• Title/Summary/Keyword: enlarged clitoris

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Analysis of SRY-negative XX True Hermaphroditism in an English Cocker Spaniel

  • Jang, Goo;Byeon, Ye-Eun;Kim, Min-Kyu;Koo, Ok-Jae;Lee, Byeong-Chun
    • Journal of Veterinary Clinics
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    • v.25 no.3
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    • pp.221-223
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    • 2008
  • SRY gene is normally responsible for testis induction, yet testis development can occur in the absence of SRY. In here, we analyzed the SRY-negative sex reversal in cocker spaniel, at 1.5 year-old. The attacked dog was suffered from enlarged clitoris, and resulted in disorder of urination. By surgically approach, enlarged clitoris and one testis, which are apparently seen, are removed. Additionally, thorough the abdomen surgery, uterus and ovary-like mass were removed. The dog had XX, chromosome, showed negative for SRY-gene, and the mass had the ovary-testis structure. In other words, based on the macroscopic, cytogenic, and histological study, we can diagnose the cocker spaniel as SRY-negative sex reversal.

Relations between Testicular Feminization and Seminiferous Tubule (Testicular Feminization과 세정관과의 관계)

  • Lee, Sok-Woo;Lee, Kwang-Ho
    • The Korean Journal of Zoology
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    • v.29 no.1
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    • pp.61-69
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    • 1986
  • Teter and Boczkowski (1966) classified testicular feminization syndrome into two groups; One with no pubic hair and normal clitoris (A group) and the other with pubic hair and enlarged clitoris (B group). However, the patient discussed in this paper shows a mid-form of these two groups (C group). To find out differences among A, B and C groups, we have observed the micro-structure of testes removed from her inguinal canal and analyzed the chromosomes obtained from testicular and blood culture. Her seminiferous tubules show some differences in the maturation and distribution of Leydig and Sertoli cells and in the thickening of basement membrane as compared with group A and B. We suppose that such differences are responsible for the morphological changes of clitoris and pubic hair.

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A Female Hermaphrodite American Cocker Spaniel Dog with Sry-negative XX Sex Reversal

  • Kang, Hyun-Gu;Kim, Ill-Hwa;Kim, Hyung-Jin;Hwang, Dae-Yeon;Jee, Seung-Wan;Noh, Gyu-Jin
    • Journal of Embryo Transfer
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    • v.23 no.2
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    • pp.119-125
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    • 2008
  • A 3-month-old American Cocker spaniel was presented at the Veterinary Teaching Hospital, Chungbuk National University, for examination of urinary tract after dissection of vaginal mass at local clinic before 10 days. Clinical examination of the affected bitch revealed a normal sized vulva in a normal anatomical position with a grossly enlarged clitoris, which contained an os clitoris. On examinations of the genital gland, there were testis, epididymis, ductus deferens and uterus. The histology of both gonads was primarily testis. Seminiferous tubules were divided into many parts by fibrous connective tissue. A small number of spermatogonia was present, but large numbers of Leydig's cells were existed. A normal female karyotype (78, XX) was detected in metaphase spreads obtained from cultured peripheral lymphocytes. Y chromosome specific sequences were not detected in genomic DNA by PCR. After 27 months, the os clitoris was larger than 3-month-old dog and os bone was more calcified than young age. Combining the results of cytogenetic, molecular genetic and histological examinations, the dog was diagnosed as a female hermaphrodite with Sry-negative XX sex reversal.

Disorder of Sexual Development in a Cocker Spaniel Dog: Sry-negative XX Sex Reversal (코커 스파니엘 개에서 발생한 성-발달장애: Sry-negative XX 성전환)

  • Lee, Sung-Lim;Maeng, Geun-Ho;Kim, Na-Hyun;Park, Ki-Tae;Lee, Hee-Chun;Lee, Jae-Hoon
    • Journal of Veterinary Clinics
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    • v.29 no.5
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    • pp.422-426
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    • 2012
  • A 3-year-old Cocker spaniel was presented for evaluation because of a mass protruding from the vulva. This mass confirmed the presence of an internal bone in clitoris on the radiography. We recommended to the owner of the surgical removal of the gonads and uterus as well as the excision of the enlarged clitoris and os clitoris. The dog had gonads in the region of where the ovaries were located and presented what appeared to be a bicornate uterus and ductus deferens. Histological analysis revealed a morphologically normal uterus and two testes with their epididymis and ductus deferens. Karyotyping revealed a normal female chromosome constitution (78, XX), and polymerase chain reaction (PCR) identified the absence of Sry. Based on these findings, the patient was diagnosed with Sry-negative XX sex reversal.

An Intersex with Os Clitoris and Ovotestes in Korean Native Jindo Dog (진도개에서 발생한 Os clitoris와 Ovotestes를 특징으로 하는 양성자 사례 연구)

  • Cho, Sung-Jin;Lee, Hyun-A;Park, Sang-Ho;Kim, Ok-Jin
    • Journal of Veterinary Clinics
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    • v.27 no.1
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    • pp.83-87
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    • 2010
  • Hermaphroditism occurs rarely in human and animal populations. Previously, in Korea, The hermaphrodite dog in American Cocker Spaniel dogs have been reported in six cases. However, in this case, we found a hermaphrodite dog in Korean native Jindo dog. The characteristics were its enlarged os clitoris that was shown a reddish fingerlike structure protruding from the vulva. The dog was diagnosed as hermaphroditism with ovotestes. To our knowledge, this report is the first case of hermaphroditism in Korean native dog.