• Title/Summary/Keyword: environmental cancer

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Age or environmental radiation dose rate: Which is more correlated with cancer incidence rates in the Republic of Korea?

  • Joo, Han Young;Kim, Jae Wook;Jeong, So Yun;Choi, Jin Sik;Moon, Joo Hyun
    • Nuclear Engineering and Technology
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    • v.54 no.9
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    • pp.3452-3458
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    • 2022
  • Our study adopted a big data analysis approach to determine whether there was a significant relationship between environmental radiation dose rates or age and cancer incidence rates in the Republic of Korea. The data for this analysis included environmental radiation dose rates, number of cancer patients, and age distributions of the residents from 2009 to 2016 in the administrative districts where environmental radiation monitoring posts were located. For this analysis, the environmental radiation dose rates were obtained from 171 monitoring posts located in 113 elementary administrative districts in the Republic of Korea. The number of cancer patients and the age distributions were obtained from the Central Cancer Information Center of the National Cancer Center of Korea and the Ministry of the Interior and Safety, respectively. Our findings indicated that there was no statistically significant relationship between the environmental radiation dose rate and the cancer incidence rate. However, age had a considerable influence on the cancer incidence rate of the monitored regions.

ANTICLASTOGENIC, ANTIGENOTOXIC AND APOPTOTIC ACTIVITY OF NATURAL POLYPHENOLS

  • Chakraborty, S.;Sinha, D.;Roy, M.;Bhattacharya, R.K.;Siddiqi, M.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.56-57
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    • 2001
  • Modulation of events characteristic of carcinogenesis or of cancer cells is being emphasized as a rational strategy to combat cancer. This is achieved through chemoprevention by a variety of agents. Phenolic compounds, particularly polyphenols, have been shown to be highly active in this regard. Certain cellular and molecular events relevant to carcinogenesis are modified by polyphenols. The present investigation has been carried out to examine some of these aspects.(omitted)

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ANTICLASTOGENIC, ANTIGENOTOXIC AND APOPTOTIC ACTIVITY OF NATURAL POLYPHENOLS

  • Chakraborty, S.;Sinha, D.;Roy, M.;Bhattacharya, R.K.;Siddiqi, M.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10b
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    • pp.13-14
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    • 2001
  • Modulation of events characteristic of carcinogenesis or of cancer cells is being emphasized as a rational strategy to combat cancer. This is achieved through chemoprevention by a variety of agents. Phenolic compounds, particularly polyphenols, have been shown to be highly active in this regard. Certain cellular and molecular events relevant to carcinogenesis are modified by polyphenols. The present investigation has been carried out to examine some of these aspects.(omitted)

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Analysis of the Relationships between Esophageal Cancer Cases and Climatic Factors Using a Geographic Information System (GIS): a Case Study of Ardabil province in Iran

  • Ahari, Saeid Sadeghieh;Agdam, Fridoon Babaei;Amani, Firouz;Yazdanbod, Abbas;Akhghari, Leyla
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.2071-2077
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    • 2013
  • Esophageal cancer is a mjaor health problems in many parts of the world. A geographical information system (GIS) allows investigation of the geographical distribution of diseases. The purpose of the present study was to explore the relationship between esophageal cancer and effective climatic factors using GIS. The dispersion distribution and the relationship between environmental factors effective on cancer were measured using Arc GIS. The highest degree of spread was in Germi town and the least was in Ardabil city. There was a significant relationship between effective environmental factors and esophageal cancer in Ardabil province. The results indicated that environmental factors probably are influential in determining the incidence of esophageal cancer. Also, these results can be considered as a window to future comprehensive research on esophageal cancer and related risk factors.

Ethanol but not Aqueous Extracts of Tubers of Sauromatum Giganteum(Engl.) Cusimano and Hett Inhibit Cancer Cell Proliferation

  • Gao, Shi-Yong;Li, Jun;Wang, Long;Sun, Qiu-Jia;Gong, Yun-Fei;Gang, Jian;Su, Yi-Jun;Ji, Yu-Bin
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.24
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    • pp.10613-10619
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    • 2015
  • Background: Both alcohol and aqueous extracts of Sauromatum giganteum(Engl.) Cusimano and Hett, the dried root tuber of which is named Baifuzi in Chinese, have been used for folklore treatment of cancer in Northeast of China. However, little is known about which is most suitable to the cancer therapy. Materials and Methods: Serum pharmacology and MTT assays were adopted to detect the effects of ethanol and aqueous extracts of Sauromatum giganteum(Engl.) Cusimano and Hett, prepared by heat reflux methods, on proliferation of different cancer cells. Results: Cancer cells treated with medium supplemented with 10%, 20%, 40% serum(v/v) containing ethanol extract had a decline in viability, with inhibition rates of 7.69%, 21.8%, 41.9% in MCF-7 cells, 42.8%, 48.1%, 51.8% in SGC-7901 cells, 44.1%, 49.2%, 53.7% in SMMC-7721 cells, 6.8%, 15.2%, 39.8% in HepG2 cells, 7.57%, 16.3%, 36.2% in HeLa cells, 6.24%, 12.5%, 27.4% in A549 cells, and 7.20%, 17.5%, 31.3% in MDA-MB-231 cells, respectively. Viability in the aqueous extract groups was no different with that of controls. Conclusions: An ethanol extract of Sauromatum giganteum(Engl.) Cusimano and Hett inhibited the proliferation of SMMC-7721, SGC-7901 and MCF-7 cells, which supports the use of alcoholic but not aqueous extracts for control of sensive cancers, which might include hepatocarcinoma, gastric cancer and breast cancer.

Necessity for a National Carcinogen List in Korea, Based on International Harmonization

  • Leem, Jong Han;Kim, Hwan Cheol;Park, Myungsook;Kim, Jung Ae;Kim, Shin-Bum;Ha, Mina;Lim, Min-Kyeong;Kim, Jeongseon;Park, Eun Young;Paek, Domyung
    • Environmental Analysis Health and Toxicology
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    • v.28
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    • pp.8.1-8.5
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    • 2013
  • Cancer has been the leading cause of death in Korea for the last 30 years. Cancer patients' 5-year survival rate between 2005 and 2009 was 62.0%, representing a highly advanced standard of care, as much as developed countries in the EU and the US. The Korean government formulated its first 10-year plan for cancer control in 1996 and has been carrying out a second 10-year plan for cancer control since 2006. But despite the Korean government's efforts, the cancer burden in Korea continues to increase. Many separate laws have gone into effect concerning the management of carcinogen exposure. However, there are no integrated regulatory laws or management systems against carcinogen exposure in Korea. Dead zones remain where carcinogen exposure cannot be controlled properly in Korea. In this paper, we suggest the need to establish a national carcinogen list based on international harmonization as a prerequisite for a paradigm shift in cancer control policy from treatment to primary prevention.