• Journal of Pharmaceutical Investigation
• /
• v.35 no.3
• /
• pp.173-177
• /
• 2005

Addition of 30% propylene glycol was required to maintain sink condition in the evaluation of percutaneous absorption of estradiol and norethindrone acetate. The permeability of estradiol was higher in silicone and SIS adhesives. However, estradiol was crystallized in silicone, SIS, and SBS adhesive matrix. The permeability ratio of estradiol or norethindrone acetate from acrylic pressure sensitive adhesives varied widely depending on the functional group of the acrylic adhesives. PEO grafting to acrylic adhesive seemed to change physicochemical property of acrylic adhesive and increased the permeability of estradiol and norethindrone acetate significantly. On the contrary, highly cross-linked enhancer compatible acrylic adhesive decreased the permeability of both estradiol and norethindrone acetate. $Span^{\circledR}$ 20 provided the highest enhancing effect on the permeability of both estradiol and norethindrone acetate followed by oleic acid and $Crovol^{\circledR}$ EP40. The permeability of the drugs from the developed system was comparable to that from commercial $Combitran^{\circledR}$, although significantly lower amount of estradiol and norethindrone acetate were loaded in the developed system.

• Journal of Microbiology and Biotechnology
• /
• v.16 no.5
• /
• pp.791-794
• /
• 2006

Cyclosophoraose (cyclic $\beta-(1,2)-glucan$, Cys) isolated from Rhizobium meliloti, a soil microorganism, was used as a solubility enhancer for flavonoids. The complexes of the cyclic oligosaccharide with flavonoids were confirmed through $^1H$ nuclear magnetic resonance (NMR) spectroscopic analysis. Flavonoids solubilized by Cys were quantitatively analyzed through high-performance liquid chromatography (HPLC). Among the flavonoids tested, the solubility of naringenin was greatly enhanced by Cys, compared with other compounds. The solubility of naringenin was enhanced about 7.1-fold by adding 10 mM Cys, compared with a control. $^1H$ NMR spectroscopic analysis indicated that the H-6 and H-8 protons, which are located on the A ring of naringenin, were greatly shifted upfield upon the complexation with Cys. This result suggested that Cys showed a regioselective interaction with the naringenin molecule upon the complexation, resulting in the solubility enhancement of naringenin.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 1996.11a
• /
• pp.283-287
• /
• 1996

The exhaust noise reduction of automobile with the active muffler is experimentally investigated. The control algorithm is the filtered-x LMS algorithm and the inverse algorithm with the adaptive line enhancer. Also, the control efficiency is increased with synthesized second harmonic engine frequency. In the experiment, the active muffler is applied to the end of exhaust system in automobile and the control with on-line secondary path modeling method(inverse algorithm) is compared the control of off-line secondary path modeling method. As secondary path transfer functions are changed, the experimental results show that the control performance with on-line method is more efficient than that with off-line method in the exhaust noise reduction of automobile.

• Preventive Nutrition and Food Science
• /
• v.4 no.2
• /
• pp.103-106
• /
• 1999

Fish sauce is a liquid form of salt-fermented fish and has played an important role in Korean dietary life. Fish sauce was manufactured by utilizing Alaska pollack scrap from Himedara(seasoned and dried Alaska pollack tail) processing . In addition, the effects of squid viscera as a fermentation enhancer were also evaluate.Ph of Alaska plllack scrap sauce with squid viscera was lower than that of control over the entire fermentation process. Squid viscera acceleraged the production of amino-nitrogen, VBN , TBA and free amino acids, and the degradation of IMP and Inosine. The addition of squid viscera and koji at 5% concentration, respectively , also accelerated the digestion of Alaska pollack scrap and was similar to the results of squid viscera at 10% concentration.

• Journal of Environmental Health Sciences
• /
• v.26 no.2
• /
• pp.91-96
• /
• 2000

We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying drug delivery system(DDS). Natural gums were selected as material of TTS. The permeation of natural gums ointment containing drug in rat skin using diffusion cell model. Permeation properties of materials were investigated for water soluble drug such as riboflavin in vitro. We used glycerin, PEG 600 and oleic acid as enhancers. Since dermis has more hydration than the stratum corneum, skin permeation rate at steady state was highly influenced when glycerin was used in riboflavin. The permeation rate of content enhancer and drug was found to be faster than that of content riboflavin only. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. All the gum ointment tested showed good safety. Proper selection of the materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.

• Journal of the Korean Institute of Navigation
• /
• v.25 no.3
• /
• pp.237-245
• /
• 2001

Radar is an indispensible equipment in all vessels under way. In Korea there are many fishing net buoys near the coast, which causes an enormous threat to safe navigation because it is very difficult to detect the buoys by radar due to their small radar cross section. In this study RTE(Radar Target Enhancer) was installed on the fishing net buoy and its echo was analysed carefully. The results showed the possibility of wide detection of targets, especially small targets such as fishing net buoys, navigation buoys and etc.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.415.2-415.2
• /
• 2002

We investigated the absorption enhancing effect of BuOH extract of the root of Aralia elata (BERAE) in Caco-2 cell monolayers and rats. At the concentration of both 0.04% and 0.08% (w/v). BERAE decreased the transepithelial electrical resistance (TEER) values and increased the permeability of intact chondroitin sulfate (CS) and its digestion products as hydrophilic macromolecules in a dose dependent manner. We also evaluated the cytotoxicity of BERAE for the determination of a proper concentration as an absorption enhancer. (omitted)

• Journal of the Korean Applied Science and Technology
• /
• v.24 no.2
• /
• pp.117-123
• /
• 2007

• Proceedings of the Korean DIstribution Association Conference
• /
• 2004.05a
• /
• pp.97-117
• /
• 2004

• The Microorganisms and Industry
• /
• v.11 no.1
• /
• pp.13-20
• /
• 1985

특이 단백질(gene II protein)의 정성적 또는 정량적 변화에 의해 DNA 복제에 필요한 replication orgin sequence의 일부분이었단 replication enhancer를 불필요하게 함으로써 minimum replication origin을 core region만으로 국한 되게 함이었다.