• Obstetrics & gynecology science
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• 제61권6호
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• pp.702-706
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• 2018

A supernumerary ovary is a rare gynecological anomaly, and is usually excised due to its malignant transformation potential. We report a case of a supernumerary ovary and endometriosis situated on the anterior rectosigmoid colon. When laparoscopy was conducted, a firm, 5-cm mass was discovered on the anterior rectosigmoid colon along with normal ovaries. In this case, the discovery of a supernumerary ovary implied the presence of endometriosis. It is unusual for endometriosis and a supernumerary ovary to exist simultaneously.

• Clinical and Experimental Reproductive Medicine
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• 제41권4호
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• pp.151-157
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• 2014

Objective: To evaluate the association between the severity of endometriosis and the preoperative neutrophil-to-lymphocyte ratio (NLR) and serum level of cancer antigen 125 (CA 125). Methods: Data were obtained from the medical records of 419 patients who underwent laparoscopic conservative surgery for ovarian endometrioma between April 2005 and March 2013. Each patient's preoperative complete blood count was recorded and the endometriosis score was assessed. Results: The endometriosis score was not associated with either the NLR or the serum level of CA 125. The endometriosis score was negatively related to preoperative hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. The only positive association was between NLR and the patients' age. NLR and preoperative serum anti-M$\ddot{u}$llerian hormone level were found to be negatively related. Conclusion: The severity of endometriosis was not associated with the serum level of CA 125 or the NLR. The presence of a negative correlation between the severity of endometriosis and red blood cell dynamics needs further investigation.

• Clinical and Experimental Reproductive Medicine
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• 제48권1호
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• pp.80-84
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• 2021

Objective: The aim of the study was to investigate pregnancy, obstetric, and neonatal outcomes in women with small (<4 cm) unilateral endometriomas. Methods: This retrospective study included 177 patients: 91 patients with small endometriomas and 86 controls with unexplained or tubal factor infertility who were treated at the Süleymaniye Gynecology and Maternity Training and Research Hospital Infertility Unit between January 2010 and July 2015. The groups were matched with regards to demographic characteristics such as age, body mass index, and infertility duration. All of the women in this study conceived via intracytoplasmic sperm injection. We compared pregnancy, obstetric, and neonatal outcomes between these groups. Results: Women with endometriomas had a higher biochemical pregnancy rate, but lower clinical pregnancy and live birth rates than women with unexplained and tubal factor infertility (p<0.05 for all). However no significant differences were found in terms of obstetric and neonatal complications between the two groups (p>0.05 for all). Conclusion: In this study, we found that women with endometriomas less than 4 cm were more prone to early pregnancy complications. We also showed that this group did not have any increased risks of late pregnancy, obstetric, and neonatal complications.

• 대한한방부인과학회지
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• 제36권3호
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• pp.25-45
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• 2023

Objectives: The purpose of this study is to review the clinical research trends of ovarian cysts and to recognize the efficacy of Korean medicine intervention. Methods: Based on four domestic databases, including Korean studies Information Service System (KISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Medical Database (KMbase) and Research Information Sharing Service (RISS), we analyzed the case reports using Korean medicine intervention, which include acupuncture, moxibustion and herbal medicine. Data retrieval was carried out from May 12^th, to 18^th, 2022, and a total of 9 papers were included. Results: All papers were published in Korea and they contain seventeen case reports in total. The most frequently used intervention was herbal medicine, especially Gyejibokryeong-hwan-gami (桂枝茯苓丸加味), Guichulpajing-tang-gagam (歸朮破癥湯加減), Guibiondam-tang-gami (歸脾溫膽湯加味). Most cases reported statistically significant results on using Korean-medicine intervention. Also, there was no serious side effect of Korean medicine. Conclusions: In this study, we investigated the efficacy of Korean medicine intervention as an adjuvant therapy for ovarian cyst patients and research trends on ovarian cysts. Further studies are needed to supplement the safety and the evaluation of Korean medicine. However, the results should be taken cautiously as more clinical studies are needed.

• Clinical and Experimental Reproductive Medicine
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• 제50권4호
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• pp.270-276
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• 2023

Objective: This study investigated the clinical and laboratory factors associated with the presence of dysmorphic oocytes in intracytoplasmic sperm injection (ICSI) cycles. Methods: The study involved 200 ICSI cycles, performed from 2020 to 2021, that yielded at least one mature oocyte. Clinical characteristics and ovarian stimulation methods were compared between 68 cycles with at least one dysmorphic oocyte (the dysmorphic group) and 132 cycles with normal-form oocytes only (the non-dysmorphic group). Dysmorphic oocytes were characterized by dark cytoplasm, cytoplasmic granularity, cytoplasmic vacuoles, refractile bodies in the cytoplasm, smooth endoplasmic reticulum in the cytoplasm, an oval shape, an abnormal zona pellucida, a large perivitelline space, debris in the perivitelline space, or an abnormal polar body. Results: The ages of the women, indications for in vitro fertilization, serum anti-Müllerian hormone levels, and rates of current ovarian endometrioma were similar between the dysmorphic and non-dysmorphic groups. In both groups, the three ovarian stimulation regimens, two types of pituitary suppression, and total gonadotropin dose were employed similarly. However, the dual-trigger method was used more frequently in the dysmorphic group (67.6% vs. 50%, p=0.024). The dysmorphic group contained significantly more immature oocytes and exhibited significantly lower oocyte maturity (50% vs. 66.7%, p=0.001) than the non-dysmorphic cycles. Within the dysmorphic group, significantly lower oocyte maturity was found in the cycles using a dual-trigger, but not in those with a human chorionic gonadotropin trigger. Conclusion: ICSI cycles with dysmorphic oocytes are closely associated with reduced oocyte maturity. This association was observed exclusively in dual-trigger cycles.

• Clinical and Experimental Reproductive Medicine
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• 제34권3호
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• pp.149-157
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• 2007

목 적: 본 연구는 세포간 부착과 유착에 관여하는 당단백질의 하나인 osteopontin (OPN)의 mRNA와 단백질의 발현 양상을 자궁내막증 환자의 정상위치 자궁내막조직과 이소성 자궁내막조직, 대조군의 자궁내막조직에서 비교, 분석하기 위해 시행되었다. 연구방법: 개복 또는 복강경 수술을 통하여 자궁내막증으로 확진된 환자 32명을 연구 대상으로 하였고 같은 시기에 자궁경부 상피내암 또는 자궁내막증 이외의 양성 부인과 질환으로 수술적 치료를 받은 환자 34명을 대조군으로 하였다. 수술 시 자궁내막종 또는 복강내 자궁내막 이식물로부터 이소성 자궁내막조직을 얻었고, 동시에 정상위치 자궁내막조직을 생검하였다. 자궁내막조직 내의 OPN mRNA의 발현 정도는 실시간 역전사 중합효소연쇄반응을 이용하여 비교하고 단백질 발현에는 western blot 분석을 사용하였다. 각 군 간의 비교에는 ANOVA와 Krusxal-Wallis test를 사용하였으며 p-value 0.05 미만을 유의한 것으로 판정하였다. 결 과: 월경주기의 증식기와 분비기 모두에서 자궁내막중 환자의 정상위치 및 이소성 자궁내막조직에서의 OPN mRNA의 발현은 대조군의 자궁내막조직에 비해 유의하게 높은 것으로 나타났다 자궁내막중 환자에서 정상위치 자궁내막조직의 경우 OPN mRNA의 발현은 증식기에 비해 분비 기에서 의미 있게 증가하였으나 이소성 자궁내막 조직에서는 분비기에서 뚜렷하게 감소하는 양상으로 나타났다. OPN 단백질의 발현도 mRNA의 발현과 마찬가지로 자궁내막중 환자에서 유의하게 높은 것으로 확인되었다. 결 론: 본 연구의 결과는 자궁내막증이 있는 여성의 정상위치 및 이소성 자궁내막 조직에서의 증가된 OPN mRNA 및 단백질의 발현이 자궁내막 조직의 유착 및 침습에 관여할 수 있음을 시사한다.