antibiotic resistancy and high reinfectability of H. pylori. In this regard, we studied the environmental factors that can induce the morphological change in vitro of H. pylori, and the change of fatty acid composition of plasma membrane. The morphological change from bacillary to coccoid could be observed with the depletion of nutrients, pH variation and reactive oxygen species added in the culture media. This morphologic conversion was paralleled by a dramatic decrease in unsaturated fatty acids and an increase in saturated fattv acids of plasma membrane. The change in composition of membrane fatty acid seems to be a kind of protection mechanism of H. pylori against these environmental stresses.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• v.10 no.S_4
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• pp.189-196
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• 2001

The blue green alga, Microcystis aeruginosa, was found to accumulate proline under the stressful concentration of cupric ions. The changes of proline level in Microcystis aeruginosa in response to copper(Cu) have been monitored and the function of the accumulated proline was studied with respect to its effect on Cu uptake. Exposure of Microcystis aeruginosa elevated concentrations of Cu led to accumulation of fee proline depending on the concentrations of the metal in the external medium. The greater the toxicity or accumulation of the metal, the higher the amount of proline in algal cells were found. When proline was exogenously supplied prior to Cu treatment, the absorption of Cu was markedly reduced. When exogenous proline was supplied after Cu treatment, it resulted in a remarkable desorption of the adsorbed Cu immediately after the addition of proline. Pretreatment of Microcystis aeruginosa with proline counteracted with metal-induced lipid peroxidation. The results of the present study showed a protective elect of proline on metal toxicity through inhibition of lipid peroxidation and suggested that the accumulation of proline may be related to the tolerance mechanism for dealing with Cu stress.

• International journal of steel structures
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• v.18 no.4
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• pp.1397-1409
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• 2018

Stiffened plates with high slenderness parameters show large out-of-plane deflections, due to elastic buckling, which may occur before the plates reach their ultimate strength. From a serviceability point of view, restriction of out-of-plane deflections exceeding the fabrication tolerance is of primary importance. Compressive strength at the serviceability limit state (SLS) for slender stiffened plates under uniaxial stress was investigated through nonlinear elasto-plastic finite element analysis, considering both geometric and material nonlinearity. Both normal and high-performance steel were considered in the study. The SLS was defined based on a deflection limit and an elastic buckling strength. Probabilistic distributions of the SLS strengths were obtained through Monte Carlo simulations, in association with the response surface method. On the basis of the obtained statistical distributions, partial safety factors were proposed for SLS. Comparisons with the ultimate strength of different design codes e.g. Japanese Code, AASHTO, and Canadian Code indicate that AASHTO and Canadian Code provide significantly conservative design, while Japanese Code matches well with a 5% non-exceedance probability for compressive strength at SLS.

• Geomechanics and Engineering
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• v.32 no.3
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• pp.335-346
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• 2023

For structures with underground basement walls, the soil-structure-interaction between the side soil and the walls affects the response of the system. There is interest in quantifying the relationship between the lateral earth pressure and the wall displacement using p-y curves. To date, passive p-y curves in available limited studies were assumed elastic-perfectly plastic. In reality, the relationship between earth pressure and wall displacement is complex. This paper focuses on studying the development of passive p-y curves behind rigid walls supporting granular soils. The study aims at identifying the different components of the passive p-y relationship and proposing a rigorous non-linear p-y model in place of simplified elastic-plastic models. The results of the study show that (1) the p-y relationship that models the stress-displacement response behind a rigid basement wall is highly non-linear, (2) passive p-y curves are affected by the height of the wall, relative density, and depth below the ground surface, and (3) passive p-y curves can be expressed using a truncated hyperbolic model that is defined by a limit state passive pressure that is determined using available logarithmic spiral methods and an initial slope that is expressed using a depth-dependent soil stiffness model.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.36 no.5
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• pp.83-91
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• 2020

Environmental conditions are known to impact human health and behavior, emotions such as pleasure, anxiety, and depression, and reduce stress. Interior design that elevates emotional comfort and satisfaction can help improve mental health and well-being. This study is a systematic review that analyzed previous empirical studies that explored the effect of interior design elements on the user's emotional response which is quantitatively evaluated by bio-signal and qualitatively evaluated through self-reported questionnaire surveys. This paper aims to derive the attributes of interior design and biometric indicators that affect the user's positive emotion through the synthesis of previous studies and to confirm the feasibility of measuring bio-signals as an objective evaluation tool for architectural design and as a quantitative research method. As a result of the review, the biometric data from EEG, fMRI, ECG, EMG, GSR, and eye-tracking were used to measure the participants' emotional responses, which were manifested as positive or negative depending on certain attributes of interior design such as the form, color, lighting, material and furniture. The attributes of interior design related to the positive emotional response were the curved shape, high ceiling, openness of space, and subdued tone colors. Standard lighting conditions and wooden spaces were related to stress reduction in terms of comfort and relaxation. The free arrangement of furniture was related to the user's positive emotions. On the other hand, consistent experimental protocols could not be found, and although the sample sizes of the studies were small, the studies have demonstrated the feasibility of the emotional response measurement by using the biometric data. Therefore this method can be a useful objective tool in the measurement of human-centric data in architectural design, and to develop the evidence-based design to induce positive emotions and minimize stress.

• Journal of the Korean Geotechnical Society
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• v.36 no.12
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• pp.117-124
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• 2020

The present research focuses on a methodology to describe shearing response of clay with respect to temperature. An increase of temperature shifts the normal consolidation line to move down in the plane of void ratio and mean effective stress. The critical state line, however, does not move as much as the normal consolidation line in accordance with temperature increase. As temperature increase, therefore, the difference between the critical state mean effective stress and the pre-consolidation pressure reduces. To reflect this easily, the present study applies a bounding surface consisting of two parts divided by the critical state mean effective stress. This study calibrated a bounding surface for the soft Bangkok clay and performed elemental simulation for undrained triaxial compression tests. The elemental simulation showed that the model can describe the mechanical response upon temperature of clay without complex hardening and evolution rules compared to the experimental data.