Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of BuOH Extract of the Root of Aralia elata as an Absorption Enhancer on the Transport of Chondroitin Sulfate and Its Digestion Products In Vitro and In Vivo

  • Sim, Joon-Soo (Natural Products Reseach Institute, Seoul National University) ;
  • Li, Da-Wei (Natural Products Reseach Institute, Seoul National University) ;
  • Cho, Hai-Lim (Natural Products Reseach Institute, Seoul National University) ;
  • Cho, So-Yean (Division of Herbal Medicines Standardization Korea Food and Drug Administratio) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Woman′s University) ;
  • Lee, Eun-Bang (Natural Products Reseach Institute, Seoul National University) ;
  • Kim, Yeong-Shik (Natural Products Reseach Institute, Seoul National University)
  • Published : 2002.10.01
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Abstract

We investigated the absorption enhancing effect of BuOH extract of the root of Aralia elata (BERAE) in Caco-2 cell monolayers and rats. At the concentration of both 0.04% and 0.08% (w/v). BERAE decreased the transepithelial electrical resistance (TEER) values and increased the permeability of intact chondroitin sulfate (CS) and its digestion products as hydrophilic macromolecules in a dose dependent manner. We also evaluated the cytotoxicity of BERAE for the determination of a proper concentration as an absorption enhancer. (omitted)

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