• Genomics & Informatics
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• v.14 no.3
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• pp.104-111
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• 2016

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. In this study, we performed molecular docking analysis of these drugs against nonstructural 3 (NS3) protein of ZIKV. The protease activity of NS3 is necessary for viral replication and its prohibition could be considered as a strategy for treatment of ZIKV infection. Amongst these four drugs, berberine has shown highest binding affinity of -5.8 kcal/mol and it is binding around the active site region of the receptor. Based on the properties of berberine, more similar compounds were retrieved from ZINC database and a structure-based virtual screening was carried out by AutoDock Vina in PyRx 0.8. Best 10 novel drug-like compounds were identified and amongst them ZINC53047591 (2-(benzylsulfanyl)-3-cyclohexyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one) was found to interact with NS3 protein with binding energy of -7.1 kcal/mol and formed H-bonds with Ser135 and Asn152 amino acid residues. Observations made in this study may extend an assuring platform for developing anti-viral competitive inhibitors against ZIKV infection.

• Journal of Digital Contents Society
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• v.18 no.2
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• pp.249-256
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• 2017

As single-person households increase, demands for self interior design has been also increasing. The furniture arrangement takes big part of interior design. But sometimes people need professional helps for the proper and effective arrangement of furniture which makes self-interior design harder. Often, people share information and advices about interior design through Social Network Service. Experts could help directly but this approach would have several issues: First, the detailed and accurate advice would be difficult because experts have to examine the space through 2D pictures or video. Second, they have to make an appointment which would cause inconvenience to both customer and expert. In this paper, the furniture arrangement application for real-time sharing of interior design based on virtual reality is proposed to make up for the weak points. People can precisely share information and advice about self-interior design through this application in realtime, reducing waste of time and energy.

• Journal of IKEEE
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• v.15 no.4
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• pp.345-353
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• 2011

Recently portable mobile devices such as smart-phones and notebooks have rapidly increasing demands. Those devices consume more power because they are expected to offer more complex functionality including multimedia features. For these reasons engineering efforts are changing to focus on maximizing energy efficiency within a limited battery capacity instead of increasing computational performance. In this paper, we propose a battery management system using event driven programming technique on a embedded processor. We also show that the proposed system satisfies SBS (Smart Battery Specification) v1.1. The proposed system maintains minimum code size and memory size comparing to those of RTOSs. The proposed system can be also easily incorporated in the conventional RTOSs as a form of firmware.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.7
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• pp.1039-1046
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• 2017

Campus microgrid is designed and built by considering not only power generation but also power consumption management as connected microgrid type because the main goal of the campus microgrid is to save power consumption costs. There are many functions to achieve the goal and they are mainly to use generation-based functions such as islanding operation for peak management and for emergency events. In power distribution operation, Conservation Voltage Reduction (CVR) is applied in order to reduce power consumption. The CVR is defined as a function for load consumption reduction by voltage reduction in order to reduce peak demands and energy consumption. However, application of CVR to microgrid is difficult because the microgrid cannot control a tap of transformer in a substation and the microgrid normally is not designed with phase modifying equipment like a step-voltage-regulator which can control voltage in power distribution system operation. In addition, an impact of the CVR is depended on load characteristics such as a normal load, a rated power, and synchronous motors. Therefore, this paper proposes an application of CVR using linear voltage control based AVR in campus microgrid with power consumption reduction considering characteristics of load and component in the microgrid. The proposed system can be applied to each buildings by a configuration of power distribution cables; and the application results and CVR factor are presented in this paper.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.17 no.1
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• pp.54-60
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• 2003

Feeding traction loads from the public power system may lead to some current and voltage unbalance and consequently affects the operation of its energy-supply system and other equipment connected with it. This paper introduces an analysis of the current unbalance caused by the demands of an electric railway on a public power system. And the results with compensator and without compensator are simulated, and eventually the formula about the current unbalance is suggested. The Scott-connected transformer is adopted in Korea National Railway System. So Scott-connected transformer among the various transformer connection schemes is analyzed in this paper. Also, the formulas about the unbalance and compensating current can be derived by using two parameters(M-phase and T-phase current) of secondary Scott-connected transformer. So, the practical and accurate simulation can be done through dynamic models by using scheduling of traction.

• Journal of the Korean Institute of Gas
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• v.11 no.2 s.35
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• pp.43-54
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• 2007

Despite the importance of customer satisfaction corresponding to the phenomenal development of the gas industries, supplier-centered management still prevails in the city gas industry due to the monopolistic market environment. However, customer's demands for diverse and higher services are ever growing in the midst of the development and the accelerated competition of the service industries. In this context, customer satisfaction management may be the best style of management for establishing a short, mid and long-term foundation of growth. This paper derives directions for improving customer satisfaction management in such 3 areas as systematic, technological and service improvement from the environmental changes as well as from the customer needs. Based on the survey and comparative analysis of customer satisfaction, we also suggest 5 growth strategies to maintain sustainable development of the gas industry in the midst of competitive environment between city gas companies and among diversified energy businesses and to protect rights of the city gas consumers.

• Journal of the Korean Applied Science and Technology
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• v.36 no.1
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• pp.189-199
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• 2019

The aim of this study was to investigate the effect of combine exercise on the fall injury related index and myokine in elderly women. Sarcopenia leads to a loss of strength, alter on to a decreased functional status, impaired mobility, a higher risk of falls, and eventually an increased risk of mortality. Aerobic exercise characterized by rhythmic and repetitive movements of large muscles, for sustained periods that depends primarily on the use of oxygen to meet energy demands through aerobic metabolism, and that is structured and intended to generate improvements in cardiopulmonary fitness, body composition, and cardiorespiratory health. Resistance training has performance in the elderly. As combined exercise therapy can be used to enhance muscle functions and cardiopulmonary functions, it is being highlighted as an effective health management methods for the aged. The myokine has been regarded an important factor of exercise how muscle communicate adipose tissue, bone and muscle to exert beneficial effects at the whole body level.

• Food Science and Industry
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• v.51 no.3
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• pp.238-244
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• 2018

Hanwoo cattle have been genetically selected for enhancing meat quality and meat quantity since the last few decades. Beef consumption in South Korea has also increased to 11.6 kg per year in 2016 and is expected to continue to increase. For improving meat quality, Hanwoo cattle has been raised a high-energy corn-based diet for long fattening periods, which causes not increment of fat percentage in the loin muscle but increment of feeding costs. Consumer demands on the Korean beef industry are driving differing beef production systems and also changes to the beef grading system. For a sustainable Hanwoo industry, researcher in Korea have attempted to develop feeds for efficient fattening periods and precision feeding systems based on genetic information for Hanwoo cattle. Therefore, representatives of government, academics, and market association need to provide efficient collaboration for the future prospective or develop a precise management system for Hanwoo industry in Korea.

• Journal of Trauma and Injury
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• v.35 no.3
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• pp.209-214
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• 2022

We describe a case of hyperbaric oxygen therapy (HBOt) as an adjunct to treatment of a crush injury to the hand. A 34-year-old male paramedic was involved in a motor vehicle accident and admitted for diagnosis and surgical treatment. He sustained a crush injury to his right hand and presented with significant muscle damage, including multiple fractures and dislocations, an avulsion injury of the flexor tendons, and amputation of the distal phalanx of the little finger. He underwent reconstructive surgery and received HBOt over the following days. In the following 2 months, he lost the distal and middle phalanges of the little finger and recovered hand function. Posttraumatic compartment syndrome responds well to HBOt, which reduces edema and contributes to angiogenesis, as well as promoting the cascade of healing events. High-energy trauma causes massive cell destruction, and the blood supply is usually not sufficient to meet the oxygen demands of viable tissues. Hyperbaric oxygenation by diffusion through interstitial and cellular fluids increases tissue oxygenation to levels sufficient for the host's responses to injury to work and helps control the delayed inflammatory reaction. HBOt used as an adjunct to surgical treatment resulted in early healing and rehabilitation, accelerating functional recovery. The results suggest that adjunctive HBOt can be beneficial for the treatment of crush injuries of the hand, resulting in better functional outcomes and helping to avoid unnecessary amputations.

• Earthquakes and Structures
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• v.21 no.5
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• pp.551-562
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• 2021

In this study, the generalized intensity measure (IM) named I_Npg is analyzed. The recently proposed proxy of the spectral shape named N_pg is the base of this intensity measure, which is similar to the traditional N_p based on the spectral shape in terms of pseudo-acceleration; however, in this case the new generalized intensity measure can be defined through other types of spectral shapes such as those obtained with velocity, displacement, input energy, inelastic parameters and so on. It is shown that this IM is able to increase the efficiency in the prediction of nonlinear behavior of structures subjected to earthquake ground motions. For this work, the efficiency of two particular cases (based on acceleration and velocity) of the generalized I_Npg to predict the peak floor acceleration demands on steel frames under 30 earthquake ground motions with respect to the traditional spectral acceleration at first mode of vibration Sa(T₁) is compared. Additionally, a 3D reinforced concrete building and an irregular steel frame is used as a basis for comparison. It is concluded that the use of velocity and acceleration spectral shape increase the efficiency to predict peak floor accelerations in comparison with the traditional and most used around the world spectral acceleration at first mode of vibration.