• Journal of Ginseng Research
• /
• v.48 no.1
• /
• pp.89-97
• /
• 2024

Background: Ginsenoside F2 (GF2), the protopanaxadiol-type constituent in Panax ginseng, has been reported to attenuate metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanism of action is not fully understood. Here, this study investigates the molecular mechanism by which GF2 regulates MASLD progression through liver X receptor (LXR). Methods: To demonstrate the effect of GF2 on LXR activity, computational modeling of protein-ligand binding, Time-resolved fluorescence resonance energy transfer (TR-FRET) assay for LXR cofactor recruitment, and luciferase reporter assay were performed. LXR agonist T0901317 was used for LXR activation in hepatocytes and macrophages. MASLD was induced by high-fat diet (HFD) feeding with or without GF2 administration in WT and LXRα^-/- mice. Results: Computational modeling showed that GF2 had a high affinity with LXRα. LXRE-luciferase reporter assay with amino acid substitution at the predicted ligand binding site revealed that the S264 residue of LXRα was the crucial interaction site of GF2. TR-FRET assay demonstrated that GF2 suppressed LXRα activity by favoring the binding of corepressors to LXRα while inhibiting the accessibility of coactivators. In vitro, GF2 treatments reduced T0901317-induced fat accumulation and pro-inflammatory cytokine expression in hepatocytes and macrophages, respectively. Consistently, GF2 administration ameliorated hepatic steatohepatitis and improved glucose or insulin tolerance in WT but not in LXRα^-/- mice. Conclusion: GF2 alters the binding affinities of LXRα coregulators, thereby interrupting hepatic steatosis and inflammation in macrophages. Therefore, we propose that GF2 might be a potential therapeutic agent for the intervention in patients with MASLD.

• Korean Journal of Applied Biomechanics
• /
• v.33 no.4
• /
• pp.175-184
• /
• 2023

Objective: The purpose of this study is to investigate the effects of human motion and javelin kinematics during the energy transfer in javelin throwing on records, and to provide evidence-based training insights for athletes and coaches to enhance records. Method: Three javelin throw athletes (age: 22.67 ± 0.58 years, height: 178.33 ± 7.37 cm, weight: 83.67 ± 1.15 kg) were recruited for this study. Each athlete attempted ten maximum record trials, and the kinematic data from each performance were analyzed to determine their influence on the records. The Theia3d Markerless system was used for motion analysis. Results: Key factors were modeled and identified at each moment. In E1, main variables were COM Y (𝛽 8.162, p<.05) and COM velocity Z (𝛽 -72.489, p<.05); in E2, COM X (𝛽 -17.604, p<.05); in E3, COM X (𝛽 -18.606, p<.05), COM velocity Y (𝛽 38.694, p<.05), and COM velocity X (𝛽 66.323, p<.05). For the javelin throw dynamics in E3, key determinants were Attitude angle and Javelin velocity in the Y-axis. Conclusion: The study reveals that controlled vertical movement, center of mass management during braking, and enhanced pelvic rotation significantly improve javelin throw performance. These kinematic strategies are critical for record enhancement in javelin throwing.

• Nuclear Engineering and Technology
• /
• v.56 no.1
• /
• pp.257-264
• /
• 2024

The sodium cooled fast reactor (SFR) is one of the Gen-IV reactors with the most operating experience accumulated. Although the technology level is the most mature among the Gen-IV reactors, there is still a safety problem that has not been solved, which is the sodium-water reaction. Since sodium and water are separated only by a heat transfer tube with a thickness of only a few mm, there is inherently a risk of a sodium-water reaction (SWR) accident in the SFR. In this study, it is attempted to quantitatively evaluate the resistance of SWR accidents by replacing the shell and tube steam generator with printed circuit steam generator (PCSG) as a method to mitigate the SWR accident. To do this, a CATS-S (Compact Accident Tolerance Steam Generator-SWR) facility was designed and built. And for the quantitative evaluation of accident resistance, a methodology for measuring the impingement wastage rate was established. As a result of this research, the impingement wastage rate caused by SWR generated in a PCSG was measured first time. It was confirmed that the impingement wastage phenomenon was suppressed in the PCSG, and the accident resistance was higher than that of the SWR through comparison with the experimental results performed in the existing shell and tube steam generator. In conclusion, a PCSG is more resistant to impingement wastage as a result of the SWR accident than existing shell and tube steam generators, and it is estimated that a PCSG can mitigate SWR accidents, an inherent problem of SFR.

• The Journal of the Acoustical Society of Korea
• /
• v.30 no.4
• /
• pp.181-189
• /
• 2011

According to developments of digital signal processing, 3D sound come into focus on multimedia systems. Many studies on 3d sound have proposed lots of clues to create realistic sounds. But these clues are only focused on binaural systems which two ears are normal. If we make the 3d sound using those clues at monaural systems, the performance goes down dramatically. In order to use the clues for monaural systems, we have studies algorithms such as duplex theory. In duplex theory, the sounds that we listen are affected by human's body, pinna and shoulder. So, we can enhance sound localization performances using its characteristics. In this paper, we propose a new method to use psychoacoustic theory that creates realistic 3D audio at monaural systems. To improve 3d sound, we calculate the excitation energy rates of each symmetric HRTF and extract the weights in each bark range. Finally, they are applied to emphasize the characteristics related to each direction. Informal listening tests show that the proposed method improves sound localization performances much better than the conventional methods.

• Journal of the Korean Society for Marine Environment & Energy
• /
• v.19 no.1
• /
• pp.1-6
• /
• 2016

Ballast water in ship operation is essential for a safe voyage. However ballast water can contain unwanted organisms that are the cause of disturbing the ecosystem by the transfer of potential invasive species. To prevent the destruction of the environment, the International Convention for the Control and Management of Ship's Ballast Water and Sediments(BWM Convention) was adopted in 2004. BWMS (Ballast Water Management System) has been developed to prevent the transportation of organisms to another region in order to fulfill the requirements IMO (International Maritime Organization) regulations. Nowadays there are about 50 approved Ballast Water Management Systems of various types globally. The most common BWMS types are UV (Ultra Violet), Electrolysis and Ozone. Among these types there are many difficulties in determining the optimum type of BWMS which can be suitable for the user and designer's requirements. The main objective of this research is to select the best BWMS type by using AHP. To apply AHP, the most important criteria for the BWMS development are derived by users and designers. From our results, we can give a guide BWMS type to the developers of BWMS.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2016.02a
• /
• pp.286-286
• /
• 2016

Hexagonal boron nitride (hBN) is a dielectric insulator with a two-dimensional (2D) layered structure. It is an appealing substrate dielectric for many applications due to its favorable properties, such as a wide band gap energy, chemical inertness and high thermal conductivity[1]. Furthermore, its remarkable mechanical strength renders few-layered hBN a flexible and transparent substrate, ideal for next-generation electronics and optoelectronics in applications. However, the difficulty of preparing high quality large-area hBN films has hindered their widespread use. Generally, large-area hBN layers prepared by chemical vapor deposition (CVD) usually exhibit polycrystalline structures with a typical average grain size of several microns. It has been reported that grain boundaries or dislocations in hBN can degrade its electronic or mechanical properties. Accordingly, large-area single crystalline hBN layers are desired to fully realize the potential advantages of hBN in device applications. In this presentation, we report the growth and transfer of centimeter-sized, nearly single crystal hexagonal boron nitride (hBN) few-layer films using Ni(111) single crystal substrates. The hBN films were grown on Ni(111) substrates using atmospheric pressure chemical vapor deposition (APCVD). The grown films were transferred to arbitrary substrates via an electrochemical delamination technique, and remaining Ni(111) substrates were repeatedly re-used. The crystallinity of the grown films from the atomic to centimeter scale was confirmed based on transmission electron microscopy (TEM) and reflection high energy electron diffraction (RHEED). Careful study of the growth parameters was also carried out. Moreover, various characterizations confirmed that the grown films exhibited typical characteristics of hexagonal boron nitride layers over the entire area. Our results suggest that hBN can be widely used in various applications where large-area, high quality, and single crystalline 2D insulating layers are required.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.37 no.4
• /
• pp.331-341
• /
• 2013

In a solar domestic hot water (SDHW) system, solar energy is collected using collector panels, transferred to a circulating heat transfer fluid (brine), and eventually stored in a thermal storage tank (TST) as hot water. In this study, a computational fluid dynamics (CFD) model was developed to predict the solar thermal energy storage in a hybrid-type TST equipped with a helical jacket heater (mantle heat exchanger) and an immersed spiral coil heater. The helical jacket heater, which is the brine flow path attached to the side wall of a TST, has advantages including simple system design, low brine flow rate, and enhanced thermal stratification. In addition, the spiral coil heater further enhances the thermal performance and thermal stratification of the TST. The developed model was validated by the good agreement between the CFD results and the experimental results performed with the hybrid-type TST in SDHW settings.

• Journal of Energy Engineering
• /
• v.5 no.2
• /
• pp.108-114
• /
• 1996

It is one of the most important factors to enhance the efficiency of the solar collectors by in-creasing collecting efficiency and decreasing heat loss. The pulse electrodeposition method has been involved in this study to improve characteristics of the solar selective coating on 230cm${\times}$60cm substrates and electrical efficiency of the process. The composition of the electrolyte was 280 g/$\ell$ chromic acid, 15 g/$\ell$ propionic acid, and 10 g/$\ell$ appropriate additive. 230cm${\times}$60cm copper and aluminium sheets were utilized as the substrates. It has been observed that the black chrome coatings exhibited reasonable optical properties for commercialization when the plating parameters were properly controlled; the absorptance was 0.98 and 0.97 and omittance was 0.17 and 0.23 for copper and aluminium substrate, respectively. This study implies that the pulse current electrolysis method could be applied to the large scale substrates, and the various products can be avilable after the consideration of the thermal conductivity, heat transfer efficiency and cost problems of the substrates.

• Journal of Broadcast Engineering
• /
• v.21 no.3
• /
• pp.298-306
• /
• 2016

With the advent of Internet of Things (IoT) technology that allows the communications between things and devices over the Internet, a lot of researches on the IoT services, such as smart home or healthcare, have been progressed. In the existing machine-to-machine (M2M) communications, however, since the underlying link-layer technologies, such as Bluetooth or ZigBee, do not use the Internet Protocol (IP) communication, those technologies are not suitable to provide the IoT services. Accordingly, this paper discusses how to provide the Internet services in the M2M communication, and propose an implementation of the Constrained Application Protocol (CoAP) over 6LoWPAN for providing IoT services in the BLE networks. Based on the implementation, we compared the performance between HTTP and CoAP for IoT communications. From the experimental results, we can see that the CoAP protocol gives better performance than the HTTP protocol with two times higher throughput, 21% faster transmission time, and 22% smaller amount of generated packets.

• Analytical Science and Technology
• /
• v.6 no.5
• /
• pp.417-424
• /
• 1993

Eight-coordinate tetrakis molybdenum(IV) complexes containing 5,7-dichloro-8-hydroxyquinolinol(Hdcq) and 2-mercaptopyrimidine(Hmpd) has been prepared. $Mo(mpd)_4$, $Mo(dcq)(mpd)_3$, $Mo(dcq)_2(mpd)_2$, $Mo(dcq)_3(mpd)$ and $Mo(dcq)_4$ complexes have been isolated by thin-layer chromatography on silicagel plates. These complexes have been charaterized by $^1H-nmr$ spectrum and UV-Vis. spectrum. The chemical shift values of the protons ${\alpha}$ to the nitrogen in the ligands are shifted to down field. The relative intensities of the peaks which are positioned at the same proton of $Mo(dcq)(mpd)_3$ and $Mo(dcq)_3(mpd)$ are observed in 2:1 ratio, in case of $Mo(dcq)_2(mpd)_2$ appears in approximately a 1:1 ratio. The stereochemistry of the complexes in discussed in terms of their nmr spectrum and Orgel's rule. By vertue of the intensities (${\varepsilon}$>10,000~25,000) the low energy($16,600{\sim}19,800cm^{-1}$) bands are observed for the electronic spectra of the complexes are assigned as charge transfer bands.