• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 1999년도 학술발표회 진행표 및 논문초록
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• pp.34-34
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• 1999

TRAIL (also known as Apo-2L) is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule in that it induces apoptosis in a wide variety of tumor cells but not in normal cells. In order to help elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL.(omitted)

• 한국주거학회논문집
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• 제12권3호
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• pp.109-116
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• 2001

Street is an important factor that street quality determines urban quality as the space of the high public nature in city. The research method considering sequence landscape is important because it is considered that the impression of such a street is formed by the wholeness of consecutive landscape and experience in moving street. Therefore, this study are pursued to structure the analysis of psychological evaluation and environmental attribute base on the physical characteristics of sequence landscape to supply the basic materials for seeking the national direction as qualitative improvement of urban street space and the attractive urban street space. Then the results are as follows. It is shown that the psychological evaluation structure of sequence landscape is evaluated by ornamental nature, intimacy, orderliness, openness and movability and that of environmental attributes is evaluated by four factors such as activity, intimacy, spatial attribute and openness.

• 비만대사연구학술지
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• 제2권2호
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• pp.37-44
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• 2023

Weight gain is defined as the increase in body weight, increasing the prevalence of obesity, and results in metabolic diseases. Weight gain was reportedly caused by the interaction between the obesogenic environmental factors and individual metabolic factors. Sociodemographic and environmental factors (demographic factors, lifestyle/behavioral factors, food/nutritional factors, socioeconomic factors), drug-related secondary causes (some of the corticosteroids, antihyperglycemics, antihypertensives, antidepressants, etc.), and metabolic factors (aging and hormonal changes, menopause and decreased sex hormones, decreased adipocyte degradation, decreased fibroblast growth factor 21, central sympathetic nervous system hyperactivity, decreased sympathetic-adrenomedullary system activity) are significant factors related to weight gain. It is crucial to prevent weight gain and maintain an ideal weight, but studies on the risk factors of weight gain are insufficient. Therefore, this study evaluated the factors associated with weight gain to find strategies for preventing unnecessary weight gain.

• Toxicological Research
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• 제33권1호
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• pp.55-62
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• 2017

We evaluated the antioxidant activity and anti-melanogenic effects of Oenothera laciniata methanol extract (OLME) in vitro by using melan-a cells. The total polyphenol and flavonoid content of OLME was 66.3 and 19.0 mg/g, respectively. The electron-donating ability, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity, and superoxide dismutase (SOD)-like activity of OLME ($500{\mu}g/mL$) were 94.5%, 95.6%, and 63.6%, respectively. OLME and arbutin treatment at $50{\mu}g/mL$ significantly decreased melanin content by 35.5% and 14.2%, respectively, compared to control (p < 0.05). OLME and arbutin treatment at $50{\mu}g/mL$ significantly inhibited intra-cellular tyrosinase activity by 22.6% and 12.6%, respectively, compared to control (p < 0.05). OLME ($50{\mu}g/mL$) significantly decreased tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor-M (MITF-M) mRNA expression by 57.1%, 67.3%, 99.0%, and 77.0%, respectively, compared to control (p < 0.05). Arbutin ($50{\mu}g/mL$) significantly decreased tyrosinase, TRP-1, and TRP-2 mRNA expression by 24.2%, 42.9%, and 48.5%, respectively, compared to control (p < 0.05). However, arbutin ($50{\mu}g/mL$) did not affect MITF-M mRNA expression. Taken together, OLME showed a good antioxidant activity and anti-melanogenic effect in melan-a cells that was superior to that of arbutin, a well-known skin-whitening agent. The potential mechanism underlying the anti-melanogenic effect of OLME was inhibition of tyrosinase activity and down-regulation of tyrosinase, TRP-1, TRP-2, and MITF-M mRNA expression.

• 한국환경과학회지
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• 제27권10호
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• pp.865-874
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• 2018

Fruit trees are a key part of agriculture in rural areas and have recently been a part of ecotourism or agrotourism. This study analyzes user segmentation based on user motivation to determine characteristics of potential customers in fruit tree farms, and thereby develop fruit tree experience and educational programs. We conducted a survey of 253 potential customers of fruit tree experience programs in September 2017. Data were evaluated using factor and cluster analyses. The results of the cluster analysis identified four distinct segments based on potential customers' motivations, that is, activity-oriented, learning-oriented, leisure-oriented, and purchase-oriented. These clusters showed that significant differences in the preference of potential customers exist. Different markets were segmented based on the benefits sought by users. The segments' characteristics were identified and activities relevant to each segment were proposed for rural tourism. Lastly, this study suggests directions for development of fruit tree farm experience and educational programs.

• 한국의류산업학회지
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• 제15권1호
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• pp.73-83
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• 2013

This study explores the ideal corporate social responsibility(CSR) that fashion consumers expect from a fashion firm in the identification of dimensions and levels of consumer expectations as well as examines the impact of CSR expectations on customer-base brand equity. The data of 315 adults were collected through a nationwide online survey. In order to analyze the data, this study employed Confirmatory factor analysis (CFA), paired t-test, structural equation modeling(SEM), and descriptive analysis. This study first identified seven fashion CSR expectations (environmental, ethical, social, internal management, philanthropic, economic, and legal expectations). Internal management and environmental activities were highly expected from fashion firms; however, economic activity was low in expectations. Five models separately tested the relationship between CSR expectations and brand equity (trustworthiness, attachment, performance, social image, and value). Economic, environmental, internal management, social and ethical CSR expectations influenced customer-based brand equity; however, philanthropic and legal expectations did not influence any dimension of customer-based brand equity. This study provides a framework of ideal CSR from a consumer perspective and suggests that fashion marketers should focus on economic, environmental, internal management, social and ethical CSR activities to meet the expect Haitians of fashion consumers and build stronger brand equity.

• Asian-Australasian Journal of Animal Sciences
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• 제30권1호
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• pp.111-118
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• 2017

Objective: Adipose tissue plays a key role in the development of obesity and diabetes. We previously reported that lignosulfonic acid suppresses the rise in blood glucose levels through the inhibition of ${\alpha}$-glucosidase activity and intestinal glucose absorption. The purpose of this study is to examine further biological activities of lignosulfonic acid. Methods: In this study, we examined the effect of lignosulfonic acid on differentiation of 3T3-L1 cells. Results: While lignosulfonic acid inhibited proliferation (mitotic clonal expansion) after induction of differentiation, lignosulfonic acid significantly increased the size of accumulated lipid droplets in the cells. Semi-quantitative reverse transcription polymerase chain reaction analysis showed that lignosulfonic acid increased the expression of the adipogenic transcription factor, peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$), leading to increased glucose transporter 4 (Glut-4) expression and 2-deoxyglucose uptake in differentiated 3T3-L1 cells. Additionally, feeding lignosulfonic acid to diabetic KK-Ay mice suppressed increase of blood glucose level. Conclusion: Lignosulfonic acid may be useful as a functional anti-diabetic component of food.

• 한국응용곤충학회지
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• 제44권4호
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• pp.283-286
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• 2005

우리나라에서 한약재로 활용되고 있는 흰점박이꽃무지(Protaetia brevitarsis)와 장수풍뎅이(Allomyrina dichotoma)의 산란과 발육에 관여하는 환경요인을 밝히고자 본 시험을 실시하였다. 부엽토수분함량은 두 종 모두에서 과습이나 과습은 산란을 저하시켰고 산란 시 최적의 수분함량은 $65{\sim}75%$로 추정되었다. 부엽토 수분함량은 흰점박이꽃무지와 장수풍뎅이의 알 및 유충의 생존율과 발육기간, 그리고 유충의 섭식활동에 크게 영향을 주는 것으로 이들의 생육에 관여하는 가장 중요한 요인이었다.

• 농촌계획
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• 제27권3호
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• pp.35-46
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• 2021

Ecosystem services play a role in promoting sustainable development by contributing to human welfare. For sustainable development, a balance between supply and demand for ecosystem services must be made. In this regard, in this study, factor analysis was performed using the results of measuring ecosystem services for the supply of ecosystem services and national statistical data representing socio-economic factors for demand for ecosystem services The results of analysis for Gyeong-gi Province are as follows. The service supply based on the result of ecosystem services was divided into the mixed service provisioning as factor1, the food provisioning as factor2, and the P retention service provisioning area as factor3. As for the demand for services based on socio-economic factors, factor1 is divided into urbanized areas, factor2 is forest development area, and factor3 is agricultural activity development area. Local governments that maintain balance were evaluated as Pocheon, Yangpyeong, Icheon, Pyeongtaek, Goyang, Suwon, Gwangmyeong, and Osan, and imbalanced local governments appeared in Gimpo, Uiwang, Anseong, and Yeoju. A management plan to maintain the balance between supply and demand of ecosystem services was suggested. The analysis method and results of this study are expected to be applicable to various local governments through regional expansion.

• 문화기술의 융합
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• 제6권3호
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• pp.67-74
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• 2020

중년여성들은 여성성의 상실과 함께 신체적, 정신적 변화를 겪게 되며, 자녀의 성장과 독립으로 돌봄과 양육의 역할이 감소되면서 심리적으로 공허함을 느끼기도 한다. 이 여성들은 자신의 역할감소에 따른 상실감과 공허함을 자신의 여가생활을 위해 자신의 가치관과 신념을 유지하는 계기로 이해하고 있다. 이에 중년여성들은 공예활동체험을 통하여 인간과 인간의 소통을 통한 사회적 관계에서 이루어지는 관계형성과 자아실현의 기회로 인식하여 우울감이나 공허한 마음과 같은 중년의 위기에 나타나는 부정적 감정을 극복하고 자아존중감과 사회적 지지를 확립하고 있다. 우리는 이 연구에서 공예활동의 체험요소가 중년여성의 자아존중감과 사회적 지지에 미치는 영향을 분석하기 위하여 공예활동의 체험요소를 독립변수로, 자아존중감과 사회적 지지를 종속변수로 하는 연구모형을 설정하였다. 연구결과 교육적 체험, 오락적 체험, 일탈적 체험은 자아존중감에 유의한 영향을 미치고 있으나 심미적 체험은 유의한 영향을 미치지 못하고 있다. 그리고 오락적 체험, 심미적 체험은 사회적 지지에 유의한 영향을 주지만 교육적 체험, 일탈적 체험에는 유의한 영향을 주지 못하였다. 따라서 중년여성의 감각과 감성의 변화에 영향을 줄 수 있는 체험공간의 환경적 특성인 미학적 요소와 시각적 요소를 살릴 수 있는 콘텐츠와 교류할 수 할 수 있는 출발에서 접근할 수 있도록 공예체험에 대하여 제도적으로 지원하는 방안이 제공되어야 한다. 그리고 공예활동으로 궁극적인 삶에 변화를 주는 요인을 고려하지 않은 한계가 있어 웰빙과 관련된 변수 등을 도출하여 새로운 모형을 제시할 것을 제안하고자 한다.