• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.118-131
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• 1995

According to the oriental medicine study on G.B.S, we obtained the result as follows : 1. G.B.S was inclined in flacid paralysis and pain and numbness(痺) in oriental medicine. 2. Etiology factors of G.B.S was classified exogenous and endogenous pathogenic factors. The formers was warmth and heat(濕熱), summer heat and dampness(暑濕), dampness and heat(濕熱), and cool and dampness(寒濕), the latter was the deficiency in both the spleen and the stomach(脾胃虛弱), deficiency of Yin(vital essence) in both the liver and kidney(肝腎陰虛) the factor of dampness and heat(濕熱) was most numerous. 3. Pathological mechanism of G.B.S was close connected with the five viscera - the spleen(脾), the stomach(胃), the liver(肝), the kidney(腎), the lung(肺) 4. Differentiation of Symptom-Complexes(辨症) in the G.B.S was consumption type of nutrient fluid due to heat symptom in the lung(肺熱傷津), fullness type of dampness and heat(濕熱侵淫), defiency type in both the spleen and the kidney(脾腎不足), deficiency type in both the spleen and the stomach(脾胃虛弱), deficiency type in the liver and the kidney(肝腎兩虛) 5. Acupuncture treatment for G.B.S was mainly Yangmoung channels of both the hand and the foot.(手足陽明經)

• The Journal of Internal Korean Medicine
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• v.21 no.5
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• pp.739-745
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• 2000

xWe studied about the causes of hypertension in the occidental and oriental medical records and the results are as follows. 1. The causes of hypertension in oriental medicine can be divided into wind, fire, phlegm and deficiency of Qi in our body, and broadly into three categories as emotions in excess, improper diet and damages of endogenous etiological factors. 2. Hypertension is the disease of undermining of fundamental aspects while prevailing incidental aspects and liver, heart and kidneys are the organs mainly related to hypertension. 3. The main pathological factors of hypertension are as follows; the disorder of Yin and Yang makes the situation of the deficiency of the vital essence of kidneys and the exuberance of the vital essence of liver and they are the fundamentals to be taken hypertension and finally make the state of the deficiency of both Yin and Yang. 4. In the point of occidental medical view, the essential hypertension is a disease of unknown etiology and we think it occurs not on the only one factor but on the various factors and secondary hypertension occurs from the diseases of the substances and the vessels of kidneys.

• Research in Community and Public Health Nursing
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• v.31 no.3
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• pp.395-404
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• 2020

Purpose: This study was conducted to develop a predictive model for happiness of students in general high schools. The study was based on the theory of happiness integration and the literature review. Methods: Data were collected using a convenience sample of 231 first and second grade students in five general high schools in D city and K Province. The exogenous variables were optimism as personality factors, parenting attitude, academic stress and friend's support as happiness. The endogenous variables were self-esteem and resilience as mediating variables, and happiness of students in general high schools. Data collection was done from March 14 to March 28, 2019. The AMOS 22.0 and SPSS programs were used to verify the validity of confirmatory factor analysis and hypothesis models. Results: The factors that have the greatest influence on happiness of high school students are self-esteem and resilience. The explanatory power of happiness by these variables was 98.1%. The individual mediating effect and double mediation effect of these variables were found to be significant. Conclusion: As student's optimistic personality, parent's positive parenting attitude, and friend's support improve student's self-esteem and resilience, ultimately positively affecting high school students' happiness, so it is necessary to consider these factors and try to develop a happiness improvement program.

• Journal of Korean Academy of Nursing Administration
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• v.21 no.4
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• pp.366-374
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• 2015

Purpose: This study was designed to identify a path model that anticipates the interpersonal competence of nurses by anticipating factors that explain interpersonal competence within an organization, and analyzing the effects of these factors. A hypothetical model was formulated based on a literature review of interpersonal competence. For the study, influential factors were divided into two variables: exogenous variables including communication style, coaching leadership, and social support, and endogenous variables of self-efficacy, job satisfaction, and organizational commitment. Methods: The sample included 202 hospital nurses. Data were collected through questionnaires and analyzed using SPSS and AMOS. Results: The overall fitness was good ($x^2=74.707$, p<.001), d.f=19, $x^2/df=3.932$, GFI=.940, AGFI=.826, RMR=.009). Social support, self-efficacy, horizontal communication and organizational commitment directly affected the interpersonal competence of the nurses, and informal type of communication, horizontal, upward communication and coaching leadership indirectly effected the interpersonal competence of the nurses. Horizontal communication, social support, self-efficacy, and organizational commitment explained 46.5% of the variance in interpersonal competence of nurses. Conclusion: Based on the study results, nurses in hospitals need informal types of communication, horizontal, upward communication and coaching leadership to increase their interpersonal competence.

• BMB Reports
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• v.35 no.1
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• pp.87-93
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• 2002

Neural cell survival is an essential concern in the aging brain and many diseases of the central nervous system. Neural transplantation of the stem cells are already applied to clinical trials for many degenerative neurological diseases, including Huntington's disease, Parkinson's disease, and strokes. A critical problem of the neural transplantation is how to reduce their apoptosis and improve cell survival. Neurotrophic factors generally contribute as extrinsic cues to promote cell survival of specific neurons in the developing mammalian brains, but the survival factor for neural stem cell is poorly defined. To understand the mechanism controlling stem cell death and improve cell survival of the transplanted stem cells, we investigated the effect of plausible neurotrophic factors on stem cell survival. The neural stem cell, HiB5, when treated with PDGF prior to transplantation, survived better than cells without PDGF. The resulting survival rate was two fold for four weeks and up to three fold for twelve weeks. When transplanted into dorsal hippocampus, they migrated along hippocampal alveus and integrated into pyramidal cell layers and dentate granule cell layers in an inside out sequence, which is perhaps the endogenous pathway that is similar to that in embryonic neurogenesis. Promotion of the long term-survival and differentiation of the transplanted neural precursors by PDGF may facilitate regeneration in the aging adult brain and probably in the injury sites of the brain.

• Land and Housing Review
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• v.11 no.1
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• pp.79-86
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• 2020

The number of business closure is one of key indicators diagnosing the status of local economy. The increases in closure are attributed to various endogenous/exogenous factors such as decreases in sales of stores, decline of local market, deterioration of global financial condition, but it is not trivial task to figure out the cause and effect mechanism among variables. The effects of those factors are expected to show geographical variations, which the empirical analysis results in this study presented. As such, the objective of this study is to estimate the effects of variables on increase in the number of business closure and examine the distributional properties of the geographic variations of the effects among spatial units of analysis. To this end, GWR (Geographically Weighted Regression) model was utilized to draw empirical analysis outcomes. It is expected that the outcomes of the sort in this research may be useful in aiding decision-making process of drafting locality-specific policies and/or deciding where to prioritize the limited public resources available.

• Journal of Information Technology Services
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• v.20 no.4
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• pp.113-128
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• 2021

In the rapidly developing 4th industrial revolution. RPA is increasing in use at home and abroad due to its advantages of simplifying workflow and providing flexibility and scalability at the same time. Thus, this paper conducted an empirical study on companies using RPA to determine which factors affect the intention to use the services provided by RPA systems. As system characteristics, exogenous variables were selected as information quality, system quality, and service quality of the information system success model. The endogenous variables were selected as the system acceptance factors for the performance and effort expectancy of the integrated technology acceptance model, and the perceived economic values and functional values were additionally selected. For the purpose of this study, a structured questionnaire was used for empirical analysis and the proposed hypothesis was verified through the path analysis of structural equations. As a result of the study, there was no significant relationship between service quality and effort expectancy, between service quality and economic value, and it was verified that the relationship between other factors was positively significant.

• International Journal of Industrial Entomology and Biomaterials
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• v.37 no.1
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• pp.21-28
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• 2018

CRISPR/Cas9 gene editing system is an efficient method to mutation in a sequence specific manner. Here we report the direct transfection of the Cas9 nuclease and gene specific guide RNA can be used in BM-N cell line derived from Bombyx mori ovarian tissue to enfeeble function of endogenous gene in vitro. We have used gene editing system to negative regulation components of major signaling cascade, the Toll pathway, which controls B. mori resistance to microbe infections, such as fungi and gram positive bacteria. We demonstrate that the $I{\kappa}B-like$ protein Cactus may controls the activation of transcription factors such as Rel A and Rel B. The direct transfection of Cas9 nuclease and Cactus-specific guide-RNA complex may be used in BM-N cells to disrupt the function of endogenous genes in vitro. A mutation frequency of 30-40% was observed in the transfected cells, and various mutations caused the target region. Moreover, RT-PCR analysis revealed that Cactus gene was down regulated after these mutations. More importantly, mutation of BmCactus stimulated expression of lysozyme, moricin, and lebocin genes. These results suggest that the CRISPR/Cas9 systems are expected to efficiently induce site-specific mutations and it was possible to produce antimicrobial peptide through the gene editing.

• Journal of Microbiology and Biotechnology
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• v.30 no.10
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• pp.1597-1606
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• 2020

Transcription factor engineering to regulate multiple genes has shown promise in the field of microalgae genetic engineering. Here, we report the first use of transcription factor engineering in Chlorella sp. HS2, thought to have potential for producing biofuels and bioproducts. We identified seven endogenous bZIP transcription factors in Chlorella sp. HS2 and named them HSbZIP1 through HSbZIP7. We overexpressed HSbZIP1, a C-type bZIP transcription factor, in Chlorella sp. HS2 with the goal of enhancing lipid production. Phenotype screening under heterotrophic conditions showed that all transformants exhibited increased fatty acid production. In particular, HSbZIP1 37 and 58 showed fatty acid methyl ester (FAME) yields of 859 and 1,052 mg/l, respectively, at day 10 of growth under heterotrophic conditions, and these yields were 74% and 113% higher, respectively, than that of WT. To elucidate the mechanism underlying the improved phenotypes, we identified candidate HSbZIP1-regulated genes via transcription factor binding site analysis. We then selected three genes involved in fatty acid synthesis and investigated mRNA expression levels of the genes by qRT-PCR. The result revealed that the possible HSbZIP1-regulated genes involved in fatty acid synthesis were upregulated in the HSbZIP1 transformants. Taken together, our results demonstrate that HSbZIP1 can be utilized to improve lipid production in Chlorella sp. HS2 under heterotrophic conditions.

• Korean Journal of Social Welfare
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• v.38
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• pp.33-67
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• 1999

This study is the second phase of the author's larger attempt to investigate the factors affecting housewives' caregiving behavior to their elderly parents-in-law. Specifically, it revises and expands the previous model (1998) and develops a new one by rectifying the three major problems inherent in the previous study: (1) misspecification error; (2) non-equivalent comparison of results between the father-in-law model and mother-in-law model that stems from the inclusion of heterogeneous group of caregivers; (3) measurement problems for the two endogenous variables of eldercare attitude and behavior. To do this, the current study proposes a more comprehensive model by additionally incorporating other salient exogenous variables, renders the comparison of results between the father-in-law and mother-in-law models equivalent by including only homogeneous group of caregivers (i. e., only those housewives whose parents-in-law are both alive), and introduces standardized measurement scales for the endogenous variables. Estimation of the model in terms of maximum likelihood procedures in LISREL8 attests to a better overall performance over the previous model when judged from several criteria such as coefficient of determination, model fit statistics, proportion of significant causal paths, and measurement properties of reliability and validity for the variables. Interpretation of the findings suggests several salient theoretical implications that concern such crucial issues as the inconsistency between eldercare attitude and behavior, patterns of association among the subdimensions of eldercare, and the difference in the antecedents explaining attitude as opposed to behavior of eldercare. In particular, the finding that indicates almost no differences in the determinants between the father-in-law and mother-in-law models suggests a strong case to argue that caregiving behavior to fathers-in-law and mothers-in-law, respectively, is likely to be a uniform phenomenon sharing virtual1y the same antecedents, and that a unified single model is sufficient to account for caregiving behavior to both parties.