• BMB Reports
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• 제52권10호
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• pp.607-612
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• 2019

During meiosis, programmed double-strand breaks (DSBs) are repaired via recombination pathways that are required for faithful chromosomal segregation and genetic diversity. In meiotic progression, the non-homologous end joining (NHEJ) pathway is suppressed and instead meiotic recombination initiated by nucleolytic resection of DSB ends is the major pathway employed. This requires diverse recombinase proteins and regulatory factors involved in the formation of crossovers (COs) and non-crossovers (NCOs). In mitosis, spontaneous DSBs occurring at the G1 phase are predominantly repaired via NHEJ, mediating the joining of DNA ends. The Ku complex binds to these DSB ends, inhibiting additional DSB resection and mediating end joining with Dnl4, Lif1, and Nej1, which join the Ku complex and DSB ends. Here, we report the role of the Ku complex in DSB repair using a physical analysis of recombination in Saccharomyces cerevisiae during meiosis. We found that the Ku complex is not essential for meiotic progression, DSB formation, joint molecule formation, or CO/NCO formation during normal meiosis. Surprisingly, in the absence of the Ku complex and functional Mre11-Rad50-Xrs2 (MRX) complex, a large portion of meiotic DSBs was repaired via the recombination pathway to form COs and NCOs. Our data suggested that Ku complex prevents meiotic recombination in the elimination of MRX activity.

• 대한기계학회논문집A
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• 제34권6호
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• pp.771-780
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• 2010

본 논문에서는 제작이 용이한 십자형 구조를 기본구조로 사용하여 판스프링 고정단을 가진 유연한 6축 로드셀을 설계하였다. 이를 위하여 유한요소법해석을 이용하여 강체 고정단과 판스프링 고정단에 대한 변형 분석을 하였으며 이로부터 특성이 우수한 6축 힘/토크 센서를 설계하였다. 변형률 분포를 이용하여 각 축의 하중에 대한 출력변형률이 비슷한 수준이 되도록 스트레인 게이지 위치를 정하고 상호간섭 변형률이 최소화 되도록 이들로 연결된 브리지회로를 구성하였다. 강체 고정단 대신에 스프링판 고정단을 이용하면 고정 경계부의 조건을 변화시킬 수 있어서 십자형 로드셀의 특성을 획기적으로 개선시킬 수 있었다. 치수 변경을 통하여 설계된 6축 로드셀에 대한 상호 간섭오차는 모든 축에서 0으로 계산되었으며 각 축에서 발생하는 출력변형률 값도 $400\;{\mu}m/m$의 비슷한 수준으로 결정되었다.

• 대한기계학회논문집B
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• 제28권12호
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• pp.1484-1493
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• 2004

In this study, it induced to a conclusion below by experiment consideration to regarding an effective supercooling ends method of the flow cooling water in a tube of continuous ice making method and the static cooling water in a tube of continuous ice making method which used magneticfluid in a dynamic type ice storage system. Continuous ice making in a tube of the flow cooling water was shortened about 12 minutes until supercooling ends that case which gave vertical eccentricity rotation magnetic field 120rpm than did not provide magnetic field by experimental result that was tested to supercooling ends effect from shape control of magneticfluid. Continuous ice making method in a tube of the static cooling water compared with and reviewed the case that was not provided with the magnetic field and exposed cooling surface instantaneously by magnetic field. It confirmed that supercooling degree $\Delta$ $T_{c}$, $\Delta$ $T_{s}$, and $\Delta$ $T_{w}$ became lower because of heat transfering increasing by the occurrence of natural convection between after cooling starting progress time 1∼3 minutes if it did not give a magnetic field, and peformed the supercooling ends when natural convection occurred confirmed that refrigerating capacity was better. That relation $\Delta$ $T_{c}$, and $t_{e}$/($\Delta$ $T_{c}$-$\Delta$ $T_{s}$) after convection occurred, was not depended on $T_{b}$ and initial temperature if the depth of water and thickness of magneticfluid were regular and it was possible to verify conjecture of tp from $\Delta$ $T_{s}$ and $\Delta$ $T_{c}$.lar and it was possible to verify conjecture of tp from $\Delta$ $T_{s}$ and $\Delta$ $T_{c}$.c}$.>.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1993년도 봄 학술발표회 논문집
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• pp.154-159
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• 1993

To develop the detailing methods at the ends of flexural shear walls. which are satisfying the ductility requirement corresponding to R = 3.5 and capable of improving the consturctibility, tests of ten isolated cantilever shear walls were carried out under the load condition comprising the cyclic lateral and constant vertical loads. major test parameters include the way of detailing and arrangement of transverse reinforcement in the boundary elements at the ends of walls, and placement of vertical reinforcement. From tests, comparable ductile behavior in test specimens incorporating the channel type of open hoops, compared with those incorporating the regular type of closed hoops, was observed.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2004년도 추계학술발표대회 개요집
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• pp.73-75
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• 2004

The purpose of this study is to optimize Nd:YAG laser welding parameters to seaz a Rf source into a Ti micro capsule. Ti tube ends can be sealed as some length of ぉbe end is melted and coalesced. The exact control of the melted length is the most important to get sound sealing. The Nozzle type, tube rotating speed, tilt angle, focal position, pumping voltage, pulse frequency and pulse width were selected as the Nd:YAG laser welding Parameters. These Parameters were optimized by the Taguchi experimental method using 115 orthogonal array. Appearance and cross section of the seated tube ends were examined by SEM.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.333_335
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• 2009

It is expected, in the near future, that the use of distributed generation systems should be increased considerably. In this case, distance relay algorithm should be developed in the manner that it can reduce the error due to the in-feed effect. This paper presents a method to consider the fault current rushed from the remote end of a line. In the steady-state, the relays in both ends exchange the voltages of upper nodes. If a fault is perceived, the relay calculates fault location taking the fault current from the remote end by using voltage data of the remote ends obtained just before the fault. Even though this method has inevitable error, it can show more precise fault allocation. The suggested method is applied to a typical transmission system with two power sources in both ends to verify its effectiveness.

• 한국농공학회지
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• 제19권3호
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• pp.4462-4471
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• 1977

The governing differential equations for the tapered circular arch with fixed ends have been derived, and a numerical procedure for the solution of these equations have been developed. The governing differential equations were solved numerically by an initial value integration procedure and Shooting Methods for boundary value problems. The Rungekutta fourth order integration technique was used. The methods was programmed for a Cyber 73-18 computer System, and all esults were obtained on this computer. A detailed study has been made for a fixed arch with an angle of opening equal to 0.7 radian, and the results are presented in detail in tables and curves. It is hoped that the results presented herein is applied to the deformations of gives point from the tri-axial direction of tapered circular arch with fixed ends, bending moment, and torsional moment, and that at the same time results to be used for archwise structures in steel structure.

• Structural Engineering and Mechanics
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• 제67권4호
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• pp.337-346
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• 2018

The purpose of this study is to investigate thermal post-buckling analysis of a laminated composite beam subjected under uniform temperature rising with temperature dependent physical properties. The beam is pinned at both ends and immovable ends. Under temperature rising, thermal buckling and post-buckling phenomena occurs with immovable ends of the beam. In the nonlinear kinematic model of the post-buckling problem, total Lagrangian approach is used in conjunction with the Timoshenko beam theory. Also, material properties of the laminated composite beam are temperature dependent: that is the coefficients of the governing equations are not constant. In the solution of the nonlinear problem, incremental displacement-based finite element method is used with Newton-Raphson iteration method. The effects of the fibber orientation angles, the stacking sequence of laminates and temperature rising on the post-buckling deflections, configurations and critical buckling temperatures of the composite laminated beam are illustrated and discussed in the numerical results. Also, the differences between temperature dependent and independent physical properties are investigated for post-buckling responses of laminated composite beams.

• 한국임상수의학회지
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• 제18권2호
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• pp.156-159
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• 2001

A 6-year-old male mongrel dog with a 7-month history of ulnar-radial nonunion fracture was treated with implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2). The dog had received surgical correction three times prior to the admission but radiography of the affected limb revealed a typical figure of nonunion fracture. Glossly, the fractured ends were sclerotic and the area between the ends was filled with fibrous tissue. After debridement the shaft was fixed by an 10-hole plate. rhBMP-2 at a total dose of 256 micrograms was implanted with a synthetic carrier into the 10-mm defect formed by the debridement. Callus formation responding to rhBMP-2 was radiographically observed at 4 weeks after implantation and the defect bridged both fracture ends by 8 weeks after implantation. The plate was removed at 12 months after implantation. Any complications were not observed for 5 months after removal of the plate.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 춘계 학술논문 발표대회 2부
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• pp.133-136
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• 2011

This study concerned with the steel beam of bonding method and bonded steel beams by this method and both ends of different height, steel beams and steel beams in the center makes the junction. Both ends and the central part of steel beams connecting the lower flange by additional combining steel plates to convey stress, the stress to focus on the beam connections are passed to both ends of steel beams, and strength of beam connections is improved and steel structural beams is proposed to minimize the loss by Incision. If you use the developed method, the construction period is shortened, and reducing the amount of material can decrease the cost and reduction in floor height can be maximized business feasibility.